eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
263
268
article
SIGNIFICANT CHANGES IN THE ACTIVITY OF GABATRANSAMINASE AND SUCCINATE SEMIALDEHYDE DEHYDROGENASE OF MOUSE HYPOTHALAMUS FOLLOWING PERIPHERAL INJECTION OF CHOLECYSTOKININ-8 AND/OR CAERULEIN
R YAZDANPARAST
1
D QUJEQ
2
From the Institute of Biochemistry and Biophysics, University of Tehran
the Dept. Biochemistry, Tarbiat Modarres University, Tehran, Islamic Republic of Iran.
The activities of 4-aminobutyric-2-oxoglutaric acid transaminase (GABA-T)
and succinate semialdehyde dehydrogenase (SSADH) were determined in mouse
hypothalamus after peripheral injections of cholecystokinin-8 (CCK-X)and/or
caerulein (CLN). GABA transaminase activity was measured utilizing endogenous
succinate semialdellyde dehydrogenase to convert the product of GAB A-T, succinate
semialdehyde, to succinate. The concurrently formed NADH was used as an estimate
of GABA-T activity. Similarly, the activity of SSADH was determined in terms of
NADH. Injection of CCK-8 and/or CLN inhibited the GABA-T and SSADH
activities in dose-dependent responses. The activities of GAB A-Tand SSADH were
diminished by 52 and 66 percent respectively, 30 minutes after injection of CCK-8
(50 µg/kg body weight).Similarly, peripheral injection of CLN (50 µg/kg body
weight) reduced the activity of GABA-T and SSADH by 56 and 65 percent
respectively, in 30 minutes. Using ill vitro models, the full activities of GABA-T and/
or SSADH, after incubation with CCK-8 and/or CLN, were restored following 30
hours of dialysis at 4°C. These results indicate direct and reversible interactions
between the catabolizing enzymes of GABA (GABA-T and SSADH) and the
peptides CCK-8 and CLN.
http://mjiri.iums.ac.ir/article-1-1419-en.pdf
Caerulein. Cholecystokinin-8
Catabolism. GABA-transaminase
Succinate semialdehyde
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
259
261
article
ANALYSIS OF PROGNOSTIC FE ATURES IN CHILDREN WITH THE HEMOLYTIC-UREMIC SYNDROME
GH HASHEMI
1
MH FALLAHZADEH
2
From the Department of Pediatric Nephrology, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
The purpose of this study has been to evaluate various factors influencing
prognosis in children with hemolytic-uremic syndrome (HUS). Forty children with
classical picture of HUS were seen in 1986-1 991. Boys and girls were equally
affected, aged from two months to ten years. In 35 patients (87.5%) there was a
history of diarrhea which was bloody in25. All were treated with peritoneal dialysis
within the first 24 hours. Fresh frozen plasma (FFP) was transfused in the first two
days for all except II patients for whom it was transfused in the third to fifth day of
admission. Fifteen patients died (37.5%) of these, 12 (80%) had diarrhea for longer
than 7 days, II (73%) had prominent neutrophilia, and 9 (60%) had significant
neurological symptoms. Eleven of the fifteen patients had been transfused with FFP
after the third clay of hospitalization. Statistical analysis of data relating to mortality
revealed the following regarding prognostic factors in HUS among children:
mortality is higher in those with longer prodromal period (p<0.001), in those with
bloody diarrhea (p<0.025), in patients with prominent neutrophilia (p<0.001), and
in those who had delayed treatment with FFP (p<0.001). Prognosis was not affected
by age, sex, or season of presentation.
http://mjiri.iums.ac.ir/article-1-1418-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
253
257
article
AN EPIDEMIOLOGICAL APPROACH TO THE ZOOPHILIC DERMATOPHYTOSES IN IRAN
ALIREZA KHOSRAVI
1
PARIVASH KORDBACHEH
2
SAEED BOKAEE
3
From the Faculty of Veterinary Medicine and * School of Public Health, University of Tehran, Tehran, Islamic Republic of Iran.
Dematophytosis in domestic animals constitutes a constant source of infection
for persons in contact with them. To have an epidemiological picture of zoophilic
dermatophyte infections in Iran, a study has been carried out during a period of three
years (1986-1989) in an attempt to find the causative dermatophytes which infect
cats and cattle and also infected human subjects in contact with them.
For this purpose, 9850 samples of hair and skin were collected from suspected
cattle, 953 from suspected cats, and 2326 from infected human subjects. Clinical
diagnosis was confirmed by direct microscopic examination and c!llture. The species
isolated from all cattle were Trichophyton verrucosum from cats, Microsporum
canis and man, M. callis, 1583(68.1 %) and T. verrucosum 743(31.9%). From the
infected human cases, mostly Tinea capitis and Tinea co/paris were detected among
the age groups of 1-9 and 20-29 years old, respectively. The incidence rate observed
in winter and fall was higher than spring and summer.
http://mjiri.iums.ac.ir/article-1-1417-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
249
251
article
PREVALENCE OF ANTI- RUBELLA ANTIBODIES IN HAZARA DIVISION
ANIS UR-REHMAN
1
MEHR DIL KHAN WAZIR
2
S HUMAYUN SHAH
3
From the Department of Pediatrics, and the Dept. of Pathology, Ayub Medical College, Abottabad, Pakistan.
Two hundred and twenty five school going girls belonging to three districts of
Hazara Division, Pakistan were sampied for rubella antibodies. Age range selected
was 5 to 15 years. IgG was positive in 7X.22% of cases and IgM in 24.44% of cases.
The antibodies pattern and prevalence was the same in all the three districts. A clear
increase of IgG was seen up to the age of II years but between 12 and 15 years of
age the increase of IgG was not very significant. This study reveals high prevalence
of IgG (7X.22%) up to the age of 15 years but still a very high figure of about 21.74%
of girls remained susceptible to rubella at a critical period of child-bearing age (i.e.
15 years). This is in contrast to the susceptible subjects of 1.1-4.2% in developed
countries.
http://mjiri.iums.ac.ir/article-1-1416-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
245
248
article
A SURVEY OF ENDEMIC GOITER IN SCHOOL CHILDREN IN KERMANSHAH
H . KHARRAZI
1
G SALIMI
2
From the Biochemistry Department, School of Medicine, Kermanshah University of Medical Sciences, Imam Khomeini Hospital, Kermanshah, Islamic Republic of Iran.
In the fall of 1991, the incidence of goiter was determined in I07X male and
female school children in Kermanshah city. The study was considered from two view
points i.e., clinical examinations and measurements of levels of iodine excreted in
urine, and was performed in three age groups: 7-11 years of age, 12-15 years of age
and 16-18 years of age.
Clinical examination showed 16.5% occurrence of goiter in boys and 21.2'70
occurrence iIi girls of all age groups. The most common type of goiter in boys was
la with occurrence of about 14.2% whereas la and Ib were the most common in girls
with occurrence of 14.9% and 3.0%, respectively.
The results obtained from laboratory studies showed that the levels of iodine in
urine of healthy boys was about XlJ.17 ± 4.7 micrograms iodine per gram of
creatinine, and in healthy girls 97.9 ± 3.5 micrograms iodine per gram creatinine,
which indicates a significant difference in the levels of excreted iodine between the
two sexes. The levels of iodine in urine was decreased considerably in children with
goiter, lip to 47% in boys and 5R% in girls.
The results obtained from this survey indicate that Kermanshah province fits in
the moderate-deficiency region of the Hetzel classification for having a maximum
of 35% occurrence of goiter. Furthermore, 25 to 50 µg iodine consumption per gram
creatinine becomes one of the urgent priorities of the national campaign against
iodine deficiency disorders.
http://mjiri.iums.ac.ir/article-1-1415-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
239
243
article
Pulmonary Tuberculosis
M Keshmiri
1
M Towhidi
2
http://mjiri.iums.ac.ir/article-1-1414-en.html
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
235
237
article
Vision in Hyphema
HA Shahriari
1
http://mjiri.iums.ac.ir/article-1-1413-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
227
233
article
STUDY OF BACTERIAL AGENTS OF INTESTINE IN INFANTS UNDER ONE YEAR OF AGE SUFFERING GASTROENTERITIS OBSERVED AMONG THE IRAQI REFUGEES RESIDING AT IRAN\'S WESTERN CAMPS
ALI AKBAR VELAYATI
1
KIUMARS GHAZI SAIDI
2
HAMED HOSSEINZADEH
3
From the Dept. of Pediatrics, Tehran University of Medical Sciences,
theDept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
theDept. of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
One hundred and thirty specimens of faeces of infants under one year old
suffering form gastroenteritis and residing at the Camp of Iraqi Kurdish refugees
(Paveh and Sar Pol Zahab cities) were collected and evaluated from the point of some
bacterial agents. At the same time, some importantc1inical findings and environmental
conditions were also collected for the study. The results showed that gastroenteritis
mostly had a rapid incidence accompanied by fever, pain, straining, tenesmus and
mucus-containing faeces. From a total number of 130 specimens collected, 10%
Proteus, 18%Pseudomollas, 10% Aeromonas, 1 % Serratia, 1 % enteropathogenic E.
coli, 4% Klebsiella, 2% Shigella, and 3% Yersinia were isolated. Antibiotic sensitivity
test indicated a severe resistance of opportunistic pathogens against two antibiotics,
i.e., chloramphenicol and co-trimoxazole which were mostly isolated in Sar-PolZahab
Camp. We can link this to prophylaxis with these two antibiotics the result of
which is the augmentation of normal flora and its change to pathogens. The studies
have shown that there is a significant relation between the camp's living conditions,
nutrition, public health and isolated microbes.
http://mjiri.iums.ac.ir/article-1-1412-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
221
225
article
EVALUATION OF SERUM IgG SUBCLASS LEVELS IN ASTHMATIC AND ATOPIC CHILDREN WITH RECURRENT INFECTION
A FARHOUDl
1
MB ESLAMI
2
A SHAKURNIA
3
From the Department of Immunology and Allergy, Children's Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Serum IgG subclass levels were measured using an indirect immunoenzymatic
assay (ELISA) with monoclonal antibodies in 16 children with asthma and 13
children with atopy who had mostly recurrent infections. Seven of the asthmatic
children had marked low or low normal levels of IgG4, six had marked low or low
normal levels of IgG 3, two had marked low normal levels of both IgG2, and IgG 3 and
one had low levels of IgG2 " IgG3, and IgG4 •. All these patients suffered from recurrent
sinopulmonary infections. There were low percentages of IgG3, and IgG4. defects
(about 15%) in the atopic patients, while a significant increase in the serum IgG4.
levels were observed (six patient out of 13 patients, 46.2%).
http://mjiri.iums.ac.ir/article-1-1411-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1994-02
7
4
217
219
article
EVALUATION OF GASTROINTESTINAL COMPLICATIONS OF SULFUR MUSTARD POISONING IN IRANIAN COMBATANTS
K NOORBAKHSH
1
M BALALI-MOOD
2
From the Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
A total of360 Iranian combatants who were exposed to mustard gas by the Iraqi
forces in the war fronts were studied. Acute effects and gastrointestinal (GI)
complications of sulfur mustard (S M) intoxication were studied separately in Iranian
combatants admitted to Imam Reza Hospital from January 1984, to May 198X, In
order to record the clinical and paraclinical findings, a special examination sheet and
a questionnaire were designed. Routine laboratory tests such as CBC and ESR were
performed for all patients and further investigation such as upper G [ endoscopy were
done as clinically indicated. Common GI symptoms were: nausea (47%), vomiting
(42%), anorexia (40%), abdominal pain (35%), diarrhea (15%), melena (7%), and
hematemesis (5%). Based on physical examination and endoscopy, acute esophagitis
and gastritis were diagnosed. In the chronic phase 298 patients were observed two
months to six years after exposure. Common GI symptoms were recorded as nausea
(45%), anorexia (42%), abdominal pain (38%), hematochezia (12%), and hematemesis
(5%). Based on upper GI series and endoscopy, gastritis (12%), duodenitis (8%), and
duodenal ulcer (I %) were diagnosed. Other complications such as hepatomegaly and
gastric carcinoma that were reported in the literature from the First World War
experience, have not yet been observed in our patients. Only in one patient who was
admitted for abdominal discomfort five years after SM poisoning, gastritis with
intestinal metaplasia was observed on endoscopy and biopsy from the stomach.
http://mjiri.iums.ac.ir/article-1-1410-en.pdf