eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
65
67
article
PINWORM OF THE EYE TREATED WITH GARLIC JUICE
MR NIAKAN LAHIDJI
1
M PESSIAN
2
I MOBEDI
3
AA SEPIDGAR
4
From the School of Pharmacy
School of Medicine, Gorgan University , Gorgan
the School of Public Healt, Tehran University of Medical Sciences, Tehran
the Mazandaran Medical Sciences, Mazandaran, Islamic Republic of Iran.
This is the second report of conjunctival sac pinworm infection in the
literature. The patient was treated with garlic juice, which was prepared as an eye
drop. The first case reported from India was a IS year old girl who had pinworm
infection of her left eye. She had wonnexpulsion•at night. Our case was a 13 year
old girl who had worm infestation in both eyes, along with frequent pinworm
discharge at night and occasionally during the day.
No single male worm was collected during infection. All collected pinworms
were identical to Enterobills vermielilaris, though a little smaller in size.
Our patient was from a crowded family, and probably acquired eye infection
through infected fingers or towels. Infection was present for one year before
treatment. During this period no reinfection had occurred but the conjunctiva were
not able to cease infection spontaneously, as this usually occurs in intact mucosa
of the human intestine during natural infection in two months.
http://mjiri.iums.ac.ir/article-1-1355-en.pdf
Pinworm (Oxyuris)
Garlic (Allium sativum)
Conjunctiva.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
61
64
article
THE CONUNDRUM OF EUTHANASIA
ZAHlD HUSSAIN KHAN
1
From the Department of Anesthesiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
http://mjiri.iums.ac.ir/article-1-1354-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
53
60
article
THE CYTOTOXIC EFFEC T OF CHELIDONIUM ALKALOIDS ON CELLS ISOLATED FROM ADULT RAT LIVER
SULEIMAN AFSHARYPOUR
1
MOHAMMAD SUZANGAR
2
NAJMEH BARADARAN
3
From the Faculty of Pharmacy & pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Alkaloids of the aerial parts of chelidonium were extracted in the salt
form, and their aqueous solutions were prepared in different concentrations.
Rat hepatocytes were obtained by liver perfusion. The alkaloidal solutions
were added to suspensions of hepatocytes in petri dishes and the mixtures
were incubated. Two types of controls have been used in one type. no
alkaloidal extract was added to the media, and in the other, alkaloidal extract
of datura which has no cytotoxic activity was added to the hepatocytes.
Intracellular LOH activity as well as the activity of leaked LOH into the
media, the glucose uptake by the cells, and the glycogen contents of the cells
were determined after incubation.
The results indicate that 0.05 ml of the alkaloidal solution of chelidonium
has no detectable effect on LOH activity during a 240 minute incubation
period. With n.1 ml doses, detectable changes were observed only after 240
minutes of incubation. When 0.2 ml doses were used, the intracellular LOH
activity was lowered by 3.23,n.71) and 30.XI) percent after nO,120 and 240
minutes of incubation respectively, as compared with the controls. The activity
of leaked LOH into the media duration of incubation was increased. Determination of glucose in different
media showed that the uptake of this sugar by the hepatocytes incubated with
chelidonium decreased as the dose and incubation periods increased. On the
other hand, as the glycogen content of the hepatocytes incubated with
chelidonium was the same as that of the controls, we believe that the hepatocytes
lost their viability in the presence of chelidonium-derived cytotoxic
alkaloids.
http://mjiri.iums.ac.ir/article-1-1353-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
47
51
article
THE DISTURBANCES IN IRON TRANSPORT AND STORES AND TOTAL FREE RADICAL TRAPPING ABILITY OF BLOOD PLASMA IN BABIES WITH MITOCHONDRIAL ENCEPHALO MYOPATHIES
A JENDRYCZKO
1
E MARSZAL
2
M KRAUZE
3
From the Department of Drag Chemistry, Silesian School of Medicine, 41-200 Sosnowiec
Babies with mitochondrial encephalomyopathies had higher ferritin levels
than controls. Although plasma iron levels were simi lar in both groups, babies with
mitochondrial encephalomyopathies had lower transferrin levels. Thiobarbituric
acid reactive substances in plasma of babies with mitochondrial
encephalomyopathies were higher thun in controls suggesting increased lipid
oxidation. We studied the total radical trapping capacity of the antioxidants in
plasma (TRAP) and compared the TRAP level in children with mitochondrial
encephalomyopathies with that in healthy controls. I n addition, the concentrations
of various known antioxidants were measured and the theoretical contribution of
these antioxidants to the TRAP calculated. The measured and calculated TRAP
were higher in the control group than the group of children with mitochondrial
encephalomyopathies. Uric acid, vitamins E and C and sulphides concentrations
were lower in children with mitochondrial encephalomyopathies compared with
controls. The main conclusion from this work is that forchildren with mitochondrial
encephalomyopathies, plasma contents of vitamin E, vitamin C, and cysteine-rich
proteins which are all essential nutrients are too low for optimal activity of
antioxidant systems.
http://mjiri.iums.ac.ir/article-1-1352-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
41
46
article
MICROBIOLOGICAL EVALUATION OF SOME OPHTHALMIC PREPARATIONS CONTAINING DIFFERENT CONCENTRATIONS OF BENZALKONIUM CHLORIDE
HASAN ADIL
1
From the Department of Pharmaccutics, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan.
Zinc sulphate and boric acid ophthalmic preparations, containing benzalkonium
chloride as preservative, have been investigated against gram-negative and
positive bacteria. Viability of bacteria was found after 7 days, although it was
completely suppressed after 24 hours of inoculation. Zinc sulphate generally
increases the antimicrobial activity of benzalkonium chloride, whereas boric acid
or its combination with zinc sulphate reduce it. Pseudomonas aeruginosa was
shown to be viable against zinc sulphate, boric acid, and their combination at a
concentration of 0.0 I % to 0.005% of the preservative. Escherichia coli and
Staphylococcus aureus were also found to be resistant but to a lesser extent than
Pseudomonas aeruginosa. This viability may be dangerous in case of multidose
ophthalmic preparations.
http://mjiri.iums.ac.ir/article-1-1351-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
37
40
article
LA BORATORY IDE NTIFICATION OF DERMATOPHYTES USING PROTOPLAST HYBRIDIZATION
MOSTAFA CHADEGANIPOUR
1
VERNON AHMADJIAN
2
From the' Dept. of Mycology and Parasitology, Isfahan University of Medical Sciences, Isfahan
the Mycology Laboratory, Clark University, Massachusetts, U.S.A.
In this study techniques for laboratory identification of dermatophyte fungi
through protoplast hybridization were established. Firstly, auxotrophic mutants of
different species of microsporum and trichophyton were induced and identified.
Secondly, protoplasts from these mutants were isolated by digestion of their
mycelium with Novozyme 234 using CaCI, (O.4M) as an osmotic stabilizer and
glycine + HCI (pH 4.5) as the buffer system. Thirdly, isolated protoplasts from
different species were fused using a solution containing 35% polyethylene glycol,
I M KCI, 0.05 M CaCI, and 0.05 M glycine with pH 6.1. Afterwards, the fusion
products were plated onto minimal and complete media. It was found that
protoplasts from different auxotrophic mutants from the same species hybridized
and complemented each other and grew on both minimal and complete media.
whereas mutants from different species did not have the ability to complement
each other and therefore grew only on complete media. Information obtained in
this study may prove useful for definite identification of suspected species of
dennatophytes other than morphological criteria in laboratories.
http://mjiri.iums.ac.ir/article-1-1350-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
33
36
article
BIOLOGICAL MONITORING OF MERCURY EXPOSURE IN DENTISTS OF TEHRAN
FARIDEH GOLBABAIE
1
PARVIN NASSIRI
2
MAHMOUD MAHMOUDl
3
From the Department of Occupational Health, School of Public Health, P.O. Box 6446-14155 Tehran, Islamic Republic of Iran.
In order to assess the risk for mercury poisoning in dentists, urine specimens
were collected and analysed from 250 dentists (190 male, 60 female). Subject data
and pertinent health symptoms were asked via a questionnaire. The results indicate
that the mean and standard deviation of mercury values were 51.3± 38.0 µg/L,
while 27.2 percent of dentists had levels within normal limits (0-19 µg/L). The
results also showed that values for general practitioners tended to be higher, but
was not significant for the specialists. The data demonstrated that there is an
association between health symptoms pertinent to mercury poisoning and urine
mercury values above 50 µg/L
http://mjiri.iums.ac.ir/article-1-1349-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
27
32
article
IS TAR ANJEBIN A PROPHYLACTIC AGENT FOR NEONATAL JAUNDICE?
ZAHRA PANJVANI
1
HAMED KHARRAZI-SABET
2
SAID TAWAKKULI
3
MOHAMMAD REZA RAMAZANI
4
MOHAMMAD TAGHI SARRAF
5
From the Department of Pediatrics and Pharmacology, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
Taranjebin is a plant resin obtained from camel's thorn, a shrub abundant in
desert areas of Iran. It contains saccharose and has been traditionally used by
grandmothers to treat neonatal jaundice. This study was conducted to test the
effectiveness of taranjebin in reducing bilirubin in physiologic ranges when used
prophylactically in normal full-term newborns. ,95 term healthy newborns were
given 10,20, or 30% taranjebin starting at4 hours of age for 3 days, while ')0 infants
were given placebo. Mean serum bilirubin levels were determined on day S for
both study groups, as were daily transcutaneous bilirubin indices. In the 30%
taranjebin group, 5 of 29 treated infants developed jaundice (bilirubin I Ii mg per
dl) compared to none in the control group (p< 0.05).
Taranjebin was thus not found to be effective in preventing hyperbilirubinemia
in normal healthy term newborns.
http://mjiri.iums.ac.ir/article-1-1348-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
19
25
article
ENDEMIC GOITER AND HYPOTHYROIDISM IN ORANG ASLI AND MALAYS IN PENINSULAR MALAYSIA
OSMAN ALI
1
B.A.K. KHALID
2
T.T. TAN
3
O SAKlNAH
4
LL WU
5
ML NG
6
From the Department of Community Health
'Department of Medicine
'Department of Medicine
'Department of Medicine
Department of Paediatrics
Department of Biochemistry, Medical Faculty, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
The study was conducted to determine the prevalence of goiter and
hypothyroidism in two groups of the population at various stages of social development
and to determine its association with malnutrition and dietary intake. Aboriginal
inhabitants (Orang Asli), a resettlement rural village (Betau Post), a traditional
village in the jungle (Lanai Post) and a modern village settlement near Kuala Lumpur
City (Bukit Lanjan) were selected. Three Malay villages with almost similar
environments were selected for comparison. The study included house to house
interviews, anthropometric, clinical and biochemical assessment of 1419 samples
and estimation of iodine concentration in the drinking water of the areas studied. The
World Health Organization criteria for classification of goiter were used. It was
found that all Orang Asli settlements in rural areas were iodine deficient. The
prevalence of goiter and hypothyroidism were higher among Orang Asli at all ages
compared to Malays, and increased with remoteness of the areas (20-70% and 20-
30% respectively). Apart from iodine deficiency, a high intake of cassava and
deficient intake of sea foods and protein diets were also significantly related with
high prevalence of goiter. Among children, goiter was associated with the level of
thyroid stimulating hormone (TSH) whereas among adults, body mass index (BM!),
triiodothyronine and thyroxine levels were predictors for the presence of goiter. In
conclusion, goiter and hypothyroidism were more common among Orang Asli
compared to Malays, and were associated with rural location and poverty.
http://mjiri.iums.ac.ir/article-1-1347-en.pdf
Goiter
Hypothyroidism
Malay
Orang Asli
Malaysia.
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
15
17
article
24-HOUR URINARY CALCIUM EVALUATION IN A HEALTHY POPULATION SAMPLE AND IN PATIENTS WITH UROLITHIASIS
SEYYED MOHAMMAD KAZEMINY
1
From the Department of Urology, Shahid Rahnemoon Hospital, Shahid sadoughy University of Medical Sciences, Yazd, I.R. Iran.
A study was designed to evaluate the normal value of 24 hr urinary calcium
levels in the city of Yazd. The average urinary excretion of calcium in a sample of
329 persons randomly selected was 232 mg/day, while patients with a history of
recurrent urolithiasis excreted 20X mg/day. There is evidence which shows that
more important factors than the amount of urinary calcium exist which influence
stone formation. On the other hand the urinary excretion of calcium was related to
blood pressure. These observations showed that measuring the amount of urinary
calcium excretion in patients with urolithiasis provided little or no helpful
information for the evaluation of these patients. Nevertheless, this test may be
valuable in other diseases such as hypertension.
http://mjiri.iums.ac.ir/article-1-1346-en.pdf
Urinary Calcium
Urinary stones
Hypercalciuria
Hypertension
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
13
14
article
COLONOSCOPIC POLYPECTOMY IN CHILDREN
HOSSEIN FOROUTAN
1
From the Department of Gastroenterology, Imam Khomeini Medical Center, Tehran University of Medical Sciences ,Tehran, Islamic Republic of Iran
34 children aged 9 months to 12 years presenting with chronic and intermittent
rectal bleeding were diagnosed as having colorectal polyps by fiberoptic
colonoscopy performed under sedation. Bleeding per rectum (mean duration, 15
months) was the chief presenting symptom and was present in 97% of these
patients. In 85% of patients polypectomy was carried out without using general
anesthesia. 7R% of patients had juvenile polyps and 22% had solitary adenomatous
polyps. Two children had two polyps. The majority (33%) of the polyps were
located in the rectosigmoid. Polypectomy was performed on all patients, and no
case of massive bleeding, bacterial infection or perforation occurred post-operatively.
Therefore, it seems that colonoscopic snare polypectomy is an effective and
safe procedure for the treatment of colorectal polyps in children.
http://mjiri.iums.ac.ir/article-1-1345-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1995-05
9
1
1
11
article
ESOPHAGEAL ATRESIA: RESULTS OF 108 CASES IN AN 11 YEAR PERIOD
A KHALEGHNEJAD TABARI
1
HR NOBLETT
2
D FRANK
3
From the Dept. of Paediaric Surgery, Bristol Royal Hospital for Sick Children, Bristol, England.
From October 1977 to December 1988, 108 neonates born with esophageal
atresia (EA) and/or a tracheoesophageal fistula (TEF) were treated at
the Bristol Royal Hospital for Sick Children.
An incidence of I :4000-4500 live births was noted. 1I2.4% had the common-
type anomaly, 5.5% had pure esophageal atresia, and 6.5% had an H-type
anomaly. 2.8% had upper and lower fistulae and 2.8% had upper fistulae.
Forty-nine patients (45.3%) had associated anomalies of which the cardiovascular
system (16.6%) was the most commom. With consideration of
the urogenital system as a unique system, urogenital anomalies were the
most common associated anomalies (20.3%). Thirty (27.7%) of lOll neonates
had V ACTERL associated anomalies, which were more frequent in the common-
type anomaly. Seven of 9 deaths in the VACTERL associated group
were because of associated anomalies and cardiac anomalies were a common
cause of late death in this study. In full-term and well babies with common-type
anomalies, transanastomotic tubes significantly decreased hospital stay.
Every effort was made to maintain the neonate's own esophagus, and in
pure esophageal atresia 5 of 6 neonates were successfully treated by spontaneous
growth and anastomosis and only I neonate underwent gastric- tube
formation as an esophageal replacement. Anastomosis was done in one layer
by 5/0 silk , and 17.14% developed leak, 29.62% strictures, 1.90% recurrent
fistula, and the rate of anastomotic complications was markedly higher in
delayed and staged operations. Fifty-three neonates (50.47%) had respiratory
complications which were the most common complication. Thirty-three
(31.4%) had gastroesophageal reflux (GER), all but one of which were
treated medically. The routine policy now is that all babies are put on
Gaviscon until the child can adopt an upright position.
Low birth weight and pneumonia are not contraindications for surgery,
and with the improvement of surgical technique and postoperative care, do
not affect survival. There was 12.03% mortality and the main cause of death
was associated anomalies.
http://mjiri.iums.ac.ir/article-1-1344-en.pdf