Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1391
2
1
gregorian
2012
5
1
26
2
online
1
fulltext
en
The role of Human papilloma virus (HPV) genotyping in recurrent respiratory papillomatosis in Rasoul Akram Hospital
Otorhinolaryngology
Otorhinolaryngology
Original Research
Original Research
<font size="3" face="Times New Roman"> </font><font face="Calibri"><font size="3"><b>Background:</b> The most common laryngeal mass in children is recurrent respiratory papillomatosis (RRP). <span style="mso-spacerun: yes"> </span></font><font size="3">Studies have attempted to correlate viral typing and its aggressiveness.<p></p></font></font><font size="3" face="Times New Roman"> </font><p style="TEXT-ALIGN: justify MARGIN: 0in 0in 10pt" class="MsoNormal"><font face="Calibri"><font size="3"><b>Method:</b> 29 patients with histologically confirmed RRP enrolled in adjuvant therapies. Patients underwent several surgical interventions.<p></p></font></font></p><font size="3" face="Times New Roman"> </font><font face="Calibri"><font size="3"><b>Results:</b> HPV genotyping demonstrated 45% HPV-6 and 55% HPV-11. The mean age at the first surgical intervention was 52.39 months (SD=102.28) (range from 4 months to 426 months). The mean number of surgical intervention was 10.39 (SD=7.76) (range from 2 to 30). The mean time of surgical intervals was 4.63 months (SD=4.02) (range from 2 to 24 months). In fourteen patients (48%) tracheotomy was done. All patients who had tracheotomy received alpha-interferon. One of our cases was a male who had pulmonary extension with HPV-6.<p></p></font></font><font size="3" face="Times New Roman"> </font><p style="TEXT-ALIGN: justify MARGIN: 0in 0in 10pt" class="MsoNormal"><font size="3"><font face="Calibri"><b>Conclusion:</b> A review of patients with RRP was regarding to HPV genotyping and need for adjuvant therapy and tracheostomy. Mean number of surgical procedure was 10/40 and nearly fourteen patients (48%) need to tracheotomy. The clinical differences between HPV6 and HPV11 disease may not be accurately predictable. Patients with less age and with HPV-11 seemed to have more severe problems, but these differences were not statistically significant which needs much more investigations for reasonable starting point of evaluation for these differences.<p></p></font></font></p><font size="3" face="Times New Roman"> </font>
Respiratory tract diseases, Papillomatosis, Laryngeal neoplasms, Human papillomavirus, Human papillomavirus.
90
93
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-304&slc_lang=en&sid=1
Farzad
Izadi
izadimd@yahoo.com
20031947532846007492
20031947532846007492
No
Department of Otolaryngology, ENT.HNS research center, Tehran University of Medical Sciences, Tehran, Iran.
Rasool
Hamkar
rhamkar@ Sina.tums.ac.ir
20031947532846007493
20031947532846007493
No
Department of Virology, Tehran University of Medical Sciences, Tehran, Iran.
Hadi
Ghanbari
ghanbari_md@tums.ac.ir
20031947532846007494
20031947532846007494
Yes
Department of Otolaryngology, ENT.HNSresearch center, Tehran University of Medical Sciences. Rasoul Akram Hospital/Niayesh St. Sattarkhan Avenue, Tehran, Iran.
Fereshteh
Abdolmotallebi
fereshteh_abdolmotallebi@yahoo.com
20031947532846007495
20031947532846007495
No
Department of Otolaryngology, ENT.HNS research center, Tehran University of Medical Sciences.
Hesam
Jahandideh
hesam_jahandideh@yahoo.com
20031947532846007496
20031947532846007496
No
Department of Otolaryngology, ENT.HNS research center, Tehran University of Medical Sciences, Tehran, Iran.