Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1378
2
1
gregorian
1999
5
1
13
1
online
1
fulltext
en
THE SYNTHESIS AND EVALUATION OF NEW DERIVATIVES OF 2,4 DIAMINOPYRIMIDINES WITH MALE CONTRACEPTIVE ACTIVITY
Physiology
Physiology
Original Research
Original Research
The discovery of the antifertility activity of gossypol led scientists and researchers to the development of compounds with antifertility activity that can be used as male contraceptives. These studies resulted in discovery of the antifertility activity of several classes of compounds which have been reported in the literature. This article deals with the synthesis of four new analogues of pyrimethamine, the derivatives of 2, 4-diamino-5 (3,4-dichlorophenyl)-6-alkyloxymethyl pyrimidine (methyl ethyl, n-propyl, iso-propyl), and the results of experimental antifertility evaluation of these compounds on male rats, which revealed a significant decrease in motility, viability, ESR and DSP indices in treated animals
2, 4-Diaminopyrimidines; Male contraception; Male reproduction; Spermatogenesis; Fertility
27
32
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-419&slc_lang=en&sid=1
H
SADEGHIPOUR ROODSARIE
20031947532846005823
20031947532846005823
Yes
From the Departments of Physiology Tehran University of Medical Sciences. Tehran. I.R. lran.
M
VOSOOGHl
20031947532846005824
20031947532846005824
No
From the Departments of 'Medicinal Chemistry Tehran University of Medical Sciences. Tehran. I.R. lran.
M
ZAHRAIE
20031947532846005825
20031947532846005825
No
From the Departments of Clinical Biochemistry. Tehran University of Medical Sciences. Tehran. I.R. lran.