Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1397
11
1
gregorian
2019
2
1
33
1
online
1
fulltext
en
Association between Parvovirus B19 and anemia in HIV-infected patients
Virology
Virology
Original Research
Original Research
<strong>Background: </strong>Human parvovirus B19 (B19V) can cause anemia in some patients, including those with compromised immunity system. There are a few studies on molecular epidemiology of B19V and its association with anemia in Iran. Therefore, the aim of this study was to determine the B19V DNA, IgM, IgG, genotyping, and viral load in HIV patients in different groups of pregnant women, general population, injection drug users (IDU), and Elite controllers. Also, the possible association of B19V with anemia was studied.<br>
<strong> Methods:</strong> In this case-control study, B19V DNA, anti-B19V IgM, anti-B19V IgG, viral load, and hemoglobin level were assessed in 113 HIV positive patients and 72 healthy controls. Also, CD4+ T cell counts and HIV load were measured in the patients’ group. All statistical analyses were done using STATA 14.2 software (Stata Corporation, College Station, Texas, USA). P value < 0.05 was considered statistically significant.<br>
<strong>Results:</strong> Among HIV patients, 19 (16.8%) cases had B19V DNA, 3 (2.7%) had B19V IgM, and 7 (6.2%) had B19V IgG. In control group, the prevalence of B19V DNA, IgM, and IgG was 6 (8.33%), 7(9.7%), and 19 (26.4%), respectively. In subpopulations based on transmission routes, general population had the highest B19V IgG and DNA positivity prevalence and viral load level. There was no significant association between B19V antibodies and DNA with anemia.<br>
<strong>Conclusion:</strong> The results demonstrated that B19V infection cannot be considered as a high-risk factor for anemia in adult HIV patients. However, further studies are needed to determine the exact role of B19V infection in HIV patients.<br>
Anemia, Parvovirus B19, Human immunodeficiency virus, Iran
835
840
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-2447-9&slc_lang=en&sid=1
Majid
Nouri
Dr.majid.nouri@gmail.com
200319475328460062248
200319475328460062248
No
Golestan Hospital Research Center, Tehran, Iran
Parvin
Kamakifar
Aseman.shima@yahoo.com
200319475328460062249
200319475328460062249
No
Department of Microbiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Niloofar
Khodabandehlou
med.virologist@gmail.com
200319475328460062250
200319475328460062250
No
Department of Internal Medicine, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Javid
Sadri Nahand
Javidsadri65@gmail.com
200319475328460062251
200319475328460062251
No
Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Ahmad
Tavakoli
ahmad.tavakoli66@gmail.com
200319475328460062252
200319475328460062252
No
Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Fatemeh
Norooznezhad
Fateme.norouznezhad@gmail.com
200319475328460062253
200319475328460062253
No
Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Saba
Sorayyayi
200319475328460062254
200319475328460062254
No
Department of Clinical Biochemistry, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Farhad
Babaei
farhadbabaii@yahoo.com
200319475328460062255
200319475328460062255
No
Department of Microbiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Shayan
Mostafaei
shayanmostafaee@yahoo.com
200319475328460062256
200319475328460062256
No
Medical Biology Research Center, Institute of Health and Technology, Kermanshah University of Medical Sciences, Kermanshah, & Epidemiology and Biostatistics Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Mohsen
Moghoofei
mohsenmoghoofei@yahoo.com
200319475328460062257
200319475328460062257
Yes
Department of Microbiology, Faculty of Medicine, & Medical Biology Research Center, Institute of Health and Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran