eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
203
204
article
PREVALENCE OF HEUCOBACTER PYLORI IN PEDIATRIC PEPTIC DISEASE
MEHRI NAJAFI SANI
1
From the Department of Pediatric Gastroenterology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, I.R. Iran.
http://mjiri.iums.ac.ir/article-1-1036-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
201
203
article
SERA FROM SYPIllLI ATIC PATIENTS CROSS REACT WITH SPECIFIC GLYCOPEPTIDOLIPID AND WHOLE LIPID EXTRACT OF MYCOBACTERIUM AVIUM COMPLEX IN AN ANTICARDI OLIPIN ANTIBODY TEST
MOHAMMED R POURSHAFIE
1
HOSSAIN MOTIElAN NAJAR
2
From the Department of Microbiology, Pasteur Institute of Iran, Tehran
the Cell Bank Department, Pasteur Institute of Iran, Tehran, I.R. Iran.
http://mjiri.iums.ac.ir/article-1-1035-en.pdf
: Cardiolipin
Glycopeptidolipid
Syphilis
Mycobacterium
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
199
204
article
EVA LUATION OF THE CYTOGENETIC EFFECTS OF FUNDERMOL BY MICRONUCLEUS ASSAY
MR NOORI-DALOII
1
HA SASAN
2
S MOHAGHEGH HAZRATI
3
From the Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences
the Department of Genetics, Faculty of Basic Sciences, Tarbiat Modarres University
the Immunology Department, Faculty of Hygiene, Tehran University of Medical Sciences, Tehran, I.R.lran.
http://mjiri.iums.ac.ir/article-1-1034-en.pdf
Micronucleus assay
Fundennol
Burn.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
195
197
article
PENE1RATING HEAD INJURY WITH A KNIFE-A CASE REPORT
S AZHARI
1
A KARIMI
2
From the Department of Neurosurgery, Imam Hosein Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
A case of a transcranial stab wound is presented in which the patient was
stabbed in the left temporal bone with a knife which, after traversing the
tentorium, passed through the occipital squama and its tip reached the upper
cervical area. The subject underwent surgery and was discharged without
neurological sequelae. The fundamental principles of management in this
specific type of head injury are discussed.
http://mjiri.iums.ac.ir/article-1-1033-en.pdf
Stab wound
penetrating head injury.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
193
194
article
A CASE REPORT OF LINGUATULA SERRATA IN HUMAN PHARYNX FROM SHIRAZ, SOUTHERN IRAN
SM SADJJADI
1
SM ARDEHALI
2
A SHOJAEI
3
From the Parasitology Department, Shahid Beheshti Hospital, Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
From the Parasitology Department, Shahid Beheshti Hospital, Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
From the Mycology Department, Shahid Beheshti Hospital, Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
A case of linguatulosis due to Linguatula serrata, a zoonotic pentastomid parasite
in the pharynx of a 35 year old woman from Shiraz is described. After removal of the
parasites the patient was discharged without any further complaints.
http://mjiri.iums.ac.ir/article-1-1032-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
191
192
article
TORSION AND GANGRENE OF THE GALLBLADDER IN A CHILD
AKBAR BEHDAD
1
From the Department of Surgery, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Torsion of the gallbladder with gangrene is a rare condition which is generally
due to an abnormal anatomical variation of the organ i.e., loss of fixation of the
organ to the inferior margin of the liver and the presence of a long meso cyst.
The case considered is a seven year old boy who presented with acute
abdominal pain. He underwent laparotomy 36 hours after having sustained blunt
abdominal trauma. Operation was limited to cholecystectomy and removal of a
gangrenous gallbladder which had undergone torsion. The postoperative course
was uneventful.
http://mjiri.iums.ac.ir/article-1-1031-en.pdf
gallbladder
diseases
torsion
trauma
cholecystectomy.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
185
189
article
ANEURYSMAL BONE CYST ASSOCIATED WITH A PATHOLOGIC FRACTURE OF THE MANDIBLE: A CASE REPORT AND LITERATURE REVIEW
MOHAMMAD HOSEIN KALANTAR MOTAMEDI
1
From the Department of Oral and Maxillofacial Surgery, Baqiyatallah Medical Center, Baqiyatallah University of Medical Sciences, Tehran, I R.lran.
Pathologic fractures of the jaw are usually associated with aggressive,
destructive lesions or malignant lesions of the jaws. Aneurysmal bone cysts
(ABC) of the jaws are benign lesions which normally do not cause destruction
to such an extent. This article reports a relatively aggressive ABC of the
mandible in a 19 year-old male which destroyed the buccal and lingual cortices
as well as the inferior border of the mandible resulting in a pathologic fracture.
Although pathologic fractures associated with ABC's of the skeleton are
common, however, to our knowledge this is the first report of an AB C associated
with a pathologic fracture of the jaw.
http://mjiri.iums.ac.ir/article-1-1030-en.pdf
Cyst
bone
aneurysmal; mandible.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
181
183
article
INTERFERON INDUCED CARDIOMYOPATHY: CASE REPORTS
MA SADR-AMELI
1
A FOROOD
2
F SAFI
3
From the Dept. of Cardiology. Shahid Rajaee Heart Hospital, Tehran, I. R. Iran.
There are few reports concerning interferon induced myocardial dysfunction.
A known case of multiple myeloma who was receiving interferon alpha (IFA)
for 14 months was brought to the emergency room in frank: pulmonary edema.
After treatment of heart failure and discontinuation of interferon alpha, he
remained asymptomatic thereafter. Another case of chronic active hepatitis on
IFA complained of dyspnea that became asymptomatic after cessation of IFA.
http://mjiri.iums.ac.ir/article-1-1029-en.pdf
cardiomyopathy
interferon.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
177
179
article
INGUINAL HYDATID CYST: REPORT OF A RARE CASE
MR KOUHSARI
1
HA MANZAR
2
From the Department of Surgery, Razi Hospital, Guilan University of Medical Sciences, Rasht, Islamic
Hydatid cyst, the larval stage of Echinococcus spp., is a common parasitic
disease in Iran. The liver and the lungs are the most commonly involved organs.
Hydatid cysts have also been reported in bones and soft tissues such as muscle, brain
tissue, spleen, thyroid and even in the heart. Hydatid cyst of the inguinal area,
resembling a hernia is a rarity presenting at an unusual site. A hypersensitivity
reaction to components of hydatid fluid may cause a serious or even fatal reaction if
cyst rupture occurs. Sudden occurrence, lack of a good clinical history, and the
severity and complexity of symptoms and signs makes the diagnosis difficult. This
paper reports sudden rupture of an inguinal hydatid cyst in a patient while taking a
bath, resulting in severe anaphylactic shock and acute pulmonary edema, wrongly
described by the patient's family as "steam suffocation". This case report emphasizes
the value of a good and detailed clinical history, the need to include hydatid cyst in
the list of inguinal swellings in endemic areas, and to consider hydatid cyst rupture
in the differential diagnosis of sudden shock, sudden LVF, pulmonary edema and
severe allergic reactions.
http://mjiri.iums.ac.ir/article-1-1028-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
171
176
article
PHEOCHROMOCYTOMA OF URINARY BLADDER: REPORT OF A CASE AND BRIEF REVIEW OF THE LITERATURE
SM HOMAYOUNI
1
SZ LATIFZADEH
2
MH KALANTAR MOTAMEDI
3
From the Department of Internal Medicine, Shohada Medical Center, Shahid Beheshti University of Medical Sciences
From the Department of Internal Medicine, Shohada Medical Center, Shahid Beheshti University of Medical Sciences
the Dept. of Cardiovascular Surgery, Baqiat. University of Medical Sciences, Tehran, Islamic Republic of Iran.
A case of pheochromocytoma of the bladder is presented with a r eview of the
literature. We discuss general management principles of bladder pheochromocytoma.
Successful diagnosis and treatment of this lesion requires a high index of suspicion
based upon the patient's symptom complex, allowing preoperative preparation prior
to surgical treatment.
http://mjiri.iums.ac.ir/article-1-1027-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
167
169
article
INFERIOR VENA CAVA THROMBOSIS IN A PATIENT WITH ESSENTIAL THROMBOCYTHEMIA
J EIVAZI ZIAEI
1
From the Dept. of Hematology, Gazi Hospital, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.
Essential thrombocythemia is a chronic myeloproliferative disorder
characterized by a sustained proliferation of megakaryocytes, which leads to
increased numbers of circulating platelets. Hemorrhagic and/or thrombotic episodes
are frequent, and thrombosis of both veins and arteries may develop. Vessels in
unusual sites may be involved, e.g., the hepatic veins, mesenteric veins, and the
digital vessels. Thrombosis of the inferior vena cava has not been reported
previously. In this paper we report inferior vena cava thrombosis in a patient with
essential thrombocythemia.
http://mjiri.iums.ac.ir/article-1-1026-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
163
165
article
ACUTE LOWER LIMB ISCHEMIA DUE TO FEMOROPOPLITEAL EMBOLISM OF HYDATID CYST
SEYYED MASSOUD KHATAMI
1
From the Department of Surgery. BaqiaJallah Hospital. Baqiatallah University of Medical Sciences. Tehran. I.R. Iran
In addition to the liver, human hydatidosis has been reported in the lung, brain,
abdominal viscera, muscles, and heart chambers. Infarction of the brain has also
been documented. Arterial embolism of the lower extremities by hydatid cyst,
however, is extremely rare. In the presented case, acute ischemia of the patient's
left leg led to gangrene and amputation. Complete workup for localization of the
primary focus of hydatid cyst was inconclusive however, the most probable
explanation is spontaneous rupture of a left ventricular wall hydatid cyst which
subsequently embolized to the aorta and lodged in the left femoral artery
http://mjiri.iums.ac.ir/article-1-1025-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
159
162
article
SUPRAVENTRICULAR TACHYCARDIA FOLLOWING SECOND INDUCTION OF ANESTHESIA IN A PATIENT DIAGNOSED AS MALIGNANT HYPERTHERMIA AFTER FIRST ANESTHETIC EXPOSURE: TERMINOLOGY REQUIRES A SECOND LOOK
ZAHID HUSSAIN KHAN
1
From the Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
A 17 year old male who underwent surgery for thoracic outlet syndrome
developed a postoperative complication which was labelled and diagnosed as
malignant hyperthermia in Kerman Medical Center. The temperature recorded
was 43°C, PaC02 70 mmHg and serum potassium level was 7 mEq/L. The patient
was hospitalized in the intensive care unit for 10 days. On discharge, the patient
had aphasia and incoordination in gait. Gradually the symptoms improved.
However dysarthria, a reduction in muscle force and a staggering gait persisted.
The same patient underwent a second operation for a spinal cord tumor located in
the cervical region at this center. Following induction of anesthesia, the pulse rate
showed a stepladder rise reaching a peak: of 198 per minute. Except for a rapid heart
rate, the patient had an uneventful operative course and a speedy recovery
following the operation without any sequelae. The case is being reviewed and the
plethora of diverse symptomatology and clinical picture explored to highlight the
controversy of malignant hyperthermia in this particular case.
http://mjiri.iums.ac.ir/article-1-1024-en.pdf
Malignant hyperthermia
Anesthesia
Supraventricular tachycardia.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
153
157
article
PRE- AND POSTJUNCTIONAL α-ADRENOCEPTORS IN RABBIT ARTICULAR BLOOD VESSELS
A A. KHOSHBATEN
1
WR FERRELL
2
From the Department of Physiology and Biophysics. Baghiyatollah University of Medical Sciences, Tehran, I.R.lran
the Institute of Physiology. University of Glasgow, G12 8QQ. Scotland.
Previous in vitro work on rabbit knee joint vessels showed that vasoconstrictor
effects of nerve stimulation and administration of α-adrenoceptor agonists were
mediated predominantly by α1-adrenoceptors5,9 The present experiments were
performed to assess the nature of α-adrenoceptor subtypes within these blood
vessels in vivo. Dose/response relationships for adrenaline and noradrenaline
produced a similar pattern of increasing constriction of articular vessels with
increasing doses of drug. The u} agonist phenylephrine also produced dosedependent
constrictor responses which were diminished by prazosin. Using the α2
agonists clonidine and UK -14304,responses in vivo differed from those previously
observed in vitro. There was virtually no response to clonidine in vitro while
responses were obvious in vivo. Although UK-14304 was found to have small
effects in vitro, but only at high doses, this agent exerted more potent effects in
vivo, significantly greater than those obtained with phenylephrine. Responses to
the α2 agonists were not altered significantly by prazosin but were reduced by
rauwolscine. Following injection of UK -14304, the constrictor response to nerve
stimulation was reduced.
The results suggest that both α1 and α2 adrenoceptors are present
postjunctionally within articular blood vessels, and also that prejunctional α2
receptors are present which presumably regulate neurotransmitter release from
sympathetic nerve endings in the joint capsule.
http://mjiri.iums.ac.ir/article-1-1023-en.pdf
Blood flow
Joint
Adrenoceptor
Prejunctional
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
147
152
article
ATTENUATION OF PARAQUAT TOXICITY IN MICE
M REZAYAT
1
M OMIDI
2
M RAMAZANI
3
M KARAMI
4
H SABERI
5
A BAKHTIARIAN
6
From the Dept. of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Paraquat (PQ) is a widely used herbicide. However, a large number of cases
of accidental or suicidal poisoning from PQ has been reported. Membrane
damage induced by lipid peroxidation, inactivation of protein or damage to
DNA by radical formation have been suggested as toxicity mechanisms of PQ.
In the present work, the effects of atropine, propranolol, procainamide and
dipyridamole on PQ-induced intoxication have been studied.
Oroups of male albino mice were used under standard conditions. All the
drugs were injected intraperitoneally in different doses. The results indicated
that administration of PQ (40 mg/kg, i.p.) increased the death rate of animals
(77%) during 3 days, whereas a dose of 20 mg/kg of PQ only decreased the lung
tissue total protein and glutathione (OS H) content. This poison also produced
serious histopathologic changes in lung tissue. Administration of propranolol
( 10 and 20 mg/kg), procainamide (20 and 40 mg/kg), dipyridamole (30 and 60
Mg/kg) and atropine (5 and 10 mg/kg) decreased the PQ (40 mg/kg)-induced
mortality rate in the pre- or post-treatment regimens. These drugs were also
effective in reversing the PQ-induced alteration in the lung tissue protein and
OSH content, however the pathological findings attenuated in the treated
animals. Although the exact mechanism of these drugs against paraquat-toxicity
in mice is still unknown, it appears that some of the drugs used may be effective
in reversing PQ-induced poisoning in mice and possibly their effects are related
to the inhibition of membrane lipid peroxidation via different mechanisms.
http://mjiri.iums.ac.ir/article-1-1022-en.pdf
Paraquat
atropine
propranolol
procainamide
dipyridamole
mice
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
141
146
article
A LTERATION OF PENTYL ENETETRAZOLINDUCED KINDLING PARAMETERS BY PRETREATMENT OF RATS WITH PROPYLTHIOURACIL AND LEAD ACETATE
ABBAS KEBRIAEE-ZADEH
1
MOHAMMAD SHARIFZADEH
2
MOHAMMAD ABDOLLAHI
3
KAMBIZ SOLTANINEJAD
4
From the Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, I.R.lran.
Lead is known to be a potent neurotoxin that can cause seizure activity in
humans and animals. Also, epileptic type convulsion is a known complication
of hypothyroidism. This study was performed to determine the effect of
propylthiouracil (PTU)-induced hypothyroidism and chronic lead exposure on
pentylenetetrazol (PTZ)-induced kindling parameters. The test was carried out
by using male albino rats weighing 180-230 g which were divided into four
groups as follows:
Group 1: rats which received distilled water for 25 days (control group)
Group 2: rats pretreated with an orally administered lead acetate solution
(0.05%) for 25 days
Group 3: rats rendered hypothyroid with PTU solution (O.I%WIV) for 25
days and
Group 4: rats co-treated with lead acetate solution (0.05% W IV) and PTU
solution (0.1 % W IV) for 25 days.
On the 26th day of the experiment PTZ (ip, 30 mg/kg) was injected once a day
in order to induce seizure behaviors.
Kindling parameters such as seizure latency, index, stage and frequency were
evaluated. In animals, both lead acetate (0.05% WIV) and PTU (0.1 %WIV)
pretreatment caused significant alterations in kindling parameters separately.
But in animals pretreated with a combination of lead acetate and PTU, potentiation
of kindling parameters was not observed compared to groups one and two. In
conclusion, lead acetate and PTU may affect kindling parameters by different
mechanisms.
http://mjiri.iums.ac.ir/article-1-1021-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
135
140
article
EFFECT OF IRON OVERLOAD ON 7, 12-DIMETHYLBENZ (A) ANTHRACENE-INDUCED SKIN TUMORIGENESIS
HASSAN REZAZADEH
1
AMIR ALLAMEH
2
MOHAMMAD ATHAR
3
From the Department of Medical Elementology and Toxicology, Hamdard University, New Delhi-
the Department of Biochemistry, School of Medical Sciences, Tarbiat Modarres University, Tehran, Islamic Republic of Iran.
From the Department of Medical Elementology and Toxicology, Hamdard University, New Delhi-
Iron overload is known to occur in the West European and American
population due to the consumption of iron-rich diets. On the other hand, genetic
disorders leading to iron overload are also known. Iron overload leads to increased
peroxidation and disruptive disintegration of lipid-rich membranes, and predisposes
humans for an enhanced risk of cancer induction. In experimental animals iron
overload enhances intestinal, colonic, hepatic, pulmonary and mammary
carcinogenesis. In this study, we have shown that iron overload is a mild tumor
promotor in mouse skin. Female albino Swiss mice were iron overloaded and their
backs were shaved. Tumors were initiated using a complete tumorigenesis
protocol by applying 200lig 7, 12-dimethylbenz (a) anthracene (DMBA)/mouse in
multiple doses of 40llg DMBA/day for 5 consecutive days. The appearance of the
first tumor (latency period), percent of tumor incidence and number of tumors/
mouse were recorded. When compared to the positive control group, the iron
overloaded mice showed an increased incidence of tumors. In iron overloaded
animals, the tumors appeared about four weeks earlier. The number of tumors per
mouse were significantly higher in the iron overloaded group. Biochemical studies
performed in the present study include the determination of the activity of lipid
peroxidation, catalase and xanthine oxidase measurement in mice skin tissue. We
observed an iron-mediated induction in lipid peroxidation (LPO) and xanthine
oxidase (XOD) and diminished catalase (CAT) activity in skin tissues of mice
overloaded with iron as compared to the normal unloaded control group. Based on
these studies we propose that iron increases tumor promotion potentials significantly.
An induction in LPO in the iron overloaded group suggests that oxidative stress
may be responsible for such an observed augmentation of cutaneous carcinogenesis
in mice. Our data indicate that iron overload exerts tumor promoting potential in
mouse skin, and that oxidative stress generated by iron overload is responsible for
the augmentation of cutaneous tumorigenesis
http://mjiri.iums.ac.ir/article-1-1019-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
129
133
article
USE OF VECTORETTE AND SUBVECTORETTE PCR FOR THE ISOLATION OF TERMINAL SEQUENCES FROM Y EAST ARTIFICIAL CHROMOSOME (YAC) CLONES
ABBAS SAMADI
1
ALDAMARIA PULITI
2
MICHEL GOOSSENS
3
From the Dept. of Biochemistry, Kashan Medical University, Kashan, Islamic Republic of Iran
the Dept. of Medical Genetics, University of Paris, INSERM U91, Creteil 940IO, France
the Dept. of Medical Genetics, University of Paris, INSERM U91, Creteil 940IO, France
Development of yeast artificial chromosome (Y AC) vectors, molecular
cloning of large segments of chromosomal DNA, and their propagation in yeast
cells has become feasible. Overlapping Y AC provides a route to the development
of physical maps of entire mammalian chromosomes. A rapid method was
developed to isolate and sequence termini of Y AC inserts quickly. The Y AC clone
is digested with a range of restriction enzymes, and ligated with a linker at its ends.
The digested fragments were amplified using modified vector specific primers and
a universal linker primer. PCR products were sequenced and the information used
to drive new sets of primers for screening of Y AC libraries to obtain overlapping
clones and construct existing Y AC contig.
http://mjiri.iums.ac.ir/article-1-1018-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
123
128
article
PCR-MEDIATED CLONING A ND EXPRESSION OF THE GENE FOR THE B-SUBUNIT OF VIBRIO CHOLERAE TOXIN ISOLATED RECENTLY IN IRAN
MH SHAH-HOSSEINY
1
MR AKBARI
2
B TABARRAI
3
V RECHINSKY
4
From the Biology Unit, Faculty of Science, Imam Hossein University, Tehran
the Biochemistry Unit, Pasteur Institute of Iran
the Biochemistry Unit, Pasteur Institute of Iran
the Office for Scientific and Industrial Studies, Presidency, Tehran, I.R. Iran.
Knowing the nucleotide sequence of the cholera toxin operon, we designed
oligonucleotide primers for its-PCR amplification from local clinical isolates of
V. cholerae. The resulting amplification product was cloned in a common
pUC18 vector. Subsequently, a part of this operon encoding the cholera toxin Bsubunit
(CTB) was reamplified and cloned between the BamH1 and EcoR1 sites
of the same vector to create a recombinant plasmid pR18CTB. Temperaturecontrolled
expression of the target protein was achieved by supplementing
pR18CTB with a DNA fragment which contained a strong promoter PR and the
gene for a heat-sensitive repressor cI857 of bacteriophage lambda from a n
expression vector pCQV2. When induced, the constructed plasmid pSCTB18
provided for the production of recombinant CTB secreted into the periplasmic
space in a yield of about 3mg per liter of bacterial culture, as revealed by OM 1-
ELISA.
http://mjiri.iums.ac.ir/article-1-1017-en.pdf
V. cholerae
toxin
cloning
PCR
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
119
121
article
TREATMENT OF HELICOBACTER PYLORI (H. PYLORI) INFECTION IN CHILDREN: A PROSPECTIVE STUDY COMPA R ING TWO DIFFERENT THERAPEUTIC REGIMENS
M HAGHIGHAT
1
From the Division of Pediatric Gastroenterology and Nutrition, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
During a period of 10 months from May to February 1995, 120 children (72
girls, 48 boys) with an age range of 4-16 years (mean age 10.87, S.D.±2.7) with
chronic abdominal pain who had an abnormal endoscopy (gastroduodenal mucosal
defect) and positive urease test were treated for H. pylori. Patients were treated
randomly with either metronidazole and amoxicillin (double therapy, group A) or
metronidazole, amoxicillin and bismuth subsalicylate (triple therapy, group B),
each for two weeks. 6-8 weeks after completion of treatment, patients were reevaluated
by endoscopy and urease test. Endoscopy was normal in 75 cases (63 % ).
Of the 45 cases with abnormal endoscopy, 37 patients (82%) were in group A and
8 patients (18%) in group B (p<0.00 l ). The urease test was positive in 44 cases
(70%) of group A and 12 cases (20%) of group B (p<0.001). It is concluded that
double therapy is relatively ineffective in eradication of H. pylori and triple
therapy is less effective in this area compared with reports from industrialized
countries. This difference is most probably due to greater drug resistance in this
part of the world.
http://mjiri.iums.ac.ir/article-1-1016-en.pdf
Chronic abdominal pain
children
endoscopy
urease test
H. pylori
antibiotic therapy.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
113
118
article
PREVALENCE OF HYDATIDOSIS IN NOMADIC TRIBES OF SOUTHERN IRAN
M SABERI-FIROUZI
1
F KAFFASHIAN
2
E HAYATI
3
AA GHADERI
4
H KESHAVARZ
5
S ARSHADI
6
C ARSHADI
7
MSE SOTUDEHMARAM
8
MS MASSARRAT
9
MA GHALAMBOR
10
From the Schools of Medicine Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
Paramedical Sciences Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
Paramedical Sciences Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
Paramedical Sciences Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
Public Health, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
From the Schools of Medicine Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
From the Schools of Medicine Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
From the Schools of Medicine Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
Philips University, Marburg, Germany.
Paramedical Sciences Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
In order to assess the prevalence of Echinococcus granulosus (EO) infection
(hydatidosis) in nomadic tribes of southern Iran, 1000 individuals from a total
population of 1 12,519 were selected by randomized single blind cluster sampling
method and studied from 1994- 1995. The study included: ( l ) a physical
examination by a gastroenterologist, (2) abdominal ultrasonography (US), and
(3) detection of anti-EO-antibodies (EOA) by an enzyme-linked immunosorbent
assay (ELISA) and counterimmunoelectrophoresis (CIE). The statistically
significant prevalences were: US: 1.8%, eIE: 6.8%, and ELISA, 13.7%. The
rate of infection varied with age, sex, education, occupation, life style,
geographical location of tribal subgroups and the frequency of contact with dogs
and cattle. The power of agreement between a combination of each two methods
were significant as determined by kappa statistics method. The results obtained
indicated that a combination of ELISA and CIE was the most reliable method
with a high sensitivity and specificity.
http://mjiri.iums.ac.ir/article-1-1015-en.pdf
Echinococcus granulosus
echinococcosis
hydatidosis
nomadic and migrant tribes.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
109
112
article
CRUSH PREPARATION CYTOLOGIC FINDINGS OF CNS TUMORS: A STUDY OF 199 CASES
PERIKALA V. KUMAR
1
A MONABBATI
2
From the Department of Pathology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Crush preparation cytology technique was used during the operative procedure
for the diagnosis of 199 CNS tumors. This technique is simple, easy to perform, rapid,
and inexpensive. The cytomorphologic findings were excellent and helped achieve
a rapid and correct diagnosis. This technique was used on the tiny, small specimens
which were not suitable for frozen sectioning. The results were compared with
biopsy reports. The overall diagnostic accuracy by this technique was about 97.7 %.
http://mjiri.iums.ac.ir/article-1-1014-en.pdf
CNS
Neoplasms
Cytology study.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
105
108
article
COMPARISON OF UROLOGICAL COMP LICATIONS OF BARRY\'S AND MODIFIED LICHT\'S TECHNIQUES OF EXTRAVESICAL URE TERONEOCY STOSTOMY IN RENAL TRANSP LANT PATIENTS IN URUMIEH
A TAGHlZADEH AFSHARI
1
MR MOHAMMADIFALLAH
2
From the Department of Kidney Transplantation, Taleghani Hospital, Urumieh University of Medical Sciences, Urumieh, Islamic Republic of Iran
Between April 5, 1988 and Sept. 3, 1992, 204 cases of kidney transplantation
were performed using modified Licht's implantation technique and from Sept. 4,
1992 to Sept. 3, 1993, 57 cases were done with Barry's method. Age ranged from
11 to 60 years and in both groups had nearly similar distribution. Kidneys were
provided from live donors. Immunosuppressive therapy was similar in all patients
and included cyclosporin A, azathioprine and corticosteroids.I-3
After transplantation, all patients were followed and meticulous attention was
paid to determining the occurrence of possible urologic complications. Sonography,
LV.V. and/or radioisotope scanning was performed as indicated. In this study, 15
patients (7 % ) in the Licht group and one patient (2%) in the Barry group developed
urological complications.
http://mjiri.iums.ac.ir/article-1-1013-en.pdf
Kidney transplantation
complications
ureteral reimplantation.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-08
12
2
101
104
article
LAPAROSCOPIC DIAGNOSIS OF CRYPTORCHIDISM AND LAPAROSCOPIC ORCHIOPEXY: THE FIRST REPORT FROM THE MIDDLE EAST
N SIMFOROOSH
1
From the Department of Urology, Shahid Labbafi-Nejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Laparoscopic orchiopexy (LO) was used in place of open surgery in 10
patients for diagnosing cryptorchidism in our department. In this method a large
abdominal incision was not given in search of intra-abdominal testes. Anorchia
was diagnosed in four patients, which was shown to be bilateral in one. In one
subject with ambiguous genitalia, revealing the presence of intra-abdominal
gonads established the infant's gender as male. In four patients, five laparoscopic
orchiopexies were performed without celiotomy for the first time in Iran and the
middle east which was bilateral in one patient.
Except for two patients, all procedures were performed on an outpatient basis.
Today laparoscopy is the method of choice for diagnosing cryptorchidism.
Our report has shown that orchiopexy can be performed for intra-abdominal testes
without submitting to open surgical techniques.
http://mjiri.iums.ac.ir/article-1-1012-en.pdf