Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1396
11
1
gregorian
2018
2
1
32
1
online
1
fulltext
en
A double blind randomized clinical trial to investigate the effect of vitamin D supplementation on metabolic and hepato-renal markers in type 2 diabetes and obesity
Nutrition
Nutrition
Original Research
Original Research
<strong>Background: </strong>According to the recent studies, vitamin D deficiency has been correlated with progress in type 2 Diabetes and Metabolic Syndrome. The aim of this study was to assess the effect of vitamin D supplementation on glucose and lipid profiles, blood pressure, and biomarkers of liver and kidney in type 2 diabetic patients.<br>
<strong> Methods:</strong> In this Double blinded randomized clinical trial, 90 patients with type 2 diabetes and serum 25-Hydroxy vitamin D levels of less than 30 ng/ml recruited from “Besat Diabetes Clinic” in Rasht, North of Iran. The subjects took 50000 IU vitamin D supplements or placebo for 8 weeks. We assessed the levels of serum 25 (OH) vitamin D, glucose and lipid profiles, oxidative and inflammatory indices, liver and kidney biomarkers, blood pressure, and sun exposure time, physical activity before and after intervention, and compared them between cases and controls.<br>
<strong> Results:</strong> Vitamin D supplementation significantly increased serum vitamin D level, Superoxide Dismutase (SOD) activity, and significantly decreased serum HbA1C (Glycosylated Hemoglobin) level (p<0.001). High Density Lipoprotein (HDL) Cholesterol increased significantly (p=0.016), and Erythrocyte Sedimentation Rate (ESR) significantly decreased (p=0.039) after the intervention.<br>
<strong> Conclusion:</strong> Our results represented that weekly supplementation with 50000 IU vitamin D for 8 weeks may be effective by improving HbA1C and lipid profile in type 2 diabetes mellitus.<br>
Vitamin D, Glucose, Diabetes, Lipid, Diet, Nutrition, Liver, Kidney, Type 2 diabetes, Inflammation
201
204
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-3755-3&slc_lang=en&sid=1
Peivasteh
Safarpour
Peivastehsafarpour@yahoo.com
200319475328460038797
200319475328460038797
No
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Reza
Vafa
Rezavafa@yahoo.com
200319475328460038798
200319475328460038798
Yes
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Fatemehsadat
Amiri
f.amiri58@yahoo.com
200319475328460038799
200319475328460038799
No
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Leila
Janani
Leila_Janani@yahoo.com
200319475328460038800
200319475328460038800
No
Department of Biostatistics, School of Public Health, Preventive Medicine and Public Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
Mitra
Noorbakhsh
Nourbakhsh.m@iums.ac.ir
200319475328460038801
200319475328460038801
No
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Ensieh
Rajabpour Nikoo
ncnikoo2@gmail.com
200319475328460038802
200319475328460038802
No
Homa
Sadeghi
homa.sadeghi@gmail.com
200319475328460038803
200319475328460038803
No
Department of Epidemiology, School of Massachusetts Lowell, Massachusetts, USA.