eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
315
319
article
MALIGNANT LYMPHOMA OF THE UTERUS: REPORT OF A CASE AND LITERATURE REVIEW
MANOOCHEHR M. LARI
1
ABBAS SHIRDEL
2
R AJAMI
3
TAGHI GHIASSI
4
SHAHRAZAD M. LARI
5
From the Departments of Medicine and Surgery, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
Uterine lymphoma is a rare disease therefore, information regarding histologic
type, immunophenotype of tumor cells and etiologic factors are limited. although
secondary involvement of the genital tract occurs in up to 40% of cases• of
disseminated lymphoma, lymphoma presenting with primary female genital tract
. symptomatology is very unusual. We report a case of B-cell lymphoma in the
uterine corpus of a 27-year-old white female and review the literature.
http://mjiri.iums.ac.ir/article-1-929-en.pdf
Malignant lymphoma
Uterus
Immunohistochemistry
B-lymphocyte
Burkitt.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
311
314
article
EFFECT OF INTRAOCULAR POVIDONE-IODINE SOLUTION IN PREVENTION OF BACTERIAL ENDOPHTHALMITIS IN A RABBIT MODEL
HA SHAHRIARI
1
A SALEHI
2
From the Dept. of Ophthalmology, Zahedan University of Medical Sciences, Dr Shariati Ave, Zahedan, 98134, I.R. Iran.
In order to determine the effects of intraocular 0.05% povidone-iodine
preparation in the prevention of bacterial endophthalmitis in a rabbit model, 28
albino rabbits were randomly assigned to 4 equal groups. A concentration of 5x
108 organisms (0.03 mL) in logarithmic growth phase of S. epidermidis, S. aureus,
Proteus mirabilis and Pseudomonas aeruginosa, were injected separately in the
anterior chamber of right and left eyes of each group. Then 0.03 mL of 0.05%
povidone-iodine solution was injected in the left eyes. Eye examinations were
performed with a slit-lamp daily for two weeks following injection.
From 28 eyes injected with bacteria and povidone-iodine, 20 cases did not
develop endophthalrnitis, one developed mild, one developed moderate, and 6
developed severe endophthalmitis. In comparison, from 28 eyes injected with
bacteria and balanced salt solution, 9 cases developed mild, 10 developed
moderate and 9 developed severe endophthalmitis (p<0.00 1) .
Povidone-iodine solution is therefore effective in prevention of bacterial
endophthalmitis, although its efficacy has a direct relationship to the bacteria type
and species.
http://mjiri.iums.ac.ir/article-1-928-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
305
310
article
THE EFFECT OF ADRIAMYCIN ON SALT FRACTIONATED CHROMATIN
AZRA RABBANI
1
MAHVASH JAFARI
2
From the Institute of Biochemistry and Biophysics, University of Tehran, Tehran
the Department of Biochemistry, Faculty of Medicine, Baghiatollah University of Medical Sciences, Tehran, I.R. Iran.
In this study calf thymus chromatin was fractionated into active (S1 and S2) and
inactive (P 2) chromatin. Then the interaction of an anthracyc1ine antibiotic,
adriamycin, with these fractions was investigated employing absorption and
difference UV Nis spectroscopy and SDS and agarose gel electrophoreses.
The results suggest that the binding of adriamycin to the S 1 fraction is slight but
S2 and P 2 were considerably affected by drug action. In both cases the absorbances
at 260 and 480 nm were decreased. As drug concentration is increased in the
mixture, core his tones are aggregated and coprecipitate with the chromatin. The
extent of condensation in P2 is higher when compared to the S2 fraction.
http://mjiri.iums.ac.ir/article-1-927-en.pdf
Chromatin
Core histone
Adriamycin
Anthracycline.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
297
303
article
HYPOVENTILATION PRIOR TO ISCHEMIA PRECONDITIONS RAT MYOCARDIUM
A GARJANI
1
N MALEKI
2
A MAHDINIA
3
H BABAEI
4
From the Department of Pharmacology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz-51664, I.R.lran.
Repetitive episodes of brief regional ischemia have been shown to reduce the severity
of life-threatening ventricular anhythrnias and infarct size that occur during prolonged
occlusion of the coronary artery. This phenomenon is known as ischemic preconditioning.
During studies in anesthetized, open chest Wistar rats, we accidentally observed that
poorly ventilated animals had a reduced severity of ischemic arrhythmias. Therefore, we
wished to (1) find out whether acute hypoventilation prior to coronary ligation affords
protection to the ischemic rat hearts, and (2) to evaluate the effect of recovery period of
normoventilation between hypoventilation and prolonged ischemia on the degree of
protection. Male Wistar rats were anesthetized and prepared for left coronary artery
ligation. Following a left thoracotomy, artificial respiration was immediately started with
room air of 1.5 mLll00g and 54 strokes/min. Analysis of ventricular anhythrnias during
30 min occlusion was performed. In some experiments 30 min. sustained ischemia
followed by 2 hours reperfusion and then the percentage of infarct size was measured. The
reduction of volume of ventilation to 1.1 and 0.7 mL/l00g only for 10 min immediately
prior to coronary artery occlusion resulted in a marked decrease (p<0.01) in the total
number of ventricular ectopic beats from 1336±100 in control to 485 ±75 and 328±51,
respectively, mainly by reduction of beats occurring as ventricular tachycardia (VT).
Also, the time spent in VT and in reversible ventricular fibrillation was reduced
significantly (p<0.01 and p<O.OOI, respectively). There was no mortality in animals
subjected to hypoventilation, while 33% of control rats died due to irreversible VF.
Hypoventilation also limited the infarct size very considerably (p<0.0 1) from 43.4 ±2.9%
in control animals to 12.1 ± 1 % and 9.1 ±2.9% in hypoventilated rats. The presence of an
intervening period of normoventilation between hypoventilation and prolonged ischemia
did not affect the antianhythrnic effect of hypoventilation but abolished the protective
effects of hypoventilated preconditioning against the infarction. These results may
suggest that the heart can be preconditioned by hypoventilation prior to prolonged
ischemia despite the lack of an intervening period of normoventilation.
http://mjiri.iums.ac.ir/article-1-926-en.pdf
Hypoventilation
Preconditioning
Myocardial ischemia
Arrhythmia
Infarction.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
291
295
article
CHARACTERIZATION OF AN ANTICOAGULANT AGENT IN THE VENOM OF IRANIAN COBRA (NAJA NAJA OXIANA).
Z ZAMANI
1
H ZOLFAGHARIAN
2
H TOWFIGHI
3
S KHATAMI
4
A ANSARI
5
From the Biochemistry Dept., Pasteur Institute of Iran, Tehran, and the *Poisonous Animals Dept., Razi Institute of Serology, Hesarak, Karaj, I.R. Iran
Snake venoms contain a rich variety of factors which affect blood coagulation.
There have been few reports on the anticoagulant activity of the venom of different
cobras, but no such observations have been made on the Iranian cobra, although a
procoagulant factor has been described.
In this study an anticoagulant factor has been purified from the venom of Naja
naja oxiana using gel filtration followed by isopycnic ultracentrifugation with
30% KBr. The factor was a glycoprotein with a molecular weight of 45.36 kDa and
increased plasma recalcification time by 224 sec which was 7.7 times greater than
the activity of crude venom.
http://mjiri.iums.ac.ir/article-1-925-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
287
290
article
CIRCADIAN VARIATION OF THE ACUTE TOXICITY AND NOCICEPTIVE ACTIVITY OF AMINOPHYLLINE IN MICE
HOSSEIN HOSSEINZADEH
hosseinzadeh@mums.ac.ir
1
MASSUMEH FADISHEI
2
From the Faculty of Pharmacy, Department of Pharmacodynamy and Toxicology, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, I.R. Iran
The circadian variation of the toxicity and nociceptive actIvity of
aminophylline as an important methylxanthine was studied in mice. The animals
were housed under controlled light-dark cycles for at least 2 weeks. Acute
toxicity was determined by LD50. Hot-plate test was used for determination of
thermal pain threshold. Doses of 200, 250, 280 and 340 mg/kg of aminophylline
were injected intraperitoneally to four separate groups of six male mice at six
hour intervals (09:00,15:00,21:00,03:00). Mortality was recorded at 1,24, and
48 hours after injection and LD50 value was measured by logit method after 48
hours. The results showed that the lowest nociceptive effect was at the beginning
of the dark phase. The lowest LD50 value was also at the beginning of the dark
phase. This study indicated that the toxicity of aminophylline was maximum at
night and had a different rhythm pattern of nociceptive activity. This indicates
different mechanisms of action for these effects.
http://mjiri.iums.ac.ir/article-1-924-en.pdf
Chronotoxicity; Aminophylline; Nociceptive effect; Circadian variation.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
283
286
article
VASODILATOR EFFECTS OF THE β -AGONIST ISOPRENALINE IN AN EXPERIMENTAL MODEL OF HEART FAILURE
MUSTAFA MOHAMMADI NAGHADEH
1
J.e McGRATH
2
From the Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, I.R.lran
the Clinical Research Initiative in Heart Failure, West Medical Building, University of Glasgow, Glasgow G21 8QQ, UK.
Heart failure is a clinical syndrome characterized by the inability of the heart
to provide nutrient supply to tissues. In 75% of cases, the underlying pathology
causing heart failure in patients with cardiac death is coronary heart disease. A
rabbit model of heart failure with coronary ligation was produced to mimic
coronary heart disease in humans. After producing the model, two arteries and two
veins were investigated in the two groups (control and with coronary ligation).
Arteries and veins were cut as rings and bathed in Krebs solution maintained at 37
DC, and gassed with 95% oxygen and 5% CO
2
, Then all tissues were placed under
different resting tensions and allowed to equilibrate for 1 hour. Then all the tissues
were contracted with U -46619 (0.1 µM) nearly ten minutes before initial application
of isoprenaline. When the U -46619 (0.1 µM)-induced contraction reached a
plateau, concentration-response curves to isoprenaline were obtained. Isoprenaline
was chosen as a vasodilator, it's effect resulting from stimulating beta receptors in
blood vessels. Isoprenaline induced relaxation in all tissues, but the renal artery
was the most sensitive and showed maximum relaxation.20-26 Compared to
acetylcholine, relaxation responses were small and maximum responses observed
in the vena cava, aorta and renal vein were only 10 percent. In all tissues, relaxation
responses to the vasodilator agent isoprenaline showed no significant difference
between control and coronary ligated rabbits 8 weeks after operation.
http://mjiri.iums.ac.ir/article-1-923-en.pdf
Heart failure
coronary ligation
isoprenaline.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
279
282
article
MECHANISMS OF BLOOD FLOW INCREASE INDUCED BY ELECTRICAL STIMULATION
S HAJIZADEH
1
A KHOSHBATEN
2
A ASGARI
3
From the Dept. of Physiology, School of Medical Sciences, Tarbiat Modarres University, and the *Dept. of Physiology and Biophysics, Baghiatollah University of Medical Sciences, Tehran, I.R. Iran.
Previous studies have shown that electrical stimulation (ES) increases blood
flow, but the exact mechanisms are not clear. The present study was designed to
clarify some of the underlying mechanisms involved in this phenomenon. White
adult rabbits Lt.-6 months old were used. Animals were anesthetized by sodium
pentobarbital (40 mg/kg, IV) and skin blood flow in the thoracic back was recorded
using a Laser Doppler flowmeter (LDF). Square waves (20 Hz frequency, 0.5 ms
duration, 15 V strength) were applied through a pair of surface electrodes placed
on the skin of animals. Drugs were applied to the skin close to the tip of the laser
optic probe. The results obtained were as follows: 1. Electrical stimulation
increases local blood flow. 2. Blood flow increases dose-dependently by
administration of substance P (SP). 3. The response of ES on local blood flow was
augmented in the presence of SP. 4. SP-antagonists did not have any effect on basal
local blood flow. 5. The effect of ES was attenuated in the presence of SP-antagonists,
but this was not statistically significant. 6. Local blood flow increased
in reserpinized animals. 7. The electrically-induced increase in blood flow in
reserpinized animals was not statistically different from that of non-reserpinized
animals. Based on the above findings, it could be concluded that release of
vasodilating compounds such as SP from sensory nerve endings may contribute in
electrical stimulation and increase blood flow.
http://mjiri.iums.ac.ir/article-1-921-en.pdf
Substance P
Blood flow
Electrical stimulation.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
273
278
article
STIMULATORY EFFECT OF CARUM COPT/CUM ON β2 ADRENOCEPTORS OF ISOLATED GUINEA PIG TRACHEAL CHAINS
MH BOSKABADY
1
A MOEMENI
2
From the Department of Physiology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
The β2-adrenergic effects of macerated extract, aqueous extract, ethanol extract, and
essential oil of Carum copticum, 5 nM propranolol, and saline were tested by performing
cumulative Log concentration-response curves of isoprenaline-induced relaxation of
precontracted isolated guinea pig tracheal chains in three different conditions including:
non-incubated (group 1, n=9) incubated with 1 µM chlorpheniramine and 1 µM atropine
(group 2, n=8) and incubated with 1 µM chlorpheniramine (group 3, n=6). The effective
concentration of isoprenaline, causing 50% of maximum response (EC50), the maximum
response, and the slope of isoprenaline curves obtained in the presence of extracts,
essential oil, and propranolol were compared with those of saline.
The results showed clear leftward shifts in isoprenaline curves obtained in the
presence of only the ethanol extract compared with those of saline in group 1. In groups
2 and 3 the same finding was observed, although the effect of ethanol extract was tested
in the presence of propranolol. The EC50 and maximum response obtained in the presence
of ethanol extract were similar to those of saline in all three sets of experiments. However,
the maximum response obtained in the presence of other extracts, essential oil, and even
propranolol were lower than those for saline in all sets of experiments (p<0.05 to
p<0.001). The EC50s obtained in the presence of essential oil, macerated and aqueous
extracts, and even propranolol were greater than those obtained in the presence of saline
in the two last sets of experiments (p<0.05 to p<0.001). The maximum response obtained
in the presence of only ethanol extract in group 3 compared to group 2 was reduced
(p<0.05).
The results of this study indicate a stimulatory effect of only the ethanol extract of
Carum copticum on β2-adrenoceptors.
http://mjiri.iums.ac.ir/article-1-920-en.pdf
Carum copticum
antihistaminic effect
trachea
guinea pig.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
269
272
article
ANTINOCICEPTIVE A CTIVITY OF ANTIDEPRESSANTS AND CORRELATI ON WITH NEUROTRANSMITIER INHIBITORY POTENCY
M RAFIEIAN-KOPAEI
1
From the Pharmacology Dept., Shahrekord University of Medical Sciences, Shahrekord, I.R. Iran.
Antidepressant agents inhibit the neuronal reuptake of monoamines such as
serotonin (5-HT), noradrenaline (NA), and dopamine (DA). Several clinical and
animal studies have advocated the use of these agents in the management of pain.
In this study, therefore, the possibility of a correlation between the analgesic
activity of six serotonin specific reuptake inhibitor (SSRI) antidepressants and
their reported relative inhibitory potencies on monoamine reuptake was studied.
The antidepressants studied were citalopram, fluoxetine, fluvoxamine, sertraline,
and zimelidine.
Male ICI-WSP mice were given a 30 min pretreatment with antidepressants,
subcutaneously before challenge with 1 % intraperitoneal acetic acid. Abdominal
constrictions were evaluated over 20 min and percentage inhibition compared to
vehicle controls was calculated as a measure of analgesia. All the antidepressants
yielded linear log dose-analgesic response relationships from which ED50 values
were converted into relative potencies against fluoxetine as unity. Spearman's rank
correlations between relative potencies for analgesia and inhibition of monoamine
reuptake were examined. It was found that the correlation coefficients between
analgesia and 5HT, NA and DA reuptake were -0.54, -0.54 and -0.43,respectively,
suggesting that there was no overall rank correlation between these parameters.
This is somewhat surprising since monoamines are involved in the expression of
analgesia and their reuptake is considered to be a major component of the
pharmacology of these compounds. It is probable, however, that other differing
pharmacological properties such as opioid-like activity or diversity of
pharmacokinetic characteristics may disrupt any straightforward correlation
between monoamine reuptake and analgesia for the compounds examined.
http://mjiri.iums.ac.ir/article-1-919-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
265
267
article
ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODI ES IN RHEUMATOID ARTHRITIS
M VODJGANI
1
KE ANSARI
2
J HAJATI
3
From the Department of Immunology. Faculty of Medicine. Tehran University of Medical Sciences. Tehran. I.R. Iran.
Antineutrophil cytoplasmic autoantibodies (ANCA) were detected in patients
with autoimmune and vascular diseases such as Wegener's granulomatosis,
polyarteritis nodosa and systemic lupus erythematosus. Indirect
immunofluorescence (IIF) technique was employed to detect these autoantibodies.
By this method, two general patterns of ANCA were seen: a cytoplasmic (cANCA)
and a perinuclear form (p-ANCA). These antibodies were also observed
in rheumatoid arthritis (RA) but their prevalence and clinical significance have not
been determined. In this study the presence of ANCA in 52 RA patients (10 males
and 42 females) and its relationship with disease activity was evaluated. 26.9% of
patients were ANCA-positive, 36% of whom had c-ANCA and 64% a p-ANCA
pattern. The results also showed that there is no significant correlation between
ANCA titer and disease activity (p<O.05).
Thus according to the results obtained, the detection of these autoantibodies
are not useful for the diagnosis or prognosis of these disorders.
http://mjiri.iums.ac.ir/article-1-918-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
261
263
article
MALNUTRITION-RELATED DIABETES MELLITUS IN SOUTHERN IRAN
Z KARAMIZADEH
1
GH AMIRHAKIMI
2
H BAGHERI
3
From the Section of Endocrinology and Metabolism, Dept. of Pediatrics, and the *Dept. of Radiology, Shiraz University of Medical Sciences, Shiraz, I R. Iran.
Malnutrition-related diabetes mellitus (MRDM) is a major form of secondary diabetes,
restricted to tropical developing countries. We studied 200 cases of diabetes mellitus aged
6-18 years in Fars Province to find the prevalence of MRDM. There were 14 cases who
had clinical and laboratory findings compatible with MRDM. The mean age at presentation
was 8.6±3 years, with a male to female ratio of3:4. Moderate to severe malnutrition was
noted in 92.9% of the subjects. Insulin requirement was more than 2 U/kg/day in 85.7%
of the patients. 57.2 % of the patients were from poor socioeconomical class (income less
than 200,000 rials per month and a family size>7 members).
Recurrent abdominal pain, painless bilateral parotid swelling, lower extremity edema,
ascites, retinopathy and renal failure were observed in 50%, 21.4%,35.7%, 14.3%, and
7.1 % of the cases, respectively.
An abnormal pancreatic ultrasonography was noted in 35.7% of the subjects.
Ketoacidosis, regardless of other findings , was seen in 42 % of the patients. Malabsorption,
chronic diarrhea and pancreatic calcifications were not observed.
Finally, the prevalence of malnutrition-related diabetes mellitus was 7% in the
diabetic population of Fars Province.
http://mjiri.iums.ac.ir/article-1-917-en.pdf
Malnutrition-related diabetes mellitus
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
257
259
article
MAST CELLS IN INFLAMMATORY AURAL POLYPS
DRAGO SLAVA R. DJERICJ
1
From the Institute of Otorhinolaryngology and Maxillofacial Surgery, Pasterova 2, Belgrade 11000, Yugoslavia
This study investigated the presence of mast cells in inflammatory aural polyps
using light microscopy. The number of mast cells was increased in all examined
cases and varied from 2.33 to 41.54 per mm2• The cells were located most commonly
around small blood vessels. Occurrence of mast cells was not different in various
types of polyps, but their density was severely increased in active inflamed polypous
tissue. These findings suggest that mast cells may be a contributory factor in the
pathogenesis of middle ear inflammatory processes.
http://mjiri.iums.ac.ir/article-1-915-en.pdf
Mast cells
Inflammatory aural polyps
Pathogenesis.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
251
255
article
INFECTIVE ENDOCARDITIS IN CHILDREN OF SOUTHERN IRAN
M BORZOUEE
1
F PAYRAVIAN
2
R GHARIB
3
From the Department of Pediatrics, Division of Pediatric Cardiology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
Infective endocarditis is an uncommon heart disease with a variable incidence,
mostly related to the ever-increasing development of cardiac surgery and the
longer survival of patients with congenital heart disease (CHD). Thirty-seven
episodes of infective endocarditis (IE) were evaluated in 36 children (under 15
years of age) admitted to hospitals affiliated to Shiraz University of Medical
Sciences during a 10 year period. The mean age was 9.2 years, only one boy was
under one year of age and 6 of the children were under 5. Overall, the male to female
ratio was 1.46/1, but the ratio was equal in children under 5 years. The frequency
of IE was 3 per 1000 pediatric admissions. CHD was the most common underlying
disease (27 patients, 73.0%), followed by rheumatic heart disease (RHD) (7
patients, 18.9%). Ventricular septal defect was the most common acyanotic CHD
and tetralogy of Fallot was the most common cyanotic CHD. Blood cultures were
positive in 54% and vegetations were present in 57.5% by 2-dimensional
echocardiography. Streptococcus species (mostly viridans) was the most common
infecting micro-organism. The most common site of vegetation was the pulmonary
valve, followed by the aortic valve. There were 6 deaths (16.2%) due to different
causes. Mortality occurred mostly in culture negatives or in those infected by
Gram-negative micro-organisms (p<0.0 1). All mortalities had left-sided vegetations
(p<0.001). In conclusion, despite medical and surgical advances, this fatal
complication of heart disease remains a significant medical problem. An effective
chemoprophylaxis strategy for rheumatic fever and IE will decrease the incidence
and outcome of this potentially serious illness.
http://mjiri.iums.ac.ir/article-1-914-en.pdf
Bacterial endocarditis
Congenital heart disease
Rheumatic heart disease
Children
Developing countries.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
247
249
article
RADIOTHERAPY IN IMMUNOPROLIFERATIVE SMALL INTESTINAL DISEA SE: A RETROSPECTIVE COMPA RISON OF CHEMOTHERAPY PLUS RADIATION WITH CHEMOTHERAPY ALONE
AHMAD MOSALAEI
1
From the Department of Radiation Oncology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
In order to evaluate the results of abdominal radiation plus chemotherapy in cases with
stage II and III of immunoproliferative small intestinal disease in comparison to
chemotherapy alone, fifty-one patients referred to Shiraz University of Medical Sciences'
affiliated hospitals were studied between 1980 and 1994. Out of them 38 patients who had
an abdominal mass were gathered into two groups retrospectively. Group A, including 21
patients, had received only chemotherapy after operation and tissue diagnosis. Group B,
consisting of 17 patients, received radiation to the whole abdomen in addition to systemic
chemotherapy.
Four patients (19%) in group A were alive with no evidence of disease after three years
and in the other group (B) 7 patients (41 %) who had received radiation in addition to
systemic chemotherapy had survived in disease free status.
It therefore appears that radiation to the whole abdomen in small daily fraction doses
and a total dose not greater than the optimal tolerance of the liver and other critical
abdominal organs plus chemotherapy can be an effective adjuvant treatment in stage II and
III disease.
http://mjiri.iums.ac.ir/article-1-913-en.pdf
Intestinal lymphoma
IPSID
Radiotherapy
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
2000-02
13
4
241
246
article
A COMPARATIVE ST UDY OF THERAPEUTIC RESULTS OF RIGH T AND LEFT COLONIC INJURIES SUSTAINED BY IRANIAN SOLDIERS IN THE IRAN-IRAQ WAR
AR TALEI
1
SM GHOREISHI
2
From the Dept. of Surgery, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, I R. Iran.
The treatment strategy of colonic injuries is a debatable and highly controversial
subject worldwide in various medical centers. The method of treatment of left and
.. right colonic injuries, diversity or similarity in their management and particularly
differences between the treatment of war-associated injury from other types of
colonic damage are among the unsettled issues.
The present study involves a review of 226 medical records belonging to male
Iranian soldiers 15-54 years of age admitted to 3 hospitals affiliated to Shiraz
University of Medical Sciences for injuries sustained during eight years of the
Iran-Iraq war. Differences with respect to therapeutic results, symptoms and
mortality rates were studied between the two groups of patients with left and right
colonic injury with reference to the various surgical treatments employed. Ninety two
(40.7%) and 134 (59.3%) cases suffered from injuries of the right and left
colon, respectively. The majority (91.6%) had undergone primary surgical
treatment in field hospitals before being dispatched to our hospital for convalescence
and continuation of therapy.
Our study indicates that in the presence of identical side-conditions and
regardless of anatomical sites, both right and left colon injury can be treated
similarly with no significant differences between the two groups (p=0.804). The
peculiarities relating to each case demanded a particular surgical therapy. As
compared with the results obtained from other surgical therapies the best surgical
management of war-associated colonic injuries with the least sequelae is
exteriorization (p=0.0000002) which is of first priority, whereas resection of the
damaged segment accompanied by colostomy or ileostomy is of second preference.
The use of antibiotics in the early phases of colonic injury is mandatory and a rapid
diagnosis followed by expedient surgical therapy is of fundamental importance.
Therefore, the most effective and convenient process for immediate treatment of
wartime injuries is the establishment of reliable and equipped centers in the
vicinity of battle zones.
http://mjiri.iums.ac.ir/article-1-912-en.pdf