Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1399
10
1
gregorian
2021
1
1
35
1
online
1
fulltext
en
Evaluation of Helicobacter pylori eradication on the course of childhood nephrotic syndrome and its response to treatment
Nephrology
Nephrology
Original Research
Original Research
<strong>Background: </strong>Idiopathic nephrotic syndrome is one of the most common glomerular diseases, which may be secondary to infections or systemic diseases. The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) eradication on childhood nephrotic syndrome.<br>
<strong>Methods: </strong>In this randomized controlled clinical trial study, 38 children with concomitant idiopathic nephrotic syndrome and H. pylori infection were divided into 2 equal groups; the intervention group received a cotreatment for both diseases and the control group received only nephrotic syndrome treatment. Patients were followed for 6 months. Data were analyzed using SPSS 21 software. Chi square test, Fisher exact test, and student t test were used. P value <0.05 was considered statistically significant.<br>
<strong> Results:</strong> The mean interval time from treatment to the recovery of nephrotic syndrome was 48.36±14.48 days in the intervention group and 51.68± 17.32 days in control groups, which was shorter in the intervention group, but not statistically significant. The recurrence of nephrotic syndrome and the mean number of recurrences in the intervention group were lower than the control group, but were not statistically significant. The frequency of diarrhea in the intervention group was significantly higher than the control group (p=0.003).<br>
<strong>Conclusion: </strong>In children with concomitant idiopathic nephrotic syndrome and H. pylori infection, the treatment of both diseases may accelerate the recovery and decrease the recurrence of nephrotic syndrome.
Nephrotic Syndrome, Helicobacter pylori Infection, Children
409
412
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6172-1&slc_lang=en&sid=1
Hassan
Bazmamoun
Hbazmamoun@yahoo.com
200319475328460063308
200319475328460063308
No
Department of Pediatric Gastroenterology, Hamadan University of Medical Sciences, Hamadan, Iran
Danyal
Isapour
Danyal-Isapour@yahoo.com
200319475328460063309
200319475328460063309
No
Department of Pediatric Gastroenterology, Hamadan University of Medical Sciences, Hamadan, Iran
Zahra
Sanaei
zahrasanaei58@yahoo.com
200319475328460063310
200319475328460063310
No
Department of Community Medicine, Education Development Office, Hamadan University of Medical Sciences, Hamadan, Iran
Rahimpour
Amiri
amirirahimpour@yahoo.com
200319475328460063311
200319475328460063311
Yes
Department of Pediatric Nephrology, Hamadan University of Medical Sciences, Hamadan, Iran