Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1382
8
1
gregorian
2003
11
1
17
3
online
1
fulltext
en
A PROSPECTIVE, RANDOMIZED, CONTROLLED TRIAL OF HIGH AND LOW DOSES OF MAGNESIUM SULFATE FOR ACUTE TOCOLYSIS
Drug
Drug
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
At the present, many drugs are used for inhibition of uterine contractions,
but the proportions of preterm labors are increasing. Although magnesium sulfate
is the most commonly prescribed parenteral tocolytic agent, but its optimal use
has yet to be delineated. In this study a high-dose protocol for magnesium sulfate
tocolytic therapy was compared with a low-dose regimen. One-hundred patients
admitted to the labor unit of Imam Reza's hospital with preterm labor were enrolled
in the trial. The median times to successful tocolysis were 8 hours in the
low-dose group and 4 hours in the high-dose group (p<0.001). Patients treated
with higher doses were also more likely to spend significantly less time in the
labor and delivery unit (p<0.001). The median gestational age at delivery was 33
weeks in the low-dose group and 36 weeks in the high-dose group (p=O.OO l).
There were not any statistically significant differences between the two groups
with respect to pre- and post magnesium infusion side effects. These results suggest
that in the high-dose group, tocolysis was achieved more rapidly and patients
required shorter admissions to the labor and delivery unit without increased maternal
or neonatal morbidity.
Magnesium sulfate, Tocolysis, Tocolytic agent, Preterm labor, Preterm birth.
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238
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-146&slc_lang=en&sid=1
VIDA
BEHRAD
v_behrad@yaboo.com
20031947532846003747
20031947532846003747
Yes
From theDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
NEZHAT
MOOSAVIFAR
20031947532846003748
20031947532846003748
No
the Dept. of Obstetrics and Gynecology, Imam Reza Hospital, Mashhad University ofMedical Sciences, Mashhad
MOJTABA
MOJTAHEDZADEH
20031947532846003749
20031947532846003749
No
From theDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
HABID-OLLAH
ESMAILI
20031947532846003750
20031947532846003750
No
the Department of Community-Medical & Public Health, GhaemHospital, Mashhad University of Medical Sciences, Mashhad, Iran.
PARISSA
MOGHTADAII
20031947532846003751
20031947532846003751
No
the Dept. of Obstetrics and Gynecology, Imam Reza Hospital, Mashhad University ofMedical Sciences, Mashhad