eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
59
61
article
STATISTICS IN INTERNATIONAL MEDICAL JOURNALS OF IRAN
SMT AYATOLLAHI
1
M MOHAMMADI
2
P JAFARY
3
A KHADEMI
4
From the Department of Biostatistics and Epidemiology, Shiraz University of Medical Sciences, Shiraz, l.R. Iran.
http://mjiri.iums.ac.ir/article-1-779-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
55
58
article
PHAEOHYPHOMYCOSIS OF THE SINUSES AND CHEST BY CLADOSPORIUM BANTIANUM
S BASIRI JAHROMI
1
A KHAKSAR
2
K IRAVANI
3
From the Department of Medical Mycology, Pasteur Institute of Iran, Tehran, and the E.N.T. Ostad Motahari Hospital, lahrom University of Medical Sciences, lahrom, Islamic Republic of Iran.
Fungal sinus infections are being recognized with increasing frequency.
We report a case with rhino cerebral and chest phaeohyphomycosis infection
caused by Cladosporium bantianum in an 18 year old man with Wegener's
granulomatosis. The diagnosis was established by histopathological appearance,
direct examination, culture and computerized tomography (CT) scan.
This case was successfully treated by a combination of surgery and amphotericin
B.The present that is of paranasal sinus mycosis due to Cladosporium
bantianum is the first that is reported in Iran.
http://mjiri.iums.ac.ir/article-1-778-en.pdf
Fungal infection
Paranasal sinus infection
Cladosporium bantianum
Phaeohyphomycosis.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
51
53
article
AUTOERYTHROCYTE SENSITIZATION SYNDROME: REPORT OF A CASE AND REVIEW OF THE LITERATURE
L DASTGHEIB
1
P PEYRAVI
2
FS ASLANI
3
From the Departments of Dermatology and Pathology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
Autoerythrocyte sensitization syndrome CABS) is a rare purpuric disorder of
women characterized by inflammatory and painful ecchymotic lesions unrelated
to blood clotting or vascular abnormalities. Gastrointestinal bleeding, hematuria,
headache or syncopal attacks may also be observed.
Our patient is a 33-year-old woman presenting with recurrent severe painful
ecchymotic lesions on both lower extremities associated with headache, palpitation
and weakness. The diagnosis of AES was confirmed by skin testing with
autologous washed red blood cells. No internal bleeding was detected. She was
treated with vitamin C with some success.
http://mjiri.iums.ac.ir/article-1-777-en.pdf
AES
Gardner-Diamond Syndrome
Painful Bruising Syndrome
Psychogenic Purpura
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
47
49
article
PSEUDOANEURYSM OF RIGHT VENTRICLE DUE TO LOCALIZED TUBERCULOSIS OF MYOCARDIUM: A CASE REPORT
M MASOUMI
aalihospitai@kums.ac.ir
1
G SOLGY
2
From Emam Ali Heart Center, Kermanshah University of Medical Sciences, Kermanshah. l.R. Iran.
A 5-year-old girl was admitted to the hospital with chest pain, fever and
dyspnea. Physical examination showed normal heart sounds, diminished pulmonary
sounds in the left hemithorax and a normal ECG. On chest X-ray the heart
was slightly enlarged with moderate left pleural effusion. CT scan revealed pleural
effusion and a hypodense mass at the apex of the heart. A cystic mass was
detected by echocardiography as well. The patient was operated as a case of hydatid
cyst of the right ventricle. Intraoperatively a pseudoaneurysm of the right
ventricle was found. The mass centrally consisted of clots and necrotic tissue and
peripherally was composed of fibrosis and calcification. All of these tissues were
removed and the communication between the aneurysm and right ventricle was
repaired. The diagnosis of tuberculosis was confirmed by culture and microscopic
examination. The patient underwent anti-TB treatment for 6 months and remained
symptom-free after 4 years. It is believed that local expansion of tuberculous adenitis
near the pericardium has caused a TB abscess, which in turn affected the
myocardium and destroyed it.
http://mjiri.iums.ac.ir/article-1-776-en.pdf
Tuberculosis
Pseudoaneurysm
Heart surgery.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
41
46
article
PRODUCTIO N OF PROSTATE-SPECIFIC ANTIGEN (PSA) BY A BREAST CANCER CELL LINE, SK-Br-3
E KAMALI SARVESTANI
immunol 2@sums.ac.ir
1
A GHADERI
2
B GHARESI-FARD
3
From the Department of Immunology,Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
PSA is a 33-KDa serine protease that is produced predominantly by prostate
epithelium. However, it has been shown that about 30-40% of female breast tumors
produce PSA and its production is associated with the presence of estrogen
and progesterone receptors. We have now developed a new tissue culture system
to study PSA production in breast cancer and its association with prognostic factors
such as progesterone receptor and c-erbB-2. For this purpose we investigated
the ability of PSA production in five different cell lines, including two breast
cancer cell lines, SK-Br-3 and MDA-MB-453. The PSA in tissue culture supernatant
and cytoplasm of the Sk-Br-3 cell line was detected by western blotting
and immunoperoxidase, respectively. Furthermore, we found lower expression of
c-erbB-2 in Sk-Br-3 than non-PSA producer breast cancer cell line, MDA-MB-
453. Progesterone receptor was expressed by both PSA-positive and -negative
cell lines and only the intensity of staining and the number of positive cells in SkBr-
3 population was higher than MDA-MB-453. According to our findings PSA
can be considered as a good prognostic factor in breast cancer and we suggest that
these two cell lines are a good in vitro model to study the relationship of different
breast cancer prognostic factors and their regulations.
Keywords: PSA, c-erbB-2, Progesterone receptor, Breast cancer, SK-Br-3.
http://mjiri.iums.ac.ir/article-1-775-en.pdf
PSA
c-erbB-2
Progesterone receptor
Breast cancer
SK-Br-3.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
35
40
article
PHENYTOIN AND THE REPRODUCTIVE SYSTEM
GD NAYERI KAMAN
1
F MOTIOLLAH
2
From the Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
In order to evaluate the effects of phenytoin on the reproductive system of
rats in detail, 60 male rats were divided equally into 6 groups: 1-5 received 10
mg/kg/day phenytoin IP for 1,2,3,4 and 5 weeks, respectively. However, group 5
did not receive any phenytoin for the last 5th week. The control group (group 6)
did not receive any treatment. The results revealed that phenytoin does not have
any effect on body weight, weight of testes, seminal vesicle and prostate, serum
testosterone and sperm count taken from left and right vas deferenses. However,
the percentage of total motile sperm and sperm with full and sluggish motility
decreased and the percentage of low motile sperm increased in all experimental
groups. Nevertheless, phenytoin caused atrophy and hypoplasia in seminiferous
tubules and not Leydig cells. These pathological changes were dose-dependent
and more pronounced in the left testis. But phenytoin caused more changes in
sperm count and motility of the right testis. This phenomenon was discussed i n
relation t o the existence of asymmetrical control b y the hypothalamus, and compensation
of the left testis. In summary, it could be concluded that phenytoin
affected the seminiferous tubules directly and decreased the total number of motile
sperm. It was also discussed that these effects are not reversible after termination
of injection.
http://mjiri.iums.ac.ir/article-1-774-en.pdf
Phenytoin
testosterone
spenn count and motility
genital system.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
29
33
article
SERUM CYSTATIN C AS A NEW MARKER OF GLOMERULAR FILTRATION RATE (GFR)
H VAHHAB AGHAI
1
P PASALAR
2
I NAJAFI
3
M KADKHODAEE
4
the Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran
the Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran
the Department of Nephrology of Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
the Department of Physiology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran
Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily
of cysteine protease inhibitors. The cystatin C gene seems to be a house
keeping gene, which is compatible with a stable production rate of cystatin C by
most cells. This protein is freely filtered through the glomerulus and almost completely
reabsorbed and catabolized by proximal tubular cells.
Because of these characteristics cystatin C is assumed to be a better marker
of glomerular filtration rate than other markers.
115 new cases of renal disease aged between 14 and 88 years and 121 healthy
subjects, aged between 11 and 78 years were studied.
In all of the subjects serum cystatin C and creatinine were determined and
creatinine clearance was determined only in patients. Cystatin C was determined
by a particle-enhanced turbidimetric assay and creatinine was measured by Jaffe's
method.
In addition, to assess the diagnostic efficiency of serum cystatin C in comparison
to that of serum creatinine and creatinine clearance in predicting changes
in GFR, we performed Tc99m - DTPA clearance on 53 subjects including controls
and patients.
A linear relationship was found between Tc99m - DTPA clearance and 11
serum cystatin C (r= 0.712, p-value <0.001), l/serum creatinine (r= 0.709, pvalue<
0.001) and creatinine clearance (r= 0.777, p- value <0.001).
Diagnostic accuracy in the identification of reduced GFR measured as area
under the receiver-operating characteristic plot was 0.878±0.050 (Mean±SE) for
cystatin C, 0.866±0.051 for creatinine and 0.866±0.051 for creatinine clearance.
The serum cystatin C reference values (mean±1.96 SD) determined was 0.83 -
0.88 mg/L.
A cutoff cystatin C concentration of 0.82 mg/L had 92% sensitivity and 79%
specificity for detecting abnormal GFR.
There was no significant correlation between cystatin C and age (p- value
<0.219) and weight (p- value <0.193).
This study demonstrates that serum cystatin C has an increased diagnostic
accuracy for reduced GFR when compared with serum creatinine and creatinine
clearance. Hence, cystatin C seems to be an alternative for the estimation of GFR.
http://mjiri.iums.ac.ir/article-1-773-en.pdf
Glomerular filtration rate (GFR)
Cystatin C
Creatinine
Renal diseases.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
25
28
article
PARENTAL KNOWLEDGE OF BACTERIAL ENDOCARDITIS PROPHYLAXIS: A REPORT FROM SOUTHERN IRAN
GR AJAMI
ghajami@hotmail.com
1
M BORZOEE
2
E SADEGHI
3
From the Division of Pediatric Cardiology and Infectious Diseases, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, l.R. Iran.
From the Division of Pediatric Cardiology and Infectious Diseases, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, l.R. Iran.
From the Division of Pediatric Cardiology and Infectious Diseases, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, l.R. Iran.
We determined the knowledge of parents of 200 pediatric patients for bacterial
endocarditis prophylaxis (BEP ), using an eight question survey pertaining to
their knowledge of their child's cardiac disease, medications, and BEP. The patient's
cardiac lesion and current medications were verified at the time of admission for
diagnostic or interventional cardiac catheterization. Each patient's need for BEP
was determined according to American Heart Association (AHA) recommendations.
Eighty-one respondents (40-5%) were high school graduates. Only 12 parents
(6%) correctly defmed endocarditis. One-hundred and fifty-eight parents (77%)
knew the name or condition of their child's cardiac problem, one-hundred (50%)
of the families had knowledge of BEP, and only 46 parents (23%) knew that
antibiotics are needed for prophylaxis at the time of dental procedures. It is concluded
that while most parents know the name of their child's heart lesion and
current medications, their knowledge of endocarditis and BEP is limited, and for
prevention of such a major complication for pediatric patients with heart diseases,
intensified education and awareness programs are needed.
http://mjiri.iums.ac.ir/article-1-1642-en.pdf
Endocarditis
Prophylaxis
Parental knowledge
Southern Iran
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
19
23
article
PREVALENCE OF HELICOBACTER PYLORI IN CHILDREN AND TEENAGERS IN TABRIZ, IRAN
E FATTAHI
1
B RAHNEMA
2
N GANDCHILAR
3
From the Departments of Internal Medicine, Immunology and Physiology, Medical School, Tabriz University of Medical Sciences, Tabriz, l.R. Iran.
Seroepidemiologic studies in developing countries show a high rate of
Helicobacter pylori (H. pylori) infections in children, in contrast to developed
countries. The aim of this study was to evaluate the prevalence of H. pylori in
children and teenagers in Tabriz, northwest of Iran.
In this prospective study 44 children and teenagers were randomly selected
to study serum IgG against H. pylori using ELISA method.
Our results indicated the presence of IgG in 83.5% of test subjects (83.7% in
females and 83.4% in males). In the 2-5 years age group 71.7% were IgG positive
and this percentage increased by age, i.e., 95.2% recorded as IgG positive in the
14-18 years age group (p<O.05).
Considering the risk factors in relation to H. pylori infection, an increasing
number of family members (above 3 persons) showed a statistically significant
difference (p
http://mjiri.iums.ac.ir/article-1-772-en.pdf
H. pylori
Seroepidemiology
Children
Teenager.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
13
17
article
A SURVEY OF CARDIOVASCULAR RISK FACT ORS IN BABOLIAN RURAL HYPERTENSIVES
E MOHAMMADI
1
HA ABEDI
2
F GOFRANIPOUR
3
F JALALI
4
A KAZEMNEJAD
5
From the Department of Nursing, Tarbiat Modarres University, Tehran
the Department of Nursing, Esfahan University of Medical Sciences, Esfahan
the Department of Health Education, Tarbiat Modarres University, Tehran
the Medical Faculty, Babol University of Medical Sciences, Babol
the Department of Biostatistics, Tarbiat Modarres University, Tehran, I.R. Iran.
High blood pressure control (HBPC) is a common goal of WHO and the
world hypertension league (WHL). The two important strategies in HBPC are
identifying cardiovascular (CVD) risk factors and planning to modify controllable
factors. This study was accomplished to determine the CVD risk factors in
high blood pressure (HBP) patients of the rural population, residing in the Babol
region, north of Iran, in the year 2000. This study was a cross-sectional research.
150 hypertensive patients were selected by cluster random sampling method. The
data were collected with two questionnaires (demographic characters and behavioral
habits questionnaire and Eschpel Burger's anxiety record) and laboratory
tests. The data analysis has indicated that the rate of most risk factors such as
cholesterol leve1, body mass index, anxiety score and other factors is highly elevated.
The results demonstrated that the rates of CVD risk factors were higher in
Iranian hypertensive patients compared to other countries. Probably, because of
this, the maximum rate of achievement of high blood pressure control was only
18.4%
http://mjiri.iums.ac.ir/article-1-771-en.pdf
Cardiovascular Risk Factors
Hypertension
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
9
12
article
LEFT VENTRICULAR DIASTOLIC ABNORMALITIES IN β-THALASSEMIA MAJOR WITH NORMAL SYSTOLIC FUNCTION
A GHAEMIAN
1
A HOSEINI
2
M KOSARIAN
3
From the Department of Cardiology, Mazandaran University of MedicaL Sciences, Sari, I.R. Iran.
In order to identify left ventricular diastolic function in patients with betathalassemia
major and normal systolic function by noninvasive M-mode and
Doppler echocardiography, an analytic study was designed in a university hospital
in Sari. We have studied 44 patients (23 men and 21 women), mean age
15.48±2.16 (range 12 to 20) and 43 age and sex matched control subjects. Peak
flow velocity in early diastole increased in patients compared with controls
(98±14vs. 86±13 cm/sec p<0.0001), rate of deceleration of flow velocity was
also increased (778±142vs. 592±193 cm/sec2 and 2.24±0.51 vs. 1.73±0.36, respectively
p<0.0001). Peak flow velocity during atrial contraction was not significantly
different in patients and normal control subjects. Doppler diastolic indices
had no correlation with age, serum ferritin levels and cumulative blood
transfused in thalassemic patients. We concluded that left ventricular diastolic
flow indices identified noninvasively by Doppler echocardiography in patients
with thalassemia major are altered in an early phase, when systolic function is
normal.
http://mjiri.iums.ac.ir/article-1-770-en.pdf
Thalassemia
Echocardiography
L eft ventricular function.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
5
8
article
HENOCH-SCHONLEIN PURPURA IN CHILDREN: OUR EXPERIENCE WITH 165 CASES FROM SOUTHERN IRAN
M HAGHIGHAT
1
G HASHEMI
2
L HASHEMI
3
From the Department of Pediatric Gastroenterology and Nephrology,Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
During a 6 year period from September 1992 to September 1998, 165 children
with a final diagnosis of Henoch-Schonlein purpura (HSP) were managed
and followed in our center.
There were 87 (52%) boys and 78 (48%) girls, with age ranges of 1-16 years
and mean age of 7.8 years. Forty-one percent of the patients had evidence of
preceding upper respiratory tract infection (URI). The main clinical features were:
skin eruption in 100%, OI symptoms in 79.5%,joint problems in 59.5% and renal
involvement in 26.5% of cases.
Thrombocytosis in 31 % and increased ESR in 55% of cases were the main
significant laboratory findings. Abdominal sonography was done in 58 cases with
GI symptoms, and was abnormal in 28 cases (48%): free peritoneal fluid in 26%,
thickened bowel wall in 14%, ileus in 5% and intussusception in 3%. Sixty percent
of the patients received prednisolone for OI problems or renal involvement.
Nine percent of the cases had relapse and there was no death.
It was concluded that:
a) There is no significant sex difference in children with HSP in this area.
b) The age of children with HSP in this area is the same as those in eastern
countries, but relatively higher than that reported in western countries.
c) Abdominal sonography can be a helpful means of diagnosis in patients
with OI manifestations of HSP before skin eruption.
d) The morbidity and mortality of HSP is very low if the disease is diagnosed
in its early stages and managed properly.
http://mjiri.iums.ac.ir/article-1-769-en.pdf
Henoch-Schonlein purpura
Children
Ultrasonography
Mortality and Morbidity.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2002-05
16
1
1
4
article
ACCURACY OF INTRAOPERATIVE FROZEN SECTION DIAGNOSIS AND TOUCH IMPRINT CYTOLOGY: STUDY ON 1000 CONSECUTIVE CASES
SZ TABEI
1
M HOSSEINZADEH
2
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Frozen section and touch imprint cytology are important diagnostic procedures
for surgeons during operation and must be accurate if the patient is to
receive maximum benefit.
To assess the accuracy of intraoperative pathologic consultation including
frozen section and touch imprint cytology during a five year period (1995-
2000), a retrospective survey of 1000 consecutive cases of frozen sections
performed by the staff pathologists of Shiraz Medical School and 211 touch
imprint cytology cases related to some of these sections were studied focusing
on accuracy.
Also some 462 cases of frozen sections related to the 1000 samples were
reviewed by the staff pathologists without complete clinical data and without
any data from the surgeon to determine the importance of the surgeon pathologist
relationship.
The gold standard method for comparing the results of frozen section
and cytology was permanent tissue diagnosis.
The overall accuracy of frozen section for the 1000 cases was 93.6%.
The accuracy of cytology was 93.1 %. Also the accuracy of 462 frozen sections
which were reviewed without clinical data was 85%.
In conclusion, frozen section diagnosis is a highly accurate method. Touch
imprint cytology is also a specific method and can be used in areas where
facilities of frozen section studies are not available.
The frozen section method achieves its highest accuracy when there is
cooperation between the surgeon and pathologist and when used in combination
with touch imprint cytology.
http://mjiri.iums.ac.ir/article-1-768-en.pdf
Frozen section
Intraoperative consultation
Accuracy.