Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1399
10
1
gregorian
2021
1
1
35
1
online
1
fulltext
en
Effect of N-Acetylcysteine on the treatment of acute respiratory distress syndrome in mechanically ventilated patients admitted to the intensive care unit
Anesthesia
Anesthesia
Original Research: Clinical Science
Original Research: Clinical Science
<strong>Background: </strong>N-acetylcysteine (NAC) is an antioxidant derived from the amino acid cysteine and is one of the drugs used in the treatment of respiratory diseases. The aim of this study was to investigate the effect of NAC on the treatment of acute respiratory distress syndrome in mechanically ventilated patients admitted to the intensive care unit.<br>
<strong>Methods:</strong> This study was a randomized clinical trial. Patients under mechanical ventilation admitted to the intensive care unit were examined. Patients in the intervention group received daily 150 mg/kg of NAC on the first day of admission and then 50 mg/kg up to the fourth day of admission. Patients in the control group received routine care. The vital signs, level of consciousness, and other important variables were recorded. Data were analyzed using statistical tests and SPSS software version 24.<br>
<strong>Results:</strong> There was no significant difference between MAP, heart rate, respiratory rate, O<sub>2</sub>Sat, APACHE II score, and pulmonary capacity of the patients in the two groups on the first, second, third and fourth days after the intervention (p>0.05 ). There was no significant difference between the level of consciousness (according to GCS criteria), respiratory index (PAO<sub>2</sub>/FIO<sub>2</sub>) and PEEP of patients in the two study groups within 1 to 2 days after the intervention (p>0.05). There was a significant difference between the level of consciousness (based on GCS criteria), respiratory index (PAO<sub>2</sub>/FIO<sub>2</sub>) and PEEP of patients in the two study groups within 3 to 4 days after the intervention (p<0.05). There was no significant difference between the duration of hospitalization in the ICU, the time required for mechanical ventilation and the mortality rate of the patients in the two groups (p>0.05).<br>
<strong>Conclusion:</strong> It seems that N-acetylcysteine has a positive effect on the treatment of acute respiratory distress syndrome in mechanically ventilated patients admitted to the intensive care unit.
N-acetylcysteine, Acute respiratory distress syndrome, Mechanical ventilation, Intensive care
681
687
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-6581-1&slc_lang=en&sid=1
Mojtaba
Ghorbi
ghorbi.m@ajums.ac.ir
200319475328460063100
200319475328460063100
No
Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Mahboobe
Rashidi
rashidi-m@ajums.ac.ir
200319475328460063101
200319475328460063101
Yes
Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Alireza
Olapour
olapour-ar@ajums.ac.ir
200319475328460063102
200319475328460063102
No
Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Fatemeh
Javaherfrooshzade
javaherforoosh-f@ajums.ac.ir
200319475328460063103
200319475328460063103
No
Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Reza
Akhondzadeh
rezaakh@hotmail.com
200319475328460063104
200319475328460063104
No
Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran