Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1399
10
1
gregorian
2021
1
1
35
1
online
1
fulltext
en
Frequency of neurological involvement in patients with/without diarrhea hemolytic uremic syndrome: A Systematic review and meta-analysis
Neurology
Neurology
Systematic Review
<strong>Background: </strong>Diarrhea-associated-hemolytic-uremic-syndrome (D+HUS) is a common from of HUS. Central-nervous-system (CNS) involvement is one of the most common extrarenal organ involvements in children with D+HUS. This systematic review and meta-analysis aim to recognize the frequency of neurological complications in pts with HUS.<br>
<strong>Methods: </strong>Databases of PubMed, Embase, and Web of Science were searched systematically to find the papers on neurological involvement in HUS pts. Two researchers independently assessed the papers’ quality and extracted data. CMA v. 2.2.064. was used for data analysis. Heterogeneity was evaluated using the I-squared (I2) test, and a fixed/random-effects model was used when appropriate.<br>
<strong>Results: </strong>In this review, 21 studies including 2,189 participants with a median age between 1.3-40-year-old, entered the meta-analysis. The meta-analysis in D+HUS patients indicated 27.0% with neurological complications (95% CI, 22.0%-32.6%), 25.5% of symptoms weren’t categorized (95% CI, 15.9%-38.3%), 20.8% of them developed the seizures (95% CI, 2.3%-74.4%). In D-HUS pts, 20.8% of them were presented neurological symptoms (95% CI, 17.9%-24.0%), of which 29.0% weren’t categorized (95% CI, 19.2%-41.2%), 17.5% of pts got into coma (95% CI, 9.6%-29.7%), 5.6 % showed hemiparesis (95% CI, 2.8%-10.9%), 17.2% experienced lethargy (95% CI, 5.2%-44.1%), 30.5% developed the seizures (95% CI, 18.2%-46.2%), 7.4% manifested speech abnormalities (95% CI, 0.2%-7.22%), 6.4% of D-HUS pts presented visual-disturbances (95% CI, 3.4%-11.6%).<br>
<strong>Conclusion:</strong> This systematic review and meta-analysis indicated more than one-fourth of both D+HUS and D-HUS patients were presented with neurological symptoms, and the most prevalent symptoms were seizures, which can lead to an epilepsy sequel.<br>
HUS, CNS, Diarrhea, Neurological symptoms, Pediatrics, Adults
716
726
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6500-1&slc_lang=en&sid=1
Azita
Tavasoli
Azita_tavasoli@yahoo.com
200319475328460063078
200319475328460063078
No
Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran
Shahrbanoo
Nakhaiee
S.nakhaiee@yahoo.com
200319475328460063079
200319475328460063079
No
Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran
Nazanin
Zafaranloo
bbrokh@yahoo.com
200319475328460063080
200319475328460063080
No
Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran
Rozita
Hoseini
Rozitahoseini@yahoo.com
200319475328460063081
200319475328460063081
No
Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran
Hasan
Otukesh
Hasanotukesh@yahoo.com
200319475328460063082
200319475328460063082
No
Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran
Behnam
Sobouti
Sobouti.b@iums.ac.ir
200319475328460063083
200319475328460063083
Yes
Ali-Asghar Children Hospital, Iran University of Medical and Sciences, Tehran, Iran