eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
63
66
article
N-GLUCOSIDES: NEW PHASE-II METABOLITES OF TWO BARBITURATES
MA AL-SHARIFI
1
From the Department of Pharmacology, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.
The new phase-II N-glucoside metabolites of butobarbitone and
pentobarbitone are identified and quantified in human urine after single
doses of these drugs. The identification and quantification of these metabolites
were carried out by mass spectroscopy technique (accurate mass
measurement and high voltage scanning).
It was found that the butobarbitone N-glucoside comprised 26% of the
dose with tl/2= 44h, while the pentobarbitone N-glucoside was 43% with
t1/2= 40h.
http://mjiri.iums.ac.ir/article-1-1511-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
59
62
article
EVALUATION OF CEFTAZIDIME ANTIMICROBIAL ACTIVITY IN INFECTIONS CAUSED BY BURNS
JAVAD GHANAAT
1
From the Department of Microbiology, Ghaem Medical Center, Mashhad University of Medical Science, Mashhad, Islamic Republic of Iran.
In vitro evaluation of ceftazidime antimicrobial activity in infections
caused by burn and its comparison to the other antibiotics is presented.
In vitro tests for susceptibility to ceftazidime and other antibiotics were
carried out on 744 bacterial strains collected from burn infections. The
results have shown that generally ceftazidime was more active against
Pseudomollas aeruginosa and other gram-negative bacilli like Klebsiella
pneumolliae, Escherichia coli, and Proteus than amikacin, gentamicin,
tobramycin, carbenicillin, kanamycin, and streptomycin in terms of potency
and activity. In addition, and according to our in vitro studies we suggest that
ceftazidime could be considered a valuable alternative to other antibiotics in
the treatment of burn infections caused by P. aeruginosa and other gramnegative
bacilli.
http://mjiri.iums.ac.ir/article-1-1510-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
55
58
article
A NEW BIOLOGICAL SCREENING SYSTEM FOR LOCAL ANAESTHETICS BY INHIBITION MOBILITY OF TETRAHYMENA PYRIFORMIS
D AL-SAADI
1
WE SNEADER
2
From the' School of Pharmacy, Mashhad University of Medical Sciences, Mashhad , lslamic Republic of Iran
the School of Pharmacy and Pharmacology, University of Strathclyde, Glasgow, Scotland.
An alternative in vitro approach to drug screening has been the use of
human cell cultures for antiviral agents and microbial cell cultures for the
assessment of the carcinogenic potential of selected compounds. A number
of protozoan species have been also used as drug screens for anti-protozoal
agents. The ciliated protozoan Tetrahymena pyriformis species has been
widely utilised as a drug screen for a variety of pharmacologically active
agents.
Accordingly, it was decided to investigate whether T. pyriformis could
be used as a preliminary drug screen for evaluation of the local anaesthetic
activity and duration of action of certain commercially available local
anaesthetics. In this communication, the results of this new in vitro biological
drug screen are reported. It is based on the complete protozoan cell
immobilisation by the anaesthetic solution. A positive inverse correlation
was observed between the lowest concentration (minimum inhibitory
concentration=MIC) that wholly inhibits the mobility of all cells of T.
pyriformis and the duration of action of the test compounds. Generally, MIC
was high for the short-acting anaesthetics and low for the long-acting ones.
The results suggest the suitability of this new microbiological assay system for
the evaluation of local anaesthetic activity and duration of action and
possibly irritancy and toxicity of other local anaesthetics as well as potentially
active therapeutic agents which possess surface activity.
http://mjiri.iums.ac.ir/article-1-1509-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
49
53
article
DETERMINATION OF THE OPTIMUM HEAT STRESS INDEX AT A FOUNDRY
P NASSIRI
1
M JAAFARI
2
F GOLBABAI
3
M MAHMOODI
4
From the Department of Occupational Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
This paper presents a case study to determine the efficiency of the
currently used heat stress indices in correlation with wet bulb globe
temperature (WBGT) as a permissible index at a foundry plant and to
evaluate the extent of the physiological responses such as heart rate and body
temperature in correlation with heat stress indices. The field consisted of a
foundry plant where a shift work was in operation. The results indicated that
wet globe temperature (WGT), corrected effective temperature (CET), and
predicted four-hour sweat rate (P4SR) indices have the best correlation with
WBGT index respectively, and P4SR and CET indices correlate well with
physiological responses more successfully than WBGT does in hot-dry
conditions, CET index gives the best correlation with body temperature
while P4SR is the most accurate with the heart rate.
http://mjiri.iums.ac.ir/article-1-1508-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
45
48
article
CHROMOSOMAL PROTEINS IN PULMONARY ALVEOLAR MACROPHAGES
AZRA RABBANI
1
ROYA NAVAB
2
BAHRAM GOLIAEI
3
From the Institute of Biochemistry and Biophysics, University of Tehran, Islamic Republic of Iran.
In this study the nature of chromosomal proteins, his tones and nonhistone
in resident alveolar macrophages was investigated in comparison to
peritoneal neutrophils and calf thymus proteins. Cells were obtained by
lavaging the lung and after purity determination they were subjected to
fractional extraction procedures. Proteins were then analysed on SDS
polyacrylamide gels and densitometric scans were obtained. The results
show that in macrophages, the pattern of histone and nonhistone proteins
were similar to thymus proteins, two distinct and specific proteins HI° and
HMGI4b and also a protein with a molecular weight of I2kd (Hx) were
present. These data suggest a different chromatin protein pattern in
pulmonary alveolar macrophages.
http://mjiri.iums.ac.ir/article-1-1507-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
43
44
article
MANAGEMENT OF HEATSTROKE IN 304 PATIENTS DURING HAJJ PILGRIMAGE
FEREYDOUN NOUHI
1
REZA FARID HOSSEINI
2
MOHAMMAD HASSAN BASTANHAQ
3
ALI ASGHAR DADGAR
4
From the Department of Medicine, Imam Reza and Ghaem Medical Centers, Mashhad University of Medical Sciences, and the Department of Medicine. Kerman University, of Medical Sciences, Kerman, Islamic Republic of lran.
Three hundred and four patients with different degrees of heatstroke
were treated by the Hajj medical team of the Islamic Republic of Iran. Four
percent of the patients had associated diseases. A simple method using
immersion in iced tap water was used for management of heatstroke.
Advantages and wide applicability of the technique are described, achieving
good results without using sophisticated and expensive means.
http://mjiri.iums.ac.ir/article-1-1506-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
39
41
article
RAZI AND HIS BOOK ON AL-TIN AL NISHABURI
M MOHAGHEGH
1
http://mjiri.iums.ac.ir/article-1-1505-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
35
37
article
BRUCELLA MELLITENSIS ENDOCARDITIS: DIAGNOSIS AND TREATMENT IN SIX ADULT PATIENTS.
IRAJ NAZERY
1
MASSOUD ESLAMI
2
From the Department of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Brucella endocarditis is an uncommon but not rare manifestation of
brucellosis in our country. We report six adult patients aged 20 to 45 years.
Two of our patients were female, and this is the first time that Brucella
endocarditis was reported in adult females.
In five cases, aortic valve replacement was performed in addition to
combined antibiotic therapy. One of them died due to immediate complication
of cardiac surgery, but the others had an excellent recovery. Our study
shows that medical treatment is not sufficient for Brucella mellitensis
endocarditis, and urgent cardiac valve replacement must be considered.
The prognosis will not be poor with combined medical and surgical
therapy.
http://mjiri.iums.ac.ir/article-1-1504-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
29
34
article
EXPERIENCE WITH ADRENOCORTICAL TUMORS IN CHILDREN: A REPORT OF ELEVEN CASES
M RAZZAGHIAZAR
1
J AHMADI
2
A RABBANI
3
N NEZAKATGOO
4
M MOSAVATI
5
Y SHAFEGHATY
6
From the Department of Pediatric Surgery and Pediatric Endocrinology, Children's Medical Center Hospital.Tehran University of Medical Sciences
From the Department of Pediatric Surgery and Pediatric Endocrinology, Children's Medical Center Hospital. Tehran University of Medical Sciences
From the Department of Pediatric Surgery and Pediatric Endocrinology, Children's Medical Center Hospital. Tehran University of Medical Sciences
From the Department of Pediatric Surgery and Pediatric Endocrinology, Children's Medical Center Hospital. Tehran University of Medical Sciences
From the Department of Pediatric Surgery and Pediatric Endocrinology, Children's Medical Center Hospital. Tehran University of Medical Sciences
Shahid Rahnamoon hospital, Iran University of Medical Sciences, Tehran, Islamic Republic of lran.
During a period of IS years from 1975 to 1989, eleven children with
adrenocortical tumors were managed with relatively favorable results in our
center. Despite its rarity in the pediatric age group, our series is one of the
largest reported in the literature in the given period of time. All of our 11
patients presented with hyperfunction of the adrenal cortex. Virilization
alone was the most frequent presenting sign, occurring in eight patients.
Two patients suffered from Cushing's syndrome and one patient had
mixed presentation of Cushing's syndrome and virilization. There were six
females and five males in the series. Four of five males presented before two
years of age. Female patients presented at an older age.
In nine out of 11 patients the tumor was on the right side. Mean age at
presentation was 3.55 years. Serum levels of testosterone, dehydroepiandrosterone
(DHEA), and cortisol were elevated in all cases tested and
apparently are superior alternatives to more traditional measurements of
urinary 17- ketosteroids and 17-hydroxy corticosteroids.
The majority of our cases were investigated by the employment of IVP
and sonography. In one patient I131 iodocholesterol scintigraphy was used.
Transabdominal approach through a transverse upper abdominal incision is
recommended.
In this series only one intraoperative complication was encountered. At
a mean follow-up of five years, 10 out of 11 children were alive and had no
evidence of tumor recurrence.
In all patients pre-operative steroid replacement was essential. Contrary
to our pathologic reports «six adenoma, three carcinoma, and two
undetermined» we found favorable outcomes in the majority of our patients.
We conclude that in contradiction to previous concensus, most pediatric
adrenocortical tumors will behave as a benign neoplasm and that the size and
weight are the only morphologic predictors of their biological behavior.
http://mjiri.iums.ac.ir/article-1-1503-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
25
27
article
MATERNAL AND NEWBORN PROTEIN STATUS AT DELIVERY IN A PUBLIC AND A PRIVATE MATERNITY HOSPITAL IN TEHRAN
MD FROOZANI
1
EXIR MONFARED
2
I NOURMOHAMMADI
3
From the School of Public Health, Tehran Univ. of Medical Sciences, Tehran
From the School of Public Health, Tehran Univ. of Medical Sciences, Tehran
the' Department of Biochemistry, College of Medicine, Iran University of Medical Sciences, Tehran, Islamic Republic of lran.
Protein status of 194 pregnant women and their newborn at a public and
a private maternity hospital in Tehran was studied. Blood samples were
taken from all women before delivery and from cords at delivery of the
placenta. The following determinations were made: total serum protein,
protein fractions, creatinine and urea. In the private group, significantly
higher maternal mean values were found for serum urea (P<0.01), albumin
(P<0.05) and B -globulin (P<0.01) when compared to the public group. In
cord blood, the mean serum creatinine (P<0.01) and urea (P<0.02) were
significantly higher and B -globulin (P<O.05) was lower in the private group
when compared to the public group. It can be concluded that socio-economic
status clearly affects maternal nutrition, thereby affecting to some extent the
nutritional status of the fetus.
http://mjiri.iums.ac.ir/article-1-1502-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
21
24
article
HEMOPHAGOCYTIC SYNDROME IN TYPHOID FEVER AND BRUCELLOSIS
MOJTABA TABARESTANI
1
From tile Department of Clinical Pathology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
Hemophagocytic syndrome is a non-malignant process that is characterized
clinically by fever, hepatomegaly, splenomegaly, pancytopenia in
peripheral blood, and reactive histiocytes in the bone marrow. Bacterial
infectious diseases like typhoid fever and brucellosis and viral infections
including CMV, herpes viruses, and Epstein-Barr virus are diagnosed as the
cause of this syndrome. In this paper we present six patients with hemophagocytic
syndrome who had blood culture or bone marrow culture, and or
serology positive for typhoid fever or brucellosis. This is the first report of
hemophagocytic syndrome in Iran.
http://mjiri.iums.ac.ir/article-1-1501-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
17
19
article
PAPILLARY THYROID CARCINOMA IN MASHHAD
R RAJABIAN
1
T GHIASSI
2
F HAGHIGHI
3
From the Department of Pathology and Internal Medicine', Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran.
Thyroid cancer is the most common endocrine malignancy. This study
surveys the pathologic characteristics of thyroid cancerin Mashhad and study
of papillary carcinoma in more detail. In this retrospective study, 108 out of
197 cases of thyroid cancer were papillary in type (55%), with female to male
ratio of 1.91 which is lower than current reports. The age at the time of
diagnosis ranged from five to 78. Mean age for females was 36 and for males
was 38.45 years. We hope that this study will stimulate physicians to
reevaluate their thoughts about thyroid cancer and try to recognize such
patients at an earlier stage in the course of their disease.
http://mjiri.iums.ac.ir/article-1-1500-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
13
15
article
COLORECTAL POLYPS: EVALUATION IN TWO YEARS
HOSSEIN FOROOTAN
1
From the Department of Gastroenterology, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran,
From June 1989, to June 1991, 58 patients with GI polyps were
reviewed. Except two patients who had multiple polyps, 56 had only one
polyp. The size of polyps were 0.5 to 3 em in diameter. 51 (75%) of polyps
were located in the rectosigmoid region, 25 (37%) were in the rectum and 26
(38%) in the sigmoid. (Seventeen) (25%) polyps (two in right colon, four in
transverse, and 11 in descending colon) were located in other regions.
Patients were between nine months to 70 years old. 14 polyps were reported
to be inflammatory, and 17 adenomatous. Polypectomy was done for all
patients, and no massive bleeding, bacterial infection, or perforation were
observed. Only five patients had slight bleeding which was treated by
conservative measures.
http://mjiri.iums.ac.ir/article-1-1499-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
7
12
article
A STUDY OF ADULT HEIGHT, WEIGHT, AND OBESITY IN SHIRAZ, IRAN, 1988-1989.
S.M.TAGHI AYATOLLAHI
1
RG CARPENTER
2
From the Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
the Medical Statistics Unit. London School of Hygiene and Tropical Medicine, London WCIE 7 HT, England.
Height, weight and body mass index (BMI) of married adults aged 20-69 years with a school-aged child in Shiraz (Iran) are reported. Smoothed
centile values have been derived from the raw data by Healy's nonparametric
method. Factors affecting obesity of adults are examined. Shiraz adults are
taller and heavier than most adults from developing areas of the world, but
are shorter and lighter than most European countries. They are substantially
bigger than previously reported. The results provide normal ranges of
height, weight and body mass index (BMI) appropriate for clinical work in
Iran.
http://mjiri.iums.ac.ir/article-1-1498-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1992-05
6
1
1
6
article
MODIFIED METHYLMETHACRYLATE CRANIOPLASTY IN 127 CASES OFWAR CASUALTIES
MAZIAR AZAR
1
AHMAD TAHAMY
2
AFSOUN KABOLY
3
From the Dept. of Neurosurgery, Iran University of Medical Science, Tehran, Islamic Republic of lran.
We report 127 cases who have had elective operation on cranium
because of skull bone defect during 1984-1989. Usually repair of skull bone
defect and preserving normal anatomy were the major therapeutic goals. 10, II
In these cases a new surgical technique is described which can successfully
accomplish these goals in a single but staged operative procedure.
http://mjiri.iums.ac.ir/article-1-1497-en.pdf