Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1380
2
1
gregorian
2001
5
1
15
1
online
1
fulltext
en
ULCERATIVE COLITIS AND HLA CLASS II PHENOTYPING IN IRAN
Internal Medicine
Internal Medicine
Original Research
Original Research
Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel
disease that diffusely involves the colonic mucosa. The etiology of UC has not yet
been elucidated fully. However, many studies have found that immunologic disorders
may play a role in the pathogenesis of UC. In addition, due to an increased
frequency of UC in families, especially an increased monozygotic compared with
dizygotic twin concordance, many implicate genetic factors in the development
and regulation of the immune responses, such as the HLA class II genes, as candidates
for conferring the genetic susceptibility. We studied the distribution of HLADR
and DQ antigens and duration of sickness in 42 Iranian patients suffering
from DC using the standard microlymphocytotoxicity technique. The phenotypic
frequencies ofHLA-DR2 were present in 24 of 84 controls and 18 of 42 patients
(p= 0.24, corrected p, not significant). The present study reveals no association
between HLA class II antigens and UC, suggesting that the HLA-DR2 is not a
predominant susceptibility gene for UC in the population studied.
Ulcerative colitis; HLA phenotyping
7
9
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-271&slc_lang=en&sid=1
H
FOROOTAN
20031947532846004216
20031947532846004216
Yes
From the Departments of Internal Medicine and Immunogenetics, School of Medicine, Tehran University of Medical Sciences, Tehran
B
NIKBIN
20031947532846004217
20031947532846004217
No
the Department of Immunology, School of Medicine, Birjand University of Medical Sciences, Birjand, I.R. Iran.
GH
ANANI SARAB
20031947532846004218
20031947532846004218
No
From the Departments of Internal Medicine and Immunogenetics, School of Medicine, Tehran University of Medical Sciences, Tehran