Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1398
11
1
gregorian
2020
2
1
34
1
online
1
fulltext
en
Intraoperative radiation therapy in non-breast cancer patients: A report of 26 cases from Shiraz, south of Iran
Surgery
Surgery
Original Research
Original Research
<strong>Background: </strong>Intraoperative radiation therapy (IORT) is the delivery of radiation at the time of surgery. Whereas the dose delivered by external beam radiation therapy (EBRT) is limited by the tolerance of the surrounding normal tissues, IORT allows exclusion of a part or all of the dose-limiting sensitive structures by operative mobilization and/or direct shielding of these structures. The aim of the present study was to report the non-breast cancer patients' outcomes after receiving IORT in Shiraz, Iran.<br>
<strong>Methods:</strong> In this retrospective study, all cases who had received IORT and had non-breast malignancies were selected. Diagnosis was confirmed by biopsy. Additional imaging was done by sonography, magnetic resonance imaging (MRI) and computed tomography (CT). IORT was applied by self-shielded, LIAC 6-12 MeV Sordina mobile linear accelerator. Typically, a single dose of 10-21 Gy was given for maximally resected tumors. The statistical analyses were carried out using SPSS (version 21).<br>
<strong>Results:</strong> Twenty-six patients were treated with IORT alone or combined with EBRT. Different tumors were treated, including colorectal adenocarcinoma (10 cases, 38.4 %), Soft Tissue Sarcomas (STS, 11 cases, 42.3 %), head and neck cancers (3 cases, 11.5 %), one cervix malignancy case and one paravertebral fibromatosis case. Mean ± SD overall survival was 15±14.89 (0-38) and 34.3±15.72 (14-53) months for colorectal cancer and STS, respectively.<br>
<strong>Conclusion:</strong> IORT is mostly useful for pelvic and abdominal malignancies where normal bowel limits the dose that can be delivered with EBRT. However, the dose delivered in a single fraction with IORT is rarely sufficient for tumor control; therefore, IORT is usually preceded or followed by additional EBRT which should be further evaluated preferably in prospective randomized trials.<br>
Intraoperative radiation therapy, External beam radiation therapy, Cancer
349
353
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-5450-1&slc_lang=en&sid=1
Majid
Akrami
akramimd@yahoo.com
200319475328460063974
200319475328460063974
No
Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
Hamid
Nasrollahi
nasrolahihamid@yahoo.com
200319475328460063975
200319475328460063975
Yes
Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Mostafa
Vahabi
karamiy@sums.ac.ir
200319475328460063976
200319475328460063976
No
Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
Seyed Hassan
Hamedi
hamedi142@yahoo.com
200319475328460063977
200319475328460063977
No
Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Sedigheh
Tahmasebi
tahmasebikh@gmail.com
200319475328460063978
200319475328460063978
No
Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
Sareh
Karbasi
karbasis@sums.ac.ir
200319475328460063979
200319475328460063979
No
Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Mehran
Pashnesaz
nooshinfard@gmail.com
200319475328460063980
200319475328460063980
No
Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
Vahid
Zangouri
vahid.zangouri@yahoo.com
200319475328460063981
200319475328460063981
No
Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Yasin
Karami
yasinkarami@gmail.com
200319475328460063982
200319475328460063982
No
1. Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
Ahmad
Mosalaei
mosalaa@gmail.com
200319475328460063983
200319475328460063983
No
Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Abdolrasoul
Talei
taleia@gmail.com
200319475328460063984
200319475328460063984
No
Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran