Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1379
5
1
gregorian
2000
8
1
14
2
online
1
fulltext
en
PROGNOSTIC VALUE OF MYELOID ANTIGEN EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKEMIA
Immunology
Immunology
Original Research
Original Research
Expression of cell surface molecules associated with lymphoid and myeloid
lineage differentiation on the blasts of 53 patients with acute lymphoblastic leukemia
(ALL) was investigated. 1.9% of cases were only HLA"7DR+ 7.6% were
HLA-DR+, CDI9+ 22.6% were HLA-DR+, CDI9+, CDI0+ 30.2% were HLADR+,
CDI9+, CDlO±, CD20+ and 37.7% were HLA-DR±, CD7+, CD5±. Aberrant
expression of one or more myeloid antigens including CDI3, CDI5, CD33
and CD34 was found in 30.2% of cases. The relationship of myeloid positive
(MY+ ALL) and negative cases (MY- ALL) with patient characteristics were
studied. No significant differences in clinical features, response to therapy or survival
was found between the two groups. Study of each marker separately indicated
an association between expression of CD5 and CD 1 0 with age and expression
of CD20 and CD33 with decrease in hemoglobin (p<0.03). No correlation
between expression of markers and survival was found except for CD 13 and CD 15
antigens (p<0.03). CDI5+ cases showed longer survival than negative cases
(541±72 vs. 364±34 days) whereas CDI3+ cases showed shorter survival than
negative ones (378±32 vs. 616±,106). showed a trend towards a longer or shorter survival.
Myeloid antigens, Acute lymphoblastic leukemia, Myeloid positive ALL.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-326&slc_lang=en&sid=1
Z
AMIRGHOFRAN
amirz@sums.ac.ir
20031947532846004400
20031947532846004400
Yes
From the Department of Immunology Shiraz University of Medical Sciences, Shiraz,
A
SHAMSEDDIN
20031947532846004401
20031947532846004401
No
Fasa School of Medicine, Fasa, I.R. Iran.
M
SHAHRIARI
20031947532846004402
20031947532846004402
No
From the Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz