Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1381
8
1
gregorian
2002
11
1
16
3
online
1
fulltext
en
A 20-YEAR SURVEY OF INFECTIOUS COMPLICATIONS IN 64 PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
Immunology
Immunology
Original Research
Original Research
Common variable immunodeficiency (CV ID) is a heterogeneous primary
immunodeficiency disorder, characterized by hypogammaglobulinemia and increased
susceptibility to recurrent bacterial infections.
To determine the spectrum of infectious complications in patients with common
variable immunodeficiency (CV ID), we reviewed the hospital records of 64
CVID patients, who were diagnosed in Children's Medical Center during a period
of 20 years.
Among our patients, there were 38 males and 26 females, with a median age
of 12 years (2-42 years) at the time of study. The median age of diagnosis was 6.1
years, with an average diagnostic delay of 5.2 years in our patient's group. Almost
all of our patients have suffered from acute and recurrent infections, particularly
in the respiratory and gastrointestinal systems. The majority of patients (82.5%)
had pneumonia prior to diagnosis. The other infectious complications seen in our
patients were as follows: recurrent otitis media (54%), recurrent sinusitis (50.8%),
diarrhea (65.1 %), and bacterial meningitis (11.1 %). Unusual or opportunistic infections
were also seen in some of our patient population, including oral candidiasis
in 10 patients, and Pneumocystis carinii pneumonia in 2 subjects.
Based on this study, we suggest that hypogammaglobulinemia should be considered
in any patient with a history of recurrent infections in different organs,
and such patients should have a full assessment of the immune system.
Common variable immunodeficiency (CYID), Infection, Complication, hypogammaglobulinemia.
123
128
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-198&slc_lang=en&sid=1
A
AGHAMOHAMMADI
20031947532846003946
20031947532846003946
Yes
From the Department (If Clinical Immunology, Allergy and Asthma, Children s Medical Center, Tehran University of Medical Sciences, Tehran. I.R. Iran.
A
FARHOUDI
20031947532846003947
20031947532846003947
No
M
MOEIN
20031947532846003948
20031947532846003948
No
Z
POURPAK
20031947532846003949
20031947532846003949
No
N
REZAEI
rezaei_nima@yahoo.com
20031947532846003950
20031947532846003950
No
K
ABOLMAALI
20031947532846003951
20031947532846003951
No
M
MOVAHEDI
20031947532846003952
20031947532846003952
No
M
GHARAGOZLOU
20031947532846003953
20031947532846003953
No
B
MIRSAEIDGHAZI
20031947532846003954
20031947532846003954
No
M
MAHMOUDI
20031947532846003955
20031947532846003955
No