Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1398
11
1
gregorian
2020
2
1
34
1
online
1
fulltext
en
Serum irisin levels in metabolically healthy versus metabolically unhealthy obesity: A case-control study
Nutrition
Nutrition
Original Research
Original Research
<strong>Background: </strong>Metabolically healthy obese (MHO) individuals appear to be protected or more resistant to the progression of obesity-related metabolic disorders. Hormonal regulation associated with adipose or muscular tissues such as irisin and leptin may facilitate the healthy metabolic profile of MHO cases. In this case-control study, the differences between serum level of irisin was investigated in metabolically unhealthy obese (MUO) and metabolically healthy obese (MHO) individuals.<br>
<strong>Methods:</strong> The study participants included obese individuals with metabolic syndrome (MetS) (n=51) and 2 control groups that included weight matched cases without MetS (n=51) and normal weight cases without MetS (n=51). Diagnosis of MetS was made based on the Adult Treatment Panel III (ATPIII) criteria. Serum levels of leptin and irisin were determined by enzyme-linked immune-sorbent assay (ELISA) kit. Receiver Operator Characteristic (ROC) curve, multiple linear regression, and one-way ANOVA analysis were used in SPSS 16 software. Significant level was set at 0.05.<br>
<strong>Results:</strong> Based on the statistical analysis, serum levels of irisin were 2.91±1.6, 3.14±1.4, and 4.47±3.23 (ng/mL) in MUO, MHO, and nonobese metabolically healthy participants, respectively (P = 0.001). Also, serum levels of leptin were 14.06±12.4, 11.2±9.3, and 7.09±7.1 (ng/mL) in MUO, MHO, and nonobese metabolically healthy cases, respectively (p=0.002). After adjusting for demographic variables, a significant association was found between irisin and study groups (β = 0.77, P = 0.001), weight (β=-0.03, p=0.014), BMI (β=-0.11, p=0.006), TG (β=-0.003, p=0.025), fat mass (β=-0.04, p=0.046), and fat free mass (β=0.08, p=0.014).<br>
<strong>Conclusion:</strong> Obese patients with/without MetS had lower level of irisin than normal weight participants.
Irisin, Obesity, Metabolic syndrome, Leptin
324
330
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-4648-2&slc_lang=en&sid=1
Somaye
Yosaee
S_yousai2006@yahoo.com
200319475328460063951
200319475328460063951
No
Department of Nutrition Sciences, School of Health, & Department of Nutrition, Emam Reza Teaching Hospital, Larestan University of Medical Sciences, Larestan, Iran
Reyhane
Basirat
r.basirat@yahoo.com
200319475328460063952
200319475328460063952
No
Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Abdolhamid
Hamidi
Hamidhamidi_e@yahoo.com
200319475328460063953
200319475328460063953
No
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
Alireza
Esteghamati
esteghamati@tums.ac.ir
200319475328460063954
200319475328460063954
No
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mahmoud
Khodadost
mahmodkhodadost@yahoo.com
200319475328460063955
200319475328460063955
No
Department of Epidemiology, Faculty of Health, Shahid Beheshti University of Medical Sciences, & Department of Epidemiology, Faculty of Health, Iran University of Medical Sciences, Tehran, Iran
Farzad
Shidfar
shidfar.f@iums.ac.ir
200319475328460063956
200319475328460063956
No
Department of Nutritional Sciences, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Vida
Bitarafan
bitarafanvida@gmail.com
200319475328460063957
200319475328460063957
No
Adelaide Medical School and National Health and Medical Research Council of Australia (NHMRC), Center of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia
Kurosh
Djafarian
kdjafarian@tums.ac.ir
200319475328460063958
200319475328460063958
Yes
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran