eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
299
301
article
SERIOUS ARRHYTHMIA INDUCED BY TERFENADINE-ERYTHROMYCIN INTERACTIONS
MOJTABA MOJTAHEDZADEH
1
ABBAS MOHAGHEGHI
2
MANSOOR RASTEGARPANAH
3
From the Department of Pharmacotherapy (Clinical Pharmacy). Faculty of Pharmacy. Tehran University of Medical Sciences
the Department of Cardiology. Faculty of Medicine. Tehran University of Medical Sciences. Tehran. I.R. Iran.
From the Department of Pharmacotherapy (Clinical Pharmacy). Faculty of Pharmacy. Tehran University of Medical Sciences
Since the introduction of our local manufacturing of terfenadine, we have
observed and expressed our concern about a small but increasing number of serious
ventricular arrhythmias associated with the use of this non sedating antihistamine.
In January 1997 a case of torsade de pointes ventricular tachycardia was detected
in a previously healthy woman taking terfenadine with erythromycin.
Electrocardiography revealed QT interval prolongation and QRS widening. One
hour after emergency room admission, her arrhythmia degenerated to ventricular
fibrillation and she died of cardiac arrest. Episodes of torsade de pointes are most
likely the result of the quinidine-like action of terfenadine. Dosage restriction and
awareness of the clinical conditions and drug interactions capable of inhibiting the
metabolism of terfenadine are essential for prevention of this serious reaction.
http://mjiri.iums.ac.ir/article-1-1011-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
295
298
article
CONGENITAL BRONCHO-ESOPHAGEAL FISTULA: A CASE REPORT
SA MALEK HOSSEINI
1
N NEZAKATGOO
2
From the Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Congenital broncho-esophageal fistula (BEF) is a rare anomaly usually detected
in adulthood. In one of the latest reviews of this anomaly, no more than 150 cases
were found in the world literature. We report our experience with a 49 year old male
patient referring with a classic presentation of chronic cough and choking episodes
upon liquid intake. Broncho-esophageal fistula was confirmed by an esophagogram
and the congenital nature of the fistula was established by the pathologic report
notifying the presence of squamous cell lining of the fistula tract.
We conclude that the esophagus should be investigated more frequently when
patients have respiratory complaints at their initial presentation, since pulmonary
symptoms may indirectly reflect esophageal disease.
http://mjiri.iums.ac.ir/article-1-1010-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
291
293
article
COMPARISON BETWEEN THE EFFECTS OF 5 PERCENT HYPERTONIC SODIUM CHLORIDE SOLUTION AND 0.9 PERCENT SODIUM CHLORIDE SOLUTION ON LEFT VENTRICUL AR CONTRACTION
A HEIDARPOUR
1
K BAGHERI
2
H AZARSINA
3
A BORDBAR
4
N FATEH
5
From the Department of Anesthesiology, Baghiatallah (a.s.) University of Medical Sciences, Tehran
the Depariment of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
From the Department of Anesthesiology, Baghiatallah (a.s.) University of Medical Sciences, Tehran
the Depariment of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
the Depariment of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
Hypertonic saline solution can absorb part of the intracellular fluid volume into
the extracellular space. The effects of this solution on the cardiovascular system are
increased coronary flow and increased left ventricular contraction, without sympathetic
system activation. This study was designed to assess the effects of hypertonic saline
solution in open heart surgery and to compare it with normal saline solution.
In a case control double-blind study, 46 patients (two groups of23 patients each)
were selected and treated with 2 different methods after open heart surgery. The
first group (case) received 5% hypertonic saline solution and the second group
(control) received 0.9 percent saline. Physical exam findings, left ventricular
pressure and urinary output were measured to compare the two groups.
2, 3, 5, 10 and 30 minutes after the injection of the solution, the indicators of the
study were measured. Left ventricular pressure and pulse rate were decreased and
mean arterial pressure was increased in the case group. Urinary output in the case
group was more than the control.
It therefore seems that hypertonic saline solution can increase cardiac contractility
without increasing sympathetic activity, and thus has positive inotropic effects. This
solution seems more useful regarding it's therapeutic effects in open heart surgery.
http://mjiri.iums.ac.ir/article-1-1009-en.pdf
Hypertonic solution
Left ventricular pressure
Open heart surgery
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
285
290
article
RT-PCR MEDIATED CLONING OF HUMAN GROWTH HORMONE GENE AND I TS EXPRESSION IN E. coli
M AZARNOOSH
1
S ZEINALI
2
SM TABATABAEI
3
A ZIAEE
4
From the Department of Biotechnology, Pasteur Institute of Iran, Tehran, Islamic Republic of Iran.
Human growth hormone (hGH) genomic sequence containing 5 exons and 4
introns was cloned in pcDNA-3 and the constructed plasmid was subsequently used
for transfection ofNlli-3T3 cell line using lipofection technique. Expression of hGH
in stably transfected cells was assayed using ELISA. Total RNA was extracted from
transfected cells and hGH cDNA was amplified by RT-PCR using specific primers.
The product thus obtained was cloned in pGEM-T vector and the presence of the
growth hormone coding region was verified by restriction enzyme analysis and
Southern blotting. The hGH cDNA fragment was cloned in pQE-30 and the
expression of hGH gene in E. coli was assayed using ELISA and immunoblotting.
In this experiment 20.9 µg/mL purified rhGH was obtained.
http://mjiri.iums.ac.ir/article-1-1008-en.pdf
Human growth hormone
RT-PCR.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
279
283
article
HYPERVITAMINOSIS A-INDUCED CENTRAL NERVOUS SYSTEM DEFECTS
MEHDI JALALI
1
ALIREZA FAZEL
2
From the Department of Anatomy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
In this investigation the effects of excess vitamin A administration during the
early embryonic period were studied. Intramuscular injection of a single dose of
15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day
7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major
malformations in the central nervous system (CNS) including exencephaly,
hydrocephalus, microcephalia, spina bifid a and myelocystocele and also a few other
defects such as limb malformations. The incidence and severity of these malformations
was positively correlated with the dosage and time of exposure. Among experimental
groups, the most effective dose of vitamin A which produced a high incidence of
CNS defects was 25000 IU/kg injected on day 8 of gestation (35%) compared to the
control group (0%). Histological studies on 18 day old experimental fetuses revealed
spina bifid a with and/or without spinal cord defect. These studies showed excessive
embryonic cell death localized in the neural tube region following vitamin A
exposure. In conclusion, excess vitamin A exposure in the early days and critical
periods of development may interfere with certain developmental phenomena,
resulting in various detectable CNS defects among newborn infants.
http://mjiri.iums.ac.ir/article-1-1007-en.pdf
Vitamin A
neural tube defect
neurolation.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
273
277
article
PURIFICATION AND PARTIAL CHARACTERIZATION O F PEROXIDASES FROM CULTIVATED RAPHANUS SATIVUS L. VAR. CICIL
M TABATABAIE YAZDI
1
S KHALEGHPARAST
2
SM NAYEBPOUR
3
From the Department of Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences,
Two peroxidases (EC. 1.11.1.7), POD I and POD II were purified from the roots
of cultivatedRaphanus sativus L. Var. Cicil by one step ion-exchange chromatography
after fractionation by acetone. The molecular weight of these enzymes were 43000
and 41000 Daltons and RZ 1.2 and 2.0 for POD I and POD II, respectively. Both
enzymes consisted of a single polypeptide chain on SDS-PAGE. The maximum
activity of POD I was observed at pH 4.6 and 30°C and for POD II, at pH 6.5 and
60°C. The Km value of POD I for H202 was 7.26 mM and for POD II, 2 mM toward
o-dianisidin. Both isoenzymes were stable for 48 hours in temperatures up to 40°C
and stable in pH 4-8 for 3 hours.
http://mjiri.iums.ac.ir/article-1-1006-en.pdf
Peroxidase
Horseradish
Purification
Characterization.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
265
271
article
INCREASED HISTAMINE Hi RECEPTOR BLOCKADE BY CHLORPHENIRAMINE IN TRACHEAL CHAINS OF ASTHMATIC GUINEA PIGS
MH BOSKABADY
1
M HARATI
2
From the Department of Physiology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
Receptor affinity and drug delivery to the receptor sites could be determinant
factors for the increased bronchial responsiveness seen in asthma. Competitive
antagonism blockade which is measured as dose ratio-l (DR-I) depends only on
these two factors. Therefore, in this study we have examined histamine HI blockade
by chlorpheniramine on isolated tracheal chains of asthmatic compared to control
guinea pigs.
An experimental model of asthma was induced in guinea pigs by injection and
inhalation of ovalbumin (OA), and tracheal chains of asthmatic and control animals
(for each group n= 12) were prepared. The responses of tracheal chains to cumulative
concentrations of histamine (H) in the absence and presence of 5 nM chlorpheniramine
was measured, and the effective concentration of H causing 50% of maximum
response (ECso H) was obtained. The chlorpheniramine blockade (DR-I) was
calculated by (post chlorpheniramine EC50H/EC50 H)-1. The response of tracheal
chains to 0.1 % OA relative to the contraction obtained by 10 mM methacholine was
also measured.
The tracheal response of asthmatic guinea pigs to OA was significantly higher
than that of control animals (mean ± SEM, 57.03±4.99 VS. 3.92±1 .14, p<O.OO l ).
Histamine HI receptor blockade by chlorpheniramine (DR-I) was also significantly
higher in tracheas of asthmatic compared to control animals (1 7 .34±3.8 9vs. 4.1I±I.08,
p<0.01). There was a significant correlation between (DR-I) and tracheal responses
to OA (r= 0.51 ,p<0.05).
This enhanced histamine HI receptor blockade in tracheal chains of asthmatic
animals confirms our previous findings which was predicted to be due to increased
drug delivery to the receptor. Drug delivery could also be a determinant factor for
bronchial responsiveness to most stimulating agents in asthma.
http://mjiri.iums.ac.ir/article-1-1005-en.pdf
Histamine HI receptors
chlorpheniramine blockade
asthma
bronchial responsiveness
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
259
264
article
ENZYME-LINKED IMMUNOSORBENT ASSAY OF NEOPTERIN USING PENICILLINASE AS LABEL
M MALAKANEH
1
MJ RASAEE
2
K MADANI
3
AA POURFATHOLLAH
4
From the Department of Biochemistry, Birjand University of Medical Sciences, Birjand
the Departments of Biochemistry , Tarbiat Modarres University of Medical Sciences, Tehran
the Razi Research Institute, Hesarak, Islamic Republic of Iran.
the Departments of Immunology, Tarbiat Modarres University of Medical Sciences
An enzyme-linked immunosorbent assay for neopterin using penicillinase as
marker enzyme is reported here by polyclonal antibodies against neopterin conjugated
to bovine serum albumin which were raised in rabbits. Immunoglobulin fractions
were purified and coated on wells of microtiter plates. A chain heterology was
introduced in neopterin derivative and conjugated to penicillinase. The assay is
completed within 4 hr. The limit of detection was 10 pg of neopterin with a sensitivity
range between 15-10000 pg. A low level of cross-reactivity with other pteridines was
noted (biopterin <0.05%, pteroic acid <0.05%, and pterin <5%). The sensitivity and
selectivity observed in the assay may be attributable to the selection of penicillinase
as the enzyme marker and the element of conformation (heterology between the
antigen-linked and enzyme-conjugated hapten).
http://mjiri.iums.ac.ir/article-1-1004-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
249
257
article
CYTOKINE AND GROWTH FACTOR MODULATION OF CELL CYCLE EVENTS IN HUMAN MELANOMA CELL LINES
AR ANDALIB
1
J LAWRY
2
BJ BURNS
3
AK MURRAY
4
M HERLYN
5
RC REES
6
FromEsfahan Medical School, Esfahan,I.R. Iran
Sheffield University Medical School, UK
Sheffield University Medical School, UK
Sheffield University Medical School, UK
Wistar Institute, Philadelphia, USA.
Sheffield University Medical School, UK
Cytokines influence cell cycle events, which in some but not all instances can
be associated with melanoma progression. Analysis of the G0/G 1 and S phase
fractions of the cell cycle was used to assay the proliferative or inhibitory activity
of cytokines against ten human melanoma cell lines, including pairs of cell lines
derived from primary and metastatic tissue of individual patients. Cytokines and
growth factors were generally capable of inducing either a proliferative or an
inhibitory effect, depending upon the melanoma cell line tested.
Distinct differences in responsiveness between the primary and metastatic
partners of related pairs of melanoma cell lines was observed for IL-l β, IL-6,
TNFα, TGFβ2, IFNα, IFNyand IGF-2. This data is complementary to previous
works1.2 showing IL-6 and TGFβ2 to be inhibitory to.cell lines derived from early,
but not advanced-stage melanomas. These alterations in cell cycle events were
coincidental with a reduced expression of lCAM-1 and/or MHC antigen expression
in response to some of these cytokines.
http://mjiri.iums.ac.ir/article-1-1003-en.pdf
Primary and metastatic melanoma
cytokine
cell cycle
proliferative and inhibitory effect
flow cytometry.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
241
247
article
THE EFFECT OF BENZODIA ZEPINES ON THE STRESS-INDUCED RESPONSES OF THE NORA DRENERGIC A ND SEROTONERGIC PROJECTIONS TO THE RAT HIPPOCAMPUS
A VAHABZADEH
1
M FILLENZ
2
From the Department of Physiology, Iran University of Medical Sciences, Tehran, I.R. Iran
the University Laboratory of Physiology, University of Oxford, Oxford, U.K.
Microdialysis was used to measure the effect of benzodiazepines (BDZs) on
basal levels and on stress-induced increases of 5 -hydroxytryptamine (5 -HT), 5 -
hydroxyind oleacetic acid (5 -HIAA) , noradrenaline (NA), and
dihydroxyphenylacetic acid (DOP AC). The stressors used were a 5 min tail pinch
or a 10 min period of restraint. A subcutaneous injection of 5 mg/kg diazepam
decreased basal levels of 5 -HT, 5 -HIAA, and DOPAC, but not NA. There was no
effect on the stress-induced increase in 5 -HT, NA, and 5 -HIAA, while the increase
in DOPAC was completely abolished. Local infusion of 5 µM flurazepam
decteased the basal level of 5 - HT but not 5 -HIAA and abolished the stress-induced
increase of 5 -HIAA but not 5 -HT. These results suggest that the anxiolytic action
of BDZs is unlikely to be attributable to the suppression of stress-induced increases
in the release of NA or 5 -HT in the hippocampus.
http://mjiri.iums.ac.ir/article-1-1002-en.pdf
Diazepam
Noradrenaline
Serotonin
Stress
Hippocampus
Microdialysis.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
235
239
article
EVALU ATION OF INSULIN-SUL FONYLUREA COMBINATION V ERSIJS INSULIN AL ONE IN THE T REATMENT OF NON-INSULIN D EPENDENT DIABETES MELLITU S (NID DM)
K GHOLAMI
1
M PAJOOHI
2
A MALMIR
3
N JAZAYERI
4
From the Department of Clinical Pharmacy, College of Pharmacy, Tehran University of Medical Sciences,Tehran, and the Department of Endocrinology, College of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Lowering the glucose level in diabetic patients reduces the risk of many
consequences which are usually reported in these patients. Non-insulin dependent
(type II) diabetes which cannot be controlled with sulfonylureas alone can be
controlled with a combination of sulfonylurea and insulin. In an open randomized
trial 58 patients were divided into three groups. The fIrst group received only insulin
based on their blood glucose level. The second group received a set amount of insulin
plus the required amount of glibenclamide and the third group received a set amount
of insulin plus the required amount of chlorpropamide based on their glycemic
control. All three groups had a significant reduction of blood glucose, total cholesterol
and triglyceride levels. The best long term glycemic control was in the second group
with the lowest HbAlc(% ). In these patients bedtime insulin and daytime sulfonylurea
(B IDS) gives better glycemic control. This method of therapy is a valuable option for
patients with NIDDM whose hyperglycemia cannot be controlled by sulfonylureas
and do not have compliance with more than one injection a day.
http://mjiri.iums.ac.ir/article-1-1001-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
229
233
article
A CLINICAL TRIAL TO EVALUATE THE EFFICACY OF FLUVASTATIN AND LOVASTATIN IN COMPARISON WI TH PLACEBO IN HYPERCHOLESTEROLEMIC PATIENTS
S MORADMAND
1
MR NIAKAN
2
F FOULADKOU
3
A SHAFIEE
4
From the Department of Pharmacy and Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
In this study, the effect of lovastatin and fluvastatin was compared with placebo
in patients with high levels of total cholesterol and low density lipoprotein cholesterol
(LDL-C) on the plasma lipid profile. In a prospective single blind clinical trial with
convenient sampling, 120 hypercholesterolemic men and women with Tcholesterol
≥220 mg/dL, LDL-C ≥ 160 mg/dL, and triglyceride ≤ 350 mg/dL were
selected and divided into 3 groups randomly. The fust group took lovastatin, 20 mg
daily, the second group fluvastatin, 40 mg daily, and the third group took a placebo,
all for 12 weeks. Compared with placebo, drug therapy of hypercholesterolemia with
either lovastatin or fluvastatin decreased total cholesterol and LDL-C levels
significantly but had no effect on high density lipoprotein and triglyceride values.
Decrease of total cholesterol and LD L-C levels by both drugs are similar after the first
6 weeks but lovastatin was more effective after the second 6 week period.
http://mjiri.iums.ac.ir/article-1-1000-en.pdf
Fluvastatin
Lovastatin
Hypercholesterolemia
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
225
228
article
EVALUATION OF A NEW TECHNIQUE OF ANAS TOMOSIS IN THE MODIFIED DUHAMELMARTIN OPERATION FOR HIRSCHSPRUNG\'S DISEASE
R MOOSAVI
1
A KALANTAR MOTAMEDI
2
From the Department of General and Vascular Surgery and Traumatology, ShoJuula Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, I.R.lran.
Hirschsprung's disease, also known as congenital aganglionic megacolon, is a
congenital disorder which develops due to an absence of neural ganglia in a segment
of large bowel. Most commonly, the rectum or rectosigmoid, and rarely other areas
or the entire colon are involved.
In this disease, all three neural plexi, i.e., the myenteric (Auerbach's) plexus, the
superficial submucosal (Meissner's) plexus and the deep submucosal (Henle's)
plexus are affected, therefore peristaltic waves do not occur in involved portions of
the bowel. This causes a relative stenosis in involved areas and dilatation of the prestenotic
bowel with resulting chronic constipation, recurrent diarrhea, and multiple
episodes of enterocolitis. This series of events eventually leads to severe weakness,
failure to thrive, abdominal distention and death.
The only correct and effective form of therapy for this disorder is surgery. Surgical
treatment can be performed by various methods, such as that proposed by Swenson
et al,lI Soave,9 Duhame1,2 and Rehbein and Martin.4 Studies have shown that
Martin's method has several advantages compared to other forms of surgical therapy.
These are:
1/ Sensation is spared throughout the entire rectum.
2/ No dissection is performed anteriorly.
3/ Intraoperative bleeding is less.
4/ No catheter is required postoperatively.
The modified Duhamel-Martin procedure which is the subject of this study has
some practical benefits and less complications compared to the traditional Martin
operation and is therefore our recommended technique for the treatment of
Hirschsprung's disease.
http://mjiri.iums.ac.ir/article-1-999-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
221
224
article
LAPAROSCOP ICALLY - ASSISTED VAGINAL HYSTERECTOMY: REP ORT OF 15 CASES
S ALBORZI
1
ME PARSANEJAD
2
MS ARDEKANI
3
From the Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Laparoscopically-assisted vaginal hysterectomy (LAVH) was performed in
fifteen patients without invasive cancer. Indications for hysterectomy were myomas,
abnormal uterine bleeding unresponsive to hormonal treatment and dilatation and
curettage, chronic pelvic pain with first degree uterine prolapse and possible
adenomyosis, and dysplasia and ovarian cyst in postmenopausal years. No
significant complication was observed during the operation or postoperatively.
This report proves that minimally invasive procedures (LA VH) can replace
conventional hysterectomies in experienced hands.
http://mjiri.iums.ac.ir/article-1-998-en.pdf
Laparoscopically assisted vaginal hysterectomy (LA VH)
operative laparoscopy.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
217
220
article
ALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA
P NASSERI
1
A GHAVAMZADEH
2
M JAHANI
3
A KHODABANDEH
4
I BAYBORDI
5
M MOHYEDDIN
6
G GHAHREMANI
7
From the BMT Unit, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Eighteen patients, twelve men and six women, with aplastic anemia underwent
allogenic bone marrow transplantation (BMT) from HLA-matched siblings during
the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with
or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin
(ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis,
respectively. Eleven patients are alive (61 %) and seven (39%) died. Twelve patients
developed acute GVHD. We found an inverse relationship between the incidence of
acute GVHD and the number of units of transfused packed cells and platelets before
BMT (p 1000, PLT> 100000) after BMT was inversely related to the total number of
cells transplanted (p<0.05).
http://mjiri.iums.ac.ir/article-1-997-en.pdf
Aplastic anemia
Bone marrow transplantation
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
211
215
article
PATEN T DU CTUS ART ERIOSUS: SURGICAL COMPLICATIONS, MORBIDITY AND MORTALITY IN 510 PATIENTS
M. YOUSEF AARABI MOGHADDAM
1
M. HASAN KALANTAR MOTAMEDI
2
From the Department of Pediatric Cardiology, Shahid Rajai Heart Hospital, Iran University of Medical Sciences, Tehran
the Departmeni of Cardiovascular Surgery, Jamaran Heart Hospital, Baqiat. University of Medical Sciences, Tehran, Islamic Republic of Iran.
In this retrospective study, 510 infants and children with patent ductus arteriosus
(PDA) who underwent surgery at the Shahid Rajai Heart Hospital in Tehran were
evaluated to determine the rate of surgical complications, morbidity and mortality.
30 patients (6%) developed minor to major complications postoperatively. Four
patients who had undergone PDA ligation without division required reoperation due
to recanalization of the ductus. In one patient, the left pulmonary artery was
mistakenly ligated instead of the ductus, requiring reoperation and correction. There
were two mortalities (0.4%), both in patients with pulmonary hypertension. Four
patients (0.8%) developed bacterial endocarditis with positive blood cultures.
The frequency of complications in our group of patients is in accordance with that
of the literature. We conclude that patent ductus arteriosus, when diagnosed and
treated early, can yield excellent results with very little complications. Delay in
diagnosis and treatment, especially when associated lesions coexist, significantly
increases the rate of complications, morbidity and mortality.
http://mjiri.iums.ac.ir/article-1-996-en.pdf
Ductus arteriosus
patent; surgical complications; morbidity; mortality.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-11
12
3
205
209
article
COMPARISON OF THE BRONCHODIL ATORY EFFECTS OF INHALED SALBUTAMOLAND COMBIVEN T IN ASTHMATIC PATIENTS
G DERAKHSHAN DEILAMI
1
A GHOLAMHOSSEINI
2
MH POURGHOLAMI
3
From the Division of Pulmonology, Imam Khomeini Hospital, Tehran University of Medical Sciences,
the Department of Pharmacology, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
the Department of Pharmacology, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
A randomized, double-blind, crossover trial was designed to compare the acute
effects of Combivent and salbutamol on spirometric parameters in patients with
moderate to severe asthma. Nineteen patients with a mean baseline forced expiratory
volume in 1 sec. (FEV]) less than 65% predicted, were randomized on two separate
days to receive two puffs of salbutamol (200 µg) or two puffs of Combivent (200 µg
salbutamol plus 40 µg of ipratropium bromide) by metered dose inhalers. On study
days using spirometry, FEV!, forced vital capacity (FVC), maximal mid-expiratory
flow rate (MMEF) and peak: expiratory flow rates (PEFR) were measured at baseline
and at 15, 60 and 180 minutes after drug administration. Blood pressure and pulse rate
were also determined before and 3 hours post drug inhalation.
The results of this study show that Combivent produces significantly greater
improvement compared to salbutamol in all four spirometric parameters at 15, 60,
and 180 minutes after drug treatment. The greatest differences between the
bronchodilating effects of the two re!imens were observed at 180 minutes after drug
inhalation. There were no clinically significant changes in heart rate or blood
pressure.
It may therefore be concluded that in patients with moderate to severe asthma,
Combivent provides better bronchodilation than salbutamo1 alone at clinically
relevant doses without increasing side-effects
http://mjiri.iums.ac.ir/article-1-995-en.pdf
Asthma
bronchodilator
Combivent
ipratropium
salbutamol.