eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
299
300
article
THE SYNTHESIS AND ANTIMICROBIAL PROPERTIES OF 4-CHLORO-2,6-BIS (2-HYDROXY- α- TOLYL) PHENOL
AA Moshfegh
1
A AZARIPOUR
2
H MOTTAGHIAN
3
GH HAKIMELAHI
4
From the Department of Chemistry, Microbiology, and Surgery, Shiraz University of Medical Siences, Shiraz, Islamic Republic of Iran.
The synthesis of the title compound is described. This compound was
found to be active (3c) against a number of pathogenic microorganisms in
vitro. It is a non-absorbable antibacterial topically and its pharmacologic
studies revealed that it is a non-toxic agent with a wide range of safety. It
proved to be effective in the prevention and treatment of pseudomonaswound
infections in volunteer patients.
http://mjiri.iums.ac.ir/article-1-1538-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
293
297
article
THE ISOLATION OF ENZYME TRANSKETOLASE FROM HUMAN ERYTHROCYTES: THE CHARACTERIZATION OF ITS QUARTERNARY STRUCTURE
ROSHANAK RAHIMIAN
1
BIJAN FARZAMI
2
ABBAS SAMADI
3
From the Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran
the Department of Pharmacology; School of Medicine, Gilan University of Medical Sciences, Gilan, Islamic Republic of lran.
From the Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran
Human erythrocyte transketolase (sedoheptulose-7-phosphate:
D-glyceraldehyde-3-phosphate, glycolaldehyde transferase, E.C. 2.2.1.1.)
has been isolated from erythrocytes with a specific activity of 59.84 U/mg.
SDS-PAGE and SE-HPLC were used both as a measure of purity and as a
preparative mean to obtain a higher degree of purity. Four protein bands
corresponding to molecular weights of 32,000, 39,000, 43,000 and 60,000
were obtained in electrophoresis and SE-HPLC preparations. Activity
measurements on the two fractions obtained from SE-HPLC that contained
a monomer with the molecular weight of 32,000 and a dimeric fraction with
the molecular weight of 60,000 showed that the monomeric form of the
enzyme displays activity in the presence and absence of the TPP and Mg(II).
This activity was measured to be 14.76 U/mg in the absence of TPP and
Mg(II), and 40.24 U/mg in the presence of the cofactors. The dimeric form
showed an activity of 58.84 U/mg in the presence of the cofactors.
http://mjiri.iums.ac.ir/article-1-1537-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
287
291
article
CORRELATION BETWEEN ELECTROCARDIOGRAPHIC AND HISTOPATHOLOGICAL CHANGES IN ISOPRENALINE-INDUCED MYOCARDIAL INJURY
KESHAV ANAND
1
SAROJ PANDE
2
RK GUPTA
3
Form the' Dept. of Physiology, Medical School, Kerman University of Medical Sciences, Kerman
Dept. of Physiology, Maulana Azad Medical College, New Delhi, India
Dept. of Pathology, Medical School, KermanUniversity of Medical Sciences, Kerman, Islamic Republic of Iran.
Myocardial injury was induced in 25 dogs by infusing isoprenaline, 2-4
microgram per kg per minute for the duration of six hours. 10 dogs served as
controls which received only physiological saline. Animals receiving isoprenaline
2 microgram per kg per minute were labelled as experimental group A
and other receiving microgram per kg per minute as experimental group B.
Histopathological observations in experimental groups A & B showed
subendocardial haemorrhage in the papillary muscles and apex of left
ventricle as early as two-three hours of infusion. Focal lesions characterized
by congestion, dilatation and extravasation of blood was observed near
necrotic myocardium. Group A animals showed only severe tachycardia
while in group B myocardial infarction in 80% and only ischaemic changes in
20% of animals were observed. Out of animals in group B, 37.5% developed
myocardial infarction after two hours of infusion while remaining 62.5%
developed changes after four hours. Histopathological changes were
very well correlated with ECG findings observed in the present study.
http://mjiri.iums.ac.ir/article-1-1536-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
273
286
article
A SURVEY OF THE VIEWS OF IRANIAN SA V ANTS (ESPECIALLY PERSIAN MUSLIM PHYSICIANS) ON THE SUBJECT OF CONTAGIOUS DISEASES AND IMMUNITY
HASSAN TADJBAKHSH
1
From the Faculty of Veterinary Medicine. Tehran University
http://mjiri.iums.ac.ir/article-1-1535-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
267
272
article
GROWTH MODELLING OF SCHOOL CHILDREN IN IRAN USING SHIRAZ DATA
S.M.TAGHI AYATOLLAHI
1
RG CARPENTER
2
From the Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, lran
and the Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London WCI E 7HT, England.
Centile values and growth charts for height, weight and arm circumference
are presented for school children aged six to 12 years in Shiraz (Iran).
The smooth centile values have been derived from the raw data by Healy's
nonparametric method. Girls grow faster than boys. Homogeneity of data
with population structure and universal rationing imply that these norms are
likely to be appropriate to all urban children in Iran. These observations are
in favour of using local standards in clinical diagnosis and nutritional
screening in order to develop efficient and effective health programmes.
http://mjiri.iums.ac.ir/article-1-1534-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
265
266
article
SERUM ZINC CONCENTRATIONS IN DIABETIC PATIENTS COMPARED WITH NON- DIABETICS IN ISFAHAN
AR Emami
1
Z SAMSAMSHARIAT
2
M SUZANGAR
3
F GHANNADI
4
A AZIZ-ZADEH
5
From the Nutrition Research Institute, and the Isfahan University of Medical Sciences, Department of Biochemistry,
To study the zinc concentration differential in diabetic patients compared
with non-diabetics and borderline subjects in a sample of two hundred
individuals under investigation, we gathered information on history and
duration of diabetes as well as type of treatment and diet. In addition,
capillary blood glucose and serum zinc concentrations were measured.The
serum zinc level was higher in diabetic patients compared to borderline and
non-diabetics. The higher level of zinc in diabetic patients may be due to their
change of energy source and the lower phytate and higher zinc content of
their new diets which consequently reduce the effect of this substance on zinc
absorption. The reason for lower levels of zinc in the borderline subjects is
not presently clear and needs further investigation.
http://mjiri.iums.ac.ir/article-1-1532-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
261
264
article
EFFECTIVENESS OF CHEMOTHERAPY IN 54 CASES OF ADVANCED GASTRIC CANCER IN ISFAHAN
TALEB AZARM
1
FAZLOLLAH GHANNADI
2
From the Department of Haematology and Oncology, FacuIty of Medicine, and Office of Vice-Chancellor for Research, Isfahan University of Medical Sciences. Isfahan, Islamic Republic of Iran.
To determine the effectiveness of chemotherapy in the treatment of
gastric cancer, a sample of 54 patients suffering from advanced adenocarcinomas
were studied. The results of the study showed that the disease is more
prevalent in the age group of56-60 years. The three major signs of this kind of
cancer were almost equally present among both sexes in our patients. After
chemotherapy, 74% of the patients survived up to one year and 50% survived
up to two years or more following treatment. Chemotherapy increased the
survival rate of the patients but our results were less successful compared to
that of other institutions. This probably is due to delayed referral of patients
to the physician. It is suggested that those patients in age groups 56-60
showing the slightest signs of gastric cancer be examined by a physician and it
is hoped that early detection of the disease will increase the survival rate of
the patients.
http://mjiri.iums.ac.ir/article-1-1531-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
257
260
article
EVALUATION OF CELL-MEDIATED IMMUNITY IN MUSTARD GAS INJURIES
T ZANDIEH
1
S MARZBAN
2
G HASSIRI
3
F TARABADI
4
H ANSARI
5
From the Iranian Blood Transfusion Center, Villa Ave, No.J38, Tehran, Islamic Republic of Iran.
Yamakido, et al. in 1986 have studied immunological parameters in
poison gas workers, and a depression has been observed in immunologic
response. Also, the frequency of cancer has reached as high as five-fold that
of the general population. In the present study, cell-mediated immunity
(CMI) was measured in three groups of Iranian mustard gas-injured
patients.
The first group were those who had been injured three months up to one
year before, and the second group were studied one to two years after in jury,
and the third. group were studied after two years from the time of injury. The
following results were obtained:
1- In comparison with normal controls (61.5±4), T lymphocytes
showed a significant decrease in 50% of the three groups (50.71±15. 7
46.95±15) of poison gas injury, and B lymphocytes were increased, but no
significant difference could be seen in mitogen response to PHA.
2- In comparison with normal control (47 ±9), T helpercells (T4) in 52%
of the first and second groups were significantly decreased (33. 14± 16.59).
3- T suppressor cells (T8) in 53% of the first group, and in 22% of the
second and third groups (27.29±11. 77 21. 4±6. 89) were increased in
comparison with normal controls (20±6).
4- Ratio of T4 to T8 in 71 010" of the first group and 60% of the second and
third groups were decreased. Therefore depression of CMI in poison gas
injury was observed after one, two, and three years, which will be discussed
in this paper.
http://mjiri.iums.ac.ir/article-1-1530-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
253
255
article
URETEROSCOPY IN 104 PATIENTS
MS ILBEIGI
1
From the Department of Urology, Air Force Medical Center, Tehran, Islamic Republic of lran.
From July, 1987 to Oct, 1989 , 104 patients underwent 111 transurethral
ureteroscopy procedures at the Air Force Medical Center. All intramural
ureters were dilated by flexible metal dilators. The overall success rate for
ureteral stone removal was 95.8 per cent. Ureteroscopy was done for
evaluation of gross hematuria, strictures, ureteral stent, and ureteral and
pyelocalyceal tumors. The overall mean hospital stay was 2.5 days with no
important complications.
http://mjiri.iums.ac.ir/article-1-1529-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
247
252
article
TRANS URETERAL LITHOTRIPSY
ABBAS BASIRI
1
NASSER SIMFOROOSH
2
From the Department of Urology, Labbafi- Nejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
From Sep. 1984 to Aug. 1990,99 patients were treated for ureteral stone
using the urekroscope.
In five patients ureteroscopy was repeated for a second stone. In one
patient the procedure was diagnostic in nature and in the rest of the patients it
had a curative value. In 60 patients the stone was removed by electrohydraulic
and basket combination and in25 cases, dilatation alone was enough.
Rate of success was 84.6%, with a 10% rate of complications. We
conclude that TU L is the treatment of choice for ESWL- resistant stones or in
patients with ureteral anomalies.
http://mjiri.iums.ac.ir/article-1-1528-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-11
4
4
241
246
article
VASCULAR ACCESS FOR HEMODIALYSIS: OUR EXPERIENCE WITH 3337 CASES
MOHAMMADREZA KALANTAR MOTAMEDI
1
From the Department of Surgery, Shohada Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Over a seven year period from 1982 to 1989,3337 conduits were created
in 3137 patients with end stage renal disease (ESRD) as access for chronic
dialysis. These included 2690 side-to-side arteriovenous fistulae (A VF), 168
end-to-side A VFs, 10 autogenous vein grafts, 51 homogenous frozen vein
grafts, 109 polytetrafluoroethylene (PTFE) grafts, 209 emergency external
arteriovenous shunts, three dual-lumen catheter placements with dacron felt
cuff in the superior vena cava and 13 miscellaneous vascular access procedures.
Our favorite site for creation of A VFs along with satisfactory patency
rates for as long as seven years are demonstrated for all types of fistulae and
PTFE grafts by life-table analysis.
Early failure of A VFs usually occurred in the postoperative period due
to hypotension, and late failures were due to improper use of the vein during
dialysis.
Thrombosis was the cause of the majority of the PTFE graft failures,
even though we had four cases of infection more than one year later and one
case of seroma formation due to weeping of the graft. False aneurysm
formation and secondary bleeding requiring repair were the major complications
of PTFE grafts.
Autogenous or frozen banked homogenous vein graft failures were
mainly due to gradual fibrosis and narrowing and eventual thrombosis, while
we did not have infection or false aneurysm formation or any other
complication with them.
http://mjiri.iums.ac.ir/article-1-1527-en.pdf