eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
143
145
article
THE EFFECT OF ALUMINUM ON BIOCHEMICAL PARAMETERS RELATED TO BONE METABOLISM. A MODEL STUDY OF HEMODIALYSIS PATIENTS
AA MOSHTAGHIE
1
M ANI
2
From the Dept. of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
The influence of aluminum on some serum parameters related to bone
metabolism has been investigated by daily administration of aluminum over
different periods of time. Daily administration of aluminum (1 mg/kg BW)
for 20 or 50 days elevated serum phosphorous concentration by 16 percent
and had no significant effect on serum calcium level. When aluminum was
injected as a complex with citric acid (1 :1) there was a 22 percent elevation in
serum phosphorous concentration, but again had no significant effect on
serum calcium. Same amounts of aluminum caused a 28 percent elevation in
serum alkaline phosphatase (ALKP), but had no significant effect on serum
parathormone (PTH) either with or without citric acid. A marked reduction
(about 41 percent) in serum calcitonin was observed when rats were given
aluminum with or without citric acid. The relationship between aluminum
toxicity and osteomalacia has been discussed.
http://mjiri.iums.ac.ir/article-1-1496-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
139
142
article
THE SUBACUTE EFFECTS OF CADMIUM ON SEX HORMONES IN FEMALE RATS
A SOBHANI
1
T GHAFGHAZI
2
A HAERY
3
From the Department of Pharamacology, Faculty of Medicine, Gilan Universily of Medical Sciences, Rasht
the Department of Pharmacology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
the Department of Pharmacology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Toxic effects of trace elements upon the hypothalamic- pituitarytesticular
axis and sex hormones have been reported in recent years. It is
generally considered that CdCl2 poisoning causes histopathological changes
in the testicles of male rats. Little attention had been drawn to the possible
toxic effects of CdCl2 on the ovary and female sex hormones.
The purpose of the present study was to determine the subacute
poisoning effects of CdCl2 (10 mg/kg I.P. for 15 days) on the female
gonadotropins and sex hormones such as FSH, LH, progestrone, estradiol
and prolactin.
Female wi star rats 12 weeks of age (approximately 300g) were divided
into two groups (10 in each group), one group received CdCl2 and the other
received saline as a control. Serum hormones were measured by radioimmunoassay.
In contrast to male animals, CdCl2 injection did not affect serum FSH
and LH concentration in female rats, whereas serum prolactin concentration
was significantly elevated compared with that of control animals (p<0.05)
after CdCl2 injection. This effect is not similar to the effect of CdCl2 on the
prolactin of male rats which was reported by Chandler and coworkers. No
marked differences were observed between the control and experimental
values of serum estradiol and progestrone concentrations.
http://mjiri.iums.ac.ir/article-1-1495-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
135
138
article
A STUDY OF THE INTRACELLULAR KILLING OF THE PERIPHERAL BLOOD NEUTROPHILS IN β- THALASSEMIA MAJOR PATIENTS
MOHAMMAD JAAFARI
1
MINA IZADYAR
2
MOHAMMAD RAKHSHAN
3
ABUL HASSAN FARHOUDC
4
TAHEREH ZANDIEH
5
GHOLAM-REZA BABAl
6
From the' Tarbiat Modarres University Tehran, Islamic Republic of Iran.
Children's Medical Center, Tehran University of Medical Sciences
Dept. of Pathology, Shaheed Beheshti University of Medical Sciences
Children's Medical Center, Tehran University of Medical Sciences
Blood Transfusion Organization, Tehran, Islamic Republic of Iran.
From the' Tarbiat Modarres University Tehran, Islamic Republic of Iran.
52 β- thalassemia major patients were studied. Their ages ranged from
two to 20 years. The group consisted of 22 girls and 30 boys. Candida
intracellular killing and NBT (nitroblue tetrazolium) tests were performed
on the peripheral blood neutrophils of these patients.
Average results of the intracellular killing test was within normal range
for the patients, but showed an appreciable decrease in comparison with the
results of the normal control tests (50 normal persons of the same age group
were tested as normal controls. This decrease was more pronounced in those
patients who had undergone splenectomy.
A converse relationship was observed between the results of the
patients' intracellular killing and their serum ferritin level and age.
Average results of the patients' NBT tests showed an increase in
comparison with those of the control group. The average results for the
patients who had their spleens removed due to hypersplenism was the same
as in those who had normal spleens and had no relation to the serum ferritin
level but did show a moderate relationship with the age of the patients.
A suggestion that can be put forth is the likelihood that intracellular
killing of peripheral blood neutrophils in the β- thalassemia patients is
conductive to the determination of those with greater susceptibility to
infection.
http://mjiri.iums.ac.ir/article-1-1494-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
129
133
article
ALTERATIONS OF ADP-RIBOSYLATION AND DNA-BREAKS IN AGING BRAIN CELLS
MANOUCHEHR MESSRIPOUR•
1
ALI RASTEGAR
2
LUCIEN CIESIELSKI
3
MAGALI CHABERT
4
DENIS WELTIN
5
PAUL MANDEL
6
the Department of Biochemistry, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
From the Centre de Neurochime du C.N.R.S., 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France
From the Centre de Neurochime du C.N.R.S., 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France
From the Centre de Neurochime du C.N.R.S., 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France
From the Centre de Neurochime du C.N.R.S., 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France
From the Centre de Neurochime du C.N.R.S., 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France
Neuronal and astroglial cells were prepared from whole brain of three
month and 30-month- old rats for study of alterations in the nuclear poly
ADP-ribosylation and DNA breaks with age. The relative purity of the cell
preparations was confirmed by the determination of the neurofilament (low
molecular weight) and glutamine synthetase content of the cells using
ELISA. An increase (75%) in the poly ADP-ribosylation was observed in
the whole brain cell suspension of aged rats, whereas the increase was
markedly pronounced (460%) when the reaction was measured in the
purified neuronal preparations. The rate of poly ADP-ribosylation in the
astroglial fractions prepared from aged rat brain was higher than that of adult
levels (67%). An unexpectedly high increase of ADP-ribosylation in the
neurons and a much lower rate in the astroglial cells was thus recorded. The
amount of DNA breaks was also higher in the neuronal preparation in aged
brain as compared to that of adult levels. The amount of DNA breaks was
much lower in the astroglial cells and aging had no effect on DNA breaks of
these cells. The close relationship between DNA breaks and poly ADP-ribosylation
in the different cell types suggest that neurons are more
susceptible to the metabolic alterations of the aging process
http://mjiri.iums.ac.ir/article-1-1493-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
123
127
article
ON THE EFFECTS OF ARA-A AND ARA-C ON X-RAY INDUCED DNA LESIONS IN NORMAL HUMAN AND A-T CELLS: SIMILARITIES AND DIFFERENCES.
HOSSEIN MOZDARANI
1
From the School of Medical Sciences, Tarbiat Modarres University, Tehran, Islamic Republic of Iran.
A better understanding of the mechanism of chromosomal aberration
formation could be obtained by using DNA repair inhibitors. Immortalized
normal human (MRC 5 SVI) and ataxia telangiectasia ( AT 5 BIV A )
fibroblastic cell lines were treated with adenosine arabinoside (ara-A) and
cytosine arabinoside (ara-C), both potent inhibitors of DNA dsb repair,
alone or in combination with x-rays at G2 or S-phase of the cell cycle. The
length of G2-phase for both cell lines was determined by autoradiographic
labeling to be about 4.5-5 h. A similar result was obtained by scoring of
chromosomally damaged cells following treatment with ara-A or ara-C for
various time intervals before fixation. The results obtained in this study show
that in spite of many similarities between the action of ara-A and ara-C, e.g.,
inhibition of DNA synthesis cIastogenic effects at G2 and S-phase and also
lack of synergism as a possible consequence of these similarities, ara-A was
found to have a different effect on rejoining of x-ray induced DNA lesions
than that of ara-C. Ara-A caused inhibition of chromatid deletion rejoining,
interpreted as inhibition of rejoining of DNA dsb at all sampling times before
fixation, whereas ara-C showed a synergistic effect on radiation-induced
DNA lesions, resulting in an increased frequency of chromatid deletions.
Thus there appears that these inhibitors have different modes of action on
x-ray induced DNA lesions, which may suggest a peculiar and important
difference in the nature of these two nucIeosides.
http://mjiri.iums.ac.ir/article-1-1492-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
115
122
article
NUTRITION FROM THE POINT OF VIEW OF ISLAM
S.M. TAGHI AYATOLLAHI
1
From Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
This paper aims at briefly specifying an analytical approach for the
understanding of diet and nutrition in Islam and its effects on the promotion
of health within the society. The Qur'an and other Islamic literature on
Hadiths (Traditions), Figh (Jurisprudence) and traditional medicine are
studied.
The specifications of the Islamic food, the significance of the use of a diet
compatible with the nature of the human body, manners of fostering hygienic
principles, and ways and means of improving nutrition in the society are duly
elaborated.
The study further verifies that Islam has an independent approach
towards nutrition, which is based on social and economic justice. It also
shows that people should have equal opportunities to acquire a sufficient and
legitimate amount of food for subsistence.
The study also concludes that the world oppressors are the ones who
have brought about poverty and starvation to a large number of humans in
the world. One of the most important responsibilities of Muslims and the
Islamic States is to eradicate such an oppression.
http://mjiri.iums.ac.ir/article-1-1491-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
109
113
article
BACTERIURIA DUE TO CATHETERIZATION IN HOSPITALIZED PATIENTSBACTERIURIA DUE TO CATHETERIZATION IN HOSPITALIZED PATIENTS
MOJTABA MOOSAVIAN
1
BAHRAM FATHOLLAHZADEH
2
NASRIN MOAZAMI
3
From the• Microbiology Division, School of Medicine, Tarbiat Modarres University, Tehran
In this survey, made to determine instances of bacteriuria occurring in
hospitalized patients who had undergone catheterization, 259 urine specimens
were taken from 103 patients admitted to three hospitals in Tehran. Of
the 73 patients who had no urinary tract infection or contamination, 40
(54.8%) developed bacteriuria at the end of catheterization. Incidence of
bacteriuria in patients under age 40 was 55.5%, and 53.5% in patients over
age 40. The organisms that were isolated from the urine cultures of the
patients were most often gram negative bacilli of Enterobacteriaceae,
among which E. coli (38%) and Klebsiella pneumoniae (17%) had the
highest frequency.
http://mjiri.iums.ac.ir/article-1-1490-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
105
107
article
COMPARATIVE STUDY BETWEEN EFFICACY OF METRONIDAZOLE AND FURAZOLIDONE IN 7 TO 11 YEAR OLD CHILDREN WITH GIARDIASIS
IRAJ SHARIFI
1
From the Department of Parasitology and Microbiology, Medical School, Kennan University of Medical Sciences, Kerman. lslamic Republic of Iran.
Metronidazole and furazolidone were compared for efficacy in 268
seven to 11 year old children infected with giardiasis. With metronidazole the
cure rate was 82.3% and 80.0% in boys and girls respectively, while
furazolidone showed an efficacy of74.4% and 71. 7% in the corresponding
groups. The overall efficacy was 81.1 % with metronidazole and 73.3% with
furazolidone. There were no significant differences between metronidazole
and furazolidone efficacies in regard to the age groups or sexes.
http://mjiri.iums.ac.ir/article-1-1489-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
101
103
article
IMMUNODIAGNOSTIC TESTS IN HYDATIDOSIS OF THE LUNG
J TAVAKOLl
1
Z HAGHI
2
S ZEHTABCHI
3
From the Departments of Immunology and Thoracic Surgery, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran,
Laboratory diagnostic tests are useful in diagnosis of hydatidosis of the
lung. In this study, we compare the diagnostic values of these immunodiagnostic
tests with the clinical evidence of hydatid disease. Application of these
tests, especially indirect hemagglutination and bentonite flocculation, is
shown to be very useful in diagnosis of the disease, of course in combination
with clinical findings.
http://mjiri.iums.ac.ir/article-1-1488-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
97
100
article
PATTERN OF PHYSIOLOGIC JAUNDICE AND INCIDENCE OF "EXAGGERATED PHYSIOLOGIC" HYPERBILIRUBINEMIA IN IRANIAN FULL-TERM INFANTS USING TRANSCUTANEOUS BILIRUBINOMETRY
ZFK PANGY
1
E MOHAMMAD ZADEH
2
From the Department of Pediatrics. Neonatal Division. Ghaem Hospital. Mashhad University of Medical Sciences,Mashhad. Islamic Republic of Iran.
Normal full-term infants were followed by serial transcutaneous bilirubinometry
over the first week of life. The pattern of physiologic jaundice in
our population was similar to that shown for white infants. Mean maximum
bilirubin peak was seen on day four of life and was also similar to that shown
for American white infants. The incidence of non physiologic hyperbilirubinemia
defined as 2 SD above the mean maximum peak was about three
times that reported for white infants, but similar to that reported for orientll .'
populations. Oxytocin and the type of delivery did not seem to affect this high
incidence. The role of breast feeding and G6PD deficiency needs to be
further defined.
http://mjiri.iums.ac.ir/article-1-1487-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
93
95
article
DURATION AND CAUSES OF CESSATION OF BREAST FEEDING IN WORKING MOTHERS IN GHAZVIN, IRAN
MD FROOZANI
1
R ZAVOSHI
2
F AZORDEGHAN
3
From the Department of Human Ecology. Biostatistics and Epidemiology. School of Public Health. Tehran University of Medical Sciences. Tehran, Islamic Republic of Iran.
Questionnaires were filled out during Summer 1988 from 259 working
mothers'Who terminated breast feeding, and at least had a living child aged
three years or younger. The purpose of the study was to determine the
duration and the reasons of termination of breast feeding in these working
women.
An inverse correlation was found between the duration of breast
feeding and the following parameters: The introduction of breast feeding for
the first time after birth (p<.05) and the mother's ages at the first marriage,
pregnancy and delivery, and also her age at last delivery (p<.0001, p<.002,
p<.003 and p<.006 respectively).
A positive correlation also was found between the duration of breast
feeding and the age of introduction of supplementary feeding. The difference
between the mean duration of breast feeding and the kind of first food
given after birth was statistically significant (p<.02).
Insufficient milk and work outside the home were the most common
causes of termination of breast feeding among these working mothers.
http://mjiri.iums.ac.ir/article-1-1486-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
89
91
article
SHORT-COURSE THERAPY IN TUBERCULOUS MENINGITIS. A STUDY OF 16 PATIENTS
HOSSEIN PAHLAVANZADEH
1
ABBAS MONTAZERI
2
From the Department of Medicine, Section of Infectious arid Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran.
From 1986-1989, sixteen patients suffering from TB meningitis aged
12-58, with CSF smear or culture positive for Mycobacterium tuberculosis
were hospitalized and treated with rifampin (RIF) , isoniazid (INH) , pyrazinamide
(PZA) and ethambutol (ETB) for nine months.
In all patients, ETB and PZA were withdrawn after three months and
INH and RIF were continued for the next six months. 81.2 percent of patients
were in stages 2 and 3 of this illness, and steroids were added to their
treatment regimes. In two patients whose liver enzymes and blood uric acid
levels increased during the second week of therapy, INH was discontinued
temporarily and PZA was replaced with streptomycin. In the remaining
patients, side effects of drugs and central, peripheral and other complications
were trivial. Mortality rate was 25%, follow-up of the patients
continued for 12-24 months.
According to the mortality and morbidity of classic 12-18 months
therapy with three drugs and results obtained in this study, treatment with
four drugs for nine months showed some advantages to the other protocols.
We look forward to finding more documents and similar studies from
other centers. Confirmation of results of this study could be a suggestion for
short-course therapy in TB meningitis, and this is the first report of
short-course therapy in TB meningitis from Iran.
http://mjiri.iums.ac.ir/article-1-1485-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
87
88
article
FETAL DEATHS AND PARENTAL EXPOSURE TO CHEMICAL WARFARE AGENTS
HAMID POUR-JAFARI
1
From the Dept. of Genetics, Hamadan University of Medical Sciences, Hamadan, Islamic Republic of Iran.
In the present work we studied the incidence of fetal deaths among
conceptions whose fathers or both parents were survivors of chemical
warfare attacks by Iraq. We showed that there was significant correlation
between frequency of fetal deaths among conceptions which eventuated
after exposure of the parents to gas bombs compared to the frequency of fetal
deaths among the control group. This work shows that some lethal mutations
probably result from the chemical warfare agents.
http://mjiri.iums.ac.ir/article-1-1484-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
85
86
article
SCREENING SERA FROM THE ADULT POPULATIONS OF MASHHAD AND GONBAD FOR ANTI BODIES TO HTLV-1
R FARID
1
MM ETEMADI
2
H BARADARAN
3
A SHIRDEL
4
N AHKAMI
5
S SAFAI
6
Mashhad University of Medical Sciences, Mashhad. Iran
Mashhad University of Medical Sciences, Mashhad. Iran
Mashhad University of Medical Sciences, Mashhad. Iran
Mashhad University of Medical Sciences, Mashhad. Iran
Cornell University Medical Center, New York, U.S.A.,
New Jersey University Medical School, N.J., U.S.A.
Human T-ceil lymphotropic virus, type 1 (HTL V-I) is considered to be
the causative agent of adult T-cell lymphoma/leukemia and spastic paralysis,
and seems to be common in Khorasan Province.
300 blood samples from Mashhadi and 180 from Gonbadi blood donors
were obtained (all samples from healthy subjects). Serological screening was
done by passive particJe- agglutination test and confirmed by Western blot
test.
10% of Mashhadi and 3.3% of Gonbadi residents were positive for
HTLV-1 antibodies.
Our findings suggest that Mashhad may be within a previouslyunrecognised
endemic region for HTL V-I which may be a major health problem for
Khorasan Province.
http://mjiri.iums.ac.ir/article-1-1483-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-08
6
2
82
84
article
Angiotensin Converting Enzyme in Sarcoidosis
M Keyhani
1
http://mjiri.iums.ac.ir/article-1-1482-en.pdf