eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
103
106
article
THE SPECTRUM OF BETA – THALASSEMIA MUTATIONS IN IRAN
A A. MERAT
1
M HAGHSHENAS
2
From the Departments of Biochemistry and *Internal Medicine, Shiraz University of Medical Sciences, Shiraz, IR.Iran.
http://mjiri.iums.ac.ir/article-1-911-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
101
102
article
SPERMATIC CORD HEMATOMA MIMICKING SPERMATIC CORD TORSION IN A NEONATE
ALI SHAMSA
1
From the Department of Urology, Ghaem Medical Center. Mashhad University of Medical Sciences. Mashhad, I.R.lran.
Acute scrotal swelling is an urgent urologic condition, and its failure in
diagnosis is "one of the litigious issues in urologic practice. "1-2 Although acute
scrotal pain is due to spermatic cord torsion in 25-35% of cases, the urologist
should either rule it out or treat it immediately. 2 We operated a case of acute scrotal
edema in a two-day-old boy who had, according to clinical results and color
Doppler imaging, been diagnosed as having spermatic cord torsion. Operation,
however, confirmed that the cause was spermatic cord hematoma, not torsion.
http://mjiri.iums.ac.ir/article-1-910-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
97
100
article
IN TRACRANIAL SUPPURATION FOLLOWING NEUROSURGICAL PROCEDURES DUE TO BRUCELLA SPECIES
SEYED ALI F. TABATABAI
1
HOOSHANG SABERI
2
MASOUD MEHRAZIN
3
From the Dept. of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Reported here are two cases of delayed postsurgical brucella abscess within
the cranium, treated successfully by reoperation and appropriate medical therapy.
Both patients had an occupational exposure to the pathogenic organism. Systemic
symptoms of brucellosis became manifest postoperatively in case I and were
present in case II long before operation. The diagnosis was confirmed by serology
and positive culture. Later an intracranial abscess developed in both cases at the
previous operative sites.
Hematogenous spread of bacteria to the locally low resistance host tissue was
speculated as the possible mechanism. Successful management was accomplished
by reoperation, comprised of local drainage and debridement followed by a
combined anti brucella drug regimen for a period of 6 months.
http://mjiri.iums.ac.ir/article-1-909-en.pdf
Brucellosis. Brain abscess
Local host resistance
Postoperative infection.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
93
95
article
BULL ET-INDUCED FALSE ANEURYSM OF THORACIC AORTA WITH A TEN YEAR LATENCY PERIOD IN A VICTIM OF THE IRAN-IRAQ WAR: REPORT OF A CASE
B AMINMANSOUR
1
A TABATABAI
2
From the Depts. of Neurosurgery and Thoracic Surgery, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Traumatic false aneurysm of the thoracic aorta is not uncommon. But accordingly
this case is unusual in its ten year delay between injury and presentation and
treatment.
A victim of the Iran-Iraq war is presented with a false aneurysm of the thoracic
aorta ten years after a bullet injury to the chest and thoracic spine. Penetrating chest
wounds, mechanisms of injury and diagnosis are also discussed in detail.
http://mjiri.iums.ac.ir/article-1-908-en.pdf
False aneurysm of aorta
penetrating chest trauma
bullet injury
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
87
91
article
INFLUENCE OF ENDO THELIUM REMOVAL AND LNAME ON RESPONSES OF RAT COMMON CAROTID ARTERY TO α-ADRENOCEPTOR AGONISTS
M MOHAMMADI NAGHADEH
1
J.e. McGRATH
2
From the Department of Physiology, Faculty of Medicine. Tabriz University of Medical Sciences, Tabriz. I. R. Iran
the Clinical Research Initiative in Heart Failure. West Medical Building. University of Glasgow. Glasgow G21 8QQ. U.K.
In this study we investigated the effects of endothelium removal and L-NAME
on responses to α-adrenoceptor agonists. Male Wistar rats were killed by overdose
with pentobarbitone sodium, after which the left and right common carotid arteries
were removed. Rings of arteries 3-4 mm in length were cut from each vessel and
then mounted in 10 mL isolated organ bath, bathed in Krebs maintained at 37°C
and gassed with 95% 02 plus 5% CO2, The preparations were allowed to
equilibrate for an hour. L-NAME was added approximately 10-15 min prior to the
onset of cumulative concentration-response curves (CCRC) to an agonist. In some
preparations the endothelial layer was removed mechanically by gently rolling the
tissue around a thin wire. Removal of the endothelium was confirmed
pharmacologically by a lack of relaxant response to the potent endotheliumdependent
vasodilator acetylcholine. Inhibition of NO synthesis by L-NAME
results in significant vasoconstriction. L-NAME prevented the relaxation of rat
carotid artery by acetylcholine, suggesting that both basal and stimulated release
of nitric oxide can regulate vascular tone in this artery. Mechanical disruption of
the vascular endothelium reduced, but did not abolish, the ability of L-NAME to
produce contraction. This suggests an extra-endothelial site for nitric oxide
synthesis in rat common carotid artery. Inhibition of nitric oxide synthase with LNAME
potentiated responses to phenylephrine and UK-14304 but not to
noradrenaline. Mechanical disruption of the vascular endothelium potentiated
responses to UK-14304, phenylephrine and noradrenaline. We suggest that
constitutive NO activity has substantial inhibitory influence on vasoconstrictor
responses to phenylephrine and UK-14304 but not to noradrenaline.
http://mjiri.iums.ac.ir/article-1-906-en.pdf
Endothelium
L-NAME
α-adrenoceptor agonists
NO.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
83
86
article
PREVENTIVE EFFECTS OF VITAMIN B12 AND FOLIC ACID IN METHANOL-INDUCED RETINOPATHY IN AN ANIM AL MODEL
HA SHAHRIARI
1
A HOSSEINI RAD
2
From Zahedan University of Medical Sciences, Dr. Shariati Ave, Zahedan, 98134, I.R . Iran.
In order to identify the effects of vitamin B 12 and folic acid in reducing methanolinduced
retinopathy, ERG waves were compared before and after methanol
intoxication in rabbits. In this study 34 rabbits were divided into 4 groups. All groups
received 4 g/kg of methanol intraperitoneally. In addition, the second, third and
fourth groups received vitamin B 12 injection, oral folic acid and a mixture of vitamin
B12 and folic acid, respectively.
Baseline ERGs were recorded for all rabbits prior to intoxication and then
second ERGs were taken 48-72 hours following methanol toxicity. Compared to
baseline ERGs a severe reduction in the b-wave amplitude as well as reduction in
the oscillatory potential were noticed. Among all groups, the first group had the most
and the fourth group had the least decrease in b-wave amplitude as well as oscillatory
potential. It is therefore believed that vitamin B12 has a synergistic effect with folic
acid in attenuating ophthalmic toxicity of methanol in rabbits. Further studies are
needed to evaluate these effects in humans.
http://mjiri.iums.ac.ir/article-1-907-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
83
86
article
PREVENTIVE EFFECTS OF VITAMIN B12 AND FOLIC ACID IN METHANOL-INDUCED RETINOPATHY IN AN ANIMAL MODEL
HA SHAHRIARI
1
A HOSSEINI RAD
2
From Zahedan University of Medical Sciences, Dr. Shariati Ave, Zahedan, 98134, I.R . Iran.
In order to identify the effects of vitamin B 12 and folic acid in reducing methanolinduced
retinopathy, ERG waves were compared before and after methanol
intoxication in rabbits. In this study 34 rabbits were divided into 4 groups. All groups
received 4 g/kg of methanol intraperitoneally. In addition, the second, third and
fourth groups received vitamin B 12 injection, oral folic acid and a mixture of vitamin
B12 and folic acid, respectively.
Baseline ERGs were recorded for all rabbits prior to intoxication and then
second ERGs were taken 48-72 hours following methanol toxicity. Compared to
baseline ERGs a severe reduction in the b-wave amplitude as well as reduction in
the oscillatory potential were noticed. Among all groups, the first group had the most
and the fourth group had the least decrease in b-wave amplitude as well as oscillatory
potential. It is therefore believed that vitamin B12 has a synergistic effect with folic
acid in attenuating ophthalmic toxicity of methanol in rabbits. Further studies are
needed to evaluate these effects in humans.
http://mjiri.iums.ac.ir/article-1-905-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
77
81
article
ANTINOCICEPTIVE EFFECT OF ELAEAGNUS ANGUSTIFOLIA FRUIT IN MICE
HOSSEIN HOSSEINZADEH
1
MOHAMMAD REZA TAHERI
2
From the Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, IR.Iran.
The antinociceptive effect of Elaeagnus angustifolia fruits was studied in mice.
The antinociceptive effect of ethanolic and boiling water extracts was studied
using two thermal stimuli, the hot-plate and tail-flick tests. The intraperitoneal and
oral administration of the ethanolic extract of seed 0.75-7.00 g/kg), but not
pericarp and medulla had significant antinociceptive activity in the hot-plate test.
Naloxone pretreatment did not inhibit the antinociceptive activity of the extract.
The aqueous extract of different parts of the fruit (seed, medulla and pericarp) had
antinociceptive activity in this test. The ethanolic extract of the seed had no
antinociceptive effect in the tail-flick test and its effect was not abolished by
naloxone. A 70% failure rate in the traction test (a muscle relaxation test) was
induced by ethanolic extract of the seed (3.5 g/kg), compared with the 75% induced
by the reference drug diazepam (2.5 mg/kg). It is concluded that the antinociceptive
effect of E. angustifolia may be mediated by a supraspinal effect and muscle
relaxation activity.
http://mjiri.iums.ac.ir/article-1-904-en.pdf
Elaeagnus angustifolia; Antinociceptive activity; Muscle relaxation
Hot-plate
Tail-flick
Traction test
Medicinal plants.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
69
75
article
EFFECTS OF DOPAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON BACLOFEN-INDUCED ANTINOCICEPTION IN FORM ALIN TEST
MR ZARRINDAST
1
B HASHEMI
2
V TOLUI
3
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
In this study, the influence of dopamine receptor agonists and antagonists on
antinociception induced by bac10fen has been examined in the formalin test. The
GABA-B agonist bac10fen induced antinociception in both phases of the formalin
test in mice. The dopamine receptor agonists SKF 38393 and quinpirole also
induced antinociception in both phases of the test. SKF 38393 but not quinpirole
potentiated the response to bac10fen in the first phase of the test. The dopamine
receptor antagonists SCH 23390 and sulpiride increased the response to baclofen
in the first phase. Both drugs induced antinociception in the first phase of the
fonnalin test. However, low doses of sulpiride increased the pain response in the
second phase. The peripheral dopamine receptor antagonist domperidone did not
alter the effect of the test by itself. Dopamine receptor mechanisms appear to
interact with baclofen-induced antinociception.
http://mjiri.iums.ac.ir/article-1-903-en.pdf
Baclofen
dopamine agonists
dopamine antagonists
formalin test
mice.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
61
68
article
EPINEPHRINE SUPPRESSES SECRE TION ORVLDLASSOCIATED TRIACYLGLYCEROLAND INCREASES TRIACYLGLYCEROL AND PHOSPHOL IPID CON TEN TS IN ISOL ATED RAT HEPATOCY TES
M RASOULI
MehdIRasoull@hotmall.Com
1
M SHARIF
2
M ZAHRAIE
3
From the Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran
the Dept. of Mycology and Parasitology, Sari College of Medical Sciences, Mazandaran University of Medical Sciences, Sari, I. R.lran.
From the Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran
The effect of epinephrine on triacylglycerol secretion was investigated in
isolated rat hepatocytes. The effect appeared at concentrations of more than 1 µM
and reached a plateau at 10 µM. Epinephrine concentration for half of the maximal
bioeffect (EC50) was about 1 µM. Epineplrrine at a concentration of 10 µM suppressed
triacylglycerol secretion by 33% and increased its cellular content by approximately
18%. The total triacylglycerol content of the system (sum of the cell and the
incubation medium) was constant at all concentrations of epinephrine. Time
course experiments for triacylglycerol secretion exhibited relatively similar results
on the basis of lipid analysis with or without lipid extractions. On the former basis
triacylglycerol secretion versus time followed a linear relationship with a slope of
1.47 ± 0.11 µmole TG/3h/ g wet liver. Time course curves of cellular lipids revealed
that cellular triacylglycerol and phospholipid contents in the presence of epinephrine
were higher than the control at all time points, and the difference was constant
during time. Furthermore, in the presence of glucose (20 mM) and oleate (0.25
mM), intracellular triacylglycerol content increased markedly (≥45%) whereas
cellular phospholipid content remained constant. It is proposed that epinephrine
exerts an inhibitory effect on VLDL secretion probably through blocking in the
secretory pathway.
http://mjiri.iums.ac.ir/article-1-902-en.pdf
Epinephrine
Phospholipid
Hepatocytes
Triacylglycerol
VLDL.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
53
59
article
A NEW CYTOCOLORIMETRIC ASSAY USING PHOSPHATAS E ACTIVI T Y FOR MEASURING CELLULAR FUNCTIONS
A.A.N.P.M DABARE
1
A.M.E. NOURI
2
MRC Path
3
R.T.D. OLIVER
4
From the Department of Medical Oncology, The Royal London Hospital, Whitechapel, London, E1 1BB, U.K.
In this study cellular phosphatase activity, referred to as enzyme developed
color (EDC) assay, was used for an in vitro assessment of cell proliferation and
cytotoxicity. Optimum conditions were established and found to be 10 x103 cells /
well at 37°C and 60 min incubation (for developing color). Under the same conditions
a direct correlation between optical density (00) and cell number was observed.
Thus, the ODs for a cell line, Ish at 100, 50, 25 and 10 X 103 cells/well were
1.0S ±0.05, 0.59 ±0.02, 0.33 ±0.02, and 0.17 ±0.01 respectively (r=0.995,p<0.001).
When EDC was compared with another colorimetric assay, i.e. MTT, the results
showed a direct correlation with r=0.995, p0.05), 0.19±0.01 (p>0.05),
respectively. The assay was also shown to be suitable for the measurement of cell
cytotoxicity and compared well with the MTT assay.
These findings indicated that a simple, rapid and economical EDC assay could
be used to investigate various cellular functions. The main advantage of EDC is it's
suitability to use stored cells. This provides flexibility for testing samples stored over
a long period in order to limit inter-experimental variations
http://mjiri.iums.ac.ir/article-1-901-en.pdf
Alkaline phosphatases; testis tumor; cell proliferation
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
47
51
article
RAPID EYE MOVEMENT SLEEP DEPRIVATION INDUCES ACETYLCHOLINESTERASE A CTIVITY IN THE PREOPTIC AREA OF THE RAT BRAIN
MOHAMMAD HOSSEIN NOYAN ASHRAF
noyan@cd.gu.ac.ir
1
GILA BEHZADI
2
BEHNAM JAMEIE
3
From the Department of Anatomy. Faculty of Medicine. Cuilan University of Medical Sciences. Rasht Qazvin Road. Rasht. Cuilan. I.R. Iran.
the Department of Physiology. Faculty of Medicine. Shahid Beheshti University of Medical Sciences. Evin. Tehran. I.R. Iran.
the Department of Physiology. Faculty of Medicine. Shahid Beheshti University of Medical Sciences. Evin. Tehran. I.R. Iran.
Acetylcholinesterase (AchE) is a large glycoprotein that, aside from its known
cholinolytic activity, co-exists with other transmitter systems and possesses other
functions. In the present study, the effects of short-term rapid-eye-movement sleep
deprivation (REM-SD) on AchE activity in the anterior hypothalamic area have
been investigated.
Using the flower-pot method, adult male albino rats were deprived of REM
sleep for a period of72, 96, and 120 h and perfused brains were then sectioned with
a vibratome and stained histochemically for AchE.
In comparison to control animals, marked positive AchE activity was
observed in neurons located in the preoptic area in the 120SD group only.
Results of this study have shown that AchE could be involved in some
unknown functions related to REM sleep physiology
http://mjiri.iums.ac.ir/article-1-900-en.pdf
Sleep deprivation
Acetylcholinesterase
Preoptic area
Rat brain.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
43
45
article
S TUDY OF CYTOMEGAL OVIRUS ANTIB ODY IN ATHEROSCLEROTIC PATIENTS IN TABRIZ
S EBRAHIM-POOR
1
S SAMADIKHAH
2
J JAVANMARDY
3
S MOZAFFARY
4
H KOOSHAVAR
5
S RASSY
6
From the Department of Virology and Cardiology, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.
To evaluate the correlation of cytomegalovirus (CMV) and coronary artery
disease (CAD), one-hundred patients with CAD and the same number of healthy
individuals as a control group were randomly selected and studied for anti-CMV
using ELISA method. Ninety percent of patients and 77 percent of the control
group were anti-CMV positive and statistical analysis showed a significant
correlation between these groups (p<0.05). Certain risk factors such as
hypertension, hyperlipidemia, diabetes, smoking, type A personality and familial
history were also studied. The distribution of these factors in the patient group
were higher than those of the control group and a significant correlation was
observed between these groups, but no dependency was observed between anti CMV
and the above parameters in the patient group. Results of this study
showed a meaningful correlation between the anti-CMV level and coronary
artery disease.
http://mjiri.iums.ac.ir/article-1-899-en.pdf
Atherosclerosis
Anti-cytomegalovirus antibody.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
37
41
article
THE EFFECT OF ARTERIAL O2 SATURATION AND HE ART RATE ON BLOOD PRESSURE DURING HYPOXIA
MH BOSKABADY
1
S KARBANDI
2
A ABEDINZADEH
3
From the Dept. of Physiology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad. I.R. Iran.
A periodic increase in blood pressure (BP) occurs during apneic episodes in patients
with obstructive sleep apnea (OSA). Several factors including hypoxemia and an increase
in heart rate (HR) were reported to be responsible for this increased BP.
To examine the contribution of these two factors in increasing BP, 35 healthy male
subjects (mean age±SD= 23.64±3.80) were studied in three experimental conditions,
each condition for two minutes, including breathing room air at rest (normoxic),
breathing low 02 (10%) air (hypoxic), and exercising on an ergometer while breathing
room air (exercise). During the last minutes of each condition, changes in mean BP
(ΔmBP), HR (ΔHR), and arterial O2 saturation (,ΔSaO2) were measured.
The results showed that ΔmBP and ΔHR were significantly higher in both hypoxic and
exercise conditions than normoxic condition (p<0 .00 1 for both cases). However, , ΔSaO2
was significantly lower in the hypoxic state compared to normoxic conditions. There was
no significant difference in ΔHR between hypoxic and exercise groups, but both ΔmBP
and , ΔSaO2 were significantly lower in hypoxic than exercise conditions (p<0.005 and
p< O. OOl for ΔmBP and , ΔSaO2, respectively). There was a weak correlation between
ΔmBP and ΔHR in the hypoxic condition (r=0.3, p<0.05), but the correlation between
ΔmBP and ΔHR in the exercise condition was stronger (r=0.57, p< 0.001).
These results indicated that although hypoxemia contributes to increased BP
during hypoxia, an increase in HR is a stronger mechanism for this phenomenon.
http://mjiri.iums.ac.ir/article-1-898-en.pdf
Blood pressure
Heart rate
O2 Saturation
Hypoxia.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
33
36
article
NINE CASES OF MALIGNANCY AFTER KIDNEY TRANSPLANTATION
FARAHNAZ FALLAHIAN
1
MOHAMMAD REZA KHATAMI
2
PARVIZ JABAL AMELI
3
ABAS RAHIMI
4
From the Nephrology and Kidney Transplantation Section, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R.lran.
Renal transplantation is considered one of the best long-term therapies for
chronic renal failure, but unfortunately the incidence of malignancy significantly
increases in renal transplant recipients. We analyzed nine cases of malignancy in
200 renal transplant recipients occurring in a 12-year follow-up in Imam hospital
of Tehran University, Tehran, Iran. According to this study, the organ most
commonly affected with malignancy in our series was the skin and the mean time
of neoplasm occurrence after kidney transplantation was 2.9 years.
http://mjiri.iums.ac.ir/article-1-897-en.pdf
Kidney transplantation; malignancy; immunosuppression.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
27
32
article
GROWTH PATTERN OF EXCLUSIVELY AN D NONEXCLUSIVELY BR EA ST-FED INFANTS IN THE FIRST 4 MONTHS OF LIFE
MINO D. FROOZANI
1
KOBRA PERMEHZADEH
2
BANAFSHEH GOLESTAN
3
AHMAD REZA DOROSTY M0TLAGH
4
From the Department of Nutrition, School of Public Health, Tehran University of Medical Sciences, Tehran. I.R. lran.
Thirty-two exclusive and twenty-seven non-exclusively breast-fed infants
were followed-up from birth to 4 months of age in a maternity hospital, with a
rooming-in program. Face to face BF education was given to mothers in two
groups after delivery and also during 4 months post-partum. Body weight (Wt ),
length (L) and head circumference (HC) of the infants were measured at monthly
intervals, and their feeding patterns were recorded. The Wt of exclusively breastfed
infants was higher than non-exclusively breast-fed infants. The faltering of
infant's growth from 3 months of age was seen in both groups. From the age of 3
months, the Wt of non-exclusively breast-fed infants was lower than the 50th
percentile of the reference value (NCHS), but Land HC increments were similar
in both groups. Mean Wt, Land HC of exclusively breast-fed female infants were
higher compared to non-exclusive females and also higher than exclusive male
and non-exclusively breast-fed male infants. In the present study, the faltering of
growth of infants was seen in the first 4 months of age, in comparison to breastfed
infants in the Darling study.
http://mjiri.iums.ac.ir/article-1-896-en.pdf
Exclusive breast feeding
Anthropometry
Weight
Length
Head circumference.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
23
26
article
SERUM PENICILLIN LEVEL A FTER INTRAMUSCULA R INJECTION OF 1,200,000 UNITS OF BENZATHINE PENICILLIN G IN CHILDREN WITH RHEUMATIC FEVER
MOHAMMAD REZA SABRI
1
MOHAMMAD RAHIM KADIVAR
2
MOHAMMAD BORZOUEE
3
From the Cardiology Units, Pediatric Department, Nemazee Hospital, Shiraz, l.R.lran.
From the lnfectious Disease Units, Pediatric Department, Nemazee Hospital, Shiraz, l.R.lran
From the Cardiology Units, Pediatric Department, Nemazee Hospital, Shiraz, l.R.lran.
The most accepted method of secondary prophylaxis in rheumatic fever (RF)
has been an injection of 1,200,000 units of benzathine penicillin G (BPG) every
4 weeks, but recurrences have been reported in some patients despite such a
prophylaxis program. The WHO recommended BPG injections every 3 weeks in
high risk patients and situations due to some published data in favor of inadequacy
of once every 4 weeks injection of BPG.
Our study was designed to determine serum penicillin levels (SPL) during the
4 weeks after an intramuscular injection of 1,200,000 units of BPG, in order to find
the appropriate interval between BPG injections and also to assess the effects of
weight and sex on this level. We included 42 RF patients (mean±SD=14.8±11.9
years) in our study. SPL was determined by disk agar diffusion method. In this
study the minimum accepted SPL to be effective against group A β-hemolytic
streptococci was 0.02 µg/mL. In 46% of the patients the mean SPL decreased to
<0.02 µg/mL at the end of the third week (mean ±SD=2.35 ± 1.3 weeks). The mean
SPLs were significantly higher in patients who weighed <45 kg
(mean±SD=38.6±4.3 kg) in comparison with those who weighed 2:45 kg
(mean±SD=54.25±4.87 kg), with a p value <0.0001. There was no significant
differences in mean SPL between boys and girls (p =0.145). Although in this study
the mean SPL was <0.02 µg/mL in 46% of patients at the end of the third week,
we could not recommend every 3 weeks injections of BPG in all patients, except
in high risk patients and situations as recommended by the WHO and also in those
patients who weighed 2:45 kg.
http://mjiri.iums.ac.ir/article-1-895-en.pdf
Rheumatic Fever
Secondary Benzathine Penicillin Prophylaxis
Children
Serum Penicillin Level.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
19
22
article
UNILATERAL POLYCYSTIC OVARY SYNDROME
SHAYESTEH JAHANFAR
1
JOHN A. EDEN
2
Ob-Gyn, Iran University of Medical
From the School of Obstetrics and Gynecology, Frank Ru ndle House, Royal Hospital for Women, 188 Oxford St., Paddington, NSW, Australia, 2021.
Two-hundred and seventeen subjects underwent transvaginal ultrasound -17
(8%) had unilateral polycystic ovary (PCO). Twelve percent of subjects with
unilateral scan-pea had oligomenorrhea, 24% were amenorrheic, 23% were hirsute
and 29% had acne. Biochemical parameters were compared between subjects with
unilateral scan- PCO and those with bilateral scan- PCO (n=200) as well as a group
of scan-normal women (n=29). No significant difference was found between
subjects with bilateral and unilateral scan- PCO suggesting that these 2 groups are
biochemically similar. The existence of unilateral scan- PCO suggests that peas
may be a primary ovarian disorder.
http://mjiri.iums.ac.ir/article-1-894-en.pdf
Polycystic ovary syndrome
Unilateral polycystic ovary
Primary ovarian disorder.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
15
18
article
GRADED P NEUMATIC DILATATION WI THOUT FLUOROSCOPY IN THE T REATMENT OF ESOPHAGEAL ACHALASIA
J MIKAELI
1
R MALEKZADEH
2
M KHATIBIAN
3
R ANSARI
4
H VAHEDI
5
H SOLIMANI
6
From the Department of Gastroenterology and Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran
Between 1993-1996 seventy-three consecutive patients (33 M, 40 F, mean age
35.4) with newly diagnosed achalasia underwent one or more pneumatic dilatations
with the Rigiflex balloon using a protocol of graded dilatation with a fixed inflation
pressure of 10 psi and constant duration of 30 seconds for all patients without using
fluoroscopy. Using Vantrappen's classification for assessment of response, excellent
or good results were considered as cure and fair or poor results as failure. Duration
of symptoms and the amount of weight loss before dilatation averaged 5.2 years
and 10 kg, respectively. In 62 patients one, in 5 patients two, and in 4 patients three
dilatations were performed. Dilatation failed in one patient because of previous
surgery and was followed by perforation in one patient (1.4%) and bleeding in
another patient (1.4%). Follow up period averaged 20 months (range 6-38 months)
with a cure rate of 90% (57 excellent, 9 good) and failure rate of 6.8% (3 fair, 2
poor). We conclude that graded pneumatic dilatation without fluoroscopy is a safe
and very effective treatment for achalasia with 90% of patients having a sustained
response lasting at least for an average of 20 months.
http://mjiri.iums.ac.ir/article-1-893-en.pdf
Achalasia
pneumatic dilatation
fluoroscopy
esophageal perforation.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
9
13
article
THE INCI DENC E OF PROS TATIC INTRAEPI THELIAL NEOPLASIA IN PROSTATIC HYPERPLASIA AND PROS TATIC C ARCINOMA
S TORABI-NEZHAD
1
S MAFTOUN
2
From the Department of Pathology, Shiraz University of Medical Sciences, Shiraz, I.R.lran.
Prostatic intra-epithelial neoplasia (PIN) is considered a precursor of invasive
carcinoma, characterized by proliferation and anaplasia of cells lining prostatic
ducts and acini. In this study, we applied the PIN grading system on one-hundred
cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia,
then compared the results. 74% of prostatic carcinoma and 51 % of prostatic
hyperplasia cases showed PIN foci. Most of the prostatic carcinomas (61 %)
showed foci of high-grade PIN including grade II (46%) and grade III (15%). In
benign prostatic hyperplasia cases, only PIN grade I (26%) and grade II (25%)
were seen.
It is concluded that PIN and invasive adenocarcinoma of prostate are closely
associated and the likelihood for coexistence is higher in patients with high grade
PIN and especially if other factors such as prostate specific antigen and positive
findings on sonography are also considered.
http://mjiri.iums.ac.ir/article-1-892-en.pdf
Prostate
Prostatic intra-epithelial neoplasia
Prostatic carcinoma
Benign prostatic hyperplasia.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
5
8
article
PRIMARY MALIGNANT TUMORS OF THE SMALL INTESTINE: ANALYSIS OF 156 IRANIAN PATIENTS
H SAADATNIA
1
S SERESHKI
2
T GHIASI MOGHADAM
3
From the Departments of Medicine and Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
156 Iranian patients with primary malignant tumors of the small intestine
were reviewed. Malignant lymphoma was the most common tumor type, comprising
128 patients (82%), followed by adenocarcinoma (22 patients, 14.1 %),
leiomyosarcoma (4 patients, 2.56%) and carcinoid tumor (2 patients, 1.28%).
Lymphomas and adenocarcinomas were primarily located in the duodenum
or jejunum, whereas leiomyosarcomas were more cornmon in the ileum. Abdominal
pain (73%), weight loss (68%), diarrhea (41% ), and nausea or vomiting (35%)
were the most common symptoms with these tumors.
Among the lymphoma group 95 patients (74.2%) had non-IPSID
(immunoproliferative small intestinal disease) lymphoma and 33 patients (25.8%)
had IPSID related lymphoma.
In contrast to the western world and far east countries in which malignant
small intestinal tumors are a disease of middle and old age groups and
adenocarcinoma is the most common tumor type, in our area, similar to some other
middle east and north African countries, lymphomas are much more frequent.
Although Iran is endemic for IPSID related lymphoma, the majority of these
tumors are non-IPSID lymphomas and appear in a very young age group (mean age
27 y).
http://mjiri.iums.ac.ir/article-1-891-en.pdf
Neoplasm
adenocarcinoma
malignant lymphoma
leiomyosarcoma.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-05
14
1
1
4
article
VARICOCELE SIZE AND SEMEN QUALITY
A A. SHAHRAZAD
1
SF
2
From the Division of Urology, Chamran Hospital Tehran University of Medical Sciences, Tehran, I.R.lran.
the Student's Scientific Research Center, Tehran University of Medical Sciences, Tehran, I.R.lran.
In this study we have described our varicocele cases in terms of associated
symptoms/signs. In addition, we have tested the correlation between semen
parameters and varicocele grades and compared the relative frequencies of
associated symptoms/signs in different varicocele grades. 1 19 referred cases of
varicocele were categorized based on clinical criteria into 3 grades by one
examiner. The relative frequencies of associated symptoms/signs of the grades
were compared. 52 of the cases whose semen analyses were performed at the same
laboratory were included for comparison of semen parameters.
Most of the cases were single conscripts. Age range was 1 8 to 38 years and the
mean age was 23 years. Pain was the most common associated finding in our
mostly single physically active cases. Of all the 1 19 cases, 9 were grade 1 , 63 grade
2, and 47 grade 3. Mean sperm concentration was 60.3 million per cubic
centimeter. No significant difference was found in the relative frequencies of
associated symptoms/signs among different grades. Difference in semen parameters
among grades was negligible and not significant at 0. 1 (0.05 as well).
Pain could be the most common associated finding in young single physically
active varicocele cases. It seems that varicocele grade bears no significance over
the relative frequencies of associated symptoms/signs. Our data is against any
clinically and/or statistically significant relationship between varicocele size and
semen parameters.
http://mjiri.iums.ac.ir/article-1-890-en.pdf
Varicocele
Semen
Grade.