Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1387
5
1
gregorian
2008
8
1
22
2
online
1
fulltext
en
Prevalence of hepatitis delta virus infection in various groups with HBVinfection in Tehran, Imam Khomeini Hospital (2005-2006)
Internal Medicine & Gastroenterology
Internal Medicine & Gastroenterology
Original Research
Original Research
<p> </p><p> <strong> Abstract </strong></p><p> <strong> Background: </strong>Hepatitis B virus infection is an important cause of liver morbidity and </p><p> mortality worldwide. HDV changes the natural course of HBV. The prevalence of HDV infection wasn’t determined in the various groups of HBV infection (carriers, acute hepatitis, chronic hepatitis, cirrhosis and HCC) in Iran. We aimed to research the prevalence of hepatitis D virus infection in various groups with HBV infection in Imam Khomeini Hospital, Tehran (2005-2006). </p><p> <strong>Methods:</strong> Serological markers of HBV and HDV infection [HBs Ag, Hbe Ag, Anti Hbe Ab, Anti HDVAb (IgM, IgG)] were determined by ELISA test in 206 patients with HBV infection who referred to Imam Khomeini Hospital (2005-2006).These patients were categorized to asymptomatic carriers, acute hepatitis, chronic hepatitis, cirrhosis and HCC according to history, physical examination and lab findings. </p><p> <strong>Result:</strong> HDV infection was detected in 12.6% ( 26/206) of HBV infected patients. It was detected in 1.6%(1/62) of asymptomatic carriers, 20% (1/5) of acute hepatitis, 5.6%(5/88) of chronic hepatitis, 37.2% (16/43) of cirrhosis and 37.5% (3/8) of HCC patients. HDV infection showed a five-fold increase in chronic hepatitis (P<0.05) and ~16 fold increase in cirrhosis (P< 0.001) compared to HDV infection in asymptomatic carriers. HDV infection was equally distributed between sexes. Mean ages of HDV carriers, acute hepatitis, chronic hepatitis ,cirrhosis and HCC were (28), (33), (39.521), (47.111.5), (58.69,2 ) year respectively. </p><p> <strong> Conclusion: </strong>The prevalence of HDV infection was 12.6%. The higher prevalence of </p><p> HDVinfection in more severe forms of hepatitis B virus infection suggests that HDV infection increases the severity of chronic hepatitis B. HDV infection remains a major cause of chronic liver disease in Tehran in spite of its decreasing prevalence in countries such as Italy. </p>
HBV, HDV, epidemiology
93
97
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-49&slc_lang=en&sid=1
Hossein
Foroutan
20031947532846001611
20031947532846001611
No
Tehran University of Medical Sciences, Tehran, Iran.
Alireza
Nemati
:Nematia63@yahoo.com,
20031947532846001612
20031947532846001612
Yes
Zabol University of Medical Sciences
Mohsen
Nasiri-Tosi
20031947532846001613
20031947532846001613
No
Tehran University of Medical Sciences.
Hadi
Ghofrani
20031947532846001614
20031947532846001614
No
Tehran University of Medical Sciences.
Hossein
Keivani
20031947532846001615
20031947532846001615
No
Tehran University of Medical Sciences...