eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
179
180
article
APPLICATION OF SWEET ALMOND OIL AS AN OIL IMMERSION LENS FOR MORPHOLOGICAL DIAGNOSIS OF BACTERIA FUNGI, PARASITES, CYTOLOGY AND TISSUE HISTOLOGY
M MAKVANDI
1
MJ TAHMASEBI
2
R BADRI
3
From the Virology and Biophysics Department, Ahwaz University of Medical Sciences, and the Chemistry Department, Shahid Chamran University, Ahwaz, Islamic Republic of Iran.
http://mjiri.iums.ac.ir/article-1-1130-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
178
178
article
EVALUATION OF TWO BIPHASIC CULTURE MEDIA FOR ISOLATION OF LEISHMANIA PARASITES FROM CUTANEOUS ULCERS IN IRANIAN PATIENTS
GR HATAM
1
SMH HOSSEINI
2
S ARDEHALI
3
From the Department of Parasitology, Medical School, Tarbiat Modarres University, Tehran
the Departmenc of Immunology, Pasteur Institute of Iran, Tehran
the Department of Microbiology, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
http://mjiri.iums.ac.ir/article-1-1129-en.pdf
Leishmania
Isolation
Culture media
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
177
180
article
A COMPARISON BETWEEN THE PROTEIN PROFILE OF lNT ACT AND TWO
SH HEJAZI
1
A KHAMESIPOUR
2
MH ALIMOHAMMADIAN
3
AA ALLAMEH
4
Y DOWLATI
5
From the Department of Parasitology ,School of Medical Sciences, Tarbim Modarress University, Tehran
the Center for Research and Training in Skin Diseas es and Leprosy, Tehran
lmmunology Department, Pasteur Institute, Tehran, Islamic Republic of Iran
lmmunology Department, Pasteur Institute, Tehran, Islamic Republic of Iran
the Center for Research and Training in Skin Diseas es and Leprosy, Tehran
http://mjiri.iums.ac.ir/article-1-1128-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
169
175
article
GENETIC AND NON-GENETIC THEORIES ON THE ETIOLOGY OF POLYCYSTIC OVARY SYNDROME: A REVIEW
SHAYESTEH JAHANFAR
1
JOHN A EDEN
2
From the School of Obstetrics and Gynaecology, University of New South Wales, Royal Hospital for
http://mjiri.iums.ac.ir/article-1-1127-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
163
167
article
PRIMARY MALIGNANT PERICARDIAL MESOTHELIOMA
MOHAMMAD REZA MOTAMEDI
1
P SHISHINEH
2
From the Departments of Cardiology Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran
From the Departments of Pathology, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Primary malignant neoplasms of the pericardium are rare and are predominantly
mesotheliomas, followed by benign localized fibrous mesothelioma, malignant
fibrosarcoma, angiosarcoma and benign and malignant teratomas. 1
This article concerns an atypical presentation of this malignant tumor with
symptoms and signs of pericardial effusion. This unusual feature was complete
encasement of the heart by this tumor, without pericardial effusion.
http://mjiri.iums.ac.ir/article-1-1126-en.pdf
Pericardium
tumor
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
161
162
article
UNUSU AL PRESENTATION OF TA ILGUT CYST AS A PROTRUDING MA SS BESIDE THE COCCYX
JALAL VAHEDIAN ARDEKANI
1
ALI ZARE MEHRJARDI
2
From the Departments of Surgery Bahonar Hospital, Kerman University of Medical Sciences, Kerman. Islamic Republic of Iran.
From the Departments of Pathology, Bahonar Hospital, Kerman University of Medical Sciences, Kerman. Islamic Republic of Iran.
Tailgut cyst is a very rare lesion of the retrorectal space seemingly derived
from embryonic remnants of the tail gut which often causes rectal signs and
symptoms. A unique case of this lesion presenting as a subcutaneous mass lateral
to the coccyx is hereby described
http://mjiri.iums.ac.ir/article-1-1125-en.pdf
Tailgut
tailgut cyst
retrorectal cystic hamartoma
retrorectal space
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
157
159
article
VULVa-VAGINAL-GINGIVAL SYNDROME (VVG): A CASE REPORT
S.M. SADR ASHKEVARI
1
MAN MANSOURI GHIASI
2
From the Dept. of Dermatology, Razi Hospital Gilan University of Medical Sciences, Rasht, Islamic Republic of Iran
We report a 26 year old woman with erosive vulvo-vaginal mucositis followed
by desquamative gingivitis, and typical histopathologic features of lichen planus
(vulvo-vaginal-gingival syndrome). This is to our knowledge the first report of this
syndrome from Iran and probably the youngest one in the world (with regard to the
English literature)
http://mjiri.iums.ac.ir/article-1-1124-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
153
155
article
XERODERMA PIGMENTOSUM WITH NEUROLOGICA L COMPLICATIONS: THE DESA NCTIS-CA CCHIONE SYNDROME
HAMDOLLAH KARAMIFAR
1
GHOLAMHOSEIN AMIRHAKIMI
2
From the Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
A 7 year old boy with DeSanctis-Cacchione syndrome - xeroderma
pigmentosum, microcephaly, mental deficiency, dwarfism and gonadal
hypoplasia - will be presented.
http://mjiri.iums.ac.ir/article-1-1123-en.pdf
Xeroderma pigmentosum (XP)
DeSanctis-Cacchione syndrome
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
149
152
article
PAPILLON-LEFE\'VRE SYNDROME: NEUTROPHIL MOTILITY AND KILLING DEFECT IN A CHILD WITH RECURRENT SEVERE INFECTIONS
M MOIN
1
ABOLHASAN FARHOUDI
2
ATHAR MOIN
3
From the Department of Clinical Immunology and Allergy, Children's Medical Center, Tehran University of Medical Sciences, Tehran
From the Department of Clinical Immunology and Allergy, Children's Medical Center, Tehran University of Medical Sciences, Tehran
the Department of Dermatology, Shahed University, Tehran, Islamic Republic of Iran.
A case of palmoplantar hyperkeratosis with periodontosis and a history of
recurrent severe pyoderma, pneumonia and multiple liver abscesses is described
in a 12 year old girl. The patient demonstrated neutrophil dysfunction characterized
by decreased random migration and chemotaxis and defective bactericidal activity.
The exact immunopathological mechanism for susceptibility to infections in
Papillon-Lefe'vre syndrome patients still remains to be determined. However, the
mode of clinical presentation, laboratory findings and response to retinoid treatment,
all support the speculation of Papillon-Lefe'vre syndrome as a primary immunologic
disease with a variable defect in neutrophil motility and bactericidal activity. The
pattern of clinical presentations as skin and periodontal lesions alone or with
susceptibility to infection in other sites will change accordingly.
http://mjiri.iums.ac.ir/article-1-1122-en.pdf
Keratosis
periodontosis
neutrophil
chemotaxis
chemiluminescense
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
143
147
article
FORMALDEHYDE EXPOSURE AND ITS HEALTH HAZARDS IN A MELAMINE DINNERWARE MANUFACTURING INDUSTRY
FARIDEH GOLBABAIE
1
GHOLAM HOSEIN SANAI
2
SHAHNAZ BAKAND
3
From the Department of Occupational Health, School of Public Health, Tehran University of Medical Sciences, P.O. Box 6446-14155, Tehran, Islamic Republic of Iran.
This paper reports on formaldehyde exposure and its health hazards in a
melamine manufacturing industry. The mean of workers' exposure was measured
according to 3500 NJOSH and was found to be 1.44±O.2l, and 2. 17±O.24 ppm in
morning and evening shifts, respectively. For stationary ones it was 1.37±O.20,
and 2.06±O.25ppm, respectively. The results show that formaldehyde concentration
at the sources (presses) depends on the weight of the resin used, and differences
in concentration of various quantities of the applied resin with one another was
significant (p<0.05).
Based on the results of 272 samples, it was noted that formaldehyde
concentration in the evening shift was more than that of the morning shift (p<0.05),
and from 3-6 P.M. is at maximum levels, except the polish workshop was less than
10 mg/m3 (TLV -PNOC). In pressing workshops, all particles were respirable,
whereas in the polish workshop, respirable particles comprised only 24% of all
particles.
Exposure to formaldehyde was associated with several symptoms including
eye burning, lacrimation, excessive blinking, nose and throat irritation and thirst,
which were significantly higher in concentrations over 1 ppm compared with
lower concentrations (p<0.05).
http://mjiri.iums.ac.ir/article-1-1120-en.pdf
Formaldehyde
Resin
Exposure
Health.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
137
141
article
RAPID IDENTIFICATION OF Vibrio cholera-01 BY COAGGLUTINATION TEST USING MONO-SPECIFIC ANTIBODY
SEYED ABBAS BAZARGAN
1
BAHMAN TABARAIE
2
BAHRAM FATOLLAHZADEH
3
NASRIN MOAZZAMI
4
From the Department of Microbiology, Medical School, Tarbiat Modarres University, Tehran
the Department of Bacterial Vaccine and Antigen Production, P asteur Institute of Iran
From the Department of Microbiology, Medical School, Tarbiat Modarres University, Tehran
the Biotechnology Department, Iranian Research Organization/
Mono-specific antisera against Vibrio cholera Ogawa NIH-43 and Vibrio
cholera Inaba 35-A3 were prepared from rabbit hyperimmune sera by absorbing
against a heterologous strain. Using ammonium sulphate precipitation procedure,
gamma globulins were purified and concentrated.
To visualize antigen-antibody reaction, gamma globulins were conjugated to
Staphylococcus aureus cowan-l (NCTC: 8325) in the presence of 50% propanol-
1. Then equal suspensions of each conjugated serum were mixed to prepare V.
cholera.
Rectal swab samples from suspected choleric patients were inoculated in bile
peptone broth for 5 hours at 37°C. One drop of each sample was mixed with one
drop of VBCR and coagglutination was read at 2-3 minutes. The results were
compared with corresponding results obtained from conventional culture methods.
Specificity and sensitivity of coagglutination tests were found to be 98.03%
and 95.1 %, respectively.
Regarding the fact that rapid diagnosis of cholera is vital to save patients, our
study reveals that coagglutination test, using bivalent mono-specific antisera, can
be considered as a simple, rapid and reliable test to detect V. cholera-O 1 from stool
samples of suspected patients.
http://mjiri.iums.ac.ir/article-1-1119-en.pdf
Vibrio cholera
Vibrio cholera bivalent mono-specific coagglutination reagent (VBCR)
Classical culture method.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
133
135
article
THYROXINE AND THYROTROPIN LEVELS IN CORD BLOOD SERA FROM SOUTH OF IRAN
Z KARAMIZADEH
1
GH AMIRHAKIMI
2
From the Dept. of Pediatrics, Endocrinology and Metabolism Division, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
Birth is associated with significant changes in the hypothalamic-pituitarythyroid
axis and these changes complicate the proper assessment of thyroid
function in neonates. Normal values forT4 (thyroxine) and TSH (thyroid stimulating
hormone) in cord blood are not well established. The present study was carried out
on 4000 specimens of cord sera of both sexes in order to establish reliable reference
values for these hormones. Our data imply that the level ofT4 in cord sera (mean±
1 SD: 10.99±2.46 µg/dL) is less than that of the neonatal period but is comparable
to that of older infants. The concentration of TSH (mean±1 SD: 7.09+4.54µU/mL)
is comparable to the level expected in the first week of life but is higher than that
of older infants. The values of T4 and TSH obtained from cord blood of boys and
girls did not show any statistically significant differences.
It is suggested that these values can be used as normal reference values for T4
and TSH in cord blood.
http://mjiri.iums.ac.ir/article-1-1118-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
127
131
article
VENTROMEDIAL HYPOTHALAMIC NUCLEI AND FEEDING BEHAVIOR
GD NAYERI KAMAN
1
M TAHERIAN FARD
2
From the Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, and the *Department of Physiology, Tarbiat Modarress University, Tehran, Islamic Republic of Iran.
The role of the ventromedial nuclei of the hypothalamus (VMN) in food
behavior was studied in adult male rats, allocated in 3 groups: control, sham and
lesioned. Electrolytic lesions were induced stereotaxically (1.2 mA, 15 sec).
Results revealed a significant decrease (p<O.05) in body weight (BW) and food
intake (FI) in the order of lesioned <sham <control during the fIrst week. However,
there were no significant differences in BW and FI between groups in the second
week after lesion induction. In the lesioned group, the fInikiness syndrome was
observed in the second week after lesioning. It was postulated that VMN lesions
produce the finikiness syndrome, and this in turn can cause hyperphagia and
hypothalamic obesity. Water intake (WI) was significantly lower in the lesioned
group in the first and second week after VMN lesion induction. It could be
postulated that disturbances in the regulation of WI is part of the VMN lesion
syndrome.
http://mjiri.iums.ac.ir/article-1-1117-en.pdf
VMN lesion
food intake
water intake
finikiness.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
123
125
article
COMPARISON OF ANTIULCER EFFECTS OF TRICYCLIC ANTIDEPRESSANTS WITH CIMETIDINE AND OMEPRAZOLE IN RATS
HAMID REZA JAMSIDDI
1
TAGHI GHAFGHAZI
2
From the Department of Pharmacology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
The antiulcer effects of different tricyclic antidepressants (trimipramine,
doxepin, imipramine, and amitriptyline) in comparison with those of cimetidine,
pirenzepine and omeprazole were investigated in male rats with acute gastric
ulcer. Acute gastric ulcer was induced by oral administration of O. 6N HCl solution,
1 mL/rat.
Pretreatment of animals with doxepin, trimipramine, amitriptyline, imipramine
(in doses of 10, 25, 40, 50, and 75 mg/kg, SC), cimetidine (in doses of 50,75, 100,
150 and 200 mg/kg, SC), omeprazole and pirenzepine (in doses of 10, 20, 30,40
and 50 mg/kg, SC) inhibited the formation of erosions dose-dependently.
The ED 50 of these agents revealed that the most active agents were omeprazole,
doxepin and pirenzepine, followed by trimipramine and cimetidine. Imipramine
and amitriptyline had slight antiulcer activity.
http://mjiri.iums.ac.ir/article-1-1116-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
115
122
article
ENHANCED HISTAMINE H I RECEPTOR BLOCKADE WITH CHLORPHENIRAMINE IN THE ASTHMATIC TRACHEO-BRONCHIAL TREE: FURTHER EVIDENCE FOR INCREASED DRUG DELIVERY IN ASTHMA
MOHAMMAD H. BOSKABADY
1
PHILLIP D. SNASHALL
2
From the Department of Physiology, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran
the Department of Medicine, Charing Cross and Westminster Medical School, Fulham Palace Road, London W68RF, UK.
We have measured the competitive antagonistic effect of chlorpheniramine
in bronchi of 8 normal and 12 asthmatic subjects. Classical pharmacological
theory states that the degree of competitive antagonism depends only upon 1)
antagonist concentration at the receptor, and 2) receptor affinity. Delivery and
affinity also influence agonist responsiveness, but measurement of bronchial
antagonism allows study of these factors in isolation. Bronchial responsiveness to
histamine was measured as the dose required to produce a 35% fall in specific
conductance (sGaw), called PD35• On different days, 2 measurements of control
PD35 were made on each subject. Measurements of PD35 were also repeated after
inhalation of 1.45 mg chlorpheniramine and intravenous injection of 0.17 mg/kg
chlorpheniramine. Antagonist effect of chlorpheniramine was measured as Dose
Ratio-l (DR-I), where DR= PD35 after chlorpheniramine/control PD35• Geometric
mean of DR -1 with inhaled chlorpheniramine in asthmatic subjects (5.8) was 6.8
times that of normal subjects (0.86) (p= 0.002), and DR-l with intravenous
chlorpheniramine in asthmatic subjects (4.4) was 2.75 times that of normal
subjects (1.6) (p=0.005). There were significant negative correlations between
PD35 and DR-I, whether chlorpheniramine was administered by inhalation (r=
-0.87, p<O.OO 1) or intravenously (r= -0.62, p<0.005). There was also a significant
correlation between DR-1 obtained by two routes of administration (r= 0.77,
p<0.001). Taken with our previous study showing enhanced antagonism with
atropine at bronchial muscarinic receptors in asthma, I these results suggest that
drug delivery by inhaled and parenteral routes may be increased in asthmatic
bronchi.
http://mjiri.iums.ac.ir/article-1-1115-en.pdf
histamine HI receptors
asthma
chlorpheniramine
histamine
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
111
114
article
COMPARISON OF THE ACUTE BRONCHO DILATING EFFECTS OF INHALED IPRATROPIUM BROMIDE AND SALBUTAMOL IN PATIENTS WI TH CHRONIC OBSTRUCTIVE PULMONARY DISE ASE
S MOHAMEDI
1
F ROSHANZAMIR
2
A MAHDAVI
3
MH POURGHOLAMI
4
From the Tehran University of Medical Sciences, Tehran, and the *Dept. of Pharmacology, Shaheed Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Forty-five patients with chronic obstructive pulmonary disease were studied
to compare the acute effects of ipratropium bromide (60 µg), salbutamol (300 µg)
and placebo (3 puffs) on the forced expiratory volume in 1 sec (FEV 1) and forced
vital capacity (PVC). Ipratropium bromide produced a significantly greater
improvement than salbutamol in both FEV1 and FVC at 15,60 and 180 minutes
after drug administration. It may therefore be concluded that in patients with
chronic obstructive pulmonary disease, ipratropium bromide has greater potency
and a longer duration of action than salbutamoL
http://mjiri.iums.ac.ir/article-1-1114-en.pdf
Ipratropium bromide
salbutamol
anticholinergic
chronic obstructive pulmonary disease.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
105
109
article
RELATIONSHIP BETWEEN SUCCINYLCHOLINEINDUCED APNEA AND DIBUCAINE NUMBER IN PATIENTS WITH GENETIC DEFICIENCY OF PLASMA CHOLINESTERASE
MAHINDUKHT KEYHANI
1
ZAHID HUSSAIN KHAN
2
From the Department of Bio chemistry, Iran University of Medical Sciences, and the *Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
In this study, a commercially available kit in which propionylthiocholine is
used as a substrate and a dibucaine solution to determine the variants of the enzyme
were utilized.
Plasma cholinesterase activity of 151 patients who underwent different
operations was measured during a period of six months. The mean±SD of the
enzyme activity in 150 patients was 4.39±1.17 kU/L ..
Seventeen patients (11.2%) were found to have a serum cholinesterase
activity of less th'an normal «3 Ku/L), but the period of apnea and the dibucaine
number (DN) were found to be normal. Eight patients (5.3%) displayed an
increased sensitivity to succinylcholine.
Six of these patients (4%) were heterozygous for atypical enzyme with a mean
period of apnea of 18.6 min (range 12-35 minutes) and had a dibucaine number of
less than normal (‹80%). The DN of the other two patients (1.3%) who were
homozygotes and had an exceedingly low atypical enzyme allele was 10% and
24%. The mean±SD DN value, in the 149 out of 151 patients was 84.41±2.91 %,
and the DN ranged from 10-90% in these patients. The mean±SD apnea period in
the 149 patients was 6.37±4.28 min.
http://mjiri.iums.ac.ir/article-1-1113-en.pdf
Plasma cholinesterase
Succinylcholine
Apnea
Dibucaine number (DN)
Propionylthiocholine
Homozygote
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
103
104
article
EFFECT OF SUBLINGUAL NITROGLYCERINE ON PAIN RELIEF IN RENAL AND URETERAL COLIC
A A. RAZI
1
J ZARGOOSH
2
From the Ayatollah Taleghani and Ashrafi Esfahani Hospitals, Kermanshah University of Medical Sciences' School of Medicine, Kermanshah, Islamic Republic of Iran.
The effect of sublingual nitroglycerine (TNG) on relieving pain in renal and
ureteral colic was studied in a randomized, prospective, double blind and placebo
controlled clinical trial.
One hundred out-patients between 16-60 years of age from either sex who
were admitted to the urology emergency center of Ayatollah Taleghani and
Ashrafi Esfahani hospitals were chosen for this study. They were divided into two
groups fifty-one of them were treated with TNG (0.4 mg initially and two similar
doses if necessary at 5 minute intervals) and the remaining received placebo.
The scoring of pain was performed using Lee et aI's method. Chi-square test
was used for statistical analysis of data. Although the severity of pain was reduced
one degree by TNG (p<0.07) in comparison with placebo, TNG was not effective
in the treatment of colic pain (p<0.05).
http://mjiri.iums.ac.ir/article-1-1112-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
99
102
article
EFFICACY OF FLUMAZENIL IN THE MANAGEMENT OF BENZODIAZEPINE OVERDOSE
MOHAMMAD ABDOLLAHI
1
NASER JALALI
2
RAMESH GHAFARI
3
MOHAMMAD SHARIATPANAHI
4
BEHROOZ JANAT
5
From the Department of Pharmacology and Toxicology, Tehran University of Medical Sciences, and the Toxicology Ward of Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Yale University, USA, and Tehran University of Medical Sciences
Benzodiazepine overdose is the most commonly encountered drug overdose
in Iran. It has been reported by many authors that flumazenil possesses highly
specific antagonistic activity on central benzodiazepine receptors. We conducted
a prospective study on 150 patients brought to the toxicology emergency ward in
Loghman-Hakim hospital with benzodiazepine overdose to assess the efficacy of
flumazenil to counteract benzodiazepine overdose. Upon arrival, patients were
examined thoroughly and their Glasgow coma scale was recorded. Afterwards
flumazenil was administered in sufficient dosage, between 0.25-0.50 mg. The
most commonly consumed benzodiazepine was diazepam (50%). One hundred
and thirty patients responded positively to flumazenil, characterized by improved
response to painful stimuli, and decreased amnesia.
Twenty percent of the patients (26 cases) had an increased respiratory rate
after flumazenil administration. In 86 patients, consciousness improved after 5
minutes, in 36 patients after 10 minutes and in 8 patients after 15 minutes. In 48
patients the psychomotor performance improved 5 minutes after antidote
administration, while in 15 patients psychomotor performance improved after 30
minutes. Some patients developed resedation after flumazenil administration. In
25 patients resedation occurred after 15 minutes, in 59 patients after 30 minutes,
and 34 patients showed this phenomenon after 45 minutes. Despite this last
finding, we concluded that flumazenil effectively and rapidly antagonizes the
central effects of benzodiazepines. It is also a valuable diagnostic agent with no
serious side effects.
http://mjiri.iums.ac.ir/article-1-1111-en.pdf
Flumazenil
Benzodiazepine
Overdose.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
91
97
article
DIFFERENTIAL PRODUCTION OF IgM A ND IgA RHEU MATOID FACTORS IN PERIPHERAL BLOOD AND SYNOVIUM OF PATIENTS WITH RHEUMATOID A RTHRITIS
GHASEM MOSAYYEBI
1
JAFAR FORGHANIZADEH
2
BANAFSHEH GHOLESTAN
3
FAZEL SHOKRI
4
From the Dept. of Immunology, School of Public Health, Tehran University of Medical Sciences
the Dept. of Rheumatology, Hazrate Rasool Hospital, Iran University of Medical Sciences
the Dept. of Statistics and Epidemiology, School of Public Health, Tehran University of Medical Sciences, Tehran, I.R. Iran.
From the Dept. of Immunology, School of Public Health, Tehran University of Medical Sciences
Total IgM, IgA, and IgM-rheumatoid factor (RF) and IgA-RF were
quantitated in the serum and synovial fluid of 35 seropositive and 8 seronegative
rheumatoid arthritis (RA) patients, using a sensitive enzyme-linked
immunosorbent assay (ELISA). Mononuclear cells isolated from peripheral blood
and synovial fluid of three seropositive patients were also stimulated in vitro with
phorbol myristate acetate (PMA) and culture supernatants collected for
measurement of total immunoglobulin (lg) and RF. Our results demonstrated that
as a proportion of total Ig, IgM-RF and IgA-RF were significantly higher in the
synovial fluid of seropositive patients compared to their serum level. Similar
results were observed for in vitro stimulated culture supernatants from the same
patients. This difference, however, was not evident in the seronegative group of
patients.
These results indicate that synovium could be considered as the original site
of RF production in seropositive RA patients, and that different repertoires of Blymphocytes
may be involved in RF production in peripheral blood and synovial
tissues of affected joints.
http://mjiri.iums.ac.ir/article-1-1110-en.pdf
Rheumatoid factor
Rheumatoid arthritis
Synovial fluid
Enzyme-linked immunosorbent assay (ELISA)
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
87
90
article
LIPOPRO TEIN AND APOLIPOPROTEIN ME TABOLISM AMONG PATIENTS UNDER CHRONIC HEMODIALYSIS TREATMENT
ABBAS SAMADI
1
GHOLAMREZA VALl
2
From the Department of Biochemistry, Kashan Medical University, P.O. Box 87155-111, Kashan, Islamic Republic of Iran.
Pathogenic factors that may contribute to hypertriglyceridemia were studied
in 55 patients who have been undergoing chronic hemodialysis treatment. Increased
levels of triglyceride were observed in the patient group compared to normal
controls (19o±93 mg/dL vs. 121±45 mg/dL, p<O.05). Similarly, augmented
concentrations of VLDL-C were observed among patients compared to the control
subjects (36±18 mg/dL vs. 24±8 mg/dL, p<O.05). The major fraction of serum
cholesterol was distributed in LDL and lesser amounts were measured in VLDL
and HDL. The HDL-C fraction did not display significant variation in the patient
group as compared to normal subjects. Apo B levels were higher in the patient
group compared to normal subjects (97±26 mg/dL vs. 87±14 mg/dL, p<O.05). In
addition, apo A-I levels were significantly lower in the patient group compared to
control subjects (84±13 mg/dL vs. 119±14 mg/dL, p<O.05). A reverse relationship
was observed between the concentration of plasma albumin and total cholesterol
which may explain the reason for overproduction of lipids in renal failure,
although other factors may contribute to the increased lipoprotein production
observed in patients receiving chronic hemodialysis treatment.
http://mjiri.iums.ac.ir/article-1-1109-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1997-08
11
2
81
86
article
EVENTRATION OF THE DIAPHRAGM: A 10- YEAR EXPERIENCE
N SADEGHlAN
1
EM KIELY
2
From the Department of Pedialric Surgery. Greal Ormond Street HospiJaJ for Sick Children. London. England.
Eventration of the diaphragm is a condition characterized by an attenuated but
otherwise intact diaphragm.
Twenty patients (age range: 2 days to 11 years) were treated for eventration
of the diaphragm during a ten year period (19 85-1995). There were 11 girls and 9
boys with a mean gestational age of 37 weeks. 14 patients were born with cephalic
presentation, 3 patients with breech delivery and 3 patients by caesarean section.
In 5 cases with difficult delivery, forceps were used. Mean birth weight of patients
was 2510 gm (range 900 to 3500 g). The most common clinical manifestations of
these patients were respiratory distress (16 cases) and failure to thrive (14 cases
below 3rd percentile).
50% of patients (10 cases) had from 1 to 5 associated anomalies. Cardiac
anomalies were the most common (n= 5), followed by respiratory system anomalies
(n= 4), malrotation (n= 3), and hiatal hernia (n= 2). All patients had an elevated
diaphragm in the chest radiograph (n= 20), but only some had paradoxical
movement in fluoroscopic studies (n= 5). In 8 patients GI contrast studies were
performed and three patients were found to have malrotation.
15 patients had right, 3 patients left, and two patients bilateral diaphragmatic
eventration. 18 patients underwent operation (plication), while two patients with
small and asymptomatic eventration were not operated. Operative repair was
performed with no mortality. Hospital stay was 14.5 days. 12/20 patients had come
for follow-up and they were evaluated from 5 months to 10 years. All showed good
results from diaphragmatic plication without respiratory distress or infection and
gained weight from below the 3rd percentile to above the 10th percentile. Surgical
correction is strongly recommended in patients with eventration of the diaphragm
and failure to thrive or other clinical manifestations.
http://mjiri.iums.ac.ir/article-1-1108-en.pdf
Eventration of the Diaphragm. Bilateral Even tration of the Diaphragm. Plication of the Diaphragm
Respiratory Distress
Failure to Thrive
Cytomegalovirus Infection.