Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1399
10
1
gregorian
2021
1
1
35
1
online
1
fulltext
en
Efficacy of Platelet-Rich Plasma as an Adjuvant Therapy to Endoscopic Sinus Surgery in Anosmia Patients with Sinonasal Polyposis: A Randomized Controlled Clinical Trial
Otorhinolaryngology
Otorhinolaryngology
Original Research
Original Research
<strong>Background: </strong>Treatment of patients with anosmia is a major therapeutic challenge. The present study evaluated the efficacy of platelet-rich plasma (PRP) in the treatment of anosmia in patients with sinonasal polyposis.<br>
<strong>Methods:</strong>In the present clinical trial, atotal of 48 patients with sinonasal polyposis with theIran Smell Identification Test (I-SIT) score of <6 who completed the medical treatment and were observed 3 months after the sinus surgery were included and randomly divided in to 2groups. After endoscopic sinus surgery, the intranasal injection of 1 mL PRP and normal saline was performed in the olfactory region in the intervention and control groups, respectively. Odor function was assessed using the I-SIT at the baseline and at the end of the studyby an independent samples ttest.<br>
<strong>Results:</strong> Based on the findings of the present study, the I-SIT improved in both groups during the follow-up, as it reached from 2.63 ± 2.63 to 5.85 ± 2.46 after oral steroid administration and 18.93 ± 1.14 after surgery in the intervention group and from the baseline of 2.10 ± 2.83 to 5.62 ± 2.99 after receiving standard medical treatment and 18.43 ± 1.36in the control groupafter surgery. Although this improvement was significant in both groups in either time interval (all with p<0.001), there was no significant difference between the 2groups in terms of changes in the I-SIT score (p=0.802).<br>
<strong>Conclusion:</strong> According to the current study, PRP injection showed no short-term effect on the recovery of olfactory function in patients with sinonasal polyposis.
Anosmia, Platelet-Rich Plasma, Olfactory Epithelium, Sinonasal Polyposis
1159
1165
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6337-1&slc_lang=en&sid=1
Ali
Goljanian Tabrizi
ali.goljanian@gmail.com
200319475328460066298
200319475328460066298
No
Otolaryngology and Head and Neck Surgery Department, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran
Mahboobe
Asadi
Ma_asadi@sbmu.ac.ir
200319475328460066299
200319475328460066299
Yes
Otolaryngology and Head and Neck Surgery Department, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran
Mehdi
Mohammadi
محبوبه
اسدی
dr.md.mohammadi@gmail.com
200319475328460066300
200319475328460066300
No
Otolaryngology and Head and Neck Surgery Department, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran
Amirhosein
Abedi Yekta
abedi_yekta@yahoo.com
200319475328460066301
200319475328460066301
No
Sport and Exercise Medicine Department, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran
Mohammadreza
Sohrabi
m.r.sohrabi@gmail.com
200319475328460066302
200319475328460066302
No
Community Medicine Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran