eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
65
70
article
SEPARATION OF NONHISTONE HIGH MOBILITY GROUP (HMG) FROM HUMAN LYMPHOCYTES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
ABBAS K. SAMADI
1
NASSER MALEKNIA
2
From the' Dept. of Biochemistry. Kashan University of Medical Sciences, Kashan
the Dept. of Biochemistry, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
The high mobility group (HMG) of nonhistone proteins have been
investigated using two high performance liquid chromatographic techniques
(HPLC). Reversed-phase HPLC under conditions of 50 mM triethylamine
adjusted to pH 2.2 with phosphoric acid (solvent A) and 95% acetonitrile in
water (solvent B) was used to separate proteins primarily on the basis of
differences in the overall hydrophobicity. Size exclusion HPLC under
conditions of two different solvents (A, 0.1 % trifluoroacetic acid 1FA B,
1.0% sodium dodecyl sulphate, SDS) was used to separate proteins. HMG
proteins from human lymphocytes were separated into the HMG 1, HMG 2,
HMG 14 and HMG 17 components. RP-HPLC is a proper method to resolve
all the human lymphocyte HMG-proteins. Size exclusion HPLC was employed
to resolve the HMG-protein subunits and determine their molecular
weights. Ideal SE-HPLC is not capable of resolving HMG 1 from HMG 2 or
HMG 14 from HM G 17 due to their molecular weight similarities. The purity
of protein fractions were examined by acetic acid-urea-triton X-100 gel
electrophoresis.
http://mjiri.iums.ac.ir/article-1-1573-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
61
64
article
PLASMA DEHYDROASCORBIC ACID LEVELS IN IRANIAN SUBJECTS WITH DIABETES MELLITUS
ISSA NOURMOHAMMADI
1
ZOHREH HONARI
2
ALI KESHAVARZ
3
MOSTAFA NILFORUSHAN
4
From 'he' College of Medicine, Iran University of Medical Sciences. Tehran
the College of Health, Tehran University of Medical Sciences', Tehran. Islamic Republic of Iran.
the College of Health, Tehran University of Medical Sciences', Tehran. Islamic Republic of Iran.
From 'he' College of Medicine, Iran University of Medical Sciences. Tehran
Several reports concerning high plasma dehydroascorbic acid
(DHAsA) levels in diabetics have been published and from these reports,
suggestions that monitoring of DHAsA levels in those persons with a
predisposition to diabetes mellitus would be of value. However, conflicting
reports have also appeared which do not confirm high levels of DHAsA in
diabetic subjects when compared to controls. Because of these conflicting
results, this investigation using Iranian diabetic subjects was undertaken to
ascertain whether or not periodic monitoring of DHAsA levels would be of
value as an indicator of prediabetic conditions. Our results do not confirm
high levels of DHAsA in diabetics but because of the many theories
concerning the mechanism of action and the metabolism of DHAsA,
previous findings cannot be disregarded.
http://mjiri.iums.ac.ir/article-1-1572-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
53
59
article
ENDOGENOUS RELEASE OF OPIATES BY REPETITIVE ELECTRICAL FIELD STIMULATION IN THE GUINEA-PIG AND RAT ILEAL LONGITUDINAL MUSCLE
A A. NAJAFI-FARASHAH
1
From the Department of Physiology, Medical School, Yazd University of Medical Sciences, Yazd, Islamic Republic of Iran.
The effect of repetitive electrical field stimulation and the response of
the guinea-pig and rat ileal longitudinal muscle to single pulse stimulations
was examined. Single pulse field stimulation produced twitch contraction
which was inhibited by repetitive field stimulation (10 Hz, 40V, 0.5 msec for 5
m). This inhibition was largely, though never completely, reversed by
naloxone. Contractions due to exogenous acetylcholine and histamine were
also inhibited after repetitive field stimulation. The inhibition of acetylcholine
response was party reversed by naloxone whereas that of histamine was
not. Contractions due to single pulse field stimulation or to either acetylcholine
or histamine were inhibited by prior exposure to high concentrations of
acetylcholine as a substitute for high frequency stimulation. The inhibitory
responses were resistant to naloxone. The inhibitory responses to acetylcholine
and histamine after exposure to the lowest concentration of acetylcholine
was seen in preparations treated with tetrodotoxin or hemicholinium.
The inhibition of the histamine response by acetylcholine pretreatment was
prevented by mepyramine. Response to histamine, but not those to single
pulse field stimulation or acetylcholine, were inhibited by prior exposure to
histamine. It is concluded that repetitive field stimulation possibly initiates
two distinct inhibitory processes. One involves the release of endogenous
opiates and is probably mediated by inhibition of acetylcholine release. The
second type of inhibition is not mediated by endogenous opiates and can be
explained by post-junctional desensitization. The non-specific desensitization
to histamine is probably a consequence of histamine release from mast
cells by acetylcholine.
http://mjiri.iums.ac.ir/article-1-1571-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
47
52
article
THE ROLE OF T-L YMPHOCYTE SUBPOPULATION IN RENAL ALLOGRAFT REJECTION
M NOBAKHT
1
N SIMFOROOSH
2
ALI MOHAMADIAN
3
B AMIR-ANSARI
4
From the' Department of Histology, Tarbiat Modarres University
Department of Kidney Transplantation,
the Pasteur Institute, Tehran, Islamic Republic of lran
Twenty-two recipients of HLA-nonidentical living related and nonrelated
renal allografts were studied for alterations in the relative percentage
of OKT4-positive peripheral blood T-cells after transplantation. Characteristic
shifts in the ratio of T-helper to T -suppressor/cytotoxic cells (TH/TS-C),
but not absolute cell numbers, were demonstrated to correspond with the
status of the allograft. Our results are indicative of a correlation between
rejection episodes and the increase in OKT4:0KT8 ratios, that were
characterized by a significant rise in the percentage of OKT4-positive cells
(P=0.001), and a decrease in the percentage of OKT8-positive cells
(P=0.001).
http://mjiri.iums.ac.ir/article-1-1570-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
37
46
article
NEUROPSYCHIATRIC DISORDERS IN THE OLDEST MEDICAL TEXTBOOK IN PERSIAN WRITTEN AROUND 990 A.D.
MR MOHARRERI
1
From the Department of Medical Ethics and History of Medicine, Shiraz University of Medical Sciences, Shiraz , Islamic Republic of Iran.
Written around 990 A.D., Hidayat-MllIaallemill Fit Tibb (Student's
Guide ill Medicine) is the oldest general medical text known to have been
written in modern Persian. Little is known of the author other than the fact
that he was apparently a well experienced practicing physician by the name of
Abu Bah Rabi' bin Ahmad al-Akhawaini from Bukhara who claimed to bea
second generation student of Razi.
The neuropsychiatric sections of the book are of particular interest
because the author apparently had a personal interest in and reputation for
treating the insane. According to one of the manuscripts he was known as the
"Physician of the Insane" by his contemporaries.
Following the line of other Islamic medical writers, the author has
described the major neuropsychiatric disorders in the chapter dealing with
the "Diseases of the Head and Brain". These include Melancholia, Mania,
Epilepsy, Phrenitis, Lethargy, and Delerium. Hysteria is, however, described
among the diseases of the female reproductive system.
Both the terminology used and the authorities quoted betray the
author's schooling in and devotion to the Graeco-Roman medical traditions
adopted by early Islamic medical writers. He emerges as a hard-headed
organic physician dedicated to the humoral doctrines of mental illness.
http://mjiri.iums.ac.ir/article-1-1569-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
31
36
article
A STUDY OF 17 PATIENTS WITH PULMONARY SARCOIDOSIS IN MASHAD
PARVIZ VAHEDI
1
From the Mashhad University of Medical Sciences, Imam Reza Hospital, Mashhad, Islamic Republic of Iran.
Thirty patients with bilateral lymph node enlargement with or without
parenchymal infiltrates on the chest x- ray suspected to have sarcoidosis were
studied between June 1980 and December 1989 in our institution. Eleven of
these patients who were free of parenchymal infiltrates did not have a biopsy
performed and the diagnosis of sarcoidosis was made based on self-limited
regression and clearing of the chest X-ray findings. However, these cases
Were excluded from our study along With two other cases which upon
transbronchial lung biopsy (TBLB) failed to show the disease. Seventeen
of our cases had sarcoidosis, fourteen proven by TBLB, two by skin biopsy
and one by parotid gland biopsy. Our study shows that sarcoidosis is not a
rare disease in IRAN. TBLB is a good way to diagnose sarcoidosis especially
when parenchymal involvement is present on the chest X-ray.
Although stage I of the disease was more common in our series, it is
probable that this is a false findingimd if TBLB were repeated more cases of
stage III of the disease would be found.
http://mjiri.iums.ac.ir/article-1-1568-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
25
28
article
ROTAVIRUS INFECTION IN CHILDREN WITH ACUTE DIARRHEA IN TEHRAN
SAFIEH AMINI
1
ALI ASGHAR SOLATI
2
AHMAD FAYAZ
3
MAHMOOD MAHMOODI
4
From tire Department of Virology, Pasteur Institute of Iran, Tehran
From tire Department of Virology, Pasteur Institute of Iran, Tehran
From tire Department of Virology, Pasteur Institute of Iran, Tehran
Department 0/ Epidemiology and Biostatistic, School 0/ Public Health, University a/Tehran, Islamic Republic Iran.
The etiology of acute diarrhea was studied in 915 children under 5 years
of age between March 1986 and August 1987, in 7 hospitals in Tehran. 65
healthy children in similar age groups served as controls. Rotavirus was
found in 25% of the patients and 1.5% of controls with the highest detection
rate occurring in the 7-24 month age group (28%) and declining beyond 25
months of age (5%). The infection rate was also high (19%) in the first 6
months of life and breast feeding was not protective. The rate of rotavirus
infection was highest during the months of April and May (30% and 37%
respectively) and lowest during December and January (7%).
http://mjiri.iums.ac.ir/article-1-1567-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
21
23
article
SIMPLE LIGATION VERSUS STUMP INVAGINATION DURING APPENDICECTOMY-A PROSPECTIVE TRIAL
TARIQ MUFTI
1
SYED SULTAN
2
R AHMED
3
G ALI
4
A AZIZI
5
M NAWAZ
6
From the Department of Surgery, DHQ (Teaching) Hospital, Abbottabad. Pakistan.
A prospective, randomized trial on 416 consecutive cases of appendicectomies
was carried out in which half of the cases had simple ligation of
the stump and the rest had invagination of the stump in addition. The two
groups were matched for age, sex, state of personal hygiene and nutrition.
The incidence of wound infection, and early and late post-operative
complications remained comparable between the two groups. However, the
mean operating time was significantly less in case of simple ligation. Barium
enema in suspected cases of caecal neoplasm in post-operative cases did not
reveal any ceacal deformity in the group of simple ligation thus avoiding
confusion of mistaking deformed caecum due to the invaginated stumps as
neoplasm. Simple ligation of the appendiceal stump is therefore advocated
during appendicectomy.
http://mjiri.iums.ac.ir/article-1-1566-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
13
19
article
BLOOD PRESSURE COMPONENTS AS PREDICTORS OF STROKE MORTALITY IN WEST SCOTLAND
MOHSEN JANGHORBANI
1
ANTHONY J. HEDLEY
2
RAYMOND B JONES
3
HARPER GILMOUR
4
MOTAHAREH ZHIANPOUR
5
CHARLES R. GILLIS
6
VICTOR M. HAWTHORNE
7
From the Department of Community Medicine, University of Glasgow, Glasgow GI2 800
The relative importance of systolic (SBP) versus diastolic blood
pressure (DBP) and other combinations of SBP and DBP in the prediction of
stroke have been re-examined in a long term cohort study of 10,541 men and
women aged 45-64 in West Scotland.
During a mean follow-up of 11.6 years 1, 616 deaths occurred, among
which 160 (9.9% 80 male, 80 female) were due to stroke.
In a multiple logistic regression (MLR) model the predictive values of
SBP, DBP, mean arterial pressure (MAP), mean arterial index (MAl) and
pulse pressure (PP) were examined in relation to stroke mortality after
adjustment for age, body mass index (BMI), casual blood glucose, serum
cholesterol, and cigarette smoking at entry. All blood pressure measures
were associated with stroke mortality in females the risk of stroke mortality
was more strongly associated with DBP in males SSP and DBP have the
same predictive influence on stroke mortality and the MAP and MAl have
stronger associations with it than either SBP and DBP. PP is associated with
the least excess risk in both genders.
http://mjiri.iums.ac.ir/article-1-1565-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
9
11
article
PREVALENCE OF PITYRIASIS VERSICOLOR IN WAR-WOUNDED AND CHEMICAL (MUSTARD) GAS-WOUNDED PATIENTS IN IRAN-IRAQ WAR
MASOOD EMAMI
1
MOHAMMAD GHAHRI
2
From the College of Health Sciences, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
A total of 1118 soldiers who were wounded in war and hospitalized in
Tehran, were examined for P .versicolor-a superficial mycotic infection.
Of these, 213 were war-wounded, 54 chemical (mustard) gas-wounded,
42 both war and chemical gas-wounded, 105 had infectious and noninfectious
diseases, and 704 were apparently healthy soldiers serving in war
fronts who were examined for P. versicolor and its relation with a history of
contact with mustard gas.
In this study the prevalence of P. versicolor among the above groups
was: 7.40%, 1.85%, 9.52%, 11.42% and 6.11 % respectively.
Upon microscopic examination (Scotch tape method) from hyperpigmented
parts of the skin resulting from mustard gas, P. orbiculare (the
etiologic agent of P. versicolor) was seen abundantly. This observation leads
us to hypothesize that there may be a relation between P. versicolor and
previous contact with mustard gas.
http://mjiri.iums.ac.ir/article-1-1564-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
5
8
article
THE CLINICAL APPLICATION OF PREFABRICATED FREE FLAPS FOR NASAL RECONSTRUCTION
AHMAD MOGHARI
1
KS FOROOTAN
2
SA EMAMI
3
From the Department of Hand and Reconstructive Microsurgery, Hazrate Fatimah Hospital, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.
We have found prefabrication of hairless radial forearm free flap to be a
useful technique for nasal reconstruction. Prior skin grafting and a suitable
period of maturation permits safe, reliable surgery. Its use should be
considered in those patients whose forehead tissue is not suitable or in whom
appropriate distant flaps are not available, as is often the case with hirsute
males.
http://mjiri.iums.ac.ir/article-1-1563-en.pdf
eng
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
1990-02
4
1
1
4
article
CHILDHOOD RESPIRATORY TUBERCULOSIS IN IRAN
AA VELAYATI
1
M MOHAMMADI
2
From the Department of Pediatrics, Tehran University of Medical Sciences, and the Division for Research on Pulmonary Diseases Institute Pasteur De L'lran, Tehran, Islamic Republic of lran.
To estimate the bacterio-epidemiological situation of childhood respiratory
tuberculosis in Iran, 2185 symptomatic patients of 0-14 years old
were studied. Among 110 bacteriologically confirmed cases, 60% were less
than five years old and the number of females was slightly more than males.
In 21 % of patients, the Mantoux test was negative. None of the miliary cases
had a history of BCG vaccination. In 54.6% of patients less than two years
old, one of the family members was suffering from infectious tuberculosis.
Clinical findings were fever, cough, weight loss and respiratory distress
respectively. Radiological findings were mostly pneumonia or
bronchopneumonia-like infiltrations and in 44% of cases were found in the
right lung. Mycobacterium tuberculosis strains in 11.7% of patients were
resistant to isoniazid or streptomycin.
http://mjiri.iums.ac.ir/article-1-1562-en.pdf