Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1380
2
1
gregorian
2001
5
1
15
1
online
1
fulltext
en
NMDA RECEPTOR ANTAGONISTS ATTENUATE TOLERANCE INDUCED BY MORPHINE AND NERVE LIGATION IN MICE
Pharmacology
Pharmacology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
The effect of NMDA (N-methyl-D-aspartate) receptor antagonists on tolerance
to morphine antinociception was investigated in mice. Daily subcutaneous
administration of 50 mg/kg of morphine hydrochloride for three days induced
tolerance to different (3,6 and 9 mg/kg) test doses of morphine. The tolerance
obtained was decreased by pretreatment of animals with single or repeated doses
of competitive NMDA receptor antagonists D-( -)-2-amino-5-phosphonovaleric
acid (DAP5 0.1-0.3 mg/kg) and D-(-)-2-amino-7-phosphonoheptanoic acid
(DAP7 0.1-0.3 mg/kg).
Tolerance to morphine response was also obtained 7, 14, 21 and 30 days
after unilateral sciatic nerve ligation. Single or repeated doses (0.2 mg/kg) of
DAP5 or DAP7 increased the antinociceptive response induced by morphine (9
mg/kg) in the nerve ligated animals. We report that these agents attenuate the
development of morphine tolerance, and increase the antinociceptive effect of
morphine on sciatic neuropathic pain in mice.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-278&slc_lang=en&sid=1
GR
TAGHIZADEH-JAHROMI
20031947532846004240
20031947532846004240
No
M
REZAYAT
20031947532846004241
20031947532846004241
No
MR
ZARRINDAST
20031947532846004242
20031947532846004242
Yes
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.