eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
211
214
article
REGRESSION OF METASTATIC NEUROBLASTOMA TO GANGLIONEUROMA
SHARIAR DABIRI
1
SEYYED REZA SHARIFI
2
From the Departments of Pathology, and Orthopedic, Kerman University of Medical Sciences, Kerman, Islamic Republic Of Iran.
The spontaneous regression of neuroblastoma to ganlioneuroma is a rare
occurrence. Reviewing the literature, we found no more than 12casesreported.'•2.9.,o.'4.1s
We report a case of metastatic neuroblastoma of multifocal skeletal and soft tissue
areas with gross deformities which regressed to ganglioneuroma, with good prognosis.
http://mjiri.iums.ac.ir/article-1-1435-en.pdf
Neuroblastoma
ganglioneuroma
nerve growth factors
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
209
210
article
DENTAL CAVITY MYIASIS DUE TO WOHLFAHRTIA MAGNIFICA
AMID ATHARI
1
TElMUR FALLAH
2
From the Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
A 79 year old fanner referred to a dental clinic because of toothache for one
week. After extraction of a painful tooth, three larvae, 1.5 cm in length emerged from
the dental cavity. Morphological study of the larvae proved them as W. magnifica.
This is the first report of dental cavity myiasis from Iran.
http://mjiri.iums.ac.ir/article-1-1434-en.pdf
Wohlfahrtia magnifica
dental cavity. Myiasis
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
205
207
article
SELF-INDUCED FOREIGN BODY GRANULOMAS DUE TO INJECTION OF ELEMENTAL MERCURY
M VALIKHANI
1
GH MAGHSOUDNIA
2
From Razi Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
A 24-year-old girl injected approximately I ml of elemental mercury from a few
broken thermometers to her right cubital fossa. It led to the formation of a tumoral
lesion which was erythematous, lobulated, painful, with secretory sinuses in the
injected area. Biopsy showed foreign body granulomas with metallic mercury that
appeared as dark opaque globules. X-rays showed metallic densities in the soft tissue.
General condition of the patient was good, and there was no evidence of systemic
mercury poisoning. The lesion was removed surgically, and the surgical site was
covered with skin graft because of the extent and depth of the lesion. This is the first
report of self-induced mercury injection in Iran.
http://mjiri.iums.ac.ir/article-1-1433-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
199
203
article
ROLE OF SOCIAL AND CULTURAL FACTORS IN AIDS pANDEMIC AND THEIR EFFECT ON HEALTH PROMOTION PROGRAMS
HAMIDREZA ABTAHI
1
From the Department of Internal Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
In most countries, educational programs and condom use is recommended as the
most important approaches in controlling HIV infection. We examine the role of
different approaches in controlling AIDS epidemics in our region. We find a high
failure rate and probably undesirable effects for condom recommendation in
epidemiological scale especially considering the low prevalence of HIV infection in
our region. Past experience suggests that educational programs in isolation have
insufficient effect on health-related behavior in high-risk groups. Present picture of
spread of HIV infection discloses the role of religious beliefs, moral values, social
nonacceptance of unhealthy lifestyles and illegality of homosexuality, prostitution
and drug abuse in controlling AIDS epidemics. In order for health promotion
programs to be successful these social and cultural factors should be regarded.
http://mjiri.iums.ac.ir/article-1-1432-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
193
197
article
PEROXIDE AND NON-PEROXIDE ANTIBACTERIAL ACTIVITY IN SOME IRANIAN HONEYS
M SHAHIN
1
M RAJABI
2
From the Department Of Clinical Pathology, Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran.
A range of some Iranian monofloral honeys were assayed for antibacterial
activity with and without hydrogen peroxide which is inactivated by the addition of
catalase. I t was found that the high amount of antibacterial activity in honeys was due
to a factor other than hydrogen peroxide. The test microorganism Staphylococcus
aureus, was not inhibited by the acidity or the osmolarity of the honey. The
association of high antibacterial activity with particular floral sources suggest that
the non-peroxide antibacterial activity is of floral origin. The activity of some Iranian
honeys were tested and found to be heat stable.
http://mjiri.iums.ac.ir/article-1-1431-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
187
191
article
PHARMACOLOGICAL STUDIES ON NOVEL BASIC AMINOALKYL ARYL ETHERS AS POTENTIAL LOCAL ANAESTHETICS
D AL-SAADI
1
WE SNEADER
2
From the *School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
School of Pharmacy and Pharmacology, University Of Strathclyde, Glasgow, Scotland.
Following our previous investigations on certain new aminoalkyl aryl ethers,
which showed promising and outstanding local anaesthetic properties, the local
anaesthetic activity and duration of action of a further selection of four novel
derivatives of the above-mentioned series, used as hydrochloride salts, have been
determined by the ill vivo rat sciatic nerve test. These are: N,N-dimethyl-2-(2,6-ditert-
butylphenoxy)ethylamine N, N-dimethyl-2-(4-butoxyphenoxy) ethylamine
N, N-dimethyl-2-(2,6-di-sec-butylphenoxy)ethylamine and N,N-diethyl-2-(4-secbutylphenoxy)
ethylamine. The tests have been performed by a double blind, controlled
trial (at the later stage) and in two stages. Bupivacaine hydrochloride has been
employed as the standard and normal saline as the control. The complete loss of
motor function of the injected limb of the animal is considered as a positive response,
which is assessed by observing the animal gait and ability to climb up a sloping wire
mesh. The test compounds have exhibited shorter duration of motor paralysis than
that of the standard and comparable rates of both onset of action, and recovery time
from full analgesia. They also have shown neither apparent systemic nor local side
effects such as edema, swelling, induration, ulceration, necrosis, or irritation.
http://mjiri.iums.ac.ir/article-1-1430-en.pdf
Anaesthetics
local; basic amino alkyl aryl ethers
pharmacology; rat sciatic nerve block
new local
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
183
186
article
CHANGES IN BIOCHEMICAL PARAMETERS OF CARBOHYDRATE METABOLISM FOLLOWING FENFLURAMINE ADMINIS TRATION IN RATS
M ANI
1
M MESSRIPOUR
2
N NAGHSHINEH
3
From the Dept. of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Fenfluramine, an anorexigenic agent, is widely used in the treatment of obesity.
Besides its anorectic effect, it may also have some effects on general metabolism with
the consequence of weight loss. In this study, the effect of fenfluramine on the
concentrations of some parameters related to carbohydrate metabolism was
investigated. It was shown that the serum insulin level was reduced by 41 %, four
hours after fenfluramine administration, which was accompanied by the elevation of
serum glucose levels by 26%. The liver glycogen content showed a transient
reduction, but reached the control level four hours post-treatment. Corticosterone
levels were elevated immediately, followed by a 20% reduction after four hours. The
short-term effects of fenfluramine on thyroid hormones were not statistically
significant.
Administration of fenfluramine for two weeks did not change the glycogen
content of the liver significantly, but 64% and 103% increases were observed after
four and six weeks of drug treatment, respectively. Insulin levels showed a gradual
increase so that by the end of six weeks, 153% increase in insulin level was observed.
No significant changes in serum glucose levels were seen during the period of
treatment. Corticosterone concentration remained unchanged up to four weeks of
treatment but a 32% reduction was seen after six weeks. The levels of T4 and T3
showed a transient increase, followed by a significant decrease after six weeks of
treatment. It is concluded that fenfluramine has some important metabolic effect that
is related to its action in decreasing food intake and weight loss.
http://mjiri.iums.ac.ir/article-1-1429-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
179
182
article
POSSIBLE INVOLVEMENT OF GABAA RECEPTOR SITES IN CATALEPSY
A SADEGHI-LOUYEH
1
Y SIMONIAN
2
From the Department of Physiology Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
From the Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
The present work was performed to show the possible interaction of GAB A, and
GABAB receptors in catalepsy. The following results were obtained:
1- Muscimol (MUS), a GABAA agonist, induced catalepsy. This effect was
dose-dependent. Baclofen (BAC), a GABAB agonist, had no effect in this respect.
2- Catalepsy induced by muscimol was potentiated by pretreatment of animals
with bicuculline (BIC), a GABAA antagonist, while pretreatment of animals with
picrotoxin (PIC), another GABAA antagonist, did not change the response.
3- The cataleptogenic effect of a-flupenthixol (a-FPT), a neuroleptic which is a
potent cataleptogenic drug, was also increased by bicuculline pretreatment. Aflupenthixol,
in animals pretreated with picrotoxin, induced a small but significant
increase in catalepsy.
4- Muscimol catalepsy may be due to GABA inhibitory effect of the drug upon
dopaminergic function, while potentiation of cataleptogenic effect of a-flupenthixol
or that of muscimol by bicuculline may be exerted through release of GABA from
GABAergic nerve endings
http://mjiri.iums.ac.ir/article-1-1428-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
175
178
article
REPORT OF THIRTEEN CASES OF MUCORMYCOSIS
M MOGHADDAMl
1
M MOHRAZ
2
MR SHIDFAR
3
From the Department Of Parasitology and Medical Mycology, School of Public Health
the Department of Infectious Diseasse, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran , Islamic Republic Of Iran.
From the Department Of Parasitology and Medical Mycology, School of Public Health
Thirteen cases of mucormycosis in ten diabetics, one leukemic, and one burned
patient, and one in an apparently normal person are reported. The presenting form
included rhinocerebral in II and cutaneous in two cases. The diagnosis was
established by KOH preparation and biopsy and it was confirmed with culture.
Rhizopus sp. was the causative agent in II and Mucor sp. in one case. Amphotericin
B was administered in 10 patients as soon as the diagnosis of mucormycosis was
made. Of these, four patients survived.
http://mjiri.iums.ac.ir/article-1-1427-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
173
174
article
SHEEP-AN IMPORTANT RESERVOIR OF HUMAN TOXOPLASMOSIS IN IRAN
AHMAD SHAHMORADI
1
MOSTAFA REZAEIAN
2
ABDOLHOSEIN DALIMI ASLE
3
From the Dept, of Parasitology. School of Medical Sciences. Tarbiat Modarres University
the Dept. Of Protozoology, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran,
From the Dept, of Parasitology. School of Medical Sciences. Tarbiat Modarres University
Toxoplasmosis is a zoonotic disease and ubiquitous in the world. Infection rate
in the tropical and subtropical regions with high humidity is higher than other areas.
The rate is lower in dry regions whether hot or cold. More than 200 species of warmblooded
animals are intermediate hosts and cats or members of the carnivore family
Felidae have been found to be definitive hosts.'
In Iran in the northern provinces of Mazandaran and Gilan, infection rate is
higher than other provinces (about 70%) while in the southern provinces of
Hormozgan, Sistan and Balouchestan, and Khuzestan, this rate is lower (about 12%).
Common routes of transmission of the infection are feeding of uncooked meat or
working with contaminated meat.
In this study, 3X7 blood samples of sheep from slaughterhouses in Tehran were
evaluated by the direct agglutination method. Prevalance rate was 61.24% and
indicated a potential danger for food hygiene. The main aim of this article is to inform
health officials as well as workers and housewives about this hazard.
http://mjiri.iums.ac.ir/article-1-1426-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
171
172
article
ZINC DEFICIENCY IN CHILDREN INFECTED WITH GIARDIA LAMBLIA
MOHAMMADREZA NAZARI
1
From the Department of Parasitology, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Giardia, a protozoan parasite, resides in the small intestine in man. This parasite
damages the mucosal intestinal surface and in severe cases produces malabsorption
and it may also affect mineral absorption, especially zinc.
In this study a total of 118 infested and 43 non-infested persons as a control
group were selected. From each patient a 5 ml blood sample was obtained. The serum
was separated and zinc measured by atomic absorption method.
The results show mean serum zinc level in the infested group to be 75.364
microgram percent with the standard deviation of 19.433 while in the healthy control
group it was 97.707 ± 28.258 Comparsion between the two sexes indicated that in
male subjects mean zinc content was 73.832 and 75.755 in the female group.
http://mjiri.iums.ac.ir/article-1-1425-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
165
169
article
EVA LUATION OF THE ROLE OF CELL-MEDIATED IMMUNITY IN DERMATOPHYTOSIS
AR KHOSRAVI
1
M FRANCO
2
M MAHMOUDI
3
From the Faculty of Veterinary Medicine
School of Public Health, Tehran University
the Department of Pathology, School of the Medicine and Immunology Division, UNESP, Botucath, Brazil.
For demonstration of cell-mediated immunity and its role in the process of
dermatophytosis, 98 patients with acute dermatophytosis (group I) and 131 chronic
dermatophytosis patients (group 2) were chosen. In ail patients, lymphocyte
transfonnation and skin test were used. 96 members of group I (98%) had positive
delayed-type hypersensitivity (DTH) responses to trichophytin, whereas only 43
subjects (32.8%) of group 2 had positive DTH responses. In group I, positive
lymphocyte blastogenic responses to trichophytin and phytohemagglutinin were
seen in 95 (96.lJ%) and lJX (100%) patients, respectively, but in group 2 the positive
results were observed in4lJ (34.4%) and 127 (lJ4.9%) subjects, respectively. Patients
with chronic dermatophytosis had histories of a number of systemic disorders such
as: atopy 04 patients diabetes, seven patients contact dennatitis, four patients and
tuberculosis, three patients.
http://mjiri.iums.ac.ir/article-1-1424-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
161
164
article
EVALUATION OF !FA, IHA AND BLA TESTS IN THE SEROLOGICAL DIAGNOSIS OF AMEBIC LIVER ABSCESS
M REZAEIAN
1
Y HAMZAVI
2
From the Dept. of Protozoology, School of Public Health, Tehran University of Medical Sciences,
the Dept. of Medicine, Razi University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
As there was not any previous comprehensive study on the serological tests for
hepatic amebiasis in Iran, the indirect hemagglutination (IHA), indirect fluorescent
antibody (IF A), and biocolored latex agglutination (BLA) tests were evaluated in the
serodiagnosis of amebic liver abscess(ALA). For this purpose a total of 165 serum
samples 18 of which were obtained from patients known to have ALA, were
examined for Entamoeba histolytica antibodies.
E. histolytica antigen used for IFA technique was prepared in the Intestinal
Protozoa Laboratory, Protozoology Unit, School of Public Health, Tehran University
of Medical Sciences. The results of the survey showed that the IHA and BLA were
somewhat more sensitive than IFA in the serodiagnosis of ALA. The sensitivity,
specificity, and positive and negative predictive value of these tests were compared
http://mjiri.iums.ac.ir/article-1-1423-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
157
160
article
STUDIES ON THE T-CELL PHENOTYPES IN CHILDREN WITH KALA-AZAR IN FARS PROVINCE, IRAN
S ARDEHALl
1
A MOIN REZAKHANLOU
2
E SADEGHI
3
SZ TABEI
4
From the Departments of MicrobiologyShiraz University of Medical Sciences, Shiraz, Islamic Republic of lran.
From the Departments of MicrobiologyShiraz University of Medical Sciences, Shiraz, Islamic Republic of lran.
From the Departments of Pediatrics Shiraz University of Medical Sciences, Shiraz, Islamic Republic of lran.
From the Departments of Pathology, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of lran.
The subpopulations of T-Iymphocytes were studied in children with visceral
leishmaniasis in the active stage of disease prior to treatment (n=28) and in controls
(n=15) using specific monoclonal antibodies (Behring OKT3, OKT4 and OKT8).
The percentage of total peripheral blood T-Iymphocytes (CD3+ T-cells) in patients
were within the same range as those of normal children (71.09± 1.07 vs68.89± 1.29).
The percentage of CD4+ T-Iymphocytes showed a significant increase (P<0.005) in
comparison with the control (53.92 ± 1.20 vs 45.59 ± 1.35). A decrease in the
percentage of CDS+ T-Iymphocytes (20.81 ± 0.71 vs 23.89 ± 0.72) was observed
which was significant at (P<0.025). The ratio of CD4+/CD8+T- lymphocytes was
significantly increased at P<0.005 as the value of the ratio was 2.70 ± 0.17 for kalaazar
patients and 1.91 ± 0.05 for the controls. The immunosuppression in kala-azar
patients studied could be due to dysfunction of antigen specific T-cells and its
subsequent effect on various cytokine release rather than changes in the phenotypic
characters of these cells.
http://mjiri.iums.ac.ir/article-1-1422-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
151
156
article
A ONE-YEAR REPORT OF THE COUNTRY\'S MENTAL HEALTH PROGRAM IN A 22,000 POPULATED REGION OF NORTH-EAST IRAN
SA HOSSEINI
1
G HAGHDADl
2
M ANASORI
3
J BAHADORKHAN
4
From the Dept. of Mental Health and Psychology of Shafa, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
This study began in December, 19R9, and continued for one year. 245 cases,
46.5% from urban areas and 53.5% from rural areas, were followed-up. 1 3.5% were
diagnosed by general physicians and receiving drugs accordingly before the program.
30.2% were properly diagnosed, but they did not receive reasonable drugs and
56.3% were neither properly diagnosed nor did they receive reasonable treatment.
The main diagnoses, according to ICD-9, were as follows: 35.9% mental retardation,
35.5% neurotic disorders, 12.2% epilepsy and its psychiatric aspects, 12.2%
schizophrenia, and 4.9% affective psychoses. 21.2% were disabled in different
stages. The rate of tracing in the first 6 month follow-up period was 46.15%.
http://mjiri.iums.ac.ir/article-1-1421-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1993-11
7
3
145
150
article
A STUDY OF 765 CASES OF CLINICALLY SOLITARY COLD THYROID NODULES FROM AN IODINEDEFICIENT AREA
MANOOCHEHR NAKHJAVANI
1
MOHAMMAD HASAN BASTANHAGH
2
REZA KASSAYAN
3
RADINA ESHTIAGHI
4
AFSAR ASADI
5
MOHAMMAD RAJAI
6
From the Department of Internal Medicine, Division of Endocrinology and Metabolism, Tehran University of Medical Sciences,
We studied the clinical, radioisotopic, and pathologic characteristics and the
incidence of cancer in clinically solitary cold nodules of the thyroid in an iodinedeficient
area. The study included retrospective analysis of 765 patients who
underwent thyroidectomy for a clinically single cold nodule in a ten-year period. We
compared the pathological findings with clinical data. In pathological examination,
34% of glands were multinodular. The incidence of nodular colloid goiters were
81.7% and of thyroid cancer 10.2%. Thyroid malignancy increased significantly
after age thirty (p<0.005). The incidence of cancer was 8.3% in true solitary nodules
versus 13.8% in clinically solitary nodules found to be pathologically multinodular
(p<0.05). Papillary carcinoma was the most frequent type (70.5%) and medullary
carcinoma the least frequent type (2.6%). Benign nodular lesions were the most
common cause of cold nodules. There was no sex difference in the incidence of
thyroid cancer. In the patients with thyroid carcinoma the percentage of multinodular
glands was higher. Iodine deficiency may be a factor in changing certain characteristics
of thyroid nodules.
http://mjiri.iums.ac.ir/article-1-1420-en.pdf