eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
119
121
article
COMBINED MONTEGGIA LESION AND ELBOW DISLOCATION
A AFSHAR
1
From the Department of Orthopedic Surgery, Shahid Mottahari Hospital, Orumieh University of Medical Sciences, Orumieh, I.R. Iran
This case is a 19-year-old soldier who suffered a combined elbow dislocation and posterior Monteggia fracture and dislocation (type II). The ulna fracture was managed by ORIF. The elbow dislocation was managed by closed reduction and immobilization in 900 flexion. The posteriorly dislocated radial head was kept reduced by a transarticular pin. After 6 months elbow and forearm motion was restricted and X-ray revealed heterotopic ossification around the radial head. In further follow up there was no improvement in his range of motion. Treatment of these combined elbow injuries remains challenging.
http://mjiri.iums.ac.ir/article-1-764-en.pdf
Elbow dislocation
Monteggia lesion
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
115
117
article
ZOSTERIFORM METASTASES IN A MAN WITH MALIGNANT MELANOMA
S SHAMSADINI
shamsadini@yahoo.com
1
S DABIRI
2
From the Departments of Dermatology and * Pathology, Kerman University of Medical Sciences, Kerman, I.R. Iran.
Zosteriform metastasis is a rare clinical distribution from spreading
neoplasms of every organ to the skin. Tumors most often arise from a n
internal o r hematologic malignancy. W e report a 69-year-old man, a known
case of malignant melanoma of the left heel. In this case, multiple red-brown
metastatic nodules appeared four months after diagnosis. Distribution
of metastatic lesions resembled a zosteriform configuration on his
left thigh dermatome. Histological findings of a cut section of an excised
nodule were compatible with a diagnosis of metastatic malignant melanoma.
As we know this case report is the first case of zosteriform distribution
of metastatic malignant melanoma that has been reported.
http://mjiri.iums.ac.ir/article-1-763-en.pdf
Zosteriform metastases
Malignancy
Malignant melanoma.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
111
114
article
MACRODYSTROPHIA LIPOMATOSA: CT AND M R FINDINGS
MARYAM RAHMANI
1
MOHAMMAD ALI SHABANI
2
From the Department of Radiology, Emam Khomeini Medical Center; Tehran University of Medical Sciences, Tehran, I.R. Iran.
Macrodystrophia lipomatosa is a rare congenital form of localized gigantism
characterized by an increase in all mesenchymal elements, particularly fibroadipose
tissue. MR imaging can be used to examine the soft tissue and detect the fibrous
and fatty hypertrophy that characterizes this condition and also diagnose an associated
fibrolipomatous hamartoma of the median or plantar nerve. We describe
the clinical and radiological findings (including CT scan, MRI and bone scan)
and also progression of this rare entity during a 10 year period.
http://mjiri.iums.ac.ir/article-1-762-en.pdf
Macrodystrophia lipomatosa (MDL)
Fibrolipomatous hamartoma (FLH). Magnetic resonance imaging
Computed tomography
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
107
110
article
CLINICAL EVALUATION OF BONE CEMENT AND AUTOGENOUS BONE GRAFT IN DOGS
D SHARIFI
1
GR ABEDI
2
F SASSANI
3
D SAVADKOUHI
4
J BAKHTIARI
5
I NOWROUZIAN
6
From the Faculty of Veterinary Medicine, Tehran University, Tehran, I.R.Iran
Various biological bone g rafts have been used for osteogenes i s ,
osteoconduction and even osteoinduction, but due to systemic influences and local
factors, the outcome of successful incorporation of a bone graft has not been
satisfactory. This study was therefore conducted on 15 clinically healthy adult
dogs between 1 to 3 years of age weighing 20 to 30 kg to evaluate the effect of
bone cement and autogenous bone grafts. A piece of 3 cm complete mid-shaft
right tibial cortical bone was removed in all animals. Then they were subsequently
divided into three groups of 5 animals each. In group I the bone was fixed with a
suitable intramedullary pin, whereas the gap was filled with harvested autogenous
rib bone graft in group II animals. Bone cement was used to fill the gap in animals
of group III for the first 30 days, then it was replaced with iliac bone chips and
observation was made accordingly for 60 days in all animals of the three groups.
After 60 days, before collection of callus samples, there was granulation and fibrocartilage
tissue in groups I and II respectively, whereas a thick fibrous capsule
or pseudomembrane layer was seen around bone cement on day 30 before removal
of cement and on day 60 after replacement by iliac bone graft in group III
animals. There were combinations of heavily impacted fibrous a n d
fibrocartilagineous tissues with thick bundles of collagen fibers among hypertrophic
chondroblasts in histomorphological cross section in group I animals,
whereas active sequestra were present in group II animals. Fibrotic capsule, periosteal
layer, lacunae, osteoblasts, osteocytes and well formed bone marrow with
RBC and adipose tissue were noted in group III animals. It appears that the local
reaction induced by bone cement leading to fibrotic capsule formation was quite
helpful in delaying iliac bone graft resorption and enhancing osteogenic stimulation
as to fill the gap with impacted callus with normal cortical structure.
The application of bone cement in gap non:::union:::, crushed bone and fragmental
fractures is therefore highly recommended.
http://mjiri.iums.ac.ir/article-1-761-en.pdf
Bone Cement
Autogenous Bone
Graft
Dog.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
101
105
article
PULMONARY VASCULAR MUSCLE PROLIFERATION AS A RESULT OF PROTEIN AND mRNA-eNOS ALTERATIONS IN A RAT MODEL OF CHF
MOHAMMAD REZA BIGDELY
1
SOHRAB HAJIZADEH
2
SAEED SHAHRAZ
3
From the Department of Microbiology, Islamic Azad University, Zanjan
the Department of Medical Physiology, Tarbiat Modarres University, Tehran
the School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, l.R. Iran.
Endothelial Nitric Oxide Synthase (eNOS) produces nitric oxide (NO)
from L-arginine and is important for the maintenance of cardiovascular homeostasis.
Congestive heart failure (CHF) generally results in increased pulmonary
blood flow and if untreated leads to pulmonary hypertension and end
stage heart failure. We therefore hypothesized that increased pulmonary flow
without changes in pressure would result in hypertrophy of the media (middle
layer of vascular wall). NO produced by the lung is regulated by systemic
blood flow and in turn adjusts smooth muscle proliferation via altered expression
of eNOS. To study this hypothesis, we created an artificial aortocaval
shunt in order to increase pulmonary flow for 7 weeks. The shunt resulted in
a significant thickening of the media. eNOS Western and Northern blot analysis
demonstrated no significant alterations of eNOS protein and mRNA levels
in the large-shunted group but in the small shunted one in comparison with
sham. We suggested that NO in low concentrations (about > 10µM) caused
weak hypertrophy of the media in the small-shunted group and in high concentrations
(about> 50µM) caused S-nitrosylation of eNOS protein and deamination
of eNOS mRNA and the regulatory genes in the nucleus thus the media
of the vascular wall was significantly thickened in the large-shunted group.
In higher concentrations, NO induces apoptosis and decreased cell viability.
http://mjiri.iums.ac.ir/article-1-760-en.pdf
Nitric oxide
Shunting
Congestive heart failure (CHF)
eNOS.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
95
100
article
DIFFERENTIATION BETWEEN BENIGN, REACTIVE AND MALIGNANT CELLS IN SEROSAL BODY FLUIDS BY AgNOR STAINING
S TORABI-NEZHAD
1
A AZARIAN
2
From the Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Argyrophilic nucleolar organizer regions (AgNORs) were determined in 94
pleural, pericardial and peritoneal effusions. The results were correlated with cytologic
diagnosis to determine the diagnostic potential of this technique. Cytologically
the number of normal, reactive and malignant effusions were 32, 28 and
34 respectively.
The mean AgNOR counts for normal, reactive and malignant specimens were
1.365,2.328 and 4.747 respectively. The cut-off points between normal-reactive
and reactive-malignant specimens were 1.84 and 3.53 respectively. All of the
malignant specimens (100%) had AgNOR counts above 3.53.
Neither reactive nor normal specimens had AgNOR counts above 3.53. 82.1 %
of reactive specimens had AgNOR counts above 1.84 and 87.5% of normal specimens
had AgNOR counts below this point.
There was a statistically significant difference between the AgNOR counts
in normal, reactive and malignant effusions (p<0.001).
We conclude that the AgNOR method is a specific diagnostic tool for serosal
cavity effusions, especially when malignancy is suspected.
http://mjiri.iums.ac.ir/article-1-759-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
89
93
article
SURVIVAL EXPECTANCY IN PATIEN T S WITH COLORECTAL CANCER UNDERGOING STANDARD TREATMENT METHODS
E MOHAMMADI
1
S FAGIZADEH
2
A ABASAHL
3
From the Departments of Nursery Tarbiat Modarres University
From the Departments of Biostatistics, Tarbiat Modarres University
the Dept. of Surgery, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Colorectal cancer is one of the most prevalent cancers in the world. It's survival
expectancy depends on the time of diagnosis, stage and grade of the tumor,
and general condition of the patient. Survival expectancy of this type of cancer
reveals the quality of diagnostic and therapeutic services in the community. To
improve and standardize the treatment modalities in this field, much research has
been conducted worldwide. In this study, patients with a confirmed diagnosis of
colorectal tumors (CRT) who were under treatment or referred to the Oncology
Department of Imam Khomeini Medical, Educational and Research Complex
within the years 1987-1991, were selected.
This study showed that the 5 year survival rate of these patients was maximally
21 %.
http://mjiri.iums.ac.ir/article-1-758-en.pdf
Survival Expectancy
Colorectal Tumor
Therapeutic Methods.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
85
88
article
COMPARATIVE STUDY OF PERINATAL OUTCOME OF GROWTH RESTRICTED FETUSES IN HYPERTENSIVE MOTHERS VERSUS OTHER CA USATIVE FA CTORS
MH ALAVI
1
DJ DERAKHSHAN
2
SR DADGAR
3
From the Department of Obstetrics and Gynecology, Shahid Akbar-abadi Hospital,
From July 1998 to November 1999 we have followed up 15712 deliveries
(12044 vaginal and 3668 cesarean section) in our hospital. Among
these, 182 cases were primarily diagnosed as intrauterine growth restriction
(IUGR) and 248 pregnancies were complicated with hypertensive disorders.
In these two groups we have investigated the outcome of the neonates.
Neonatal weight under the 10th percentile in these two groups was
1.63% and 36.3% and perinatal mortality was 4.4% and 6.1 % respectively
(p<0.05), due to the much higher incidence of IUGR and greater perinatal
mortality in hypertensive pregnant women as compared with the general
obstetric population. We conclude that it is valuable to manage close observation
in all cases of pregnancy induced or aggravated hypertension.
http://mjiri.iums.ac.ir/article-1-757-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
79
83
article
THE VALUE OF DIPSTICK ANALYSIS OF URINARY PROTEIN IN PREGNANCY INDUCED HYPERTENSION
J ZOLGHADRI
1
S ALBORZI
2
MS ARDEKANY
3
From the Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
In order to determine the value of dipstick analysis of urinary protein in pregnancy
induced hypertension, a prospective study analyzing pregnant patients with
a diagnosis of hypertensive disorder was conducted to compare the result of urinary
protein dipstick analysis with 24hr. urine protein collection in obstetrical
clinics affiliated to Shiraz University of Medical Sciences.
All patients fulfilling the criteria of the American College of Obstetricians
and Gynecologists' definitions for establishing a diagnosis of hypertensive
disorder on the basis of urinary dipstick measurements were included in
the study.
During the study, 102 hypertensive pregnant patients aged from 16-42 years
were included in the study. Obtained results showed that the presence of negative
value on urinary dipstick with a sensitivity of 100% is a useful method for ruling
out significant proteinuria (> 300 mg/24hr). But values of >2+ are not adequate
to confirm a diagnosis of severe hypertensive disorder because its positive predictive
value is only 22% and values of > trace-although highly suggestive of
significant proteinuria (positive predictive value: 78%)-have a false positive rate
of 23% a timed collection of urine for determination of 24-hr protein excretion
becomes mandatory in such cases.
The urinary dipstick determination of protein excretion therefore has significant
limitations for determination of the presence or severity of proteinuria.
http://mjiri.iums.ac.ir/article-1-756-en.pdf
Hypertensive disorder
Dipstick urine protein.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
75
78
article
CONGENITAL ADRENAL HYPERPLASIA IN NORTH•EAST OF IRAN: A REVIEW OF 47 PATIENTS AND THE ROLE OF PARENTAL CONSANGUINITY IN THE OCCURRENCE OF DISEASE
R VAKILI
1
From the Pediatric Endocrinology Ward, Imam Reza Hospital, Mashhad University of Medical Sciences,Mashhad, I.R. Iran.
In this study the clinical and epidemiological characteristics of congenital
adrenal hyperplasia were evaluated prospectively in 47 patients admitted in Imam
Reza Hospital in Mashhad during a 4 year period.
21-hydroxylase deficiency was present in 42 patients (89.3%), the simple
virilizing form in 6 and the salt-losing form in 36 of them. 11b hydroxylase deficiency
was present in 5 patients (10.7%). The median chronological age at diagnosis
in the salt-losing form was 68 and 47 days in boys and girls respectively. 7
girls were considered to be male before the diagnosis was established. Parental
consanguinity rate among families of patients was higher than the general population
in Mashhad (82% vs. 35%). In 16.2% of patients the history of disease was
positive in siblings.
This study showed that the incidence of congenital adrenal hyperplasia is
expected to be high due to a high rate of consanguinity in our population, hence
genetic counseling before marriage would definitely be beneficial in our population.
http://mjiri.iums.ac.ir/article-1-755-en.pdf
Congenital adrenal hyperplasia
Iran
Parental consanguinity.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
71
74
article
COMPARISON OF MEMORY QUOTIENT STATE BETWEEN NIDDM PATIENTS WITH GLYCEMIC CONTROL AND NONDIABETICS
A ATTARI
1
M SARTIP-POUR
2
M AMINI
3
N BASHARDOOST
4
From the Cardiovascular Research Center, Amin Hosptial, Isfahan, I.R. Iran.
Endocrine and Metabolism Research Center, Amin Hosptial, Isfahan, I.R. Iran.
Effect of In order to test the memory state in patients with non-insulin dependent diabetes
mellitus (NIDDM) after glycemic control, one-hundred patients referring to
Isfahan Endocrine and Metabolism Research Center were simply randomized.
They were compared in point of memory state with one hundred cases as the
control group. The Wechsler Memory Scale test was utilized to evaluate the
memory status of both groups. The average duration of diabetes was 6 years and
the lower limit was 2 years. The mean of memory scores was 72.6 in the diabetic
group and 96.4 in the control group (p<0.05). The mean value of fasting blood
sugar in diabetic patients after glycemic control was 121 mg/dL and was 97mg/
dL in the control group (p<O.05).
No significant difference was found between hypertensive and normotensive
diabetic patients. Also, Index (BMI) and HbAlc with memory in diabetic patients. However, significant association between serum cholesterol level and memory scale (p<0.05).
The mean memory score in the diabetic group was lower than the control group,
and the difference was statistically significant. In this study, cemia in NIDDM patients did not prevent or ameliorate memory disturbances. NIDDM on Memory Status
http://mjiri.iums.ac.ir/article-1-754-en.pdf
NIDDM
Memory
Diabetes.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
67
70
article
EVALUATION OF SIDE EFFECTS OF LOW DOSE CONTRACEPTIV E PILLS ADMINISTERED BY THE VAGINAL ROUTE
S ZIAEI
ZIAEI_99@yahoo.com
1
L RAJAEI
2
S FAGHIHZADEH
3
M LAMYIAN
4
From the Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, I.R. Iran.
Oral contraceptive pills have several side effects especially on the gastrointestinal
tract and liver. Absorption of low dose (LD) pills by the vaginal route avoids
the first pass of the steroids through these tracts and probably has fewer side
effects. This study was a cohort study for evaluation of side effects and acceptability
of LD pills administered by the vaginal route. In a clinical trial study,
undesirable side effects such as nausea, dysmenorrhea, breast tenderness gastrointestinal
disorders, vertigo, headache, and breakthrough bleeding (BTB) were
studied. The side effects, efficacy and acceptability were evaluated in 220 women
using contraceptive pills containing 150mg levonorgestrel and 30mg ethinyl estradiol
via the vaginal route in 660 cycles. The side effects among the patients who
used the contraceptive pills vaginally were nausea in four subjects (1.8%), vertigo
and headache in two subjects (0.9%), breast tenderness in four subjects (1.8%),
dysmenorrhea in four subjects (1.8%), gastrointestinal disorders in one subject
(0.5%), and BTB (breakthrough bleeding) in twelve subjects (5.5%). Most subjects
in this study expressed a high level of acceptability with the vaginal route.
There was only one unwanted pregnancy that occurred when the subject used the
contraceptive pill incorrectly. Using contraceptive pills administered by the vaginal
route appears to be a safe method with few side effects and high acceptability.
http://mjiri.iums.ac.ir/article-1-753-en.pdf
LD pill
Side effect
Acceptability
Vaginal route.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-08
16
2
63
66
article
AUDITORY BRAINSTEM RESPONSES (ABR) IN HYPERBILIRUBINEMIC NEWBORNS
M MOHAMMADI
1
MR ASHRAFI
2
R SHABANIAN
3
From the Department of Pediatric Neurology, Children s Medical Center, Tehran, I.R. Iran.
Assistant Professor
General Practitioner
To evaluate the changes of ABR values in hyperbilirubinemic newborns, 85
cases with severe jaundice (total bilirubin levels over 16 mg/dL and direct bilirubin
less than 2 mg/dL) were selected from those admitted to Children's Medical
Center by simple sampling method. These infants had no other problem except
jaundice. ABR was taken before treatment in all cases and in some (10 cases)
after exchange transfusion or phototherapy as treatment modalities. 41 neonates
(48%) had abnormal ABR values, such as increased hearing threshold, prolonged
latencies of waves I, III & V (p- value<0.05), prolonged interpeak latencies of I-V
; III-V (p-value<0.05), absence of waves and abnormal wave morphology. These
findings could be indicative of both peripheral (8th nerve) and brainstem disturbances.
After treatment ABRs showed improvement in some aspects, such as
latencies of waves I, III & V (p value<0.05), but not in interpeak latencies (I-III,
III -V & I-V) and hearing thresholds. In accordance with previous studies, there
was no association between serum total bilirubin concentration and ABR test
results. This could be interpreted as low significance of serum total bilirubin as a
criterion for early prediction of bilirubin induced encephalopathy.
http://mjiri.iums.ac.ir/article-1-752-en.pdf
ABR
Hyperbilirubinemic newborn
Total serum bilirubin