eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
371
373
article
CEREBRAL EDEMA: A RARE COMPLICATION IN GALACTOSEMIA
MEHRI NAJAFI
mehrinajafi @ hotmail.com. najafisa@Sina.Tums.ac.ir
1
AHMAD KHODADAD
2
GHOLAM REZA KHATAMI
3
From the Department of Pediatric Gastroenterology, Children s Medical Center; Tehran University of Medical Sciences, Tehran, I.R. Iran
A 34 day-old girl infant was admitted for poor feeding and cholestasis. She had a
bulging fontanelle, with no evidence of intracranial infection or hemorrhage. Investigations
demonstrated that she had galactosemia. Computed tomographic scans demonstrated
the presence of diffuse cerebral edema. After treatment the edema resolved.
http://mjiri.iums.ac.ir/article-1-622-en.pdf
Galactosemia
cerebral edema
increased intracranial pressure
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
365
370
article
INDUCTION OF TYPE 1 DIABETES IN DIABETES-RESISTA NT (BB-DR) RATS
LEILI YAZDCHI -MARANDI
marandil@tbzmed.ac.ir
1
SHEELA RAMANATHAN
2
PHILIPPE POUSSIER
3
From the *Immunology Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran,and the **Departments of Immunology and Medicine, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
the Departments of Immunology and Medicine, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
the Departments of Immunology and Medicine, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Ontario, Canada
The BioBreeding- Diabetes Prone (BB-DP) rat spontaneously develops an autoimmune
diabetic syndrome that is dependent on the RT1 u Major Histocompatibility
Complex (MHC) haplotype and homozygosity for an allele at the Lymphopenia (Lyp)
locus. Lyp mutation is responsible for a peripheral T -lymphopenia. There are other
genetic loci contributing to diabetes susceptibility in this strain. BB rats carrying wildtype
Lyp alleles are not lymphopenic and are resistant to spontaneous diabetes (Diabetes
R esistant [DR]). Our study shows that thymectomy and exposure to one sublethal
dose of g-irradiation (TX-R) at 4 weeks of age result in the rapid development of
insulitis followed by diabetes in 100% of DR rats. Administration of CD45RCCD4+
TCRcb+ T cells from unmanipulated syngeneic donors immediately after irradiation
prevents the disease. Splenic T cells from TX -R induced diabetic animals adoptively
transfer type 1 diabetes to T-deficient recipients. WAG, WF and LEW strains are
resistant to TX -R induced insulitis/ diabetes. This novel model of TX -R induced diabetes
in BB-DR rats can be used to identify environmental and cellular factors that are
responsible for the initiation of antipancreatic autoimmunity.
http://mjiri.iums.ac.ir/article-1-621-en.pdf
BB-DR
type 1 diabetes
TX-R
BB-DP.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
361
364
article
EFFECTS OF NOVEL 2-ALKYLAMINOSUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM
F HADIZADEH
fhadizadeh@yahoo.com
1
BF ANARAKI-FIROOZ
2
SIH TAQAVI
3
From the Department of Medicinal Chemistry, Pharmacy Faculty, Mashhad University of Medical Sciences, P.O.Box 91775-1365, Mashhad, Iran
the Biotechnology &Pharmaceutical Sciences Research Center, Postal Code 9196773117, Bu-Ali Square, Mashhad, 1ran
the Department of Pharmacology,Jinnah Medical and Dental College, Karachi, Pakistan
In order to investigate the effects of dimethylamino substituent at position 2 of the
dihydropyridine nucleus on activity, starting from dialkyl l ,4-dihydro-2,6-dimethyl-4-
(l-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis
and effects as calcium channel antagonist on guinea-pig ileum has been reported
previously, dialkyl l,4-dihydro-2-[2-(dimethylamino)ethyl]-6-methyl-4-(l-benzyl-2-
alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (6a-f) were synthesized.
Rabbit jejunum was used to determine the relaxant or antagonistic activity of the
test compounds. The test compounds (6c-e) inhibited the spontaneous contractile activity
dose-dependently and completely, while high-K+ contracted tissues were relaxed
partially.
http://mjiri.iums.ac.ir/article-1-620-en.pdf
2-Dimethylamino-substituted dihydropyridines
Rabbit jejunum
Calcium Channel.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
353
359
article
CEREBRAL BLOOD FLOW REGULATION IN ANESTHETIZED MORPHINE DEPENDENT RATS: THE ROLE OF THE ADENOSINE SYSTEM
MEHDI ZAHEDI KHORASANI
1
SOHRAB HAJIZADEH
Hajizads@modares.ac.ir
2
SAEED SEMNANIAN
3
YAGHOUB FATHOLLAID
4
From the Dept. of Physiology, Semnan Medical Sciences University, Semnan, Iran
theDept. Of Physiology, School of Medical Sciences, Tarbiat Modarres University, P.O. Box I4115-11I, Tehran, Iran
theDept. Of Physiology, School of Medical Sciences, Tarbiat Modarres University, P.O. Box I4115-11I, Tehran, Iran
theDept. Of Physiology, School of Medical Sciences, Tarbiat Modarres University, P.O. Box I4115-11I, Tehran, Iran
Adenosine has many of the characteristics of a regulator of cerebral blood flow
and adenosine receptors change in morphine dependency. In this study the changes in
adenosine receptors' responsiveness of pial vessels in the hind limb area of the sensory
cortex were evaluated in morphine dependent rats (MDR) using the laser Doppler
flowmetry technique. Adult male Sprague Dawley rats (250-350 g) were used in all
experiments. Animals were made morphine dependent, thereafter local effects of adenosine
receptor agonists and antagonists on regional cerebral blood flow ( rCBF) were
investigated.
Results obtained in this study show that adenosine (10-5, 10-4, 10-3M) increases
rCBF in a dose dependent manner in sham operated, control and MD R, so that the
increase of rCBF inMD R is statistically significant (p<0.01 ). This response was inhibited
by theophylline (5x 10-5M). Lidocaine (2%) reduced adenosine-induced increase
in rCBF o f MDR. N6-cyclohexyladenosine (10-6, 10-5, 10-4 M) and 8 -
cyclopentyltheophylline (1 G-6M) as a selective agonist and antagonist of adenosine A l
receptors had no significant effect on rCBF in control and MDR. CGS-21680 (10-6
M) as a selective adenosine A2a receptor agonist, increased rCBF in MDR significantly
(p<0.05). This response was antagonized by ZM-241385. NECA (10-6M) as
a adenosine A2b receptor agonist, increased rCBF in MDR significantly (p<0.05).
This response was antagonized by Alloxazine. The results of this study indicate an
increase in adenosine A2 receptors' (including A2a and A2b subtypes) responsiveness
in hind limb sensory cortex of MDR
http://mjiri.iums.ac.ir/article-1-619-en.pdf
Cerebral blood flow; Morphine dependent rat.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
341
343
article
SILENT BRAIN INFARCTION IN STROKE PATIENTS: A PILOT DOUBLE-CENTER STUDY
K GHANDEHARI
kavianghandehari@yahoo.com
1
A SHUAIB
2
• From theDepartment of Neurology, Valie-Asr Hospital, Southern Khorasan University of Medical Sciences, Birjand, Iran
theDepartment of Neurology, Mackenzie Hospital, University of Alberta, Edmonton, Canada.
Silent Brain Infarcts (SBI) are associated with an increased risk of subsequent
stroke. SBI are incidentally revealed by CT or MRI executed in stroke patients.
A prospective study was undertaken involving 200 consecutive patients aged >45
years with brain infarct admitted in University of Alberta Hospital, Canada (100 patients)
and Valie-Asr Hospital, Iran (100 patients) in 2003. Patients were divided in age
groups aged 65. All of the patients underwent brain CT. A stroke neurologist
with knowledge of stroke history subsequently reviewed the scans and diagnosed SBI.
The relations of race, gender and age groups with SBI were analyzed with chi-square
and Fisher exact tests.
SBr were present in 26.9% of patients aged 65. Canadian patients were significantly more preponderant to SBI in age group> 65
(p= 0.013). The mean age of Canadian patients was significantly higher than Persians
(p<0.001). Within a total of 200 patients the female gender was significantly more
preponderant to SBr (p= 0.02) which was not related to age and race groups. Small
vessel territory infarct was present in 87 % of our patients with SBI.
SBr are cornmon in stroke patients. The frequency of SBI is higher in female
gender and the elderly.
http://mjiri.iums.ac.ir/article-1-618-en.pdf
Silent stroke
infarct
gender
incidence .
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
337
340
article
S TUDYING THE RESULTS OF FEMORAL ARTERY LI GATION IN 65 PATIENTS WITH INFECTED P SEUDOANEURYSM DUE TO IV-DRUG ABUSE
A AFSHARFARD
1
M MOZAFFAR
2
AR FADAEE NAEENI
3
F AGHAEE MEYBODI
4
AM TOFIGH
5
From the Department of Vascular Surgery, Shohada Medical Center, Shahid Beheshti University of Medical Sciences, Tehran. Iran.
Regarding the increasing numbers of IV drug addicts, the incidence of infected
pseudoaneurysm is increasing. So far, different therapeutic strategies have been tried,
but each method has its own drawbacks. Therefore, discovering an appropriate therapeutic
method is necessary.
65 patients with infected pseudoaneurysm due to drug injection referred to Shohada
Medical Center from Feb 1994 till Oct 2003 were chosen. After obtaining proximal
control of the external iliac artery, femoral artery ligation was performed in all patients.
The patients were observed for signs and symptoms of ischemia.
After primary ligation of the involved artery, acute ischemia occurred in only 6
patients who later underwent extra-anatomical bypass. Only 3 patients underwent
amputation. One of them was performed after extra-anatomical bypass and two cases
after arterial ligation, as ischemia and gangrene had been present on admission. During
patient follow up (minimum 3 months, maximum 3 years and average 12 months), 8
cases of slight claudication (9.3 % ) and 3 cases of severe claudication were reported
and the rest have been symptom-free.
Various treatments have been used for infected pseudoaneurysm, but none of
them are faultless. According to infection of the site and existence of extensive necrosis
and inflammatory tissue, anatomical and even non-anatomical bypasses are almost improbable.
The results of this study indicate that arterial ligation could be the fIrst and
probably the best choice of treatment in such patients with less cost and also without
mentionable morbidity or mortality. This procedure must be performed in a vascular
surgery center to perform vascular bypass if needed.
http://mjiri.iums.ac.ir/article-1-617-en.pdf
Aneurysm
IV drug abuse
Pseudoaneurysm
Mycotic aneurysm
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
331
335
article
CERVICAL SPONDYLOTIC MYELOPATHY: THE PATTERN OF NEUROLOGIC DEF ICITS AND IMPROVEMENT FOLLOWING ANTERIOR
K HADDADIAN
1
O REZAEE
2
S SADEGHI
3
A MODARRES ZAMANI
4
G SHARIFI
guivesharifi@hotmail.com
5
A ALI ASGARI
6
From Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
We evaluated the specific pattern of pre- and postoperative neurological signs
and symptoms of cervical spondylotic myelopathy (CSM) to determine [mdings which
had a predictive value for surgical outcome. Consecutive patients with CSM caused by
osteophytic ridge or intervertebral disc herniation who underwent anterior cervical decompression
and fusion in Loghman Hakim Hospital from 1999-2003 were prospectively
enrolled. Patients were evaluated postoperatively by office visit. Outcome was
assessed by objective neurological examination and scoring with multiple functional
rating scales. Forty - three patients (30 male, 13 female) with a mean age of 48.8 years
fulfilled our inclusion criteria. The most common preoperative symptoms were sensory
deficit in distal upper limbs (88.4%), gait disturbance (69.8%) and sensory deficit of
distal lower limbs (58.1 %). The most common signs were hyperreflexia (95.3%),
Hoffman's sign (93%) and Babinski's sign (83.7%). Vertebral osteophyte and soft disc
herniation were found in 86% and 14% of the patients, respectively. Overall functional
improvement, evaluated by using a modification of the Japanese Orthopedic Association
Scale was noted in 79.7% of the patients who had an abnormal scale preoperatively.
Strength improved considerably and significantly after operation. However, less
than half of the patients experienced functional improvement in the lower limbs, a discrepancy
that was probably caused by persistent spasticity. Atrophy of the hand muscles,
preoperative spastic gait and cord atrophy as shown in MRI were poor prognostic
factors.
http://mjiri.iums.ac.ir/article-1-616-en.pdf
Cervical Spondylosis; Myelopathy; Anterior Cervical Decompression.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
327
330
article
EVALUATION OF LABORATORY FINDINGS IN CHILDREN WITH WILSON\'S DISEASE IN EMA M KHOMEINI HOSPITAL DURING 1994-2003
SHAHLA BAHREMAND
1
YAHYA AGHIGHI
2
ZOHREH OLOOMI YAZDI
3
HESHMAT MOAYERI
4
LALEH RAZAVI
5
MANSOUR NATEGHI
6
the Pediatric Gastroenterology Ward, Emam Khomeini Hospital, Tehran University of Medical Sciences
the Pediatric Rheumatology Ward, Emam Khomeini Hospital, Tehran University of Medical Sciences
thePediatric Hematology Ward, Emam Khomieni Hospital, Tehran University of Medical Sciences
the Pediatric Endocrinology Ward, Emam Khomeini Hospital, Tehran University of Medical Sciences
the Pediatric Ward, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
the Pediatric Ward, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Wilson's disease is a rare but treatable condition with variable clinical presentations.
Its diagnosis depends on a combination of clinical and laboratory findings. We
evaluated the clinical and laboratory findings in children with Wilson's disease (WD).
Twenty -seven children (4-14 years, 59.2 % male, 40.7% female) with confirmed
WD were evaluated between 1994 and 2003 at Imam Khomeini Hospital.
Seventeen patients (64%) presented with liver abnormalities, 3( 11 %) with neurological
features, 3(11 %) with fulminant hepatic failure and 4(14%) were asymptomatic
siblings of patients with WD. The presence of Kayser Fleischer rings, high urine copper
excretion, low ceruloplasmin level, and elevated liver copper concentration were detected
in 51.8%, 77.7%, 92.5% and 72.7% of patients respectively.
We emphasize on clinical findings together with one or more laboratory findings as
a diagnostic guide in WD and also recommend evaluation of serum ceruloplasmin level
and 24 hour urine copper excretion particularly when liver biopsy may not be obtained.
http://mjiri.iums.ac.ir/article-1-615-en.pdf
Wilson\'s disease
laboratory findings
children.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
319
326
article
THE EFFECT OF HEALTH EDUCATION ON HEALTH RELATED QUALITY OF LIFE IN PATIENTS WITH CORONARY ARTERY BYPASS SURGERY
A HEIDARNIA
Hidarnia@modares.ac.ir
1
T DEHDARI
2
F GHOFRANIPOUR
3
A KAZEMNEJAD
4
M HEIDARNIA
5
From the Department of Health Education & Biostatistics, Tarbiat Modares University, Tehran, I.R.lran.
The purpose of this study is to evaluate the ability of the health education program
to improve patient's health-related quality of life with coronary artery bypass graft surgery.
Seventy patients in pre-operation were randomized into the study, with 35 patients
in the experimental and 35 patients in the control group. The demographic information,
Sf-36 and Nottingham Health ProfIle questionnaire were administered and fIlled
out before surgery by seventy patients. Patients in the experimental group received the
educational intervention. Educational intervention was according to Mico' s education
planning model. For the second phase of Mico' s model, knowledge, attitude and function
were measured in seventy patients by questionnaire before education. These patients
were followed up to 1 month. Afterwards Sf- 36 and Nottingham Health Profile
questionnaires were administered I-month after education to be filled out by patients
again. SPSS and EXCEL softwares analyzed all data. Significant improvements in quality
of life between the two groups, as measured by the Nottingham Health ProfIle, were
seen in energy (p<0.00I), pain (p<0.006), emotional reaction (p<0.0000I), sleep
(p<O.01), physical mobility (p<0.00001) and total average quality of life (p<0.00001).
Significant improvements in quality of life between the two groups, as measured by the
Sf-36, were seen in physical function (p<0.0000I), role limitations resulting from emotional
status (p<0.007), role limitations resulting from physical status (p<0.005), mental
health (p<0.03), vitality (p<0.02) and total average quality of life (p<0.02). In conclusion,
the findings demonstrate that health education results in improved quality of life for
patients with CABG.
http://mjiri.iums.ac.ir/article-1-614-en.pdf
Health education
coronary artery bypass graft surgery
quality of life
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
313
317
article
EVALUATION OF THE EFFECTS OF CT- GUID ED N EUROLYTIC CELIAC BLOCK FOR MANAGING INTRACTABL E UPP ER ABDOMINAL PAIN
H LAL DOLAT ABAD
1
A JALALI
2
From the Department of Anesthesiology, Baghiatollah University, Tehran, Iran.
The purpose of this study was to evaluate the therapeutic result of CT -guided
celiac plexus block for managing intractable upper abdominal pain due to pancreatic
carcinoma or chronic pancreatitis. We treated 22 cancer patients who were on regular
narcotic medication.
After an IV infusion of 10mLlkg Ringer's lactate solution, all patients were rolled
onto prone position, and lidocaine was used to infiltrate the skin and subcutaneous
tissues. Then CT guided injection of the celiac plexus was performed with 25 mL 50%
ethyl alcohol with 0.25% bupivacaine. Vital signs, quality of analgesia and any adverse
effects were recorded.
The age range of our patients was 68.63± 7.48 years and weight was 64.68± 7.54
kg (mean±SD).All patients had a history of abdominal operation due to disease and
also a history of morphine injection due to pain. In 100% of our patients, sedation in the
first hour was gained excellent pain relief was achieved in 86.4% of cases during the
first 24 hours after the procedure. No serious complications occurred in the study, a
30% drop in systolic blood pressure or even more was found in 13.6% of the cases,
while nausea and transient orthostatic hypotension requiring no treatment developed in
31.8% and 100% of the cases respectively, and mild diarrhea was reported in 18.1 %
of the cases for two weeks.
CT-guided neurolytic celiac block appears to be a safe and effective technique for
relieving abdominal pain due to cancer.
http://mjiri.iums.ac.ir/article-1-613-en.pdf
Pancreatic cancer pain; neurolytic celiac plexus block.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
309
313
article
FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY
HASSAN MANSOURI TORGHABEH
1
ALI AKBAR POURFATHOLLAH
2
MAHMOOD MAHMOODIAN SHOOSHTARI
3
ZAHRA REZAIE YAZDI
Rezaieyazdi-z@mums.ac.ir
4
HABIBOLLAH ESMAILI
5
From the 'Experimental Hematology and Blood Banking Dept, Medical Sciences School, Tarbiat ModaresUniversity (T.M. U.),
From the 'Experimental Hematology and Blood Banking Dept, Medical Sciences School, Tarbiat ModaresUniversity (T.M. U.),
the Iranian Blood Transfusion Organization Research Center, Tehran
the Departmentof Internal Medicine, Mashhad Medical Sciences University, Mashhad
4Community Medicine and Public Health Department of Mashhad Medical Sciences University, Mashhad, Iran
Patients with coagulation factor(s) deficiency who use coagulation therapy are
susceptible to forming inhibitors against coagulation factor(s). In this survey we detected
factor V and VIII inhibitor in ten patients with combined deficiency of factors V
and VIII from north east of Iran (Khorassan province). It was revealed in our survey
that eight patients had both factor V and factor VIII inhibitors and two patients had
none. Because factor V and factor VIII share approximately 40% amino acid sequence
homology in their A and C domains, it remains to be elucidated if it is one
molecule that recognizes both factor V and VIII or whether there are two inhibitor
molecules against common sites.
http://mjiri.iums.ac.ir/article-1-612-en.pdf
Combined factor V & VIII deficiency
Factor V inhibitor
Factor VIII inhibitor.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
303
307
article
USE OF MYELOPEROXIDASE INDEX AS A SUITABLE TOOL TO MONITOR RESPONSE TO THERAPY IN PATIENTS WITH MEGALOBLASTIC ANEMIA
J EIVAZI ZIAEI
jziaei@hotmail.com
1
I ASVADI KERMANI
2
From Shahid Ghazi Hematology Oncology Research Department, Tabriz University of Medical Sciences, Tabriz, Iran.
Repeated bone marrow examination was found to be of value in assessing response
to treatment in megaloblastic anemia. The objective of this study was monitoring
the response of megaloblastics to treatment, concerning the location of neutrophilic
myeloperoxidase and myeloperoxidase index (MPXI) and their variation in megaloblastic
erythroid progeny. It is possible to follow up megaloblastic cases using a
Technicon HI (Bayer) automated cell counter. Complete blood counts (CBC) of 50
patients whose bone marrow aspirations revealed megaloblastic state and subsequently
responded to treatment with B 12 and folate were studied through pre- and post-treatment
measurements. MPXI level in 41 patients was above normal range (normal: -10
to + 10). Nine patients had normal MPXI, though mean cell volume (MCV) was higher
than 100 fL. The highest value of MPXI was 41.5 .The mean values of MPXI were
18.3 and 2.05 in pre- and post-treatment measurements respectively. MPXIs were
decreased after treatment in 92% of patients (p= 0.008). According to this investigation,
the MPXI measurement is a suitable test in monitoring the response for treatment.
http://mjiri.iums.ac.ir/article-1-611-en.pdf
Myeloperoxidase index
treatment
megaloblastic
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
293
296
article
STUDY OF THE ASSOCIATION BETWEEN ACTIVITY LEVEL AT ONSET OF SYMPTOMS AND PATIENT OUTCOME OF F IRST ACUTE MYOCARDIAL INFARCTION
JAHANBAKHSH SAMADIKHAH
1
S. HADI HAKIM
2
AZIN ALIZADEH ASL
3
RASOUL AZARFARIN
azarfarinr@yahoo.com
4
From the Shaheed Madani Heart Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
This study sought to compare the clinical features and outcome of a first acute
myocardial infarction (AMI) with onset of symptoms during or within 30 minutes of
exercise, at rest and in bed.
Information collected using a standard questionnaire was used to relate activity at
the onset of symptoms and in-hospital outcome in 500 consecutive patients admitted to
our heart center with a first AMI between 2000-2002.
Patients with exercise-related onset were more likely to be younger and male.
Those with onset in bed were more likely to be older and have a history of stable or
unstable angina. By way of comparison between patients whose symptoms began at
rest and exercise, those with exercise-related onset had lower in-hospital mortality
after adjusting for age and gender [odd's ratio (OR) 0.53, 95% confidence interval
(CI) 0.39-0.93 (p= 0.03)]. Compared with patients whose symptoms began at rest,
patients with onset in bed had a higher mortality rate [OR 1.42,95% CI 1.03 -1.98
(p= 0.028)].
The incidence of moderate or severe left ventricular dysfunction was also lower
for exercise -related onset [OR 0.79,95% CI 0.6-1.01 (p= 0.32-but not statistically
significant)] and higher when onset was in bed [OR 1.5, 95% CI 1.2-1.77 (p=0.039)].
There is an association between activity at onset and outcome of AMI. Differences
in pathophysiology or in the population at risk could explain this observation.
http://mjiri.iums.ac.ir/article-1-609-en.pdf
Activity
Acute Myocardial Infarction
Outcome.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
289
292
article
ASSESSMENT OF THE EFFECTS OF INCREASED INTRAVENOUS HYDRATION ON THE COURSE OF LABOR IN NULLIPAROUS TERM PREGNANCIES
MH ALAVI
1
Z TALAIE RAD
2
SR DADGAR
3
From the Department of Obstetrics and Gynecology, Shahid Akbarabadi Hospital, Iran University of Medical Sciences, Tehran. I. R. Iran.
Physiologists have shown that increased fluids improve skeletal muscle performance
in prolonged exercise.Typical orders provide for 125 mL of intravenous fluids
per hour in patients taking limited oral fluids during labor. Our purpose in this study was
to determine whether increased intravenous fluids affect the progress of labor. In a
prospective randomized institutional clinical trial, one-hundred ninety-four nulliparous
women with uncomplicated singleton gestations at term in spontaneous active labor
with dilatation 2-5 cm and a cephalic presentation were selected. 82 were designed to
receive 250 mL per hour of intravenous normal saline in dextrose water (first group),
and 112 to receive 125 mL per hour of the same solution (2nd or control group).
Prerandomization variables such as mother's age, weight, previous pregnancy
history, general health, sex and weight of the newborn, rupture of the membranes and
presenting part were balanced between the two groups.
The frequency of labor lasting> 10 hours was statistically higher in the 125mL
group ([16.7%] vs [7.4%] p< 0.0002).
This study showed that increasing fluid administration for nulliparous women in
labor is associated with a shorter duration of the first stage and possibly less need for
augmentation of uterine contraction ( [4.8% vs 6.25%] p= 0.OO2).Thus dehydration in
labor may be a contributing factor for dysfunctional labor and need for cesarean-section,
and oxytocin infusion.
http://mjiri.iums.ac.ir/article-1-608-en.pdf
Intravenous hydration
Labor
Nulliparous
Term pregnancies.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
289
292
article
ASSESSMENT OF THE EFFECTS OF INCREASED INTRA VENOUS HYDRATION ON THE COURSE OF LABOR IN NULLIPAROUS TERM PREGNANCIES
M.H. ALAVI
1
Z. TALAIE RAD
2
S.R. DADGAR
3
Department of Obstetrics and Gynecology, Shahid Akbarabadi Hospital, Iran University ofMedical Sciences, Tehran, J.R.lran.
Department of Obstetrics and Gynecology, Shahid Akbarabadi Hospital, Iran University ofMedical Sciences, Tehran, J.R.lran.
Department of Obstetrics and Gynecology, Shahid Akbarabadi Hospital, Iran University ofMedical Sciences, Tehran, J.R.lran.
ABSTRACT Physiologists have shown that increased fluids improve skeletal muscle performance in prolonged exercise. Typical orders provide for 125 mL of intravenous fluids per hour in patients taking limited oral fluids during labor. Our purpose in this study was to determine whether increased intravenous fluids affect the progress oflabor. In a prospective randomized institutional clinical trial, one-hundred ninety-four nulliparous women with uncomplicated singleton gestations at term in spontaneous active labor with dilatation 2-5 em and a cephalic presentation were selected. 82 were designed to receive 250 mL per hour of intravenous normal saline in dextrose water (first group), and 112 to receive 125 mL per hour of the same solution (2nd or control group). Prerandomization variables such as mother's age, weight, previous pregnancy history, general health, sex and weight of the newborn, rupture of the membranes and presenting part were balanced between the two groups. The frequency of labor lasting> 10 hours was statistically higher in the 125mL group ([16.7%] vs [7.4%] p< 0.0002). This study showed that increasing fluid administration for nulliparous women in labor is associated with a shorter duration of the first stage and possibly less need for augmentation of uterine contraction ( [4.8% vs 6.25%] p= 0.002).Thus dehydration in labor may be a contributing factor for dysfunctional labor and need for cesarean-section, and oxytocin infusion.
http://mjiri.iums.ac.ir/article-1-425-en.pdf
Intravenous hydration
Labor
Nulliparous
Term pregnancies.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
285
288
article
SYNCHRONOUS SURGICAL REMOVAL OF SUSPICIOUS OVARIAN METASTASES FROM COLORECTAL CANCER
MOHAMMAD TALEBPOOR
1
MOJGAN KARBAKHSH
2
SHOKOOFEH SABETI
3
MOOSA ZARGAR
4
From Sina Trauma & Surgery Research Center, Sina Hospital. Tehran University of Medical Sciences.Tehran. I.R. Iran.
, Sina Trauma and Surgery Research Center, Tehran, Iran
, Tehran University of Medical Sciences,
Head, Sina Trauma and Surgery Research Center, Tehran, Iran.
Metastatic ovarian cancers occur in 3-8 percent of women undergoing surgical
resection of a primary colorectal cancer. In this study we examined the characteristics
of women with colorectal cancer for whom synchronous oophorectomy had been
performed.
In this cross-sectional study, records of patients with colorectal cancer from April
1991 through October 1999 who had undergone surgery for both colorectal cancer resection
and oophorectomy for suspicious ovarian metastasis in the Cancer Institute, Imam Khomeini
Medical Center, were reviewed. SPSS version 10 was used for statistical analysis.
The studied cases (n= 82) comprised 44.1 percent of all recorded cases of women
with colorectal cancer during this period (N= 186). The mean age of our cases was
52.19 years. 54.9% of the studied women were in stage C of colorectal cancer. The
commonest pathology of tumors was adenocarcinoma (89%). Well differentiated carcinoma
was observed in 43.9%, followed by moderately differentiated carcinoma in
37.8%, poorly differentiated in 12.2% and unspecified in 6.1 %. 22 of our patients
(26.8%) had gross abnormalities of ovaries at operation. In 13 cases (15.8% of our 82
studied cases and 6.99% of all 186 women with colorectal cancer), tumoral involvement
of ovaries was proven through pathologic examination. 10 out of these 13 cases
were among those with gross abnormalities of ovaries at operation (p= 0.048). Among
the 13 patients with ovarian metastasis, 11 cases (84.6%) were in stage C at operation
(p= 0.02) and 7 (53.8%) had well differentiated carcinoma (p= 0.04).
Patients with ovarian metastases of colorectal origin are generally peri- or post menopausal.
Like similar studies, in our setting, about 7 percent of all recorded female
cases with colorectal cancer turned out to have ovarian metastases in surgical pathologic
examination. In fact, 15.8% of our 82 cases sustaining surgery for "colorectal
cancer and suspicious ovarian metastasis" proved to have ovarian metastasis. We recommend
that prophylactic oophorectomy be performed in postmenopausal women
with advanced stage colorectal cancer or any other woman with colorectal cancer with
gross abnormality of the ovaries at operation.
http://mjiri.iums.ac.ir/article-1-607-en.pdf
Ovarian metastasis
Colorectal cancer
Oophorectomy
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
285
288
article
SYNCHRONOUS SURGICAL REMOVAL OF SUSPICIOUS OVARIAN METASTASES FROM COLO RECTAL CANCER
MOHAMMAD TALEBPOOR
1
MOJGAN KARBAKHSH
2
SHOKOOFEH SABETI
3
MOOSA ZARGAR
4
Sina Trauma & Surge1y Research Center, Sina Hospital. Tehran University of Medical Sciences,Tehran, I.R. Iran.
Sina Trauma & Surge1y Research Center, Sina Hospital. Tehran University of Medical Sciences,Tehran, I.R. Iran.
Tehran University of Medical Sciences,Tehran, Iran.
Sina Trauma and Surgery Research Center, Tehran, Iran.
Metastatic ovarian cancers occur in 3-8 percent of women undergoing surgical resection of a primary colorectal cancer. In this study we examined the characteristics of women with colorectal cancer for whom synchronous oophorectomy had been performed. In this cross-sectional study, records of patients with colorectal cancer from April 1991 through October 1999 who had undergone surgery for both colorectal cancer resection and oophorectomy for suspicious ovarian metastasis in the Cancer Institute, Imam Khomeini Medical Center, were reviewed. SPSS version 10 was used for statistical analysis. The studied cases (n= 82) comprised 44.1 percent of all recorded cases of women with colorectal cancer during this period (N= 186). The mean age of our cases was 52.19 years. 54.9% of the studied women were in stage C of colorectal cancer. The commonest pathology of tumors was adenocarcinoma (89% ). Well differentiated carcinoma was observed in 43.9%, followed by moderately differentiated carcinoma in 37.8%, poorly differentiated in 12.2% and unspecified in 6.1 %. 22 of our patients (26.8%) had gross abnormalities of ovaries at operation. In 13 cases (15.8% of our 82 studied cases and 6.99% of all186 women with colorectal cancer), tumoral involvement of ovaries was proven through pathologic examination. 10 out of these 13 cases were among those with gross abnormalities of ovaries at operation (p= 0.048). Among the 13 patients with ovarian metastasis, 11 cases (84.6%) were in stage Cat operation (p= 0.02) and 7 (53.8%) had well differentiated carcinoma (p= 0.04). Patients with ovarian metastases of colorectal origin are generally peri- or postmenopausal. Like similar studies, in our setting, about 7 percent of all recorded femalecases with colorectal cancer turned out to have ovarian metastases in surgical pathologic examination. In fact, 15.8% of our 82 cases sustaining surgery for "colorectal cancer and suspicious ovarian metastasis" proved to have ovarian metastasis. We recommend that prophylactic oophorectomy be performed in postmenopausal women with advanced stage colorectal cancer or any other woman with colorectal cancer with gross abnormality of the ovaries at operation.
http://mjiri.iums.ac.ir/article-1-424-en.pdf
Ovarian metastasis
Colorectal cancer
Oophorectomy.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
0
0
article
CANDIDIAL ONYCHIA AND PARONYCHIA IN AHWAZ
Ali Zarei Mahmoudabadi
zarei40@hotmail.com
1
Mycology and Parasitology, School of Medicine, Jundishapour University of Medical Sciences, Ahwaz
http://mjiri.iums.ac.ir/article-1-623-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2005-11
18
4
0
0
article
AN INVESTIGATION OF HUMAN APOLIPOPROTEIN E POLYMORPIDSMS IN MULTIPLE SCLEROSIS PATIENTS OF IRAN
V HADAVI
hvaleh2000@yahoo.com
1
DD FARHUD
2
MH SANATI
3
SM NABAVI
4
M SEYEDIAN
5
M HUSHMAND
6
M YOUNESIAN
7
From the Department of Human Genetics & Anthropology, School of Public Health & Institute of Public Health Research, Tehran University of Medical Sciences, P.D.Box 14155-6446, Tehran
From the Department of Human Genetics & Anthropology, School of Public Health & Institute of Public Health Research, Tehran University of Medical Sciences, P.D.Box 14155-6446, Tehran
the National Research Center for Genetic Engineering and Biotechnology, Tehran
the Shahed Medical University,
Tehran University of Medical Sciences, Roozbeh Hospital
the National Research Center for Genetic Engineering and Biotechnology
Department of Environmental Health Engineering, School of Public Health & Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran.
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous
system, with a complex etiology that includes a strong genetic component. The chromosome
19q 13 region surrounding the apolipoprotein E (APOE) gene has shown consistent
evidence of involvement in MS. In a cross-sectional study, to show the APOE
genotype and allele frequency in the MS population of Iran in comparison with the
control group, we genotyped its polymorphisms (ε2, ε3 and ε4 alleles). The authors
investigated 81 patients with clinically definite MS and 93 asymptomatic elderly volunteers.
The frequency of the APOE allele in the MS population in comparison with
controls was 9.3% vs. 0.5% for ε4,44.4% vs. 51.6% for ε3, and 46.3% vs. 47.8%
for £2. The highest frequency of APOE genotype was from ε2/ ε3 with 66.7% vs.
94.6% and the lowest, £4/£4 genotype with 2.5% vs. 0%. The authors found significant
differences in the distribution of ε 4 allele between patients with MS and controls
(9.3% vs. 0.5% X2=15.2 df=2 p<0.001). The highest frequency of £4 allele in MS
patients was in Pure Turkish (25.0% vs. 5.3 % ) ethnicity. There was no signifIcant relation
between ethnicity and genotype. In the present study ε2/ε4, ε3/ε4 and ε4/ ε4
genotypes were more common in bout-onset cases compared to primary progressive
cases, and the secondary progressive disease was higher in carriers of £4 allele. Also,
the ε 2 allele was higher in relapsing remitting disease.
http://mjiri.iums.ac.ir/article-1-610-en.pdf
Multiple sclerosis
apolipoprotein E
polymorphism
disease course
Iran.