Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1380
5
1
gregorian
2001
8
1
15
2
online
1
fulltext
en
ANGIOGENESIS ASSESSMENT IN BASAL CELL CARCINOMA
Pathology
Pathology
Original Research
Original Research
Basal cell carcinoma (BCC) is currently the most common cutaneous cancer
found in humans. Although it generally shows a relatively benign course (BCCl),
some cases show aggressive behavior (BCC2). Until recently, traditional histologic
diagnostic criteria have failed to discriminate unequivocally between BCC 1
and BCC2.
In this study we selected 50 cases of BCC and categorized them into two
groups (BCCl and BCC2) on the basis of histologic criteria and then examined
the rate of angiogenesis to establish if it correlates with their histological features
and/or clinical behavior. The vessels were highlighted by immunohistochemical
staining for factor VIII-related antigen in formalin fixed paraffin embedded tissues.
All 25 cases of BCC2, whose clinical behavior was aggressive had
microvessel counts significantly higher than that of the BCC I group with mean
values of 50.24 and 20.9 for BCC2 and BCCl respectively. But there were eight
cases of morphological BCCI who had aggressive clinical behavior and interestingly
had microvessel counts higher than the other cases of BCC 1.
The findings of the present study seem to establish a correlation between
tumor angiogenesis and clinicobiologicaI parameters of aggressiveness.
From this point of view the assay of microvessel density might be helpful in
selecting patients with BCCs at high risk for recurrence or metastasis, who could
benefit from additional therapies and closer followup.
Aggressive BCC, Non-aggressive BCC, Tumor angiogenesis.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-261&slc_lang=en&sid=1
F
SARI ASLANI
20031947532846004178
20031947532846004178
Yes
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
A
ALEDAVOOD
20031947532846004179
20031947532846004179
No