eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
305
306
article
ACUTE EXTRAPYRAMIDAL SYMPTOMS FOLLOWING ABRUPT DISCONTINUATION OF PROPRANOLOL
A A. ALAVIAN GHAVANINI
alavianm@sums.ac.ir
1
From the Center for Research Consultation, School of Medicine, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
A case of acute extrapyramidal manifestations consisting of dystonia and
akathisia following abrupt discontinuation of propranolol is reported. She responded
well to oral propranolol and intramuscular diazepam. Extrapyramidal
symptoms have commonly been associated with acute or chronic administration
of neuroleptic drugs. There have been reports of a substantial number of cases
with similar clinical characteristics associated with tricyclic antidepressants,
monoamine oxidase inhibitors, and selective serotonin reuptake inhibitors. Although
it is known that beta-adrenoceptor antagonists are effective in the treatment
of extrapyramidal symptoms, especially akathisia, there has been no previous
report of such symptoms induced by abrupt withdrawal of these drugs. Although
she had been on low dose amitriptyline and had discontinued this medication
long before, prolonged use of amitriptyline may have had a predisposing role
in the development of these symptoms.
http://mjiri.iums.ac.ir/article-1-871-en.pdf
Propranolol; Extrapyramidal symptoms; Beta-adrenoceptor antagonists.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
303
304
article
SPLENIC ARTERIOVENOUS FISTULA: A RARE LESION CAUSING BLEEDING ESOPHAGEAL VARICES
AA KESHAVARZ
1
M YOUNESI
2
M RAHBAR
3
From the Department of Gastroenterology and Pathology, Imam Khomeini Hospital, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran
We report a case of a 40 year old man with portal hypertension caused by a
splenic arteriovenous fistula that was diagnosed at laparotomy. He presented with
bleeding esophageal varices and was initially treated by sclerotherapy. At laparotomy,
portal pressure was 40 cmH20 but fell to 20 cm H20 after the fistula was
treated with splenectomy.
All symptoms disappeared shortly after operation and the patient has remained
well for the past two years.
http://mjiri.iums.ac.ir/article-1-870-en.pdf
Arteriovenous fistula
Portal hypertension.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
297
301
article
EFFECT OF CHRONIC LEAD POISONING ON ERYTHROCYTE PROTOPORPHYRIN IN RATS
DURDI QUJEQ
1
From the Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, I.R. Iran
Research has shown that exposure to lead may have adverse effects at different
blood lead concentrations. Lead inhibits at least two enzymes that are essential
for the formation of heme, and because of the interaction of lead with these
enzymes, no iron is inserted into protoporphyrin. Therefore the concentration of
protoporphyrin increases in erythrocytes. The concentration of lead was measured
by atomic absorption at 217.0 nm. The erythrocyte protoporphyrin was determined
following extraction into 90% ethanol. The concentration of protoporphyrin in
the blood of the lead exposed rat group was increased compared to that in the
control group [12.46 +/- 0.57 (mean +/- S.D., n= 72) vs. 3.89 +/- 0.42, n=68,
µmollL, p<0.05]. The assay had excellent precision for both control and lead
exposed groups (intra-assay and interassay coefficient of variation<5%). The
method was linear from 0.0 to 12.46 µmollL of erythrocyte protoporphyrin. A
good relationship was obtained between erythrocyte protoporphyrin value and
blood lead concentration. The results suggest that the erythrocyte protoporphyrin
value obtained by this method could be used as a screening test for lead poisoning
http://mjiri.iums.ac.ir/article-1-869-en.pdf
Erythrocyte protoporphyrin
lead
poisoning.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
293
295
article
IMPORTANCE OF CATALASE ENZYME IN VIRULENCE OF ISONIAZID RESISTANT ST RAINS OF MYCOBACTERIUM TUBERCULOSIS IN GUINEAPIGS
M RAHBAR
1
A LAMEI
2
K GHAZI-SAIDI
3
the School of Medicine, Department of Microbiology, Urumieh University of Medical Sciences
the School of Medicine , Department of Infectious Diseases, Taleghani Hospital, Urumieh
Institute of Health Research, Tehran University of Medical Sciences, Tehran, I.R. Iran.
In this study, twenty-five strains of Mycobacterium tuberculosis resistant to
isoniazid (INH) were isolated from patients with tuberculosis (TB). Nine strains
(36%) were found to be virulent in guinea-pigs [root index virulence (RIV» 1 ].
The remaining sixteen strains (64%) were non-virulent (RIV <1). Of the nine strains
resistant to INH as well as virulent to guinea-pigs, eight of them were found to be
catalase positive and only one strain was catalase negative, whereas the remaining
sixteen INH resistant strains were catalase negative. A strong association was
observed between INH resistance and catalase positivity and virulence (p<0.0001
chi-square test). This study supports the hypothesis that catalase has an important
role in the virulence of INH-resistant strains of M tuberculosis.
http://mjiri.iums.ac.ir/article-1-868-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
289
292
article
MONOPHASIC STATE OF INSULIN SECRETION IN ISOLATED RAT ISLETS OF LANGERHANS BY K+, Ca2+ AND GLUCOSE
B MIRZAJANI
1
B FARZAMI
2
A SARRAFNEJAD
3
B LARIJANI
4
M MYERS
5
From the Department of Biochemistry Tehran University of Medical Sciences. Tehran. I. R. Iran
From the Department of Biochemistry Tehran University of Medical Sciences. Tehran. I. R. Iran
From the Department of Biochemistry Tehran University of Medical Sciences. Tehran. I. R. Iran
From the Shariati Hospital. Tehran University of Medical Sciences. Tehran. I. R. Iran
the Department of Biochemistry and Molecular Biology, University of Monash. Melbourne. Australia
Isolation of rat islets of Langerhans was carried out by using collagenase and
the destruction of exocrine tissue was performed through the injection of Hanks'
solution into the common bile duct. The identification of the islets was done by
techniques including the use of a stereomicroscope against a black background.
Vital staining was done by an injection of neutral red solution through the abdominal
aorta to observe the red tinted islets. Immunofluorescent staining with
anti-insulin was done to identify islets and nuclear staining was done with
propidium iodide. The microorgans were detected by a confocal microscope
equipped with a laser source. The secretory activities of the islets was investigated
by in vitro measurement of insulin and the effects of various concentrations
of glucose, potassium and calcium ions were studied. It was found that the insulin
secretion by these agents obeyed a monophasic trend which points to the depolarization
effect on cytoplasmic membrane induced by these agents.
http://mjiri.iums.ac.ir/article-1-867-en.pdf
Pancreas
Islets of Langerhans
Perfusion
Insulin secretion.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
283
287
article
INFLUENCES OF DIFFERENT ADRENOCEPTOR AGONISTS AND ANTAGONISTS ON AMPHETAMINE- INDUCED CLIMBING IN MICE
M SHAFIEZADEH
1
MR ZARRINDAST
2
Y FATHOLLAHI
3
S SEMNANIAN
4
From the Institute of Biochemistry & Biophysics, University of Tehran
the Department of Pharmacology, Tehran University of Medical Sciences
the Department of Physiology, Tarbiat Modarres University. Tehran, I.R. Iran.
the Department of Physiology, Tarbiat Modarres University. Tehran, I.R. Iran.
Administration of apomorphine and amphetamine induces climbing behavior
in mice due to stimulation of brain dopamine receptors. In the present study,
the effects of adrenoceptor agonists and antagonists on amphetamine-induced
climbing have been investigated. Intraperitoneal (i.p.) injection of different doses
of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p<O.OOO 1). The u2-
adrenoceptor agonist clonidine decreased the climbing induced by amphetamine
(p<0.01). The adrenoceptor antagonists prazosin, yohimbine and propranolol did
not alter amphetamine response.
It may be concluded that α1- and α2-adrenoceptor stimulation decreases amphetamine-
induced climbing behavior indirectly through changing dopamine levels.
http://mjiri.iums.ac.ir/article-1-866-en.pdf
Adrenergic agents
Amphetamine
Climbing
Mice.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
277
281
article
URINARY BLADDER RECONSTRUCTION USING FRESH AND FORMALIN-PRESERVED BOVINE AMNION IN DOGS
J BAKHTIARI
1
F SABERI-AFSHAR
2
H NOORBALA
3
MJ GHARAGOZLO
4
A VESHKINI
5
From the Faculty of Veterinary Medicine, Tehran
Chamran Universities of Medical Sciences, Tehran
Dept. of Urology, Baghiyatallah University of Medical Sciences, Tehran, l.R. Iran
From the Faculty of Veterinary Medicine, Tehran
From the Faculty of Veterinary Medicine, Tehran
The use of bovine amnion in the urinary tract for reconstructive purposes
following ablative surgery in cases of trauma, cancer or infection is now a common
practice in urological surgery.
To evaluate urinary bladder reconstruction with bovine amniotic membrane
(BAM), ten healthy mongrel dogs of either sex weighing 10-40 kg were used. The
animals were randomly divided into two groups of five animals each. A piece of
the cranial wall of the bladder 5 cm in diameter was resected and replaced with
fresh and formalin-preserved BAM respectively. The graft compatibility was evaluated
on the basis of clinical, biochemical ultrasonographical, radiological and
histopathological changes.
Clinically all of the dogs were dull and depressed with blood tinged urine for
the first few post-operative days. The biochemical parameters didn't show any
significant changes in BUN and creatinine. Ultrasonographic findings consisted
of floating masses in the bladder lumen (40%), chronic cystitis (10%), bladder
adhesion with adjacent tissues (90%) and radiological findings were lack of normal
distension of the graft site (100%) and filling defect (30%). No inflammatory
responses and leakage were observed.
The regeneration of uroepithelium, and proliferation of granulation tissue,
infiltration of lymphoid cells, degenerative changes at the junction of the bladder
and graft and heterotopic bone formation were observed. Keeping in view the
compatibility of the fresh and preserved BAM, this study showed that it can act as
a scaffold for repairing urinary bladder defects in dogs.
http://mjiri.iums.ac.ir/article-1-865-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
271
276
article
EXPRESSION OF HUMAN PROTEINASE 3 IN CHINESE HAMSTER OVARY CELLS (CHO-CELLS)
GR ASADI KARAM
1
CV KOOTEN
2
MJ RASAEE
3
MR DAHA
4
GV ZANDBERGEN
5
SS ASGHAR
6
From the Department of Biochemistry, School of Medical Sciences, Tarbiat Modarres University, Tehran, I.R. Iran
the Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands
From the Department of Biochemistry, School of Medical Sciences, Tarbiat Modarres University, Tehran, I.R. Iran
From the Department of Biochemistry, School of Medical Sciences, Tarbiat Modarres University, Tehran, I.R. Iran
the Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands
the Academic Medical Center, Amsterdam, the Netherlands.
Proteinase 3(PR3) is a human polymorphonuclear leukocyte serine proteinase
and is the main target antigen for antineutrophil cytoplasmic antibodies
(ANCA) found in Wegener's granulomatosis (WG). We developed a stable
expression system for conformationally intact recombinant PR3 (rPR3) in
Chinese hamster ovary cells (CHO-cells). The part of PR3 cDNA that encoded
the active form of PR3 was selected by using appropriate primers, and
a signal sequence was also added in front ofPR3 eDNA. The signal sequencePR3
(S-PR3) was cloned into the pME 18 expression vector and the result
product was electroporated into E. coli (DH5 a strain). After isolation and
purification, the presence of pMEI8-S-PR3 was confirmed by using appropriate
restriction endonuclease and agarose gel electrophoresis. The pMEI8-
S-PR3 was electroporated with CHO-cells and the presence of rPR3 was tested
in culture medium after 10 days. There was 12 ng/mL rPR3 in culture medium
that had activity and was recognized by ANCA in ELISA.
http://mjiri.iums.ac.ir/article-1-864-en.pdf
Proteinase 3
ANCA
Expression system
CHO-cell.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
267
270
article
DEVELOPMENT OF A METHOD FOR THE DETERMINATION OF 4-HYDROXY-3-METHOXYMANDELIC ACID (VANILLYLMANDELIC ACID) IN URINE BY PAPER CHROMATOGRAPHY
DURDI QUJEQ
1
Q USEFNIA PASHA
2
From the Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, I. R. Iran.
We have developed a simple and precise paper chromatographic method for
the determination of 4-hydroxy-3-methoxymandelic acid (VMA) in urine. Concentrations
of VMA in patients with neuroblastoma were increased in comparison
to controls. The linearity was excellent in the concentration range tested. The
within-assay coefficient of variation for control and patient urine was less than
2.2%. The recovery was in the range of 97.9-99.4%. Results from testing urine
samples of controls and patients with neuroblastoma suggest that this method is a
reliable and convenient system for quantification of VMA in urine and can be
used in the mass screening of neuroblastoma in infants. Sample preparation requires
minimal time and the entire procedure is completed within 5 h.
http://mjiri.iums.ac.ir/article-1-863-en.pdf
Vanillylmandelic acid
paper chromatography
neuroblastoma.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
261
266
article
EFFECTS OF CCK RECEPTOR AGONISTS AND ANTAGONISTS ON MORPHINE-INDUCED ANTINOCICEPTION IN MICE
MR ZARRINDAST
1
M REZAYAT
2
MR ZOLFAGHARPOOR
3
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
In the present study the effects of both CCK receptor agonists and antagonists
on antinociception induced by morphine in the tail-flick test have been evaluated.
M orphine induced dose-dependent antinociception in mice. The response of
morphine was potentiated by sulfated cholecystokinin-8 (CCK-8S) but not by
unsulfated cholecystokinin-8 (CCK-8U). The CCK receptor antagonists MK-329
and L-365, 260 decreased the potentiation of morphine antinociception induced
by CCK-8S.•The antagonists even decreased the response induced by morphine
in the pre5ence ofCCK-8U. High doses ofMK-329 and L-365, 260 also potentiated
morphine's antinociception. Single administration of the CCK receptor agonists
CCK-8 and CCK-8U or CCK receptor antagonists did not elicit any response
in the tail-flick test. It is concluded that CCK receptor mechanisms are
involved in the modulation of pain response and/or morphine antinociception.
http://mjiri.iums.ac.ir/article-1-1652-en.pdf
CCK agents
morphine
antinociception
mice
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
253
260
article
ATTITUDE AND ACADEMIC PERFORMANCE OF MEDICAL STUDENTS IN RESEARCH-CENTERED TEACHING METHOD
N RASSAIAN
1
N SADEGHI GHANDEHARI
2
S NAKHAEI
3
B TAJASOB
4
From the Physiology-Biology Department, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Islamic Republic of Iran
Man's instinct for exploring is the most natural way to enhance motivation
and, consequently, cognition. In the research-centered teaching method, developed
after many y ears of teaching experience, the principles mentioned in textbooks
are not presented directly instead, the lecture begins by posing an initial
question about how scientists have discovered a certain principle. Students are
encouraged to explore a way to reach the answer and voluntarily suggest a proposal.
The lecturer refines their views from scientific, methodological and ethical
aspects, guides their thoughts towards a conclusion, and introduces their proposals'
related references. The session then continues with customary lecturing.
This investigation-which was carried out to evaluate the effects of the initial
research-centered teaching stage in the beginning of every session-assessed the
medical student's attitudes by using a questionnaire, and their knowledge by taking
an examination including a test exam, research essay and class attentiveness
from 1993-95. The results indicated that 84.3% of the 562 students obviously
preferred the research-centered method to a customary way to lecturing. Statistical
analyses were carried out on students' attitude variables in cognition, enthusiasm,
anxiety, and not interested categories. It was concluded that cognition is in
favour of the research-centered method which, by way of exploratory thinking is
related to increased enthusiasm among the students (p= 0.001). Mean scores for
research exam and class attentiveness were also higher in this group compared
with those who chose only customary lecturing (p<0.05).
http://mjiri.iums.ac.ir/article-1-862-en.pdf
Research-centered teaching method
Motivation
Cognition
Academic achievement
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
249
251
article
DEMONSTRATION OF LOCAL ANTITOXOPLASMIC IMMUNOGLOBULIN G PRODUCTION IN OCULAR TOXOPLASMOSIS, TRACED BY ENZYME IMMUNOASSAY OF AQUEOUS HUMOR AND SERUM
M KEYHANI
1
H SABERI
2
H AHMADIEH
3
From the Department of Biochemistry, Iran University of Medical Sciences, Tehran, I.R. Iran.
Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Forty patients with cataracts, as well as 40 patients with proven ocular toxoplasmosis
were enrolled in this prospective clinical study. Serum IgG and aqueous
IgG in both groups were measured by enzyme-linked immunosorbent assay
(ELISA) and the corresponding ratios were calculated. Serum IgG/aqueous humor
IgG ratio was less than 100 in the patient group and more than 100 in the
control group. On the other hand in the chorioretinitis subgroup the ratio was less
than 13, while in the group With uveitis, the ratio was more than 13 (p<0.05). The
results revealed that calculating the ratio of Serum IgG (antitoxo) / Aqueous IgG
(antitoxo) may be helpful as an adjunct to diagnosis in cases with clinically atypical
ocular toxoplasmosis.
http://mjiri.iums.ac.ir/article-1-1649-en.pdf
Ocular toxoplasmosis
Aqueous humor
Immunoglobulin G
ELISA
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
245
248
article
TREATMENT OF SPONTANEOUS INTRACRANIAL HEMORRHAGE USING UROKINASE
AR BIRJANDI
1
S ZABIHYAN
2
From the Department of Neurological Surgery, Ghaem Medical Center, Mashhad University of Medical Sciences (MUMS), Mashhad, I.R. Iran.
From the Department of Neurological Surgery, Ghaem Medical Center, Mashhad University of Medical Sciences (MUMS), Mashhad, I.R. Iran.
Twenty patients with intracranial hematoma (ICH or IVH) were treated with
direct infusion of urokinase through a catheter.
Reduction of hematoma volume was observed within a few days. Twelve
patients showed good or excellent outcome. No infection or rebleeding was observed.
http://mjiri.iums.ac.ir/article-1-1647-en.pdf
Intracerebral hematoma
Treatment
Urokinase
Hypertension
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
241
243
article
NEOADJUVANT CHEMOTHERAPY WITH VINCRISTINE AND CISPLATIN FOLLOWED BY RADICAL HYSTERECTOMY AND PELVIC LYMPH ADENECTOMY FOR FIGO STAGE IB BULKY CERVICAL CANCER
N BEHTASH
1
M MODARES
2
F GHAEM-MAGHAMI
3
A MOUSAVI
4
K SALEHI
5
From the Department of Gynecology-Oncology, Vali-E-Asr Hospital, Tehran University 0F Medical Sciences, Tehran, I.R. Iran.
Twenty patients with bulky (>4 cm size) FIGO stage IB cervical cancer were
treated with cisplatin 50 mg/m2 and vincristine 1 mg/m2, administered intravenously
at 10-day intervals for a total of 3 courses before radical hysterectomy. A
complete clinical response was noted in 1 patient (5%) and partial response in 5
(25%). Fourteen patients (70%) had stable disease. There was no grade 3 toxicity
noted. Of the 20 patients who received chemotherapy (ChT), 3 patients had parametrial
and para-aortic involvement in these cases, the operation was aborted and
radiation therapy given. The remaining 17 patients underwent radical hysterectomy
and pelvic lymphadenectomy 10-15 days following ChT. Five of these patients
(29.4%) had pelvic node metastases. Three patients had positive margins.
These 8 patients received postoperative radiotherapy. Twenty-four months later
15 patients were alive (87%) and 2 had died.
http://mjiri.iums.ac.ir/article-1-861-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
237
240
article
THE DIAGNOSTIC VALUE OF FINE NEEDLE ASPIRATION BIOPSY OF HEAD AND NECK MASSES
BIJAN KHADEMI
1
BEHROOZ GANDOMI
2
From the Department of Otorhinolaryngology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
In an attempt to determine the diagnostic value of FNA biopsy of head and
neck masses, we reviewed FNAs performed on target lesions of the head and
neck in1 59 patients who subsequently underwent surgery in Khalili hospital dur-.
ing a 55 month period.
Results ofFNAs were compared with postsurgical histologic diagnoses. These
159 cases were broken down into four categories: thyroid masses 34 , lymph nodes
3 6, salivary gland masses 58 , and masses not classified in the first three categories
31 .
Values of specificity, sensitivity, positive predictive vlaue (in diagnosing
malignancy) and negative predictive value (in diagnosis of benign disease) were
calculated for each category and for all masses.
Overall, we obtained a sensitivity of 77%, specificity of 94%, positive predictive
value of 84% and negative predictive value of90% that was comparable
with several other studies performed elsewhere, except that our elevated numbers
of false negative in the salivary gland category lowered the sensitivity of FNA in
this category to 57% and the overall sensitivity to 77%.
The other disparity between our results and those of other studies I is our
slightly elevated false negative rate (6.9%), overall sensitivity.
http://mjiri.iums.ac.ir/article-1-860-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
231
235
article
BONE DENSITOMETRY OF MENOPAUSAL WOMEN IN TEHRAN
S JAHANFAR
1
M SADAT HASHEMI
2
F RAMEZANI TEHRANI
3
the Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran
the Department of Obstetrics and Gynecology, Ghazvin University of Medical Sciences, Ghazvin, I.R. Iran
Gazvin Medical University, NRCRH
Using a cluster sampling method, a group of menopausal women from three
geographic areas in Tehran were asked to participate in the study. Demographic
data was obtained using a questionnaire. Subjects were than referred to perform
bone mass densitometry (BMD). The relationship between various variables (i.e.
age of menarche, number of years of endogenous estrogen exposure, ... ) with mineral
density of the lumbar spine and femur were sought. Results showed that the
incidence of bone loss during menopause was high among these women. Earlier
age of menarche and longer reproductive years, higher BMI, previous usage of
OCP and HRT are likely to increase BM. Being active at home and doing household
chores can greatly influence the BMD of the femur. Poor dietary calcium
intake may be the main reason for low BMD among the studied subjects.
http://mjiri.iums.ac.ir/article-1-859-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
227
229
article
HYSTEROSCOPIC METROPLASTY: SECTION OF THE CERVICAL SEPTUM DOESN\'T IMPAIR REPRODUCTIVE OUTCOME
ME PARSANEZHAD
1
S ALBORZI
2
From the Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, l.R. Iran
The purpose of this study was to determine whether sectioning the cervical
septum is associated with intraoperative bleeding, incompetent cervix, and secondary
infertility. In this prospective observational study, fourteen women with
complete septate uterus who had a history of repeated pregnancy loss and infertility
were treated hysteroscopically. Preoperative history included 35 pregnancies
of which abortion rate was 62.8% and premature delivery 37.2%. Three infants
(8.5%) survived. The cerivcal portion of the septum was incised with Metzenbaum
scissors and the corporeal portion with micro scissors under hysteroscopic guidance.
Eleven patients achieved pregnancy (78.5%). There were ten term pregnancies
(91 %). Mean±SD of operating time was 31.1±9.74 minutes with a mean±SD
distending media deficit of 472±186 mL. No significant bleeding was encountered.
At follow up hysterosalpingography, all cervices were competent. In conclusion,
section of the cervical septum with scissors is simple, rapid and safe,
facilitates corporeal hysteroscopic metroplasty, and may be considered a valid
procedure to correct a complete septate uterus.
http://mjiri.iums.ac.ir/article-1-858-en.pdf
Septate uterus
Cervical septum
Pregnancy loss
Hysteroscopy
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
223
225
article
HLA-DRBI ALLELE FREQUENCY IN MYAS THENIA GRAVIS PATIENTS FROM SOUTHERN IRAN
A GHADERI
immunol@sums.ac.ir
1
J SHOSHTARI
2
S FARJADIAN
3
GH YOUSEFI-POUR
4
A AMIRZARGAR
5
From the Departments of Immunology and Neurology, Unit of Internal Medicine, Medical School, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
HLA-DRB1 allele frequencies of 28 myasthenia gravis (MG) patients, residents
of southern Iranian provinces, were studied using PCR-SSP method. The
control group consisted of 100 healthy individuals of the same ethnic group. The
allele HLA-DRB1 * 16 (RR= 2.04, p= 0.028) was found to be significantly increased
in MG patients compared to the control group, whereas HLADRB1
* 15(RR= 0.17 p= 0.043) and HLA-DRB1 *07 (p= 0.036) were found to be
significantly increased in the control group compared to the patients, and seem to
be negatively associated with the disease.
http://mjiri.iums.ac.ir/article-1-857-en.pdf
Myasthenia gravis
HLA-DRBl
PCR-SSP
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
217
221
article
VALUE OF INT ER-ICTAL SURFACE EEG IN THE DIAGNOSIS OF SEIZURE DISORDERS IN CHILDREN: A LOCAL ST UDY
OMID REZA FIROOZIFARD
1
SEYYED MOHAMMAD RAFIEI
2
From the Department of Pediatric Neurology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
We wished to assess the frequency of EEG positivity with our available EEG
technology to compare with those elsewhere. Between April 1996 to February
1997, of patients referred to the Pediatric Neurology Out-patient Clinic for assessment
of seizure disorders, 202 randomly selected patients aged 16 months to
17 years (mean 8.96 years) underwent a 10-minute inter-ictal EEG recording using
a standard lO-channel paper EEG, with various activation techniques performed.
Of these, 142 (70.3%) were clinically diagnosed as having some type of
seizure disorder, while the rest (60, 29.7%) had EEG performed for other reasons.
Of 142 cases with seizure disorder, 65 (45.8%) had definitely abnormal, 15
(10.5%) suspicious, and 62 (43.7%) had normal EEG's. In the 60 "other" patients,
22 (36.7%) had abnormal, 2 (3.3%) suspicious, and 36 (60%) normaI EEG's.
In 202 patients as a whole, 87 EEG's (43.06%) were abnormal, 17 (8.41 %)
suspicious, and 98 (48.51 %) normal.
In conclusion, although of lower than standard technology compared to those
taken in developed countries, EEG's taken in our laboratory could help us substantiate
our clinical impression of seizure disorders in children. The result could
be further improved by more appropriate selection of cases and further refining
the procedure, using the same instrument.
http://mjiri.iums.ac.ir/article-1-856-en.pdf
Seizure disorder (SD)
EEG.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
211
215
article
THE USE OF BREAST STIMULATION TO PREVENT POSTDATE PREGNANCY
M MODARRES
1
F RAHIMI-KlAN
2
From the Department of Obstetrics and Gynecology. Valie-Asr Hospital. Tehran University of Medical Sciences. Tehran. I.R. Iran
Postdate pregnancy is estimated to occur in 3% to 12% of all gestations.
Morbidity and mortality rates associated with this common obstetric problem are
higher than those with term gestation. The incidence of fetal distress, birth injury,
meconium aspiration, congenital malformations, macrosomia, and oligohydramnios
is also greater in postdate pregnancies. We prospectively evaluated breast
self-stimulation to determine its effect on the incidence of postdate pregnancy.
One-hundred uncomplicated patients at 40 weeks gestation were randomly assigned
to either a control group or a breast-stimulation group. Results showed
that breast stimulation reduced the number of pregnancies managed as postdates
from 22 per 100 (22%) to zero per 100 (p= 0.002).
It is concluded that breast stimulation in postdate pregnancies can decrease
significantly the number of patients that must be monitored by biochemical or
biophysical means.
http://mjiri.iums.ac.ir/article-1-855-en.pdf
Postdate
Breast stimulation
Pregnancy.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
207
209
article
NUCL EAR DNA CONTENT AND DNA PLOIDY ANALYSIS IN BREAST CANCER
F SARI ASLANI
1
B SALIMI
2
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
To investigate the patterns of DNA ploidy and proliferating activity in breast
cancer and relate them to other prognostic factors, paraffin blocks of 53 cases of
breast carcinoma were studied. Cancer cells obtained by mechanical tissue disaggregation
were examined for DNA content, ploidy and S-phase fraction. DNA
assay was done using a CAS interactive image analyzing system.
All of the cases showed high degrees of proliferation. The rate of aneuploidy
was 77% in invasive breast carcinomas. S-phase fractions were correlated with
the grades of the tumors (p<O.05). There was no statistically significant correlation
between S-phase fractions and other prognostic factors this was also true
about the pattern of ploidy and other prognostic factors.
http://mjiri.iums.ac.ir/article-1-854-en.pdf
Breast cancer
S-phase fraction
Image analysis.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
203
205
article
STUDIES ON CYTOMEGALOVIRUS INFECTION AND ANTINUCLEAR ANTIBODY AMONG VITILIGO PATIENTS IN AHWAZ IRAN
M MAKVANDI
1
N SHAHBA
2
N RADMANESH
3
EM ABBASI
4
From the Departments of Virology and Dermatology, Ahwaz University of Medical Sciences, Ahwaz, I.R. Iran.
Recently, using polymerase chain reaction (PCR) technique, the DNA of
cytomegalovirus was detected from depigmented white patches in patients with
vitiligo. The reactivation of infection and occasional anti-CMV IgM circulating
among patients infected by cytomegalovirus has been reported for years. We have
studied 26 patients with clinical signs and symptoms of vitiligo, some of whom
had a history of disease for years. Of these patients, 7 cases (26.92%) showed
positive for anti-CMV IgM, indicating the presence of cytomegalovirus infection
among vitiligo patients which differed significantly from control subjects
(p<O.OOOI). Of these 7 patients positive for anti-CMV IgM, 6 cases (85.71 %)
were also positive for antinuclear antibody (ANA). On the other hand, from among
the 19 cases negative for anti-CMV IgM, 7 cases (36.84%) were positive for
antinuclear antibody (ANA), so the difference was statistically significant (p<O.05).
The prevalence of anti-CMV IgM was higher among the active vitiligo patients
than those with stable vitiligo (p<0.02).
http://mjiri.iums.ac.ir/article-1-853-en.pdf
Cytomegalovirus (CMV)
Vitiligo
Antinuclear antibody (ANA).
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
199
202
article
EVALUATION OF ANATOMICAL VARIATIONS OF VESTIBULAR AQUEDUCT DIMENSIONS IN TEMPOR AL BONE CT SCAN
M POURSADEGH
1
G HASHEMI
2
MM JALALI
3
From the Departments of Otolaryngology and Radiology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR. Iran.
Various dimensions of the human vestibular aqueduct were evaluated in two
groups, patient and control, and these measurements were compared. Both groups
were examined clinically, followed by audiometric evaluation and temporal bone
high resolution CT scan. It was found that in approximately one third of the patient
group (with idiopathic SNHL), the vestibular aqueduct was 1.5 mm or larger.
Also, the midpoint diameter of the distal limb was larger than in the control group
(p<0.01). But there was no relation between the various dimensions of the vestibular
aqueduct and mastoid pneumatization.
http://mjiri.iums.ac.ir/article-1-852-en.pdf
Large vestibular aqueduct
Congenital SNHL
Temporal bone CT scan.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-11
14
3
195
198
article
CLINICAL EFFICACY OF HYSTEROSCOPIC ENDOMETRI AL ABLATION AND FACTORS AFFECTING ITS SUCCESS
SAEED ALBORZI
1
MOHAMMAD E PARSANEZHAD
2
From the Department of Obstetrics and Gynecology, Division of Endoscopy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
In order to assess the efficacy of hysteroscopic endometrial ablation and factors
which are important in it's success, a prospective, randomized study was
performed in Shiraz university hospitals between Sep. 1995 to Feb. 1998. 50
patients with chief complaints of menorrhagia that were in reproductive age (25-
50 years) and had shown no response to medication and D;C underwent endometrial
ablation. Thirty-seven patients received pre-op medication and thirteen
patients did not. All patients had undergone pre-operative endometrial sampling
that had demonstrated benign histology. Eleven patients had submucosal myomas
or pedunculated polyps that were resected at the time of hysteroscopic ablation.
The minimum follow-up period was 1 year.
Amenorrhea developed in 14% of patients, 50% of patients became
hypomenorrheic and 30% eumenorrheic. Menorrhagia did not respond in 3 patients
(6%). Hypermenorrhea was detected more commonly in younger patients.
Type of endometrium, depth of the uterine cavity, presence of polyp or myoma and
receiving pre-op medication were not important and did not affect patient response.
Overall, the results of this study clearly indicate that endometrial ablation is
a simple, effective and acceptable procedure for the management of intractable
menorrhagia. The only factor which was important concerning the efficacy of
endometrial ablation was patient age.
http://mjiri.iums.ac.ir/article-1-851-en.pdf
Abnormal uterine bleeding
Endometrial ablation
Hysteroscopy.