Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1383
2
1
gregorian
2004
5
1
18
1
online
1
fulltext
en
ROLE OF MAGNESIUM LOADING TEST IN DETECTING HYPOMAGNESEMIA IN CRITICALLY ILL PATIENTS
Drug
Drug
Original Research: Clinical Science
Original Research: Clinical Science
Magnesium (Mg) deficiency has not usually been considered in clinical practice
due to lack of relevant blood tests and because the symptoms are often vague and nonspecific.
Serum concentrations may not adequately reflect Mg status. Mg Loading Test
(MLT) can provide infonnation on total body Mg stores. We prospectively studied 21
critically ill patients (10 male, 11 female) admitted to the ICU, to investigate the prevalence
of Mg deficiency. Their mean age was 50±21 years. To determine serum Mg,
venous blood specimens were obtained just before the MLT. Mg sulfate (30 mmol)
was infused during an 8-hr period and 24-hr urine samples were collected from the
starting of Mg infusion. Although low serum Mg « 1.8 mmol/L) was present only in 2
patients, MLT showed Mg deficiency in 18 patients. MLT detected Mg deficiency in
13 out of 14 patients with normal serum Mg, in 2 out of 2 subjects with hypomagnesemia,
and in 3 out of 5 cases with hypennagnesemia. 0f7 fetal cases, 6 occurred in individuals
with hypomagnesemia (6118) and 1 death occurred in the nonnomagnesemic group
(1/3). There was no relationship between Mg retention, age (r= 0.33,p= 0.63) and
serum Mg concentrations (r= 0.15,p= 0.925). There was a significant correlation
between Mg uptake and APACHE II score (r= 0.46,p= 0.035).
In conclusion, Mg depletion is highly prevalent in ICU patients according to MLT.
MLT is superior to serum Mg in determining actual Mg status in this group. Therefore,
we suggest that MLT, and not serum Mg, should be carried out in patients when Mg
deficiency is suspected.
Magnesium Loading Test, Serum magnesium, Intensive Care Unit, APACHE II Score.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-108&slc_lang=en&sid=1
SM
SOHREVARDI
smsohrcvardi@yahoo.com.
20031947532846003621
20031947532846003621
Yes
the Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, I.R. Iran
M
MOJTAHEDZADEH
20031947532846003622
20031947532846003622
No
Intensive Care Unit, Sina Medical Center; Tehran University of Medical Sciences
S
SADRAY
20031947532846003623
20031947532846003623
No
the Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, I.R. Iran
A
NAJAFI
20031947532846003624
20031947532846003624
No
Intensive Care Unit, Sina Medical Center; Tehran University of Medical Sciences
JD
SPENCE
20031947532846003625
20031947532846003625
No
the Stroke Prevention and Atherosclerosis Research Centre, LHSC, Canada.
C
MUNOZ
20031947532846003626
20031947532846003626
No
the Stroke Prevention and Atherosclerosis Research Centre, LHSC, Canada.
H
TAVAKOLI
20031947532846003627
20031947532846003627
No
Intensive Care Unit, Sina Medical Center; Tehran University of Medical Sciences