Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1379
11
1
gregorian
2001
2
1
14
4
online
1
fulltext
en
PARAGANGLIOMA OF THE FILUM TERMINALE EXTERNUM AND CONCURRENT ARTERIAL HYPERTENSION: A CASE REPORT
Neurosurgery
Neurosurgery
case report
case report
Paragangliomas are extra-adrenal counterparts of pheochromocytomas and are found
at various anatomical sites such as the retroperitoneum, mediastinum, jugular foramen and
carotid bifurcation, the latter two fonns being coined as chemodectomas.
The vertebral column, especially the llUllbar zone, is one of the rarest sites to be
involved by paragangliomas. These lesions may have secretory functions and produce
symptoms and signs mimicking cathecholamine oversecretion as was noticed in
our case.
A 60-year-old woman with a sacral mass, backache, and cauda equina syndrome
along with arterial hypertension is being presented who had been managed with antihypertensive
medications. Magnetic resonance imaging revealed involvement of sacral
canal and L5 and S 1 bodies producing a soft tissue bulge near the right buttock and
computed tomography showed a destructive sacral lesion.
Surgery was performed to resect the turnor mass and surprisingly the postoperative
blood pressure reached the normal range and henceforth antihypertensive therapy
was withheld. Tissue diagnosis of paraganglioma was made on the basis of histopathological
examination and ascertained by immunohistochemical study for
chromogranin, neuron specific enolase, synaptophysin and S 1 00 protein. One month
later the tumor site was subjected to radiation for any remnants following surgery.
After two years, the patient was found to be doing well and had been normotensive
Without medications.
Spinal paragangliomas are treated with total excision and irradiation for residual
tumor, if present. The role of immunohistochemistry could not be overemphasized
for diagnostic confirmation.
Paraganglioma, Systemic hypertension, Immunohistochemistry.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-298&slc_lang=en&sid=1
H
SABERI
20031947532846004308
20031947532846004308
Yes
From the Departments of Neurosurgery Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran
I
JAHANZAD
20031947532846004309
20031947532846004309
No
From the Departments of Pathology Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran
Z
HUSSAIN KHAN
20031947532846004310
20031947532846004310
No
From the Departments of Anesthesiology, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran
N
SAFFARIAN
20031947532846004311
20031947532846004311
No
the Dept, of Cardiology, Baghiyatollah Hospital, Baghiyatollah University of Medical Sciences, Tehran, IR. Iran.