eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
257
258
article
ANTERIOR URETHRAL VALVE ASSOCIATED WITH POSTERIOR URETHRAL VALVE
A A. RAZI
1
J ZARGOUSHI
2
D MOHAMMADI
3
From the Department of Urology, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
A rare case of anterior urethral valve in association with posterior urethral
valuve is reported. Clinical findings are discussed, and the available literature will
be briefly reviewed.
http://mjiri.iums.ac.ir/article-1-1196-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
255
256
article
RECONSTRUCTION OF PENILE SKIN DEFECT BY CUTANEOUS FLAP FROM THE INNER ASPECT OF THE THIGH
AKBAR BERDAD
1
From the Department of Orthopedics, Ayatollah Kashani Hospital, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Two patients with penile skin loss who were operated in 1991 are reviewed
retrospectively. In both of them skin grafting was mandatory (due to large skin
defects on the penile shaft). Causative factors were localized infection in one case
and verrucae accuminata in another.
In both cases a random flap from the skin of the inner surface of the thigh was
applied. The pedicle flap was later transected.
http://mjiri.iums.ac.ir/article-1-1195-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
249
254
article
APPARENT MINERALOCORTICOID EXCESS IN THREE SIBLINGS
MARYAM RAZZAGHY-AZAR
1
JANOS HOMOKI
2
From the Dept. of Pediatrics, Hazrat Aliasghar Children's Hospital, lran University of Medical Sciences
the Dept. of Biochemistry, Ulm University, Ulm, Germany
Three siblings (1 boy, 2 girls) with hypertension and hypokalemia are
presented, two with low plasma aldosterone and suppressed renin activity and the
eldest with a high renin and aldosterone level due to secondary changes in her
kidneys. Urinary tetrahydrocortisol (THF) was increased relative to
tetrahydrocortisone (THE). Cortisol ring A reduction constant was also lower than
normal. These findings are suggestive of decreased cortisol-II β-hydroxysteroid
dehydrogenase activity and ring A reduction defect which has previously been
described in type 1 apparent mineralocorticoid excess.1 The existence of this
disease in three siblings from healthy parents with consanguinous marriage
reveals the genetic (autosomal recessive) nature of the disease.
Spironolactone normalized serum potassium in all three patients and hypertension
in two of them. Furosemide and captopril were required for lowering blood
pressure in the eldest one. Treatment caused growth catch up in all three patients
http://mjiri.iums.ac.ir/article-1-1194-en.pdf
Low renin hypertension
hypokalemia
cortisol metabolism
cortisol-11 β-hydroxysteroid dehydrogenase.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
247
248
article
SUDDEN VENTRICULAR FIBRILLATION DURING CATHE TERIZATION DUE TO LIDOCAINE INFILTRATION FOR LOCAL ANESTHESIA IN A 53 YEAR OLD WOMAN
SEYYED HASSAN AREFI
1
From the Department of Cardiology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Mrs. Heidari, 53 developed ventricular fibrillation and cardiopulmonary
arrest after receiving 15 mL lidocaine 2% for local anesthesia at the Dr. Shariati
Hospital Cathlab. There was no identified risk factor for her arrest preoperatively.
She had a history of exertional chest pain for about 5 years and an electrocardiogram
showed only inverted T-waves at the time of angiography. The case is
reviewed in detail and a discussion of lidocaine toxicity is presented.
http://mjiri.iums.ac.ir/article-1-1193-en.pdf
Lidocaine. toxicity; Ventricular fibrillation
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
241
246
article
MEDICAL ASPECTS OF ISLAMIC FASTING
FEREIDOUN AZIZI
1
From the Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
http://mjiri.iums.ac.ir/article-1-1192-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
237
240
article
STUDY OF THE EFFECT OF RESIDUAL CHLORINE ON SERUM IRON AND RELATED PARAMETERS
AA MOSHTAGHIE
1
H POURMOGHADAS
2
B AGHDAMIZADEH
3
From the Department of Clinical Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
The major purpose of the present investigation was to study the effects of
different concentrations of residual chlorine on serum iron related parameters in
rats. Feeding male rats with water containing 80 ppm of residual chlorine daily for
5 days reduced serum levels of ceruloplasmin, copper, iron and hemoglobin by
approximately 27%,23%,6% and 4%, respectively. Higher reductions in serum
ceruloplasmin (35%), copper (50%), Fe (17%) and hemoglobin (14%) were
observed when rats were given water containing 160 ppm of residual chlorine daily
for 5 days. The total iron binding capacity (TIBC) level was elevated by 9 and/or
13 percent respectively. Daily feeding of rats for 1 0 days with water containing 160
ppm residual chlorine caused significant reductions in serum levels of ceruloplasmin
(50%), copper (54%) iron (17%) and hemoglobin (17%). Serum TIBC was
elevated by 25%. Long term effects of residual chlorine on the above parameters
were also investigated. It can therefore be .concluded that residual chlorine in
drinking water may interfere with iron metabolism. The relationship between the
occurrence of anemia and residual chlorine toxicity has been discussed.
http://mjiri.iums.ac.ir/article-1-1191-en.pdf
Residual chlorine
ceruloplasmin
hemoglobin
copper
iron
TIBC.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
233
235
article
A RAPID AND SIMPLE METHOD OF DNA EXTRACTION FROM CLINICAL SPECIMENS CONTAINING MYCOBACTERIUM LEPRAE FOR PCR ASSAYS
ABDOLNASSER RAPI
1
MOHAMMED H. MOBAYEN
2
FRANCOIS FEVAL
3
JOHN L. STANFORD
4
From the Department of Medical Microbiology, UCL Medical School, University of London, U.K
the Baba Baghi Leprosy Hospital, Tabriz, Islamic Republic of Iran.
the Baba Baghi Leprosy Hospital, Tabriz, Islamic Republic of Iran.
From the Department of Medical Microbiology, UCL Medical School, University of London, U.K
We describe a rapid, simple, and reliable procedure for routine isolation of
Mycobacterium leprae DNA from slit-skin swab specimens. This one-step DNA
extraction method is based on the utilization of ChelexR 100, a chelating ion
exchange resin. Slit-skin swab specimens from seven untreated leprosy patients at
Baba Baghi Leprosy Hospital in Iran were processed by this procedure. The
polymerase chain reaction (PCR) was performed with primers for a 530-base pair
(bp) fragment of the gene encoding the 36 kDa antigen of M. leprae. All the
specimens were found to be PCR -positive, suggesting the efficiency of the present
DNA extraction method.
http://mjiri.iums.ac.ir/article-1-1190-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
229
232
article
PRACTICAL PROBLEMS AND THE EFFICACY OF INTRAOSSEOUS INFUSION: SOLVING THE PROBLEMS BY EMPLOYING AN ANIMAL MODEL
PEDRAM NIKNAFS
1
ALlREZA SOTUDEHNEJAD
2
HAMID TABRIZCHI
3
From the Departments of Pediatrics Kerman University of Medical Sciences and Health Services, Kerman, Islamic Republic of Iran.
From the Departments of Surgery Kerman University of Medical Sciences and Health Services, Kerman, Islamic Republic of Iran.
From the Departments of Pathology, Kerman University of Medical Sciences and Health Services, Kerman, Islamic Republic of Iran.
In critically ill infants and children, intravascular (IV) access is sometimes
very difficult. In such cases intraosseous (IO) infusion should be used as the
method of choice. However, in practice, different problems are experienced with
this procedure. To overcome the practical problems and to confirm the efficacy of
IO infusion in reversing hypovolemic shock, an animal model was used by
employing three rabbits. In rabbit I, after insertion of a 14-gauge bone marrow
aspiration needle in the proximal tibia, the flow rate of normal saline was very slow
by gravity, but pressure infusion devices including manual pushing with a syringe,
blood pressure cuffs, or infusion pumps all increased the flow rate remarkably. In
rabbit II, the circulation time of a dye given by IO route was very short therefore
drugs are expected to appear in the systemic circulation shortly after IO injection.
In rabbit III, hypovolemic shock was induced by withdrawing blood and then,
rapidly and successfully treated by IO infusion of normal saline.
http://mjiri.iums.ac.ir/article-1-1188-en.pdf
Intraosseous infusion
hypovolemic shock
animal model.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
225
228
article
LOW VOLTAGE ELECTRICAL STIMULATION AND WOUND HEALING IN RABBITS: EFFECT OF ALTERING FREQUENCY
SOHRAB HAJI ZADEH
1
ALI KHOSHBATEN
2
ALIREZA ASGARI
3
MOHAMMAD KHAKSARI
4
From the Dept. of Physiology, School of Medical Sciences, Tarbiat Modarres University, Tehran,
BaghiataUah University of Medical Sciences and the Janbazan Engineering and Medical Sciences Research Institute, Tehran, Islamic Republic of Iran.
BaghiataUah University of Medical Sciences and the Janbazan Engineering and Medical Sciences Research Institute, Tehran, Islamic Republic of Iran.
From the Dept. of Physiology, School of Medical Sciences, Tarbiat Modarres University, Tehran,
The effect of electrical currents by different modalities on wound healing has
been experimented. In this study a survey of the literature shows different results,
and the mechanisms of action have not been elucidated for certain. The aim of this
study was to compare the results obtained from low voltage-square wave stimulation
of different frequencies. Results show that the healing period for the control
group (14.9 ± 0.58 days) was reduced to 11.28 ± 0.52 and 10.37 ± 0.7 days for
groups receiving 20 and 80 Hz stimulation respectively. This implies that wound
closure as an index of wound healing was significantly increased in animals
receiving 80 Hz stimulation. Tensile strength was increased from 2013 ± 192
grams in controls to 2589 ± 235.1 grams in the 80 Hz-receiving study group. We
concluded that electrical stimulation can affect the process of healing and a
stimulation of 80Hz is more effective than other frequencies.
http://mjiri.iums.ac.ir/article-1-1187-en.pdf
Electrical stimulation
Wound healing
Tensile strength.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
219
224
article
PRODUCTION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES TO CLOSTRIDIUM PERFRINGENS ENTEROTOXIN DERIVED FROM DIFFERENT ANIMAL SPECIES
LAIA GHARAVI NAEINI
1
ROBERT P. ELLIS
2
From the National Research Center for Genetic Engineering and Biotechnology, Tehran, Islamic Republic of Iran
the Department of Microbiology, Colorado State University, Colorado, U.SA.
The enterotoxins (ETs) of Clostridium perfringens isolated from enterotoxemic
or diarrheic alpacas, pigs, calves, dogs, and horses were obtained from sporulated
cell extracts. The ETs from alpaca, pig, and calf isolates were chromatographed on
Sephadex G-lOO. Monoclonal antibodies (MAbs) against ETs derived from
alpaca, pig, and calf C. perfringens isolates were produced. The MAbs were used
in neutralization of cytotoxicity and immunoblot assays to study cross-reactivity
among all five ETs. Using neutralization of cytotoxicity technique, each MAb
exhibited neutralization against the cytopathic effect of all five ETs on Vero cells.
The neutralization ratio in this study was I ng ET: 50 ng MAb. On immunoblots,
the anti-alpaca ET and anti-pig ET cross-reacted with partially purified ETs from
pig and alpaca respectively. In addition, anti-alpaca ET and anti-pig ET crossreacted
with partially purified ETs from calf and horse, but not ET from dog
isolates. The anti-calf ET cross-reacted with alpaca, calf, dog, and pig but not with
ET from the horse isolate. The immunoblots also indicated that the MAbs
recognized aggregated ET subunits. Our data indicated that C. perfringens ETs
derived from different animal species are very similar.
http://mjiri.iums.ac.ir/article-1-1186-en.pdf
C. perfringens; Enterotoxin; Monoclonal Antibody
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
211
217
article
THE EFFECT OF HYPERTHERMIA ON THE DIFFERENTIATION OF LEUKEMIC CELL LINES
ABDOL KHALEGH DEIZAJI
1
BAHRAM GOLlAEI
2
From the Institute of Biophysics and Biochemistry, University of Tehran
the National Research Center for Genetic Engineering and Biotechnology, Tehran, Islamic Republic of Iran
Treatment of human promonocytic leukemic cell line U937 with mild
hyperthermia in the temperature range of 40-43°C resulted in differentiation of
these cells into monocyte/macrophage-like cells in a heat dose and time dependent
manner. This process was accompanied by marked morphological, functional and
proliferational changes. U937 cells which normally grow in supension in the
logarithmic phase of growth showed marked inhibition in proliferation after
treatment with heat in comparison with controls, without significant decrease in
cell viability. The clonogenicity of these cells in semisolid agar cultures was also
reduced upon heat treatment. Heat treatment increased the fraction of cells which
could reduce nitro blue tetrazolium (NBT) and phagocytize latex particles. These
data demonstrate that heat treatment can induce differentiation ofU937 cells into
monocytes/macrophages and thus have possible applications in treatment of
leukemia. Temperatures higher than 43°C or exposures of longer than 30 minutes
at such high temperatures resulted in cytotoxic effects.
http://mjiri.iums.ac.ir/article-1-1185-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
207
210
article
THE ROLE OF PACEMAKER CLINIC IN THE FOLLOW-UP OF PATIENTS WITH PERMANENT PACEMAKERS
MAJID MALEKI
1
MOHAMMADREZA MOHAMMADHASANI
2
F NOOHI
3
From the Pacemaker Clinic, Shahid Rajai Heart Hospital and Cardiovascular Research Center, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.
The Pacemaker Clinic at Shahid Rajai Cardiovascular Research Center first
started operating in August 1992. In its first year of operation, 294 permanent
pacemaker patients were studied, allowing an appraisal to be carried out of the
clinic's effectiveness in diagnosing and treating early complications. In the final
analysis, pacemaker complications were observed in 68 (23%) patients, of whom
38 (56%') were treated by reprogramming the unit and without requiring any
operation.
The most common type of pacemaker complication observed was "undersensing"
in 20 (29.5%) patients, followed by lack of myocardial capture by the
pacemaker in 17 (25%) patients.
http://mjiri.iums.ac.ir/article-1-1184-en.pdf
Pacemaker
Undersensing
Myocardial Capture.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
203
206
article
LEAD TOXICITY IN EMPLOYEES OF A PAINT FACTORY
MOHAMMAD ABDOLLAHI
1
ALI SADEGHI MOJARAD
2
NASER JALALI
3
From the Department of Toxicology, School of Pharmacy, Tehran University of Medical Sciences, Tehran,
From the Department of Toxicology, School of Pharmacy, Tehran University of Medical Sciences, Tehran,
the Loghman Hospital Toxicology Center, Tehran, Islamic Republic of Iran.
Lead-based paint is an important cause of lead poisoning. This report
describes our observation of excessive lead absorption among employees in a paint
factory in which lead naphthenate and lead oxalate were used as drying agents in
paint. In this study, blood levels of lead were compared between nineteen paint
factory employees and twenty normal controls.
The nineteen paint factory employees had a mean blood lead concentration
of 50.71 µg/dL which was significantly (P<0.01) higher than that of controls
(20.44 µg/dL). There was a good correlation between blood lead levels and job
tenures of the employees [r= 0.55, confidence= 95% (0.13-0.81)]. Lumbar pain
(47.37%), abdominal pain (42.1% ), renal complications (21 %), anxiety (39.1 %),
nervousness (52.63%), headache (42.4%), peripheral pain (36.8%) and anemia
(10.5%) were the chief complaints of these employees. The use of lead naphthenate
and lead oxalate in paint is clearly associated with excessive air-borne exposure
to lead. Technical and medical protective control of occupational exposures is
needed in paint industries.
http://mjiri.iums.ac.ir/article-1-1180-en.pdf
Poisoning
Lead; Paint
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
197
201
article
DE TERMINATION OF NEUTRALIZING ANTIBODIES AGAINS T THE MUMPS VIRUS IN SELECTED GROUPS IN TEHRAN AND TWO IRANIAN VILLAGES
MH ROUSTAI
1
R NATEGH
2
M NOROOZI
3
MB ESLAMI
4
M MAHMOODI
5
T MOKHTARI AZAD
6
K HOLAKOOE NAEENI
7
M PEZESHKI
8
From the Dept., of Virology, Faculty of Medical Sciences, Tarbiat Modarres University , P.O. Box 14155- 4838, Tehran
the School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
the School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
the School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
the School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
the School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
the School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
the School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
A micro neutralization test was used for the detection and evaluation of mumps
neutralizing antibodies. A total of 1037 blood samples from selected groups of
students aged 7 to 22 years in south and east of Tehran, 139 blood samples from the
umbilical cords of pregnant women at two Tehran hospitals at delivery time, and 190
samples from children under five years of age who were living in two villages located
in Zandjan province, were tested. The results of this study indicated that the
percentage of the above mentioned sera having mumps virus neutralizing antibodies
with a titer of 1:2 or greater was 69.6%,92.8%, and 29.5%, respectively.
Vaccination against mumps is optional in the Islamic Republic of Iran and
therefore it is believed that the virus is circulating among susceptible subjects. These
data also suggest that children could be a target for mumps vaccination.
http://mjiri.iums.ac.ir/article-1-1178-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
195
196
article
ASSESSMENT OF QUALITY OF LIFE IN 50 PATIENTS WHILE UNDER HEMODIALYSIS AND FOLLOWING KIDNEY TRANSPLANT
R MAHDAVI
1
H SADEGHI
2
From the Renal Transplant and Hemodialysis Division, Imam Reza Medical Center, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
The quality of life of 50 end stage renal disease (ESRD) patients on
hemodialysis was evaluated before and after kidney transplantation (KTx). Mean
duration of the patients' hemodialysis was 3 years and mean postoperative period
was 2.4 years when tested. Common problems of such patients such as depression,
sleep disorders, energy pattern disruption, sex-life difficulties, and appetite
disorders were assessed using a five point scale (very good, good, medium,
difficult and disabled). Following renal transplant, more than 80% of patients
showed an improvement in several aspects in this regard.
http://mjiri.iums.ac.ir/article-1-1174-en.pdf
Quality of life
Hemodialysis
Kidney transplant.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
191
194
article
ALTERATION OF T-LYMPHOCYTE SUBPOPULATIONS IN SUBACUTE AND CHRONIC BRUCELLOSIS
AA POURFATHOLLAH
1
MB ESLAMI
2
AR YALDA
3
AF SARRAF NEJAT
4
From the Dept. of Immunology, School of Medical Sciences, Tarbiat Modarress University, Tehran
the Departments of Pathobiology Tehran University of Medical Sciences,
Infectious Diseases, Tehran University of Medical Sciences,
the Departments of Pathobiology Tehran University of Medical Sciences,
Human brucellosis is a major health problem in developing countries. A
number of patients with human brucellosis do not recover from the acute stage of
the disease and pass into the chronic form. Since the pathophysiology of this
change is not well understood, we studied the T-cell subsets during the acute,
subacute and chronic forms of human brucellosis. In this study we found
alterations in T-Iymphocyte subsets and in the CD4/CD8 ratio in subacute and
chronic brucellosis while no significant change was found in T-cell subsets in
acute brucellosis. We believe that this alteration of T-cell subsets is important in
the pathophysiology of brucellosis, but it is not clear whether brucella cause this
change or a primary immunodysfunction in patients with a disturbance in T-cell
subset regulation prevents recovery from acute brucellosis and leads to the
development of chronic brucellosis.
http://mjiri.iums.ac.ir/article-1-1172-en.pdf
Brucellosis
CD4
CD8
T-Iymphocyte
Alkaline phosphatase anti-alkaline phosphatase (APAAP) method
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
183
189
article
SHORT TERM VARIATION OF ATROPINE BLOCKADE IN THE TRACHEOBRONCHIAL TREE OF ASTHMATIC SUBJECTS
MH BOSKABADY
1
PD SNASHALL
2
From the Department of Physiology. Ghaem Medical Center. Mashhad University of Medical Sciences. Mashhad. Iran
the Dept of Medicine. Charing Cross and Westminster Medical School. Fulham Palace Road. London W6 BRF. UK
In asthmatic subjects there is a pronounced diurnal variation in bronchial
responsiveness. If this phenomenon is due to variation in factors that control drug
delivery, then it should be paralleled by a similar variation in competitive
antagonist blockade.
In order to study this possibility, we performed the methacholine challenge
test and after 45 minutes, administered atropine by inhalation. Methacholine rechallenge
was performed 25 minutes after premedication with atropine. Bronchial
responsiveness to methacholine(pB3s) and atropine blockade was then measured.
Eight normal subjects and 9 asthmatic patients were tested on two separate
occasions, one in the morning at 08:00 hours and the other in the evening at 18:00
hours with at least 48 hours gap between them.
In normal subjects there was no significant difference between morning and
evening concerning airway caliber, bronchial responsiveness to methacholine and
atropine blockade. In asthmatic patients there was a significant difference between
morning and evening in bronchial responsiveness to methacholine (P<0.001) and
atropine blockade (P<0.001), although there was no significant difference in
airway caliber.
The possible explanation for' enhanced atropine blockade as well as
methacholine responsiveness in asthmatic subjects in the morning is increased
bronchial and tissue permeability due to worsening bronchial inflammation in the
early morning leading to increased drug delivery to active sites in the airways.
http://mjiri.iums.ac.ir/article-1-1170-en.pdf
Short term variation
atropine blockade
asthma.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1996-11
10
3
179
181
article
THE EFFECTS OF CAPTOPRIL ON PULMONARY AND SYS TEMIC ARTERIAL PRESSURES IN HIGHALTITUDE PULMONARY HYPERTENSION
TALANTBEK A BATYRALIEV
1
KAIRGELDY S. AYKlMBAEV
2
GULMIRA Z. KUDEYBERDIEVA
3
FERIT AKGUL
4
GYLDYZ K. SODANBEKOVA
5
From the Department of Cardiology, Balcali Hospital, Cukurova University, Adana, Turkey.
The purpose of this investigation was to assess the effect of captopril on both
systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude
pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years)
with HAPH and mild to moderate systemic arterial hypertension were included in
the study. All patients underwent right heart catheterization with measurements of
systolic PPA (PPA,syst) , mean PPA, (P¯PA) and diastolic PPA (PPA,diast)• After 4 weeks
placebo phase patients with a PPA, sst> 25 mmHg, P¯PA > 15 mm Hg and systemic
diastolic blood pressure (Pa,diast) >100 mmHg were given captopril (50-75 mg at 8
am) for a period of 12 weeks. The statistical evaluation of the results was made
using Student's t-test. It was found that captopril significantly decreases PPA and
Pa.
http://mjiri.iums.ac.ir/article-1-1167-en.pdf
Captopril
pulmonary hypertension
systemic hypertension
high-altitude pulmonary hypertension.