eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
379
380
article
TO THE EDITOR
Zahid Hussain Khan
1
Department of Anesthesiology, Tehran University of Medical Sciences
http://mjiri.iums.ac.ir/article-1-1087-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
378
379
article
THE FREQUENCY AND TYPE OF ORGANISM IN OPHTHALMIA NEONATORUM: A PROSPECTIVE STUDY IN SHIRAZ UNIVERSITY HOSPITALS IN 1992
S POURARIAN
1
A MADANI
2
From the Neonatology Unit, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
http://mjiri.iums.ac.ir/article-1-1086-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
375
380
article
LAMENESS SURVEY IN Y AZD PROVINCE IN 1992-1993
F BEHNAZ
1
M MOHAMMAD ZADEH
2
From the Infectious Diseases Ward, Afshar Hospital, Shaheed Sadooghi University of Medical Sciences, Yazd, Islamic Republic of Iran.
http://mjiri.iums.ac.ir/article-1-1085-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
373
374
article
UPPER GASTROINTESTINAL BLEEDING AND ACUTE PAINFUL EPIGASTRIC MASS DUE TO RUPTURE OF HYDATID CYST INTO THE DUODENUM
H SALAHI
1
From the Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
Various complications of hydatid cyst have been recognized to date. We have
encountered one such complication-rupture of hydatid cyst to the duodenum
leading to upper gastrointestinal bleeding in a 40 year old male, who referred with
severe right upper quadrant (RUQ) pain and gastrointestinal bleeding of a few hours'
duration. Laparotomy revealed a cyst (7 x 15 cm) in the left lobe of the liver which
was adherent to the duodenum and mesocolon. To the best of our knowledge, this is
the first report of gastrointestinal bleeding resulting from hydatid cyst rupture into
the duodenum.
http://mjiri.iums.ac.ir/article-1-1084-en.pdf
Echinococcosis
Compl ications
Gastrointestinal bleeding
Duodenal rupture
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
369
372
article
PRIMARY LOCALIZED RETROPERITONEAL AMYLOID TUMOR WITH OSSEOUS META PLASIA: CASE REPORT AND REVIEW OF THE LITERATURE
T GHIASI
1
P RAOFIAN
2
S NORUZPOUR
3
From the Department of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad,
the Sina Hospital, Reza Avenue, Mashhad, Islamic Republic of Iran.
Amyloidoma or amyloid tumor is a tumor-like localized deposit of amyloid
encountered occasionally in association with multiple myeloma, various chronic
inflammatory diseases and primary amyloidosis.
Amyloid tumors unassociated with plasmacytoma or other disease are
extremely rare in soft tissues and few cases in various situations have been
reported.
Histologic examination discloses amorphous eosinophilic material that stains
positive with congo red preparation, and shows apple-green birefringence under
polarized light. The deposits are surrounded by more or less prominent chronic
inflammatory cells, especially plasma cells and giant cells. Cartilage formation
and ossification, however, occur in some amyloid tumors.
http://mjiri.iums.ac.ir/article-1-1083-en.pdf
Tumor. amyloid. retroperitoneal; metaplasia. osseous.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
363
367
article
FREE JEJUNAL GRAFT FOR TREATMENT OF ESOPHAGEAL STRICTURE DUE TO FAMILIAL EPIDERMOLYSIS BULLOSA
M. REZA KALANTAR MOTAMEDI
1
JALALUDDIN KHOSNEVIS
2
M. HASAN KALANTAR MOTAMEDI
3
From the Department of General and Vascular Surgery and Traumatology, Shohada Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
In this paper, two patients with severe dysphagia and esophageal stricture
secondary to epidermolysis bullosa are presented and discussed. They are siblings of
an affected family. Primary resection and anastomosis had been performed previously
in both patients, but dysphagia had recurred. We treated these patients with free
jejunal graft to the esophagus with excellent results. Both patients are well and free
of dysphagia after five years.
http://mjiri.iums.ac.ir/article-1-1082-en.pdf
Stricture
esophagus; epidermolysis bullosa; graft
jejunal
free
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
355
361
article
BILIARY EXCRETION AND BLOOD/PLASMA RATIO OF NOVEL 5-BROMO-6-ALKOXY-5,6-DIHYDRO PRODRUGS OF 5-ETHYL-2\'-DEOXYVRIDINE
A MAJID CHERAGHALI
1
KEVIN W. MORIN
2
RAKESH KUMAR
3
EDWARD E KNAUS
4
LEONARD I WIEBE
5
From the Department of Pharmacology, Faculty of Medicine, Baghiatoliah Medical Sciences University, Tehran, Iran
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
The biliary excretion and blood/plasma ratios of four novel 5-bromo-6-alkoxy-
5,6-dihydro prodrugs to S-ethyl-2'-deoxyuridine (EDU) including (-)-trans-(5S,
6S)-S-bromo-S-ethyl-6-methoxy-S, 6-dihydro-2'-deoxyuridine (BMEDU), (+ )-trans(
SR, 6R)-S-bromo-S-ethyl-6-ethoxy-S, 6-deoxyuridine (BEEDU), (+ )-trans-(SR,
6R)-5-bromo-5-ethyl-6-ethoxy -S, 6-dihydro-S '-O-valeryl-2 ':.deoxyuridine
(VBEEDU) and (+)-trans-(SR, 6R)-S-bromo-S-ethyl-6-ethoxy-S, 6-dihydro-5, 6-
dihydro-3', S'-di-O-valeryl-2'-deoxyuridine (DVBEEDU) were determined using
[4-14C]-labelled compounds. Liver samples taken following iv injection of 126 kBq
(3.4IlCi) of these [4-14C]-labelled S,6-dihydro prodrugs into the tail vein of male
Balb-C mice showed a higher percentage of the injected radioactivity than blood
samples. A substantial amount of radioactivity was present in the large intestine,
small intestine and gallbladder. Intestinal samples collected at longer post injection
times showed a higher percentage of the injected dose relative to earlier post injection
times. Bile samples collected at 8 min post injection of [4-14C]-labelled BMEDU,
BEEDU, VBEEDU and DVBEEDU contained the highest radioactivity levels.
Excretion of radioactivity in rat bile following a jugular vein injection showed a
biexponential decline, but the radioactivity excretion rates in bile for all four
compounds investigated were quantitatively similar. Accumulation of radioactivity
in rat bile samples collected after injection of [4_14C]-BEEDU was substantially
higher than that for [4_14C]-BMEDU, [4_14C]_VBEEDU and [4_14C]-DVBEEDU.
The distribution of radioactivity in rat whole blood and plasma samples taken at the
same post injection times were substantially different. It was postulated that the rate
of conversion of the S, 6-dihydro prodrug to EDU is the main determinant of the
whole blood/plasma ratio.
http://mjiri.iums.ac.ir/article-1-1081-en.pdf
Biliary excretion; blood/plasma ratio; 5-ethyl-2\'-deoxyuridine; 5
6-dihydro prodrugs; herpes simplex virus.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
349
353
article
THE EFFECTS OF GLUCAGON, INSULIN AND S TEROID HORMONES ON PHOSPHATIDATE PHOSPHOHYDROLASE ACTIVITY IN RAT LIVERS
B HAGHIGHI
1
H NODEHI
2
M TAZARVI
3
From the Department of Clinical Biochemistry, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
The effects of steroid hormones, glucagon and insulin on rat liver phosphatidate
phosphohydrolase (PAP) activity were studied both in vitro and in vivo. Incubation
of rat hepatocytes with each hormone showed that dehydroepiandrosterone (DHEA),
progesterone and testosterone increase PAP activity by 44.6, 37 and 36.9%,
respectively. Estradiol, however, decreased enzyme activity by 13.6% under the
same conditions. Similar results were obtained when these hormones were injected
in rats, in which PAP activity increased by DHEA (19.7%), testosterone (17%) and
progesterone (88%) and decreased by estradiol (38.8%). Incubation of the hepatocytes
with insulin however, did not change PAP activity significantly even at 144 J.LM
concentrations, whereas glucagon progressively stimulated the enzyme activity,
reaching 7 1% at 50 J.LM concentration under the same conditions. In rats injected with
glucagon, PAP activity also rose up to 79% after 30 min, after which time it declined
but remained above the control level at 45 min. The data imply the role of PAP
activity in the mechanism by which androgens and progesterone increase serum
triacylglycerols and decrease serum HDL-c and their possible regulation by these
hormones.
http://mjiri.iums.ac.ir/article-1-1080-en.pdf
Phosphatidate phosphohydrolase
steroid honnone
insulin. Glucagon
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
341
347
article
MEDIAN NERVE STIMULATION PO TENTIATES THE MU SCLE RESPONSES TO TRANS C RANIAL MAGNETIC STIMULATION
AR JAMSHIDI FARD
1
EM SEDGWICK
2
From the Department of Physiology, Arak University of Medical Sciences, Arak, Islamic Republic of Iran,
the Department of Clinical Neurological Sciences, University of Southampton, Southampton General Hospital, Southampton, S09 4XY, U.K.
Motor responses evoked by transcranial magnetic stimulation OMS) or
transcranial electrical stimulation (TCS) can be facilitated by a prior conditioning
stimulus to an afferent nerve. Two facilitation periods are described short (SI), when
the nerve stimulus is given near 0 to 10 ms after cranial stimulation, and long (LI),
when nerve stimulation is given 25-60 ms before the cranial stimulation. I These
facilitation periods were examined in more detail in 10 normal consenting subjects.
The study has ethical committee approval. Focal cortical TMS was applied
contralaterally by a figure-of-eight coil over the "hot spot" for the right hand muscles
and the strength adjusted to be just above twitch threshold for the relaxed muscle.
Conditioning electrical stimuli were applied to the right median nerve at the wrist,
again at a strength just suprathreshold for a twitch in APE. The conditioning-test (CT)
interval was varied from -80 to + 1 0 with respect to the magnetic stimulus and 5
magnetic stimuli were tried at each interval. The results confirm the short facilitation
period when the C-T interval was -6 to +3 ms. Consideration of the timing indicates
that this must occur at the spinal segmental level. The long period of facilitation
lasted from 27-70 ms, but it was divided into two periods (27-35 and 55-70 ms) in
all subjects, separated by an interval of about 20 ms during which the test response
fell to control levels. The long late facilitations may be cortical as the earliest
facilitation began at 27 ms having the afferent volley reached the sensory cortex at
20 ms. The long interval facilitation consists of two temporally separate processes,
implying separate cortical mechanisms creating a bimodal excitability cycle at the
level of motor cortex.
http://mjiri.iums.ac.ir/article-1-1079-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
335
340
article
DETERMINATION OF SERUM CORTISOL LEVEL BY A DIREC T ENZYME IMMUNOASSAY USING PENICILLINASE AS LABEL
M POUR-AMIR
1
MJ RASAEE
2
M DJALALI
3
M MALEKANEH
4
From the Biochemistry Department, Tarbiat Modarres University, School of Medical Sciences, Tehran, I.R.lran
Serum cortisol level was measured by an enzyme immunoassay (EIA) using
the enzyme penicillinase as a label without prior extraction and purification.
Polyclonal antibodies were raised against cortisol-3-ortho-carboxymethyl-oxime
(cortisol-3-0-CMO) conjugated to bovine serum albumin (BSA). This antibody
showed a very low cross-reactivity with structurally related steroids (3.7% for
corticosterone and 4% for II-deoxycorticosterone).
Standard doses were prepared in a serum sample stripped from endogenous
cortisol. Danazol, 8-anilinonaphtalosulphonic acid (8-ANS) and salicylic acid
were used as blocking reagents. However these reagents were not suitable in this
assay. Samples were heat treated (60° C for 30 min) in order to denature the binding
proteins. The assay was sensitive from 250 pg per tube covering up to 50 ng with
each point having a coefficient of variation (CV) of less then 15% throughout ten
successive assays. CortisoI3-0-CM 0 was conjugated to the penicillinase following
a carbodiimide procedure.
The formed conjugate retained almost 90% of the enzyme activity. Recoveries
of exogenously added cortisol from charcoal-stripped plasma in three different
ranges varied between 90-100%.
Inter and intra-assay variations showed a CV of less than 12 %. The correlation
coefficient was calculated as r=0.99 using our method and the results reported by
a local hospital for 20 samples.
http://mjiri.iums.ac.ir/article-1-1078-en.pdf
EIA
Cortisol
Penicillinase
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
329
334
article
BRONCHODILATORY AND AN TICHOLINERGIC EFFECTS OF Carum copticum ON ISOLATED GUINEA PIG TRACHEAL CHAINS
MH BOSKABADY
1
H RAKHSHANDAH
2
V MOETAMED SHARIATI
3
From the Dept. of Physiology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, I. R.lran.
Carum copticum is a grassy and annual plant which is believed to have several
therapeutic effects, including anti-asthmatic properties.
We have therefore studied the bronchodilatory and anticholinergic effects of
4 rnL aqueous extract (AE), 0.0 5 mL ethanol extract (EE), and 0.0 0 5 mL essential
oil (EO) of Carum copticum and 1 rnL of a 5 mM solution of its main ingredient,
thymol (T), in comparison with 4 mL of saline (S) on isolated tracheal chains of
guinea-pigs (w=500-800 g) in a 50 mL organ bath. The bronchodilatory effects of
different solutions were examined by their relaxant effect on isometrically (1 g)
precontracted tracheal chains by 10 µM methacholine (M). The anticholinergic
effects of different solutions were tested by comparing the cumulative log
concentration -response curves of tracheal chains to cumulative concentrations of
M in the presence of AE, EE, EO, and T with that of S.
The bronchodilatory effects of AE, EE, and EO were significantly higher than
S in all cases (p<0.00 1), but T did not show any significant bronchodilatory effect.
There were also significant right-ward shifts in cumulative log concentrationresponse
curves obtained in the presence of AE, EE, and EO in comparison with
the curve obtained in the presence of S. Thymol also caused a smaller right-ward
shift in the M cumulative log concentration-response curve . However, the slopes
of methacholine response curves obtained in the presence of AE, EE, EO
(p<0 .00 l ), and T (p<0.05) were significantly lower than that of S, indicating the
functional antagonistic effects of these solutions.
These data showed the presence of bronchodilatory effects of AE, EE, and EO
of Carum copticum which was not due to the presence of T or the existence of a
competitive antagonist at the muscarinic receptors in this plant.
http://mjiri.iums.ac.ir/article-1-1077-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
325
328
article
RELATIONSHIP BETWEEN CONCENTRATION OF WELDING FUMES AND CHANGES IN WELDERS\' LUNG FUNCTIONS
HOSSEIN KAKOEE
1
From the Department of Occupational Health, School of Public Health, Tehran University of Medical Sciences, P. O. Box 6446-14155, Tehran, Islamic Republic of Iran
In order to evaluate the relationship between the concentration of welding
fumes and cigarette smoke on the bronchopulmonary system function, a comparative
study of spirometric measurements in 100 welders and 50 healthy volunteers was
performed in an automobile manufacturing company. Two groups of workers
were matched according to their age, height, smoking habit, years of service and
social class. Their health survey was evaluated by questionnaires, spirometry,
chest x-ray and clinical research. Statistical tests were done for all variables of
groups showing different types of pulmonary functions. 32 percent of welders had
a reduction in pulmonary function, and respiratory symptoms such as dyspnea,
cough, rales and sputum. Chest x-ray abnormalities (assidrosis) were higher in
welders (22%) than the control group (8%).
http://mjiri.iums.ac.ir/article-1-1076-en.pdf
Occupational Health
Welding Fumes
Welder\'s Lung Functions.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
319
324
article
THE CORRELATION BETWEEN SPERM MORPHOLOGY AND MOTILITY IN FERTILE AND INFERTILE MEN
ZAHRA SADIGHl GILANI
1
MOHAMMAD ALI SADIGHI GILANI
2
From the Department of Anatomy, Iran University of Medical Sciences, Tehran
the Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
The swim-up procedure was used to collect a sperm fraction with improved
motility and normal morphology from fertile and infertile semen samples. The
untreated and swim-up fractions were analyzed with the Hamilton-Thorn Motility
Analyser. Comparisons were made to see the effect of this sperm selection
technique on sperm motility and morphology. They were then examined by
transmission electron microscopy and the various sperm morphologies were
recorded. Fertile and infertile samples were compared for differences in these
parameters.
There were no significant differences between fertile and infertile samples in
the frequencies of various sperm morphologies in the untreated and swim-up
fractions. There was a trend towards fertile samples having a higher motility of the
untreated ejaculate, as well as more normal heads and tails and fewer morphological
abnormalities than infertile samples.
Sperm motility was found to be affected by sperm morphology, with an
increase in normal sperm morphology resulting in an increase in motility. Normal
sperm tail morphology appears to be the most important factor in motility, since
this was the only morphology to show a significant increase in the swim-up
fractions in all semen samples. Head morphology is less important to motility, but
it is thought to play a major role in fertilization of the egg.
http://mjiri.iums.ac.ir/article-1-1075-en.pdf
Morphology
motility
sperm
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
315
317
article
THE OCCURRENCE OF ENDOMETRIOSIS AMONG INFERTILE PATIENTS WITH UTERINE MYOMA AND THOSE WITH P OLYC YSTIC OVARIAN DISEASE: COMPARISON WITH INFERTILE CONTROL CASES
NASRIN MOGHADAMI-TABRIZI
1
KAZEM MOHAMMAD
2
HORMOZ DABIRASHRAFI
3
KAMBIZ ZANDINEJAD
4
SAMAN ZOMORRODIAN
5
From the Endoscopy and Fertility Research Center, Mirza Kouchek Khan Hospital, Tehran University of Medical Sciences, Tehran, I R. Iran.
In order to determine the occurrence of endometriosis in patients with uterine
myoma and in those with polycystic ovarian disease (PCOD) compared to controls,
540 infertile patients were fIrst divided into two age groups of 20-29 and 30-39. Then
each group was subdivided to patients with 1) uterine myoma, 2) PCOD, and 3) no
uterine myoma or PCOD (control subgroup). The occurrence of endometriosis was
ascertained in each subgroup. This occurrence was compared between subgroups 1
and 3, and subgroups 2 and 3. For statistical analysis the Mantel and Haenszel test
was used.
The occurrence of endometriosis in general was higher in subgroup 1 than in 3
(45.9% versus 19.9%), and the Mantel and Haenszel test gave a p<0.002. The
occurrence of endometriosis was lower in subgroup 2 than in 3 (7.3% versus 19.9%),
and the Mantel and Haenszel test gave a p<0.005.
As it is classically stated that myoma is an estrogen dependent tumor and PCOD patients have an androgenic milieu, it could be suggested that the different effects of
hormones may be the reason for the varied occurrence of endometriosis found in this
study.
http://mjiri.iums.ac.ir/article-1-1074-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
311
314
article
TREATMENT OF INTERNA L HEMORRHOIDS UTILIZING DIRECT CURRENT ELECTRICITY
A A. IZADPANAH
1
From the Department of General Surgery, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Hemorrhoids is one of the most common diseases of mankind. There are
different methods of treatment, but many problems and complications are associated
with the use these modalities. DC electrotherapy of hemorrhoids is an alternative
method which offsets many of these conditions. Two hundred and ten patients with
426 hemorrhoidal tags of different grades underwent DC electrotherapy by a DC
generator which was designed and made by our department. We used 18 rnA current
for 100 patients who underwent operation under anesthesia and for 30 patients
without anesthesia. The other 80 patients were operated on under anesthesia by using
22 rnA DC electrotherapy. Success rate was 94% when we applied 18 rnA and 97.3%
with 22 rnA, with no major complications. The therapeutic time period for a tag
correlated to the severity and grade of the tags and the amount of current used it was
6.2 ± 1.82 min when 22 rnA current was used.
DC electrotherapy is safe, effective, easy to use and cheap and can be used in
patients with or without anesthesia.
http://mjiri.iums.ac.ir/article-1-1073-en.pdf
Hemorrhoid
Electrotherapy
Direct current
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
307
310
article
THE EFFECT OF CHRONIC HYPOXIA ON THE CENTR AL NERVOUS SYSTEM OF CHILDREN WITH CYANOTIC CONGENITAL HEART DISEASE
M BORZOUEE
1
A REZAEE
2
From the Department of Pediatrics, Pediatric Cardiology Division, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Due to advanced treatments in the field of heart disease, cyanotic heart disease
patients have a greater chance of survival, and nowadays many of them live until
adolescence or middle age. One of the signs of this disease is blood hypoxia, which
has acute and chronic effects on the CNS. In this paper the effect of chronic hypoxia
on children affected by cyanotic congenital heart disease (CHD) is evaluated.
For this purpose children aged five to eleven years were divided into three major
groups: cyanotic CHD, acyanotic CHD and normal. Then they were compared
according to points achieved on the Visual Motor Gestalt Test, which established
their intelligence and mental superiority. The average value of cyanotic CHD
(mean± SD, 11.78±4.54) in all age groups was less than the other two groups.
Furthermore, the average values of acyanotic CHD children (mean± SD, 8.97±4.04)
were less than the normal subjects (mean± SD, 6.6±4.18). Statistically, the difference
of means between the values of these three groups was significant in all age groups
except for the five and nine year old groups.
The statistical insignificance of the values for 5 and 9 year old groups was due
to the high variance of normal group point values in these two age groups. The effects
of other influencing factors such as the job and education of parents, number of
children in the family and the relative filial position of the child in his family were
considered. As a result of this study, we have established that patients with CHD especially
cyanotic patients-have a considerable amount of intelligence retardation
which the cardiologist and surgeon can prevent or minimize by shortening the period
of hypoxia with rapid correction.
http://mjiri.iums.ac.ir/article-1-1072-en.pdf
Intelligence
Congenital heart disease (cyanotic)
Hypoxia.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
303
306
article
EFFEC T OF HUMAN GROWTH HORMONE TREATMEN T IN CHILDREN WI TH GROWTH HORMONE DEFICIENCY, TURNER\'S SYNDROME AND ACHONDROPLASIA: A COMPARISON OF DOSE FREQUENCY AND ROU TE OF ADMINIS1RATION
Z KARAMIZADEH
1
GH AMIRHAKIMI
2
From the Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Recombinant human growth hormone (hGH) was given for 6 months or longer
to 68 patients with GH deficiency, 6 with Turner's syndrome and 5 with achondroplasia,
during 1986-1994 in a prospective study.
The total weekly administered dose of GH was 0.6 u/kg. By random sampling,
29 of 68 GH deficient patients (42.6%) received twice weekly (2 iw) intramuscular
(im) injections, 17 (25%) received twice weekly subcutaneous (sc) injections and 22
received hGH 6 times per week (6 iw) sc during the first 6 months of therapy.
In the GH deficient group the mean pretreatment height velocity was 4 ± 1.2 cm!
yr (mean ±SD). The mean velocity during the first 6 months of treatment was 8.7 ±
2.3 cm/yr (p<0.0005), regardless of the frequency and type of GH administration.
During the second 6 months and second year of treatment, the mean growth rates
were 7.7 ± 2.2 and 6.7 ± 2.2 cm, respectively.
The mean increase in height during the first 6 months of therapy for the 2 iw im
group (7.7 ± 1.6 cm) compared with the 2 iw sc group (7.6 ± 2.1) did not exhibit any
significant difference (0.8<p<0.9).
The comparison of growth velocities after 6 months of therapy using 2 i w sc (7.6
± 2.1) and 6 iw sc (10.1 ± 3.3 cm/yr) in patients with GH deficiency revealed a
statistically significant difference (p<0.002).
6 patients with Turner's syndrome aged 4.5 to 15.3 years were also treated with
hGH. The mean pretreatment height velocity of 3.6 ± 0.9 cm/yr increased to 6.3 ± 0.8
cm/yr during treatment. 5 patients with achondroplasia aged 3-9.6 years also
received hGH for more than 6 months, and height velocity during GH therapy
increased compared to that before GH therapy (5.4 ± 1.4 cm/yr vs. 4.7 ± 0.9 cm/yr).
http://mjiri.iums.ac.ir/article-1-1071-en.pdf
Growth hormone deficiency
Turner\'s syndrome
Achondroplasia
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
299
302
article
IMPROVING ERYTHROPOIESIS BY HEMODIALYSIS: RELATIONSHIP WITH A DEQUACY, FREQUENCY A ND DURATION OF DIALYSIS
P KHAJEHDEHI
1
MA GHALAMBOR
2
From the Division of Nephrology, Department of Internal Medicine, School of Medicine,
the School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Serum erythropoietin (EPO) concentration was measured by an enzyme-linked
immunosorbent assay (ELISA) in 31 cases of chronic renal failure (CRF),
including 20 hemodialysis (HD) patients, and compared with that of 31 healthy
normal controls. Each patient served as a self-control comparing his or her
pretreatment level with post-treatment values. There was a significant negative
correlation between serum EPO and serum iron ( SI) concentration in HD patients
(p<0.05) the correlation was more prominent after three months of hemodialysis
(p<0.00l). The mean hemoglobin (Hb) concentration was significantly higher in
patients who underwent HD more than once per week as compared with those who
received HD once a week (p<0.00 1). In addition, patients on three months of HD
had a higher Hb level as compared to those who had received HD for one month
(p<0.001). Moreover, there was also a significant negative correlation between
serum EPO concentration and dialysis adequacy (p<0.05), indicating that the
erythropoietin-hematocrit feedback inhibition mechanism had improved due to
general improvement of the patients' metabolism and possible removal of dialyzable
toxins.
http://mjiri.iums.ac.ir/article-1-1070-en.pdf
Erythropoietin
anemia
chronic renal failure
hemodialysis.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
295
298
article
HEART RATE: A PREDICTOR OF EARLY MORTALITY IN PATIENTS WITH MYOCARDIAL INFARCTION
NIZAL SARRAF-ZADEGAN
1
From the Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
A number of epidemiologic studies have reported a positive relationship
between heart rate, cardiovascular disease and mortality. To examine the correlation
between heart rate and mortality after acute myocardial infarction (AMI), 2147
patients hospitalized in coronary care units in Isfahan were investigated in a cross-sectional
study. Their heart rate was measured according to an electrocardiograph
obtained during the 2nd, 5th and final days of hospitalization, and all patients were
followed for cardiovascular mortality. The means of3 measurements were divided
into four fractions.
A strong positive relationship between heart rate and cardiovascular mortality
was obtained. Confounding variables such as age, sex, type of infarction and drugs
were adjusted by regression models. The nonlinear regression relationship was
due primarily to a sharp increase in mortality in the highest quartile of heart rate.
We conclude that although sinus tachycardia can be considered as a predictive
independent risk factor for mortality after AMI, further longitudinal studies are
required.
http://mjiri.iums.ac.ir/article-1-1069-en.pdf
heart rate
myocardial infarction
mortality
prognosis
sinus tachycardia
cardiovascular
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
289
294
article
ASSESSMENT OF TUMOR MARKERS IN BENIGN, DYSPLASTIC AND MALIGNANT ORAL MUCOSAL LESIONS
BEHJAT K.H. MOGHADAM
1
ISMAIL YAZDI
2
HOURI FATOREHGHI
3
From the School of Dentistry, University of Missouri-Kansas City, 650 E. 25th Street, Kansas City, Missouri 64108, U.S.A.
Immunohistochemical demonstration of tumor-associated markers may be
valuable as an adjunct to conventional histology for determination of malignancy
development in oral mucosal diseases. Accordingly, the present study determined
the distribution of some important tumor markers such as heat shock proteins (HSP),
fibroblast growth factors (FGF) and transferrin receptors (TF-R) in 22 samples of
primary oral squamous cell carcinoma (SCC) and in 18 hyperplastic/dysplastic oral
lesions. Fifteen samples of normal buccal mucosa were included for comparison.
Serial sections taken from frozen tissues and paraffin-embedded samples were
stained immunohistochemically using monoclonal antibodies against HSP, FGF and
TF-R. Results showed that normal tissues had only a detectable level ofHSP and FGF
while dysplastic tissues had a higher level of HSP and FGF expression. Oral sces
demonstrated the highest level of HSP and FGF expression distributed widely across
the tumor specimens. TF-R expression was detected only in cryostat sections with
low immunoreactivity seen in normal tissues, and the highest level of immunoreactivity
detected in malignant tissues. Expression of TF-R in paraffin-embedded sections
was non-specific and was masked by fixation methods used to process these tissues.
It is concluded that HSP and FGF are largely expressed by malignant cells indicating
that over-expression of these markers in mucosal lesions might be a reflection of
malignancy. Secondly, these markers are preserved well in paraffin-embedded
sections and finally, expression of TF-R correlates with rapid cell proliferation but
its assessment is highly specific and is only accurate in cryostat sections.
http://mjiri.iums.ac.ir/article-1-1068-en.pdf
Tumor markers; immunohistochemistry; Oral cancer; growth factors.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
285
287
article
TRANSTYMPANIC ELECTROCOCHLEOGRAPHY FOR EVALUATION OF MENIERE\'S DISEASE
MASOOD KAVIANI
1
ABDOLHOSSEIN JAFARY
2
From the Department of Otolaryngology and Audiology, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
35 patients with unilateral sensorineural impairment and hearing levels within
the normal range in the opposite ears were investigated by bilateral transtympanic
electrocochleography (TIECoG). Only 19 patients (54%) satisfied the criteria for
Meniere's disease and 16 patients (46%) showed sensorineural impairment due to
other etiologies. Clinical studies have focused exclusively on the a mplitude ratio of
the summating potential (SP) and the action potential (AP) derived from alternating
polarity click responses (Le., SP/AP). In only clinically defined ears with Meniere's
disease have abnormally large SPs been found. Neither normal ears nor sensorineural
impaired ears of other etiologies exhibited abnormal SPs, hence we used normal ears
as a control in this study.
http://mjiri.iums.ac.ir/article-1-1067-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1998-02
11
4
281
284
article
SURGICAL ASPECTS OF PEDIATRIC COCHLEAR IMPL A NTATION
M FARHADI
1
A DANESH
2
H lMAMJOMEH
3
From the ENT Dept. and Dept. of Audiology, Rasul Akram Medical Complex, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran
Since 1991,90 cochlear implantations have been performed in the " cochlear
center" of our department, including 57 children. This paper presents the results
of 57 children who underwent cochlear implantation in the Iranian pediatric
cochlear implant program. The surgical technique is described below. No flap
problems were encountered, and no cholesteatoma or other complication was
seen. In one child secondary operation was required due to fracture of the
electrode array.
http://mjiri.iums.ac.ir/article-1-1065-en.pdf
Deafness
congenital
acquired; implantation
cochlea