Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
8
1
gregorian
1998
11
1
12
3
online
1
fulltext
en
COMPARISON OF THE BRONCHODIL ATORY EFFECTS OF INHALED SALBUTAMOLAND COMBIVEN T IN ASTHMATIC PATIENTS
Pharmacology
Pharmacology
Original Research
Original Research
A randomized, double-blind, crossover trial was designed to compare the acute
effects of Combivent and salbutamol on spirometric parameters in patients with
moderate to severe asthma. Nineteen patients with a mean baseline forced expiratory
volume in 1 sec. (FEV]) less than 65% predicted, were randomized on two separate
days to receive two puffs of salbutamol (200 µg) or two puffs of Combivent (200 µg
salbutamol plus 40 µg of ipratropium bromide) by metered dose inhalers. On study
days using spirometry, FEV!, forced vital capacity (FVC), maximal mid-expiratory
flow rate (MMEF) and peak: expiratory flow rates (PEFR) were measured at baseline
and at 15, 60 and 180 minutes after drug administration. Blood pressure and pulse rate
were also determined before and 3 hours post drug inhalation.
The results of this study show that Combivent produces significantly greater
improvement compared to salbutamol in all four spirometric parameters at 15, 60,
and 180 minutes after drug treatment. The greatest differences between the
bronchodilating effects of the two re!imens were observed at 180 minutes after drug
inhalation. There were no clinically significant changes in heart rate or blood
pressure.
It may therefore be concluded that in patients with moderate to severe asthma,
Combivent provides better bronchodilation than salbutamo1 alone at clinically
relevant doses without increasing side-effects
Asthma, bronchodilator, Combivent, ipratropium, salbutamol.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-446&slc_lang=en&sid=1
G
DERAKHSHAN DEILAMI
20031947532846004751
20031947532846004751
Yes
From the Division of Pulmonology, Imam Khomeini Hospital, Tehran University of Medical Sciences,
A
GHOLAMHOSSEINI
20031947532846004752
20031947532846004752
No
the Department of Pharmacology, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
MH
POURGHOLAMI
20031947532846004753
20031947532846004753
No
the Department of Pharmacology, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.