Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1378
5
1
gregorian
1999
8
1
13
2
online
1
fulltext
en
EFFICACY AND SAFE TY OF LAMOTRIGINE AS A DD-ON THE RAPY IN 132 CHILDREN AND ADULT IRANIAN PATIENTS WITH TREATMENT-RESISTANT EPILEPSY
Pediatric
Pediatric
Original Research
Original Research
This study was initiated to evaluate the long-term safety, tolerability and
efficacy of seizure control of lamotrigine (LTG) in children and adult patients with
partial seizures (PS) with or without secondary generalized seizure. A total of 132
patients (age 5-41 years) with treatment-resistant epilepsy received LTG as addon
therapy for up to four years. Overall, patients were treated with LTG for 27 -226
weeks. The global assessment of seizure control compared to the three-month
period before starting LTG treatment indicated that seizure control was gradually
maintained during long-term LTG treatment for up to four years. The medical
history of 23 patients who had a significant decrease in the number of seizures with
LTG treatment indicated a subjective improvement in behavior, alertness, and
quality of life. All 132 patients who received LTG as add-on therapy had used 2-
4 anti-convulsive medications 2-7 years before entering this open continuation
study. Patients had 7-45 seizures per month throughout the 3 months before
entering this study. The overall decrease in the number of seizures was 58% after
patients started receiving LTG. LTG was well tolerated. The majority of adverse
effects were classified as being mild in intensity and only 5 patients (4%) were
withdrawn from the study due to adverse effects (skin rash).
107
110
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-402&slc_lang=en&sid=1
AZAR
FALLAH
20031947532846004641
20031947532846004641
Yes
From the Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.