Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1399
10
1
gregorian
2021
1
1
35
1
online
1
fulltext
en
Muscle mass and function are related to respiratory function in chronic obstructive pulmonary disease
Nutrition
Nutrition
Original Research: Clinical Science
Original Research: Clinical Science
<strong>Background: </strong>Chronic obstructive pulmonary disease (COPD), as an airway limitation condition, is accompanied by alteration of muscle mass and function. We aimed to determine the relationship between disease severity and body composition, muscle function, and nutritional status in COPD patients. <br>
<strong>Methods: </strong>This cross-sectional study was conducted on 129 COPD participants. Muscle strength, body composition, and calf circumference (CC) were measured using a hydraulic hand dynamometer, bioelectrical impedance analysis (BIA), and a tape measure, respectively. Furthermore, fat-free mass index (FFMI), body mass index (BMI) and muscle mass value were calculated by equations. Forced expiratory volume in one second (FEV1) was assessed as well. Nutritional status was also evaluated by subjective global assessment (SGA) questionnaire. SPSS software (version 21 ) was used, chi-square, fisher’s exact test, univariate and multivariate linear regression models were used for statistical analysis. P-values less than 0.05 were considered significant.<br>
<strong>Results:</strong> Based on FEV1 classification, 52.7% of the patients had severe conditions. The reports indicated that the prevalence of low CC was 54.2%, low muscle mass 38.7%, low FFMI 34.8%, low right handgrip strength 61.2% and low left handgrip strength 64.3%. Furthermore, there was an increasing trend based on FEV1 in low CC (p=0.032), low muscle mass (p=0.005), low FFMI (p=0.002), low right handgrip strength (p=0.004) and low left handgrip strength (p=0.014). The results of univariate analysis showed muscle mass (p=0.036), total protein (p=0.043), FFM (p=0.047), FFMI (p=0.007), SGA (p=0.029), right handgrip strength (p=0.004) and left hand grip strength (p=0.023) were associated with FEV1. In addition, the results of multivariate analysis demonstrated low values of FFMI (p=0.005) and right handgrip strength (p=0.042) were the main detrimental factors for FEV1. The results of multivariate analysis were confirmed by stepwise model.<br>
<strong>Conclusion: </strong>Low values of muscle mass and function are prevalent among COPD patients. The present study revealed that low FFMI and handgrip strength were closely related to disease severity.
Muscle Mass, Lean Body Mass, Nutritional Status, Muscle Strength, Respiratory Disease
263
269
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-5705-1&slc_lang=en&sid=1
Afsane
Ahmadi
ahmadi.afsane@gmail.com
200319475328460063405
200319475328460063405
No
Research Center for Health Sciences, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
Zohreh
Mazloom
zmazloom@sums.ac.ir
200319475328460063406
200319475328460063406
Yes
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Hassan
Eftekhari
h_eftekhari@yahoo.com
200319475328460063407
200319475328460063407
No
2. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Sayed Masoom
Masoompour
masoomm@sums.ac.ir
200319475328460063408
200319475328460063408
No
Noncommunicable Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad
Fararooei
fararooei@yahoo.com
200319475328460063409
200319475328460063409
No
Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Hadi
Eskandari
eskandar@shirazu.ac.ir
200319475328460063410
200319475328460063410
No
Department of Food Sciences and Technology, School of Agriculture, Shiraz University, Shiraz, Iran
Samrad
Mehrabi
mehrabis@sums.ac.ir
200319475328460063411
200319475328460063411
No
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Morteza
Zare
zare_morteza34@yahoo.com
200319475328460063412
200319475328460063412
No
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Zahra
Sohrabi
zahra_2043@yahoo.com
200319475328460063413
200319475328460063413
No
8. Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran