eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
281
283
article
DIAGNOSIS OF SUBCUTANEOUS MUCORMYCOSIS WITH FINE NEEDLE ASPIRATION:A RARE CASE REPORT
B GERAMIZADEH
geramib@sums.ac.ir.
1
P KHElRANDISH
2
P FATHEEZADEH
3
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Mucormycosis is a fatal and life threatening infection particularly in
immunocompromised patients, so early diagnosis and rapid treatment is life saving.
A 52-year-old female, known case of diabetes mellitus, presented with chills,
fever, fatigue and anorexia. A subcutaneous mass was detected around the umbilicus
(4x4). Fine needle aspiration of the mass showed mucor hyphea with little inflammation.
The patient was treated with amphotericin B and her fever subsided. The patient
was discharged in good health and general condition.
Fine needle aspiration can therefore be a rapid and accurate method for the diagnosis
of subcutaneous mucormycosis.
http://mjiri.iums.ac.ir/article-1-605-en.pdf
Subcutaneous Muconnycosis
Fine Needle Aspiration.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
277
280
article
CHOLESTEROL LOWERING EFFECT OF RHEUM RIBS IN HYPERCHOLESTEROLEMIC RABBITS
M-AL-R. HADJZADEH
1
H PARSAEE
h-parsaee@mums.ac.ir
2
A SADEGHIAN
3
From the Departments. Of Physiology and Pharmacology
Medical School , Mashhad University of Medical Sciences . Mashhad. Iran
The effects of ethanolic and aqueous extracts of Rheum ribs L. (RR) of the
family polygonaceae was studied on serum cholesterol concentration in rabbits.
To induce hypercholesterolemia, 0.5 g/kg/day of pure cholesterol powder was
given orally to each rabbit for two weeks then cholesterol was halved and each
group of animals was treated with a different regimen for another two weeks.
Both the ethanolic and the aqueous extracts significantly decreased serum
cholesterol conc-entration. The ethanolic extract decreased serum cholesterol by
the end of the first and the second week by 43.9% and 59.1% (both p<0.001)
respectively while the cholesterol reduction with aqueous extract was 25.01%
(p<0.05) and 43.82% (p<0.0 1) at the end of the first and the second week of
treatment respectively. The ethanolic extract was found to be more potent than
the aqueous one. When comp- ared with nicotinic acid as a positive control, the
hypocholesterolemic effect of ethanolic extract was significantly higher than that
of nicotinic acid. Therefore, we may conclude that RR extracts have hypocholesterolemic
effect and thus can be used in the treatment of hypercholesterolemia
which is the major risk factor of cor-onary heart disease (CHD).
http://mjiri.iums.ac.ir/article-1-604-en.pdf
Rheum ribs; Rhubarb; Hypercholesterolemia
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
273
276
article
RADIOACTIVE DISCHARGE FROM PATIENTS WITH THYROID CANCER UNDER 131I TREATMENT AND ITS SAFE DISPOSAL TO PUBLIC DRAINAGE
MOHAMAD BAGHER TAVAKOLI
mbtavakoli@mui.ac.ir
1
From the Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan UniversityOf Medical Sciences, Isfahan, Iran
The treatment of thyroid cancer using an unsealed source of radioactive materials
is usually associated with a large amount of 131I. A major problem for hospital admission
of these patients is the waste disposal which requires protection of the public.
152 patients with thyroid cancer admitted to the nuclear medicine department of
Said AI- Shohada Hospital for UI I treatment were studied. 1311 excreted from these
patients during isolation was calculated. Exposure from patients were measured using
a Victorian 190F survey dosimeter.
More than 70 percent of the administered 131I was excreted after 24 hours, 90
percent after 48 hours and 96 percent after 72 hours of isolation. The mean biological
half life of 1311 in patients with thyroid cancer was found to be 13.9±1.9 hours. There
was no significant difference between the mean effective half life in the patients related
for the first time and second time at 95 percent significance level.
The results of this study showed that the difference in the discharge rate of 1311
from patients with thyroid cancer receiving first and second treatment was not significant.
The mean discharge rate after the first 24 hours was more than 70%, and it was
more than 96% after the third 24 hours of drug administration. The results can be used
to design safe collecting and discharge methods of the wastes.
http://mjiri.iums.ac.ir/article-1-602-en.pdf
Thyroid cancer
Radioactive waste discharge
Biological half-life
Radiation dose.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
273
276
article
RADIOACTIVE DISCHARGE FROM PATIENTS WITH THYROID CANCER UNDER 131I TREATMENT AND ITS SAFE DISPOSAL TO PUBLIC DRAINAGE
MOHAMAD BAGHER TAVAKOLI
mbtavakoli@mui.ac.ir
1
From the Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan UniversityOf Medical Sciences, Isfahan, Iran
The treatment of thyroid cancer using an unsealed source of radioactive materials
is usually associated with a large amount of 131I. A major problem for hospital admission
of these patients is the waste disposal which requires protection of the public.
152 patients with thyroid cancer admitted to the nuclear medicine department of
Said AI- Shohada Hospital for UI I treatment were studied. 1311 excreted from these
patients during isolation was calculated. Exposure from patients were measured using
a Victorian 190F survey dosimeter.
More than 70 percent of the administered 131I was excreted after 24 hours, 90
percent after 48 hours and 96 percent after 72 hours of isolation. The mean biological
half life of 1311 in patients with thyroid cancer was found to be 13.9±1.9 hours. There
was no significant difference between the mean effective half life in the patients related
for the first time and second time at 95 percent significance level.
The results of this study showed that the difference in the discharge rate of 1311
from patients with thyroid cancer receiving first and second treatment was not significant.
The mean discharge rate after the first 24 hours was more than 70%, and it was
more than 96% after the third 24 hours of drug administration. The results can be used
to design safe collecting and discharge methods of the wastes.
http://mjiri.iums.ac.ir/article-1-601-en.html
Thyroid cancer
Radioactive waste discharge
Biological half-life
Radiation dose.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
265
272
article
EFFECTS OF NEURONAL BLOCKADE OF NORADRENALINE REUPTAKE IN AN EXPERlMENTAL MODEL OF HEART FAILURE
M MOHAMMADI NAGHADEH
1
JE McGRATH
2
From the *Department of Physiology, Faculty of Medicinc, Tabriz University olMedical Sciences, Tabriz,I.R. Iran
the ClinicaI Research Initiative in Heart Failure. West Medical Building, University ofGlasgow. Glasgow G21 8QQ
We investigated neuronal uptake of noradrenaline (NA) at the level of larger
vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral
saphenous artery and lateral saphenous vein and finally central ear artery and
marginal ear vein) in a model devised to mimic heart failure. The model presented
here is the rabbit coronary ligation model in which myocardial infarction was
produced in male New Zealand white rabbits (2.6kg-3.0kg) by ligation of the
marginal branch of the left descending coronary artery. The development of chronic
heart failure was allowed to proceed over eight weeks. Animals were killed by
overdose with pentobarbitone sodium (IV injection). Arteries and veins were
carefully removed with as little connective tissue as possible and placed in cold
physiological salt solution (PSS). The arterial and venous lings were mounted in
10mL isolated organ baths, bathed in Krebs maintained at 37°C and gassed with
95% O2 plus 5% CO2. The rings were then placed under different resting tensions.
They were allowed to equilibrate for 1 hour before the experiments. Initially all
tissues were exposed to cumulative concentrations of NA (lnM-300µM). Following
complete washout, the preparations were left for 45 minutes to re-equilibrate. After
preincubation with cocaine (10µM) for 10-15 minutes to inhibit neuronal uptake of
NA, final NA cumulative concentration-response curves (CCRC) were conducted.
Alierial plasma noradrenaline is 163% higher in patients with heart failure than in
control patients. High plasma noradrenaline correlates directly with the
hemodynamic severity of the disease and inversely with survival. Activation of the
sympathetic nervous and renin-angiotensin systems may be important in the
pathophysiology of heart failure associated with severity of the disease. Elevated
levels of circulating noradrenaline in heart failure may result from impaired
peripheral reuptake of this catecholamine. Cocaine has generally been used as the
prototype drug for inhibition of neuronal uptake of catecholamines. The aim of our
study was to investigate the possibility of changing reuptake of noradrenaline by
using cocaine in this model of heart failure. In conclusion, effects of cocaine on
noradrenaline responses were identical in sham operated compared with coronary
ligated rabbits. These results suggest normal neuronal uptake of noradrenaline in this
model of heart failure.
http://mjiri.iums.ac.ir/article-1-600-en.pdf
Heart Failure
Cocaine
Noradrenaline
Larger Vessels
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
257
263
article
EXPANSION OF HUMAN CORD BLOOD PRIMITIVE PROGENITORS IN SERUM-FREE MEDIA USING HUMAN BONE MARROW MESENCHYMAL STEM CELLS
M SOLElMANI
1
H MOZDARANI
mozdaranh@modares.ac.ir
2
AA POURFATHOLLAH
3
Y MORTAZAVI
4
K ALIMOGHADDAM
5
A HAJIFATHALI
6
Z ZONOBI
7
From the Hematology Dept .. School of'Medical Sciences. Tarbiat Modares University, Tehran
Medical Genetics Dept. School of Medical Sciences, Tarbiat Modares University, Tehran
From the Hematology Dept .. School of'Medical Sciences. Tarbiat Modares University, Tehran
From the Hematology Dept .. School of'Medical Sciences. Tarbiat Modares University, Tehran
Bone Marrow Transplantation Center. Shariati Hospital, Tehran,
the Iranian Blood Trans(ilsion Organization,Tehran
Shahid Beheshti Medical Sciences University. Tehran. Iran
Ex vivo expansion of human umbilical cord blood cells (HUCBC) is explored by
several investigators to enhance the repopulating potential of HUCBC. The
proliferation and expansion of human hematopoietic stem cells (HSC) in ex
vivo culture was examined with the goal of generating a suitable clinical protocol for
expanding HSC for patient transplantation. Using primary human mesenchymal
stem cells, we established a serum-free culture system to expand human primitive
progenitors and transplantable stem cells. Non-enriched cord blood CD34+ cells
were cultured on a monolayer of human mesenchymal stem cells in the presence of
tlu-ombopoietin (TPO), flt31flk2 ligand (FL), and/or stem cell factor (SCF),
interleukin 6 (IL-6), interleukin 3 (IL-3) under serum-free conditions. After I or 2
weeks of culture, cells were examined for clonogenic progenitors and percentage of
CD34+ CD38- cells. In the presence of TPO, FL, and SCF, fetal MSC cells
supported more than a 35- and 20-fold expansion of CD34+ cells and colonyforming
units in culture after 1 and 2 weeks of incubation, respectively. In addition,
LTC-IC assay were expanded more than 7- and 16-fold after 1 and 2 weeks of
culture, respectively. UCB-HSC can be expanded in culture to numbers theoretically
adequate for safe, rapid engraftment of adult patients. Additional studies are needed
to establish the functional activity of expanded UCB-HSC. This ex vivo expansion
system should prove valuable in clinical settings in which stromal cells are available
from recipients or stem cell donors.
http://mjiri.iums.ac.ir/article-1-599-en.pdf
Ex vivo expansion; Stem cells; Umbilical cord blood; Mesenchymal stem cells.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
253
256
article
ABDOMINAL TUBERCULOSIS: A REPORT OF 32 CASES
J KHOSHNEVIS
JKHOSH2001@yahoo.com
1
SM HOMA YOONI
2
From the Departments of Ceneral and Vascular Surgery and Internal Medicine. Shohada Medical Center,
Abdominal tuberculosis is still a prevalent problem of underdeveloped countries.
Although its incidence has been reduced in developed countries, it is still seen in
immigrants and immunodeficient patients frequently. In Iran, even though it's
incidence has been reduced, we are still confronted with undesired mortality and
morbidity. In this article we have evolved new management strategies for these
patients and then we have performed a retrospective study of over 32 cases to
evaluate the results on management of these patients during a 22 year period
(1981 - 2003).
Females had more involvement, and the mean age was 27.8 years. Fever,
abdominal pain, and weight loss were common findings. There were three
mortalities (9.3%) and three morbidities (9.3%) including two intestinal fistulae
and one obstruction.
http://mjiri.iums.ac.ir/article-1-598-en.pdf
Abdominal tuberculosis
enterolysis. fistulae
pelioration.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
243
246
article
THE EFFECT OF INTRAPARTUM EPIDURAL ANALGESIA ON NULLIPAROUS LABOR
SM AMINI
1
H KIMIAE-ASADI
2
KH MANI-KASHANI
3
From the Department of Anesthesiology. Hamadan University o/Medical Sciences, Hamadall, Islamic
Ihe Departll/ent ofAnesrhesiology. Hall/adan University o/Medical Sciences, Hall/adall, Islamic
Ihe Departll/ent ofAnesrhesiology. Hall/adan University o/Medical Sciences, Hall/adall, Islamic
Our purpose was to determine the effect of epidural analgesia on nulliparous
labor and delivery. Nonnal term nulliparous women in spontaneous labor were
divided into two groups in a quazi-experimental study, 100 in each group. The
first group received epidural analgesia and the second had no analgesia at all. In
the first group, an epidural catheter was placed in 3-4 cm cervical dilatation and
the first dose of lidocaine 1 % was injected in 5-cm cervical dilatation. The next
doses were injected according to certain criteria. Then data were collected and
analyzed by EPI-6.
There was no significant difference in cesarean rate in both groups (10% in the
first group vs. 5% in the second one, p>O.l0) including cesarean for dystocia and
fetal distress. Also, there was no significant difference in the variable of
spontaneous vaginal delivery between both groups (89% in the first group vs. 94%
in the second one, p>0.10). Occurrence of instrumental vaginal delivery was the
same in both groups, no forceps, and one vacuum-assisted in each group. Also
there was no significant difference in the second stage of labor between the groups
(less than 1 hour: 79% in the first group vs. 81 % in the second group, p>O.1 0 more
than 1 hour: 11 % in the first group vs. 14% in the second group, p>0.10).
Epidural analgesia results in no significant difference in the course of labor
and delivery in normal term nulliparous women and is a safe method of pain
relief in these patients.
http://mjiri.iums.ac.ir/article-1-596-en.pdf
Analgesia
Epidural/Analgesia
Obstetrical/Labor
Nulliparous.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
237
242
article
CARDIAC ELECTRICAL DYSFUNCTION IN ACUTE BRAIN LESIONS
GHOLAMREZA BAHADORKHAN
1
MOHAMMAD REZA EHSAEI
2
AHMAD SARRESHTEH DAR
3
From the Department of Neurosurgery, Mashhad University o/Medical Sciences. P.O. Box 91375-3983.
This study briefly reviews the heart abnormalities in diverse intracranial pathologies,
including strokes, spontaneous and traumatic subarachnoid hemorrhage and intracranial
hemorrhage, and presents the results of a one-year prospective study of
heart abnormalities in patients with moderate to severe head injuries and subarachnoid
hemorrhage. Different abnormalities such as: QT -interval, T -waves, U-waves, QRS complex,
ST-Segment, arterial and ventricular flutter and PAC, heart arrhythmia, angina
pectoris and blood pressure changes were recorded and analyzed. The most
common electrocardiographic change was ST -segment depression (67%).
This report tries to identify a rational relationship among the severity of head injury,
site of lesion and level of consciousness at the time of admission, different surgical
procedures, site of operation, prognosis and cardiac abnormalities. The presence of
the complete pathway for sympathetic outflow from the orbital-frontal cortex to the
limbic system via stellate ganglia to the heart is also discussed.
In conclusion cardiac abnormalities can greatly increase the morbidity and mortality
of patients with intracranial pathologies. Emphasis is made on timely prevention and
treatment of cardiac abnormalities preferably by stabilization of homeostasis of the
brain condition by medical and surgical techniques anti-arrhythmic drugs should be
avoided unless strongly indicated. Obviously ventricular flutter and fibrillation must be
treated with countershock and anti-arrhythmic drugs.
http://mjiri.iums.ac.ir/article-1-595-en.pdf
Brain contusion
cardiac rhythm
head injury
subarachnoid hemorrhage
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
231
235
article
DOES HYPERFRACTIONATED RADIOTHERAPY CHANGE THE OUTCOME OF HEAD AND NECK CANCER? A TRIAL COMPARING CONVENTIONAL WITH HYPERFRACTIONATED RADIOTHERAPY
A MOSALAEI
mosalaa@sums.ac.ir
1
N AHMADLOO
2
S OMIDVARI
3
M MOHAMMADIANPANAH
4
From the Radiatiol1 Oncology Department, Shiraz University of Medical Sciences, Shiraz, I.R. Iran .
The optimal fractionation schedule for radiotherapy of head and neck cancer
has been controversial. The objective of this randomized trial was to test the
efficacy of hyperfractionation vs. standard fractionation.
Patients with squamous cell carcinoma of head and neck organs were randomly
assigned to receive radiotherapy delivered with A) standard fractionation at 2
Gy/fraction/day, 5 days/week, to 65-70 Gy/7 weeks B) hyperfractionation at 1.2
Gy/fraction, twice daily, 5 days/week to 75 - 80 Gy/7 weeks. All patients but one
completed the treatment. The median follow-up was 24 months for all patients.
Patients treated with hyperfractionation had significantly better local-regional
control (p<0.005) than those treated with standard fractionation. Although acute
morbidity was somewhat higher in the hyperfractionated radiotherapy group, late
disturbing effect was much lower in this group.
In conclusion, hyperfractionation is more efficacious than standard fractionation
for locally advanced head and neck cancer. Acute but not late effects are
also increased.
http://mjiri.iums.ac.ir/article-1-594-en.pdf
Head and neck
Radiotherapy
Fractionation
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
227
230
article
SUPINE VERSUS TURNING POSITION ON BILIRUBIN LEVEL DURING PHOTOTHERAPY IN HEALTHY TERM JAUNDICED NEONATES
A MOHAMMADZADEH
a-mohammadzadeh@mums.ac.ir
1
Z BOSTANI
2
F JAFARNEJAD
3
From the Department of Neonatology Imam Reza Hospital, Mashhad University of Medical Sciences. Mashhad. Iran
Position changes are believed to increase the efficacy of phototherapy and this
practice is routinely used in all neonatal departments in our country. The aim of
this study was to determine the effect of routine turning on the total serum
bilirubin (TSB) concentration versus only supine position.
In a randomized clinical trial fifty healthy term jaundiced neonates who were
admitted to the neonatal ward were selected. All babies were healthy tem1
jaundiced neonates more than 48 hours of age delivered after an uncomplicated
pregnancy and had indirect hyperbilirubinemia with TSB 2: 15 mg/dL in 49- to
72-hour-oldjaundiced infants and equal or more than 17 mg/dL in 2:72-hours-old
ones. Twenty five (turning group) babies were changed from supine to prone
position every 150 minutes followed by a break of the 30 minutes for feeding
and routine nursing care. The supine group (n=25) were kept in the supine
position during the entire study period.
TSB was obtained before phototherapy, 12, 24, and 48 hours after phototherapy.
The analysis of data was done by SPSS and paired T and T independent student test.
These two groups were similar in age, sex, weight at admission, duration of
phototherapy, hematocrit and reticulocyte count. The average of bilirubin in
these two groups, before phototherapy (p=0.93), 12 (p=0.58), 24 (p=0.74) and 48
hours (p=0.93) after phototherapy respectively were not significant.
The results of this study demonstrated that TSB is not affected by the baby's
position during phototherapy.
http://mjiri.iums.ac.ir/article-1-593-en.pdf
Phototherapy
Position of neonate
Hyperbilirubinemia
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
219
225
article
COMPARATIVE STUDY OF CHEMORADIATION AND NEOADJUV ANT CHEMOTHERAPY BEFORE RADICAL HYSTERECTOMY IN STAGE m - 1m BULKY CERVICAL CANCER AND WITH TUMOR DIAMETER GREATER THAN 4 CM
M MODARES
1
A MOUSAVI
2
N BEHTASH
3
M GOLNAVAZ
4
From the Department of Gynecology & Obstetrics, Tehran Universiry of Medical Sciences, Tehran, Iran.
Tumor size seems to be a determinant in the prognosis of early cervical cancer.
Patients with tumor size greater than 4 cm (bulky) in diameter have worse outcome.'
The purpose of this study was to compare the efficacy of preoperative combined
chemoradiation and neoadjuvant chemotherapy (NArC) programs followed by
radical hysterectomy in stage Ib - lIb bulky cervical cancer.
From September 1999 to April 2002, 60 patients with stage Ib - IIb bulky
cervical cancer were treated with preoperative extemal beam radiotherapy to
45Gy plus weekly cisplatin 50 mg/m2 or preoperative neoadjuvant chemotherapy
by cisplatin 50 mg/m2 and vincristin 1 mg/m2 every 7-10 days, for three courses,
Surgery was perfonned 4-6 weeks after completion of the preoperative treatment.
There was no significant difference between age, stage, tumor size and
histopathological type in the two groups (p>0.05).Toxicity associated with the
two treatment methods was usually mild. In the chemoradiation group, two patients
developed vesicovaginal fistula, and four patients developed long term hydronephrosis
that needed ureteral stenting. Before surgery, complete and pmiial clinical
response had no significant difference between the two groups (p>0,05). After
surgery, lymph node and parametrial involvement had no significant difference
between the two groups (p>0.05). In the NAIC group more patients had
significant residual tumor (p=0,0 12) but residual tumor size had no significant
difference between the two groups (p>0. 05). Pathological complete response was
significantly higher in the chemoradiation group (p= 0. 004),
According to the results of this study it seems that NArC and chemoradiation
have similar effects on survival prognostic factors
http://mjiri.iums.ac.ir/article-1-592-en.pdf
Chemoradiation
neoadjuvant chemotherapy
radical hysterectomy
cervical cancer
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
211
217
article
IMMUNOGENICITY OF HEPATITIS B VACCINE IN MULTI - TRANSFUSED THALASSEMIC PATIENTS WITH AND WITHOUT HEPATITIS C INFECTION: A COMP ARA TIVE STUDY WITH HEAL THY CONTROLS
H FOROUTAN
1
H GHOFRANI
2
SH . MIRMOMEN
3
S KAZEMI ASL
4
MJ FARAHVASH
5
M NASIRI TOUSI
6
From the Department of1nternal Medicine.Imom Hospital. Tehran University of Medical Sciences,
Hepatitis C virus (HCV) infection is highly prevalent in thalassemic patients,
and this may decrease the serum antibody response to hepatitis B virus (HBV)
vaccine. There is also some alteration of the immune system in multi-transfused
thalassemic patients, as a consequence of iron overload. We investigated whether
HCY infection may reduce the effectiveness of HBY vaccine in multi -
transfused thalassemic patients. Subjects were cited and studied prospectively in
three groups: group I: 125 multi-transfused thalassemic patients with negative
serum HCY antibody group 2: 96 multi-transfused thalassemic patients with
positive serum HCV antibody (ELISA II), in at least 2 different occasions group
3: 100 healthy subjects. Matching was performed between three groups in sex,
age and body mass index and subjects in all groups had negative serum HBsAg,
anti-HBc and anti-HBs and received three 20 flgr/dose injections of recombinant
HBV vaccine (Heberbiovac HB) in months 0, 1, 6. Anti-HBs titer was obtained
one month after the last dose of vaccine and it was considered seroprotective if it
was 2: 10 lUlL. Seroprotection rate was 83.2% in group 1 and 80.2% in group 2
(p=0.74) and was 86% in healthy subjects, which didn't significantly differ with
HCV positive and negative thalassemics (p>0.05). Moreover, the mean values of
ALT among the responders and non-responder thalassemic patients were 55.5 ±
4 l .9 and 57.4 ± 48.5 U/L respectively(p=0.802). During vaccination periods,
patients in all 3 groups did not show any significant adverse reactions. Our study
shows that three standard doses of HBV vaccine are immunogenic and safe in
multi-transfused thalassemic patients with or without HCV infection.
http://mjiri.iums.ac.ir/article-1-588-en.pdf
Hepatitis B
Hepatitis C
Thalassemia
Hepatitis B vaccine. anti-HBs
seroprotection
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
205
209
article
EFFECT OF A UDITORY-VERBAL REHABILITATION ON VOICE PARAMETERS IN CHILD COCHLEAR IMPLANT USERS
MOHAMMAD M GHASEMI
1
HAMID TAYARANI
2
MOHAMMAD R TALE
3
EFAT DAROUBORD
4
From the Khorasan Cochlear Implant Research Center. Mashad. I.R.Iran
This study aimed to evaluate the effects of auditory-verbal rehabilitation on voice
parameters after implantation with cochlear implants 2 and 5 months after rehabilitation
and compare them with normal voice children (under 12 years of age). A perceptive
and electroacoustic evaluation of voice was carried out through a digital analysis after
implantation and rehabilitation. The study was performed at Khorasan Cochlear Implant
Center in Ghaem Hospital, Mashad University of Medical Sciences in Mashhad.
There were 5 prelingually deaf children and 5 children with normal voice and hearing.
Voice parameters (average pitch and intensity, perturbation, jitter and shimmer), were
obtained. All patients showed better control of voice pitch and intensity and a considerable
reduction of voice perturbation, jitter and shimmer after auditory rehabilitation.
This study showed no considerable difference on voice parameters between cochlear
implanted children and normal children (voice and hearing). ft could be concluded
that auditory-verbal rehabilitation as a necessary and important training program
for cochlear implanted children provides a recognizable moment-to-moment auditory
control on parameters of voice
http://mjiri.iums.ac.ir/article-1-586-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
205
209
article
EFFECT OF A UDITORY-VERBAL REHABILITATION ON VOICE PARAMETERS IN CHILD COCHLEAR IMPLANT USERS
MOHAMMAD M GHASEMI
1
HAMID TAYARANI
2
MOHAMMAD R TALE
3
EFAT DAROUBORD
4
From the Khorasan Cochlear Implant Research Center. Mashad. I.R.Iran
This study aimed to evaluate the effects of auditory-verbal rehabilitation on voice
parameters after implantation with cochlear implants 2 and 5 months after rehabilitation
and compare them with normal voice children (under 12 years of age). A perceptive
and electroacoustic evaluation of voice was carried out through a digital analysis after
implantation and rehabilitation. The study was performed at Khorasan Cochlear Implant
Center in Ghaem Hospital, Mashad University of Medical Sciences in Mashhad.
There were 5 prelingually deaf children and 5 children with normal voice and hearing.
Voice parameters (average pitch and intensity, perturbation, jitter and shimmer), were
obtained. All patients showed better control of voice pitch and intensity and a considerable
reduction of voice perturbation, jitter and shimmer after auditory rehabilitation.
This study showed no considerable difference on voice parameters between cochlear
implanted children and normal children (voice and hearing). ft could be concluded
that auditory-verbal rehabilitation as a necessary and important training program
for cochlear implanted children provides a recognizable moment-to-moment auditory
control on parameters of voice
http://mjiri.iums.ac.ir/article-1-585-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
201
204
article
LATE EMBOLECTOMY FOR LIMB OR KNEE SALVAGE IN ACUTE LOWER LIMB ISCHEMIA: A NEW PROTOCOL
MK MOTAMEDI
1
M MOZAFFAR
mohamad_mozafar@yahoo.com
2
A AFSHARFARD
3
F MALEKPOUR
4
R VAGHARDOOST
5
From the department of Trauma and Vascular Surgery. Shohada Tajrish Medical Center Shahid Beheshti University of Medical Sciences. Tehran. I.R Iran
Embolectomy has long been the gold standard for treating limbs acutely
threatened by arterial occlusion. Delayed embolectomy has not been investigated
adequately due to the belief that accompanying mortality and morbidity render
the case futile. Following our previous experience with late arterial repair for leg
or knee salvage I we applied the same principle to limbs threatened with
prolonged ischemia as a result of missed emboli. In this study the response of
patients with delayed embolectomy in a 2-year interval is evaluated.
All of the patients who presented to Shohada Tajrish Medical Center, Tehran,
Iran between 2001 to 2003 with prolonged ischemia of the lower limb (more
than 12 hours) were selected for this study. All underwent embolectomy and
prior to reinstitution of blood to the ischemic leg, all those with calf rigor
underwent simultaneous venotomy and irrigation of the arterial tree with
heparinized solution and were studied accordingly.
Of the total 76 patients 20% had muscle rigor on admission who underwent
simultaneous venotomy and irrigation. The limb was salvaged in 45% of patients
with above knee sensory deficit and 40% of those with above knee motor deficit.
The salvage rates of the limb for below knee sensory and motor deficits were
79% and 85% respectively. We were able to save the knee in 20% of our patients.
The short term m011ality rate in the whole was 9.2%.
We had only one operative mortality in this high risk group of patients & our
figures are lower than those reported in the literature, while at the same time we
were able to salvage their limbs or knees.
http://mjiri.iums.ac.ir/article-1-582-en.pdf
Acute Limb Ischemia
Late Embolectomy
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
191
199
article
DESIGN AND STRUCTURE OF A NEW DEVICE FOR AUDITORY ELECTRICAL STIMULATION FOR SUPPRESSION OF TINNITUS
M FARHADI
farhadi@ent-hns.org
1
S MAHMOUDIAN
2
M SAMOUDI
3
H EMAMJOMEH
4
A DANESHI
5
From the Research Center of Ear, Nose, Throat, Head & Neck Surgery, Iran University of Medical
Department & Research Center of Ear, Nose, Throat, Head & Neck Surgery, Iran University of Medical Sciences, Tehran, Iran
Shiraz University
Department of Audiology, HaZl'ate Rasoul Hospital, Iran University of Medical Sciences, Tehran, Iran
Department of Otolaryngology, Hazrate Rasoul, Hospital, Iran University of Medical Sciences, Tehran, Iran
Auditory Electrical Stimulation for Tinnitus Suppression
Tinnitus is the conscious experience of sound which arises in the head of its
owner, but without a voluntary origin obvious to that person. About 10-15% of all
adults report prolonged spontaneous tinnitus (PST).
There are a lot of methods for suppressing this complaint. One of these methods is
electrical stimulation. Electrical stimulation for tinnitus suppression was investigated
by many authors that reported its effectiveness from 22% by Grahams and Hazell
(1989) to 87% by Portman (1979).
The purpose of the present project was to design and structure a new Auditory
Electrical Stimulation device for tinnitus relief in patients who suffer from tinnitus.
Our other goal was to execute a pilot project by modelling of our new device on
animals.
In this project an instrument for applying Auditory Electrical Stimulation (AES)
is designed. This device consists of two generators: one is a carrier square wave
generator (30 KHz to 100 KHz), the second is another low frequency square signal
(1 Hz through 20 KHz) that has an adjustable duty cycle. The entire user interface is
on PC, and there are a lot of options that the user can adjust.
The PC is connected to a circuit by a serial port and the serial port is isolated from
the other pat1s of the circuit. Modulation can optionally be enabled or disabled. The
amplitude of current flow can vary from 1 microamp to 1000 microamp (lmilli-
Amp) with 1 microamp resolution. The impulse duration can be adjusted (this is a
third pulse generator) by the user from 500 microsec delivered at 1/sec to 2000/sec.
The combined electrical signal has the maximum peak to peak amplitude of 10 V,
which varies to make a constant current through electrodes. A warning device
indicates insufficient skin electrode contact. In addition the impedance between
electrodes can be monitored on PC. There are several parts that increase the safety
of this system. The dimension of the PC board is 11 cm x 14cm. By now the first
version which could be used in hospital and/or clinics is made and could be used by
patients who suffer from tinnitus.
We believe that tinnitus reduction occurred or even disappeared during and after
the treatment period by AES. Our results applying Auditory Electrical Stimulation
(AES) were effective in our many patients who had clinically been identified as
having peripheral or central lesion tinnitus sites. We made a new auditory electrical
stimulation device for tinnitus relief in patients suffering from tinnitus that can do
electrical stimulations. Also, in an experimental study design on rabbits, we had
tested this new device, and evaluated the efficiency to deliver electrical currents and
other capabilities in tinnitus suppression.
Although study comparisons are confounded by differences in success criteria,
subject sampling, methodology and acute tinnitus suppression have been reported in
up to 62.5% of subjects (Mahmoud ian et aI., 2001), AES reduces the effects of
tinnitus several factors could be involved in this reduction, i.e. synchronizing
discharge of auditory nerve fibers, inhibition of the abnormal activity of the cochlear
nerve, the revival neural coding and positive neural plasticity.
http://mjiri.iums.ac.ir/article-1-576-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2004-11
18
3
0
0
article
INFANTS DEVELOPMENTAL MILESTONE PATTERN OF SHIRAZ (IRAN) IN RELATION TO THE DENVER CHART
SMT AYATOLLAHI
1
F.S.S., C. Stat
2
AR MOGHISI
3
From the Department of Biostatistics and Epidemiology, Shiraz University of Medical Sciences, Po. Box
This paper presents standardized norms of child development in Shiraz (Iran). A
birth cohort of317 randomly selected neonates born at the 14 maternity clinics of
Shiraz during 2 random consecutive weeks in 1996 were followed at homes for 2
years at 12 designed occasions and their development examined by 2 trained public
health officers and a community medicine expert. In gross-motor and personal-social
sectors, girls were earlier than boys in "crying", "head control" and social smile items
respectively. In fine motor-adaptive sector boys showed more advancement in the
"thumb-finger grasp" and "pass cubes" items. Boys development in language, personal-
social and fine motor-adaptive sectors were earlier than girls in items "ooo/aaah",
"papa, mama", "recognize relatives", "look for yarn", "recognize own nipple and bottle"
respectively. The rest of the items passed by boys and girls were the same in both
groups and not favoured to anyone. The subjects developed slower than the Denver
sample in one item in fine motor-adaptive and personal-social sector. However, Shiraz
infants were earlier than Denver ones in the item of other sectors, but, in general, no
statistically significant differences were detected. The paper concludes that the Denver
Developmental Screening Test (DDST), in general, is a valid developmental screening
instrument which may be used in Iran with the adjustments presented. Public health
nurses may apply these key item skills, in that the use of a standard gives them an
increased insight into child development.
http://mjiri.iums.ac.ir/article-1-597-en.pdf
Infants
Denver Developmental Screening Test (DDST)
Mean Age of Reaching a Milestone