eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
117
121
article
PRIMARY PANCREATIC LYMPHOMA: A CASE REPORT AND LITERATURE REVIEW
H F OROOTAN
1
F MANSOUR GHANAIE
2
H GHOFRANI
3
From the Department of Gastroenterology, Tehran University of Medical Sciences, Tehran
the Deparfment of Gastroenterology, Gastrointestinal & Liver Disease Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, I.R. Iran
From the Department of Gastroenterology, Tehran University of Medical Sciences, Tehran
Primary pancreatic lymphoma is a rare extranodal manifestation of any histopathologic
subtype of B cell non-Hodgkin's lymphoma that predominantly involves
the pancreas. It comprises less than 0.2% of pancreatic malignancies and
less than 0.7% of non-Hodgkin's lymphomas. This lymphoma is almost never
suspected clinically. It is usually diagnosed by surgical exploration for suspected
adenocarcinoma because this kind of lymphoma resembles pancreatic adenocarcinoma,
a much more common disease, in clinical presentation and radiologic
appearance. Differentiation is, however, essential because of different clinical
management and outcome. This report describes an interesting case of primary
pancreatic lymphoma and review of the literature to elucidate features that suggest
this entity.
http://mjiri.iums.ac.ir/article-1-815-en.pdf
Pancreas
Pancreatic lymphoma
B-cell lymphoma
Pancreatic mass
Chemotherapy
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
115
116
article
CHRONIC DIARRHEA DUE TO GANGLIONEUROMA IN A CHILD
AA SAYYARI
1
F IMANZADEH
2
MR BAGHARPOOR
3
MT ARZANIAN
4
K RAFIEYAN
5
S TAHAGHOGHI
6
M YAGHOOBI
7
From the Department of Pediatric Gastroenterology, Mofid Children s Medical Center. Shahid Beheshti University of Medical SciencesTehran, I.R. Iran.
Ganglioneuroma is a very rare cause of chronic diarrhea in children. This benign
tumor usually presents with diarrhea and failure to thrive. It is necessary for
physicians to be familiar with this rare cause of chronic diarrhea. Here we present
and discuss such a case.
http://mjiri.iums.ac.ir/article-1-814-en.pdf
Ganglioneuroma
children
chronic diarrhea
celiac disease.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
109
114
article
EFFECTS OF FORMALIN AS A PERIPHERAL NOXIOUS STIMULUS ON THE NUCLEUS RETICULARIS PARAGIGANTOCELLULARIS NEURONS OF ANESTHETIZED RATS
N GHEIBI
1
S SEMNANIAN
2
Y FATHOLLAHI
3
From the Department of Medical Physics, Medical School, Qazvin University of Medical Sciences, Qazvin. The Department of Physiology, School of Medical Scences, Tarbiat Modarres University, Tehran. And the Institute of Biochemistry and Biophysics, Tehran University, Tehran, I.R.Iran.
In the present study, the effects of formalin as a peripheral noxious stimulus
on spontaneously active units of the nucleus reticularis paragigantocellularis (PGi),
a narrow region of the ventral pontine reticular formation, was examined in urethane
anesthetized rats. Spontaneous discharge of the PGi neurons was variable,
ranging from I to 37 spikes per second. Formalin as a chemical irritant and prolonged
noxious stimulus induced changes in the firing of spontaneously active
PGi neurons. There were three neuronal subpopulations in the PGi that responded
to formalin: excited (19.35 %), inhibited (45.16 %) and unchanged (35.48 %).
Thus we suggest that PGi neurons may be involved in the processing of information
related to formalin as a chemical irritant.
http://mjiri.iums.ac.ir/article-1-813-en.pdf
Nucleus reticularis paragigantocellularis: Formalin: Single-unit recording.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
103
108
article
PREPARATION OF HIGHLY PURIFIED SOLVENTDETERGENT COA GULATION FACTOR VII AND FACTOR IX CONCENTRATES FROM PROTHROMBIN COMPLEX (PPSB)
S NASIRI
1
H REZVAN
2
K MOUSAVI
3
MH ROOSTAEI
4
From the Department of Research and Development, Blood Research and Fractionation Co., Tehran, and the *Department of Virology, Tarbiat Modarres University, Tehran, I.R. Iran.
In this study, anion-exchange chromatography was used to purify factor VII
and factor IX from prothrombin complex (PPSB), which contains coagulation
factors II, VII, IX and X. For this purpose, DEAE-Sepharose CL-6B gel , Pharmacia
column XK-26 , high flow rate and two stepwise gradients with phosphate citrate
buffer were used. The yield of the two lyophylized products, factor VII and factor
IX concentrates, was 61 % and 75%, respectively. Specific activity of factor VII
increased from 0.16 to 3.06 (purification-fold= 19.1) and specific activity of factor
IX increased from 12 to 4.9 (purification-fold= 4.1). Results of electrophoresis
on agarose gel-as well as immunoelectrophoresis-indicated higher purity of
factor VII and factor IX compared to PPSB. Thrombogenicity of the two products
were within the normal range defined for PPSB. In order to improve viral safety,
solvent-detergent treatment was performed prior to further purification. Factor
VII concentrate is used for patients with factor VII deficiency and also for hemophilia
patients with inhibitors. Factor IX concentrate is used for treatment of hemophilia
B patients.
http://mjiri.iums.ac.ir/article-1-812-en.pdf
Factor VII
Factor VIla
Factor IX
Hemophilia
PPSB
Viral inactivation.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
93
101
article
CORRELATION BE TWEEN ENDOTHELIAL INJURY AND CEREBRAL VASOSPASM FOLLOWING A DOUBLE SUBARACHNOID HEMORRHAGE IN THE RAT
MA KHALILI
Khalili59@hotmail.com
1
BEN R CLOWER
2
From the Department of Anatomy, Yazd University of Medical Sciences, Yazd, I.R. Iran
the *Department of Anatomy & Neurosurgery, University of Mississippi School of Medicine, USA
While a wide array of pathological changes occur in cerebral arteries following
subarachnoid hemorrhage (SAH), the most consistent is endothelial damage.
Since the endothelium normally modulates reflexes that influence vascular tone,
any damage to it may represent a significant contributor to cerebral vasospasm
following SAH.
This experimental study investigates the correlation between endothelial injury
of rat basilar (BA) and middle cerebral arteries (MCA) and vasospasm following
a double SAH.
Animals were divided into three groups of control (nonsurgical-noninjected),
saline-injected, and blood-injected rats. Rats in the blood-injected group were
injected with two 0.3 mL doses of autologous blood into the subarachnoid space
at intervals of 72 hours. Rats were killed at different time intervals to study the
time course of endothelial injury along with vasospasm following the second SAH
with scanning electron microscopy and image analysis system, respectively. Cerebral
arteries exposed to blood demonstrated severe pathological alterations during
acute (30 min. to 2 hrs.) and chronic (48 hrs.) periods of time post second
SAH. Concurrent with endothelial injury, there was widening of inter-endothelial
tight junctions. Morphometric evaluation revealed severe arterial constriction starting
at 30 min. (p<0.01) and again at 48 hrs. (p<0.05) post second SAH.
The correlation between the time course of ultrastructural alteration of endothelial
cells with arterial constriction provides further morphological contribution
to the major complication of SAH-cerebral vasospasm.
http://mjiri.iums.ac.ir/article-1-810-en.pdf
Scanning electron microscopy
Endothelium
Subarachnoid hemorrhage
Cerebral vasospasm.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
89
92
article
THE IN VITRO GROWTH PROPERTIES OF CELL LINES FROM EPSTEIN-BARR VIRUS-INDUCED TAMARIN TUMORS AND TAMARIN B CELLS TR ANSFORMED BY EPSTEIN BARR VIRUS
M MAHMOUDIAN SHOOSHTARI
1
AD WILSON
2
P WATKIN
3
S FINERTY
4
AJ MORGAN
5
From the Iranian Blood Transfusion Organization, Tehran, I.R. Iran
the Department of Pathology
the Department of Pathology
the Department of Pathology
the Department of Pathology
EBV-carrying human cell lines, depending on whether the cells are derived
from Burkitt's lymphoma (BL) tumor biopsies or transformed by EBV in vitro,
have different growth properties in vitro. In contrast, there are no clear differences
between tamarin tumor lines and tamarin LCLs in vitro. Both types of tamarin
cell lines could grow in agarose and formed colonies unlike human LCLs, although
with a lower cloning efficiency than BL lines. The growth patterns of the
tamarin tumor lines resemble more those of human LCLs than human BL lines,
although the observation that tamarin LCLs can grow in agarose whereas human
LCLs cannot may be significant. If it is accepted for arguments sake that Raji BL
cells are representative of human EBV BL tumor cells, then both tamarin LCLs
and tumor lines are more tumorigenic as judged by the single criterion of growth
in agarose
http://mjiri.iums.ac.ir/article-1-809-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
83
88
article
POTENTIATION OF RESPONSES TO UK-14304 IN RAT ISOLATED COMMON CAROTID ARTERY BY ANGIOTENSIN
M MOHAMMADI NAGHADEH
1
JC McGRATH
2
From the Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, I.R. Iran
the Clinical Research Initiative in Heart Failure, West Medical Building, University of Glasgow, Glasgow G21-BQQ, Scotland.
The selective a2 -adrenoceptor agonist UK-14304 produces a small vasoconstrictor
response in the rat isolated carotid artery. The purpose of the work presented
here was to investigate whether stimuli that produce submaximal contraction
would potentiate responses to UK-14304. Male Wistar rats were killed by
overdose with pentobarbitone sodium, after which the left and right common carotid
arteries were removed. The rings of arteries 3-4 mm in length were cut from
each vessel and then mounted in 10 mL isolated organ bath, bathed in Krebs
maintained at 37°C and gassed with 95% 02 plus 5% CO2, The preparations were
allowed to equilibrate for an hour. Cumulative concentration-response curves
(CCRC) were constructed in a cumulative manner by increasing the concentration
of the agonists in half-log increments. When antagonists were used, the preparations
were incubated at least for 45 minutes with the drugs prior to the onset of
a second CCRC. Angiotensin II (All) and other contracting factors were added
approximately 10-15 min prior to the onset of CCRC to an agonist. After inducing
tone with low concentrations of the thromboxane A2 mimetic agent U-46619
(lnM), 5HT (0.5-1 ).lM) and phenylephrine (l0 nM), exposure of the preparation
to UK-14304 resulted in concentration dependent conWrctions to
this agonist. The sensitivity and maximum response of the preparation ,to'
UK-14304 were not changed. Inducing tone with All (0.01 µM) producd
a significant leftward shift in the CCRC to UK-14304 (p<0.05). Thus
submaximal contraction with All (0.01 µ M) increased responses significantly,
but inducing tone with phenylephrine, U-46619 and 5HT had no
effect on responses to UK-14304. The α-adrenoceptor antagonists prazosin
and rauwolscine were examined to see whether UK-14304's main action
in the presence of All remained via al. The potentiated responses were
. prazosin sensitive and rauwolscine resistant, indicating an increasing effect
mediated by al-adrenoceptors.
http://mjiri.iums.ac.ir/article-1-808-en.pdf
α-adrenoceptors
UK-14304
prazosin
rauwolscine
angiotensin II
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
79
82
article
A SURVEY OF RESPIRATORY SYNCYTIAL VIRUS IN CHILDREN IN THREE EDUCATIONAL AND THERAPEUTIC PEDIATRIC CENTERS IN TEHRAN
S MODARRES GILANI
1
A RAHBARIMANESH
2
From the Department of Virology, Pasteur Institute of Iran
the Department of Pediatrics, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Nasopharyngeal swab samples from patients with an acute flu-like illness
were evaluated for the presence of respiratory syncytial virus (RSV) from October
1996 to March 1998. The relative frequency and seasonal distribution of RSV
was assessed. In addition, the virus correlated with specific clinical signs and
symptoms.
During the study, 268 samples were collected from children under the age of
14 years in Virus Transport Medium (VTM) in three educational and therapeutic
pediatric centers in Tehran by participating medical practitioners. The specimens
were tested for RSV by virus isolation and direct immunofluorescense (DIF) technique
in the virology section of Pasteur Institute of Iran. Respiratory syncytial
virus was detected from 33 samples (12.3%). In this study the highest rate of RSV
was found in children less than 1 year of age (19.5%), but the male to female ratio
in patients was approximately equal (1: 1). RSV infections peaked in the early
winter, as 85% were detected from December to March. There was a statistically
significant difference between age and RSV infection (pO.05). One of the most common clinical signs and symptoms in patients was
bronchiolitis, which was observed in 48.5% of subjects infected with RSV.
http://mjiri.iums.ac.ir/article-1-807-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
73
77
article
ANGIOGENESIS ASSESSMENT IN BASAL CELL CARCINOMA
F SARI ASLANI
1
A ALEDAVOOD
2
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Basal cell carcinoma (BCC) is currently the most common cutaneous cancer
found in humans. Although it generally shows a relatively benign course (BCCl),
some cases show aggressive behavior (BCC2). Until recently, traditional histologic
diagnostic criteria have failed to discriminate unequivocally between BCC 1
and BCC2.
In this study we selected 50 cases of BCC and categorized them into two
groups (BCCl and BCC2) on the basis of histologic criteria and then examined
the rate of angiogenesis to establish if it correlates with their histological features
and/or clinical behavior. The vessels were highlighted by immunohistochemical
staining for factor VIII-related antigen in formalin fixed paraffin embedded tissues.
All 25 cases of BCC2, whose clinical behavior was aggressive had
microvessel counts significantly higher than that of the BCC I group with mean
values of 50.24 and 20.9 for BCC2 and BCCl respectively. But there were eight
cases of morphological BCCI who had aggressive clinical behavior and interestingly
had microvessel counts higher than the other cases of BCC 1.
The findings of the present study seem to establish a correlation between
tumor angiogenesis and clinicobiologicaI parameters of aggressiveness.
From this point of view the assay of microvessel density might be helpful in
selecting patients with BCCs at high risk for recurrence or metastasis, who could
benefit from additional therapies and closer followup.
http://mjiri.iums.ac.ir/article-1-806-en.pdf
Aggressive BCC
Non-aggressive BCC
Tumor angiogenesis.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
67
71
article
BRUCELLOSIS IN IRAN: THE FARS PROVINCE EXPERIENCE
S BEHESHTI
1
GR REZAIAN
2
K AGHASADEGHI
3
Z FAGHIRI
4
M AGHAJAN SHAKERI
5
From the Departments of Clinical Pathology Shiraz University of Medical Sciences, Shiraz, I.R, Iran
From the Departments of Clinical Pathology
From the Departments of Medicine, Shiraz University of Medical Sciences, Shiraz, I.R, Iran.
From the Departments of Clinical Pathology Shiraz University of Medical Sciences, Shiraz, I.R, Iran
From the Departments of Clinical Pathology Shiraz University of Medical Sciences, Shiraz, I.R, Iran
Over a 10-year period, l30 consecutive cases of brucellosis were encountered
and were prospectively treated and followed. Twenty-one cases were children
and the remainder were adults. There were 93 males and 37 females with a
male: female ratio of 2.5 to one. The age range of the patients was from 2 to 74
years with a mean of 30 years. Fifty-five percent of cases were from rural areas
and the rest from major cities of the Fars province. The disease was most frequently
seen during spring and summer. Although it was seen in ranchers and
farmers who usually deal with small ruminants in our country, it was also frequently
seen in those with other professions. Animal contact was common (33%)
as well as consumption of raw unpasteurized milk and fresh cheese which was
seen in almost half of the cases. Fever and sweating were the most common complaints
and arthritis and splenomegaly were the most frequent physical findings.
Bilateral sacroiliac joint involvement was the most common arthritic disorder
and was exclusively seen in adults. Knee and ankle joint involvement was commonly
seen in children. They were unilateral and monoarticular in their presentation.
Seven cases had orchitis and one pregnant lady developed second trimester
abortion. Treatment with conventionally recommended antibiotics was successful
in all except two cases who had relapse secondary to an inadequate course of
drug therapy. The two, however, responded to another course of full term antibiotic
therapy with full recovery.
In contrast to western countries were cattle and swine are the most frequent sources
for human brucellosis, sheep and goats are the most common source of infection in our
country. Here, the disease is not an exclusively occupational one for young adult males and
an indirect oral route of disease transmission is quite frequent. Brucellosis, therefore, affects
both children and adults of either sex, with a wide age range. Prohibition of ingestion
of raw milk: and fresh cheese as well as control of Brucella melitensis infection in sheep
and goats can significantly reduce the burden of disease in our country.
http://mjiri.iums.ac.ir/article-1-805-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2001-08
15
2
61
66
article
EFFECT OF LONG- AND SHORT-TERM MINICONSOLIDATION ON SURVIVAL OF PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA
P NASSERI
1
A GHAVAMZADEH
2
M KEYHANI ELAHI
3
RA SHARIFIAN
4
J NATEGHI
5
K ALIMOGHADAM
6
MR MORTAZAVIZADEH
7
M ABASI
8
MR ESHRAGHIAN
9
From the Department of Hematology-Oncology, Tehran University of Medical Sciences, Tehran, I.R. Iran.
A retrospective study was done on 130 AML patients treated in Shariati and
Imam Hospitals in Tehran from 1991 to 1997 to investigate the value of three
post-remission methods of treatment.
All patients who were in complete remission (CR) (Group I) had been treated
with ARA-C (300 mg/m2/day continuous infusion for 5 days) and Daunorubicine
(45 mg/m2/day for 3 days) as induction and early consolidation therapy. Forty
patients were treated by additional similar chemotherapy as second consolidation
and no further treatment was offered. Fifty patients (Group II) were treated by
ARA-C (120 mg/m2 subcutaneously for 5 days), Etoposide (120 mg/m2 on day
one), and Mitoxantrone (12 mg/m2 on day one) on each successive month as
short-term miniconsolidation. Forty patients (Group III) were treated similarly to
Group II until relapse for up to two years as long-term miniconsolidation.
There was no difference in the three groups regarding mean age and other
prognostic factors. Treatment related mortality and morbidity were also similar.
Median duration of disease-free survival (DFS) was 36 (3.5-68 with 95% CI), 17
(12.5-21.5) and 19 (14.7-23.3) months respectively in these three groups. In a 14-
month median observation there was no difference in DFS and overall survival
(OS) among the three groups (p=0.7).
We concluded that short- or long-term miniconsolidation chemotherapy compared
to standard treatment does not improve DFS and OS in AML patients.
http://mjiri.iums.ac.ir/article-1-804-en.pdf
Acute Myelogenous Leukemia
Consolidation
Maintenance Treatment.