Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1382
8
1
gregorian
2003
11
1
17
3
online
1
fulltext
en
MORPHINE RELE ASES GLUTAMATE THROUGH AMPA RECEPTORS IN THE VENTRAL TEGMENTAL AREA: A MICRODIALYSIS STUDY IN CONSCIOUS RATS
Physiology
Physiology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
In vivo microdialysis was used to study the effects of morphine on glutamate
release from the ventral tegmentum area (VTA) in freely moving rats. Intraperitoneal
(i.p.) injection of acute and repeated morphine at increasing doses significantly
enhanced glutamate release. Only a minor tolerance developed to this dosage
of morphine. AP-S (2-amino-5-phosphonovaleric acid, 0.5 mg/kg i.p.), a
NMDA receptor antagonist, given 20 min before each repeated morphine injection,
did not have a significant effect on the stimulated glutamate release . Conversely,
injection of CNQX (6-cyano-7-nitroquinoxaline-2, 3-dione, 0.5 mg/kg
i.p.), an AMPA receptor antagonist, 20 min before each morphine dose was found
to markedly inhibit morphine-induced glutamate release in the VTA. In all experiments,
glutamate release reduced by time. These results show for the first
time that acute and repeated injection of morphine stimulates glutamate release in
the conscious rat VTA via AMPA receptors.
Morphine, Glutamate, V TA, Microdialysis.
225
231
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-145&slc_lang=en&sid=1
H
ALAEI
alaei@med.mui.ac.ir
20031947532846003741
20031947532846003741
Yes
From theDepartment of Physiology, University of Esfahan, Iran, theDepartment of Pharmacology and Toxicology, University of Kuopio, Finland
M
HUOTARI
20031947532846003742
20031947532846003742
No
theDepartment of Pharmacology and Toxicology, University of Kuopio, Finland
PT
PIEPPONEN
20031947532846003743
20031947532846003743
No
the Unit of Pharmacology and Toxicology, Department of Pharmacy, University of Helsinki, Helsinki, Finland,
L
AHTEE
20031947532846003744
20031947532846003744
No
the Unit of Pharmacology and Toxicology, Department of Pharmacy, University of Helsinki, Helsinki, Finland,
O
HANNINEN
20031947532846003745
20031947532846003745
No
Department of Physiology, University of Kuopio, Finland
PT
MANNISTO
20031947532846003746
20031947532846003746
No
theDepartment of Pharmacology and Toxicology, University of Kuopio, Finland