@article{ author = {lRAVANLOU, GUITI and MAHJOUB, FATEMEH}, title = {AN UNUSUAL ADNEXAL TUMOR WITH DIFFERENTIATION TOWARDS HAIR FOLLICLE, WITH CONCOMITANT PRESENCE OF TRICHOFOLLICULOMA, TRICHOEPITHELIOMA AND PILOMATRICOMA IN ONE LESION: A CASE REPORT}, abstract ={A case of an interesting previously unreported mixed adnexal tumor of the scalp of a 38 year old man is presented, which was composed of randomly dispersed areas of trichofolliculoma, trichoepithelioma, and pilomatricoma concomitantly. While these lesions are classified under adnexal tumors with differentiation towards hair follicle structures, controversy is present concerning the exact origin and the pathway of their differentiation. So the concomitant presence of them in one lesion may be strong evidence for a common origin or a common direction of differentiation.}, Keywords = {Trichofolliculoma, Trichoepithelioma, Pilomatricoma, Adnexal tumor, Hair follicle structures.}, volume = {14}, Number = {2}, pages = {191-194}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-889-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-889-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {FARROKH, D}, title = {GIANT HAMARTOMA OF THE BREAST: REPORT OF A CASE AND REVIEW OF THE CURRENT LITERATURE}, abstract ={Hamartoma of the breast is a rare benign breast lesion which is unfamiliar to most clinicians, although the mammographic features are usually characteristic. Hamartomas are composed of ducts, lobules, fat and fibrous tissue. These benign lesions are likely to be increasingly diagnosed because of routine screening and hence clinical awareness is paramount to prevent these lesions from being overtreated. A patient who presented with a soft mobile breast lump which was later diagnosed to be a giant breast hamartoma is presented along with a brief review of the current literature.}, Keywords = {}, volume = {14}, Number = {2}, pages = {187-189}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-888-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-888-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {A. EBRAHIMINEJAD, A and ZAREE, A}, title = {ISOLATED CEREBRAL METASTASIS OF HEPATOBLASTOMA IN A 3-YEAR OLD CHILD}, abstract ={Hepatoblastoma (HB) is a rare tumor of infancy and childhood manifesting with hepatomegaly and abdominal distention. It is seen with increased frequency in association with congenital hemihypertrophy and renal anomalies. Metastases to other organs, including the lungs, lymph nodes and even ovaries is well known. But cerebral metastasis of this tumor, especially in the absence of metastasis to other organs, has not yet been reported. In this paper a 3-year old male child with congenital hemihypertrophy and isolated metastasis of HB to the brain is presented.}, Keywords = {Cerebral metastasis, Hepatoblastoma (HB).}, volume = {14}, Number = {2}, pages = {185-186}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-887-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-887-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {GHOFRANI, M and ZAMANI, GR}, title = {MELAS SYNDROME IN TWO IRANIAN CHILDREN}, abstract ={MELAS syndrome is a mitochondrial disorder with progressive nature, because adequate treatment is not available. Diagnosis of this mitochondrial disorder depends initially on clinical suspicion, which is strengthened by additional metabolic evidence of impaired oxidative metabolism such as high serum or C.S.F. lactate levels and confirmed by demonstration of mitochondrial abnormalities-in muscle biopsy. Here we present the clinical course and management of two children with MELAS syndrome who exhibited progressive neurologic deterioration.}, Keywords = {MELAS syndrome, mitochondrial disorders.}, volume = {14}, Number = {2}, pages = {181-184}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-886-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-886-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {RASOULI, M and SHARIF, M and ZAHRAIE, M}, title = {SUPPRESSION OF VLDL-TRIACYLGLYCEROL SECRETION B Y BOTH α AND β-ADRENOCEPTOR AGONISTS IN ISOLATED RAT HEPATOCYTES}, abstract ={The effects of alpha and beta-adrenergic stimulation on triacylglycerol secretion were investigated in isolated rat hepatocytes. Epinephrine within 3h of incubation suppressed triacylglycerol secretion by 35% and increased its cellular content by 18%. The inhibitory effect of epinephrine was abolished by inclusion of phentolamine and also prazosin but not with propranolol. Trifluoperazine concealed the inhibitory effect of epinephrine in a dose-dependent manner, whereas theobromine did not have any significant effect. The secretion of triacylglycerol was suppressed not only by the a-agonist phenylephrine but also by the β-agonist isoproterenol. Dibutyryl-cyclic AMP also inhibited secretion of triacylglycerol by approximately 30%. The results indicate that epinephrine suppressed triacylglycerol secretion via the α1-adrenoceptor whereas stimulation of beta-as well as alpha-adrenoceptors can exert a similar effect. Calcium-calmodulin dependent protein kinase may be involved in the down-regulation of VLDL secretion. The unexpected effect of isoproterenol has been discussed in relation to "dual signaling" and also the "store-dependent calcium entry" hypotheses.}, Keywords = {Adrenoceptor, Epinephrine, Isoproterenol, Triacylglycerol, VLDL.}, volume = {14}, Number = {2}, pages = {175-180}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-885-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-885-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {MOZDARANI, H and TOHIDNIA, MR}, title = {CYTOGENETIC EFFECTS OF MAGNETIC AND RADIOFREQUENCY FIEL DS OF NMRI SYSTEMS ON THE FREQUENCY OF CHROMOSOMAL ABERRATIONS INHUMAN LYMPHOCYTES IN THE PRESENCE OR ABSENCE OF CYTOSINE ARABINOSIDE}, abstract ={Application of nuclear magnetic resonance imaging (NMRI) as a non-invasive and accurate imaging procedure has been widely used in recent years. Meanwhile, the biological effects of magnetic fields of several tesla (T) and high energy radiofrequency (RF) is not fully known yet. Because of controversy over this issue, the present research has been carried out in order to verify the effects of magnetic fields of 1.5 T and RF of 63.86 MHz on the frequency of chromosomal aberrations in human peripheral lymphocytes. Using metaphase analysis technique, the cytogenetic effects of NMRI was studied in GO and G2lymphocytes in the presence or absence of cytosine arabinoside (ara-C) as a DNA repair inhibitor. Cells were cultured using conventional methods. Results obtained indicate that exposure of lymphocytes to NMRI field at 30 and 60 minutes has no potential effects on chromosomal aberration induction. When using ara-C, although ara-C alone caused a rather high frequency of chromosomal aberrations, especially in G2 phase of the cell cycle, exposure of cells to NMRI in the presence of ara-C did not change the frequency of ara-C-induced damage significantly. Our results indicate that NMRI may not be able to produce DNA damage that could be potentiated by ara-C. Similar responses were also observed for cells exposed to NMRI either in vivo or in vitro. Nevertheless much remains unknown about the certain effects of MRI and RF.}, Keywords = {NMRI system, Chromosomal aberrations, Human lymphocytes, Cytosine arabinoside}, volume = {14}, Number = {2}, pages = {169-173}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-884-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-884-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {TABARAIE, BAHMAN and SHARMA, BALK and NEJATI, MEHDI and AHMADI, HOJAT and SHARMA, PARVEEN and GANGULY, NIRMAL K.}, title = {COMPARATIVE CHARACTERIZATION OF PORINS FROM SALMONELLA TYPHIO-901 AND SALMONELLA TYPHIMURIUM RA-30}, abstract ={Porins from Salmonella typhi 0-901 and Salmonella typhimurium Ra-30 were characterized and compared. The elution profile of porins from these salmonella species on Sepharose-48 and HPLC appear to be very similar. The findings were confirmed by the electrophoretic pattern which showed three types of porins, i.e. OmpC, OmpD and OmpF in both species. These porins appear to be similar, if not identical, as the LPS-absorbed antiporin antibodies reacted with homologous as well as heterologous antigens. The results of this study favour the use of porins as a common immunogen to control salmonellosis since porin patterns were found to be quite similar among the serotypes of salmonellae, unlike other enterobacterial species.}, Keywords = {Porins, S. typhi, S. typhimurium.}, volume = {14}, Number = {2}, pages = {161-168}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-883-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-883-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {ANDALIB, AR and LAWRY, J and REES, R.c}, title = {SUSCEPTIBILITY OF HUMAN WM MELANOMA CELL LINES TO NK AND LAK CYTOTOXICITY AND THEIR RELEVANCE TO THE LEVEL OF MHC CLASS I AND ICAM-l ANTIGEN EXPRESSION}, abstract ={The effect of natural killer (NK) cells and lymphokine activated killer ( LAK) cells was studied on a group of human melanoma cell lines. Peripheral blood from healthy volunteers was utilized as a fresh source of natural killer cells and rhI L-2 for producing LAK cells. The cytotoxicity of effector cells was quantified using a 4 hour SI determining the density of antigen expression on tumor cell surface. The majority of WM melanoma cell lines were relatively resistant to lysis by NK cells, but all showed high sensitivity to LAK cytotoxicity. The expression of MH C class I and I CAM-l on tumor cell lines varied, however using linear regression analysis between MH C class I and I CAM-l antigen expression, and UK/ pression of these antigens on the WM melanoma cell lines tested are independent of NK/}, Keywords = {}, volume = {14}, Number = {2}, pages = {155-160}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-882-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-882-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {REZAYAT, M and GHAZI-KHANSARI, M and MOUSTAFAVI-MEHR, B and ZARRINDAST, MR}, title = {EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA}, abstract ={The effects of cholecystokinin (CCK) receptor antagonists on hypothermia induced by cocaine or morphine have been studied in mice. In the present work, subcutaneous (SC) injection of cocaine (50-150 mg/kg) or morphine (125-500 mg/kg) induced hypothermia in mice. Administration of CCKA receptor antagonist MK-329 (0.5-1.5 mg/kg), CCKB receptor antagonist L-365, 260 (0.5-1.5 mgl kg) and CCK receptor antagonist proglumide (15-45 mg/kg) 60 min. prior to cocaine injection reduced hypothermia induced by cocaine. MK-329 or proglumide also reduced the morphine response. Single administration of MK-329 and L- 365,260 to mice decreased mice core body temperature. It is concluded that the hypothermic effect of cocaine and morphine may be mediated through CCKA and CCKB receptor mechanism(s).}, Keywords = {CCK antagonists, cocaine, morphine, hypothermia, mice.}, volume = {14}, Number = {2}, pages = {151-154}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-881-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-881-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {MOHAMMADINAGHADEH, M and McGRATH, J.e}, title = {CONTRACTIONS DUE TO α-ADRENOCEPTOR AGONISTS ARE MEDIATED BY α1-ADRENOCEPTORS IN RAT CAROTID ARTERY}, abstract ={Some large vessels have a mixed functional population of postjunctional α1- and α 2-adrenoceptors. The purpose of the work presented here was to investigate the population of postjunctional α -adrenoceptors in the rat isolated common carotid artelY Male Wi star rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings of arteries 3-4 mm in length were cut from each vessel and then mounted in 10 mL isolated organ bath, bathed in Krebs maintained at 37°C and gassed with 95% O2 plus 5% CO2, The preparations were allowed to equilibrate for an hour. When antagonists were used, the preparations were incubated for at least 45 minutes with the drugs prior to the onset of a second CCRC. The cunent study focused on the possibility of post junctional α 2-adrenoceptors that could influence adrenergic system-mediated vascular α -adrenoceptor responsiveness in this cephalic artery. The dominance of α 1-adrenoceptors is shown by the high sensitivity of noradrenaline or phenylephrine to prazosin and the ineffectiveness of rauwolscine, except in non-selective concentrations. UK-14304 produced contractions and it is theoretically possible that UK-14304 exerts its actions through combined al and α 2 activation, but the effectiveness of prazosin and the ineffectiveness of rauwolscine, except in non-selective concentrations, shows that even this effect is mediated through α1-adrenoceptors. Thus we suggest that the population of postjunctional α -adrenoceptors mediating contraction of smooth muscle in the rat carotid artery is predominantly of the α1type.}, Keywords = {α -adrenoceptors, prazosin, UK-14304,}, volume = {14}, Number = {2}, pages = {145-149}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-880-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-880-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {FALLAHIAN, FARAHNAZ and KHATAMI, MOHAMMAD REZA and JABALAMELI, PARVIZ}, title = {NEUROLOGIC AND PSYCHOLOGIC COMPLICATIONS AFTER KIDNEY TRANSPLANTATION}, abstract ={Neurologic and psychologic complications are usually related to drug toxicity, infections or symptoms induced by deterioration of renal allograft function. Metabolic encephalopathy, hypertensive encephalopathy, cerebrovascular events, and new-onset seizures have all been reported in organ-transplant recipients. Infections can be caused by listeria, cryptococcus, nocardia, aspergillus and mucor. Toxoplasma, coccidia, cytomegalovirus (CMV) and herpes infections are also reported. Cerebral hemorrhage can occur secondary to septic emboli or intracerebral aneurysms. The aim of this study is to present the results of a review on 200 renal transplant recipients concerning neuropsychologic complications during a 12-year period in the Imam Khomeini Hospital affiliated to Tehran University of Medical Sciences. According to this study, neuropsychologic disorders occurred in 3 a (15%) of the recipients and of these, peripheral neuropathy, depression and tremor were the most common and were detected in 8 (4%), 5 (2.5%), and 4 (2%) of the recipients, respectively.}, Keywords = {Kidney transplantation, Neurologic complications; Psychologic complications; Immunosuppression.}, volume = {14}, Number = {2}, pages = {141-143}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-879-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-879-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {SHAMSI, S and GOODARZI, AM}, title = {ROLE OF IRON DEFICIENCY ANEMIA IN CHILDBEARING WOMEN ON NEONATAL WEIGHT}, abstract ={Iron deficiency is one of the most common nutritional problems in the world, It is frequently found in both developed and developing countries and mainly affects women of childbearing age. The aim of this study was to investigate the relationship of iron deficiency anemia in pregnant women on neonatal weight. The study subjects were a group of 241 women aged between 20 and 34 years who were divided to anemic (118 subjects as case) and nonanemic (123 subjects as control) groups. Iron deficiency anemia was determined by measurements of plasma ferritin, T.I.B.C., total iron, hemoglobin and hematocrit, and subsequently the weight of the neonate was also determined. Results showed that depleted iron stores in the anemic group has no statistically significant effect on neonatal weight (t-test= 0.73, D,F.= 239,p>t= 0.4654). Lower, depleted iron stores were observed in the anemic group with high parity and decreased intervals of pregnancy. It is concluded that the occurrence of iron deficiency anemia in pregnant women during the third trimester has no relationship with neonatal weight, but according to some published results this relationship exists during the first trimester.}, Keywords = {Anemia, Iron deficiency, Pregnancy anemia.}, volume = {14}, Number = {2}, pages = {137-140}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-878-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-878-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {TIRGARI, F and ZAREMEHRJARDI, ALI and IRAVANLOO, GUITY}, title = {PREDICTION OF ESTROGEN RECEPTOR STATUS OF INVASIVE DUCTAL CARCINOMA OF BREAST BY HISTOLOGIC GRADE}, abstract ={In human breast cancer, estrogen receptor (ER) status of the tumor has prognostic and therapeutic significance. However, facilities to study ER are not widely available to us. We postulated that if there is a correlation between histologic grade and ER status of invasive ductal carcinoma (IDC), it may help predict the ER status of the tumor. Of 8 4 cases of breast carcinoma referred to the Cancer I:q.stitute of Tehran for immunohisto logic study of ER in 1995, 69 cases of IDC that had adequate H & E stained slides were chosen. Using the Nottingham modifi. cation of the Bloom-Richardson grading system of IDC, all cases were scored by each of us separately. Conflicting cases were jointly reassessed until a consensus was reached. Sections of paraffin blocks were stained for ER using the avidinbiotin complex method and then they were assessed by a digital image analyzer. There was an inverse relationship between ER positivity of tumors and each of the grading parameters and the•ultimate grade that were all statistically significant (p<0.0001). Moreover, further analysis revealed that low histologic grade (with scores of3 or 4) had a 92.3% positive predictive value (range 62.9%-98 .2%) for ER positivity. Similarly, histologic grade-=-in the presence of score 3 nuclei-had an 83.9% positive predictive value (range 71.2%-91.9%) of ER negativity in tumor cells. These findings suggest that in tumors with histologic grades at both ends of the spectrum, ER status may reliably be predicted in a significant number of cases.}, Keywords = {Breast carcinoma, invasive ductal carcinoma, estrogen receptor, histologic grading.}, volume = {14}, Number = {2}, pages = {133-135}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-877-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-877-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {FATTAHI, MR and KHEZRI, AA}, title = {RUPTURE OF URINARY BLADDER: AN EXPERIENCE WITH 55 CASES IN SHIRAZ}, abstract ={We reviewed 55 cases with trauma to the urinary bladder. Blunt trauma was the cause of injury in 78 percent of cases and associated pelvic fracture was present in 75 percent. Eighty percent of extraperitoneal ruptures were associated with fracture of the pelvis. The most common cause of trauma was car accident (63%), followed by war injury (20%). Nearly two-thirds of patients (63 %) had extraperitoneal rupture. The most common presentation was gross hematuria (49%), followed by abdominal pain and tenderness (38%). In 24 patients, diagnosis was made by retrograde cystography, in 9 patients by intravenous pyelography and the remaining patients were diagnosed by physical examination and diagnostic laparotomy. All of the patients were treated by surgical repair. Mortality rate was two percent.}, Keywords = {Bladder, Rupture, Extraperitoneal, Intraperitoneal, Trauma, Pelvic fracture.}, volume = {14}, Number = {2}, pages = {127-131}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-876-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-876-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {NAJMABADI, H and DeKRETSER, DM and ARVER, S and TAYLOR, W and MALLIDIS, C and GORDENBAKER, HW and McLACHLAN, RI and LOVELAND, KA and RAMIREZ, L and NIEVA, A and GUTIERREZ, M and SUH, B and SAHEBJAM, S and SAHEBJAM, F and BHASIN, S}, title = {SUBMICROSCOPIC DELETIONS OF THE Y CHROMOSOME ARE NOT LIMITED TO AZOOSPERMIC MEN, BUT ARE ALSO DETECTED IN INFERTILE MEN WITH IDIOPATHIC OLIGOZOOSPERMIA}, abstract ={It is now agreed that 10-25% of infertile men with azoospermia have submicroscopic deletions of the Y chromosome long ann (yq), consistent with the proposed location of the azoospermia locus (AZF) in Yq 11.23. However, it is not known whether Yq microdeletions are unique to men with azoospermia or whether they are also observed in infertile men with less severe defects of spermatogenesis (oligozoospermia). The objective of this study was to determine the prevalence of Yq deletions in infertile men with idiopathic oligozoospermia DN A was extracted from blood lymphocytes of 45 oligozoospermic men (sperm densities <20 million/mL) in whom known causes of infertility had been excluded. All subjects were typed for the 27 Y -specific STSs that have been mapped to deletion interval 6. An STS was considered negative if no PCR product was observed in 3 reactions, in which a fertile male gave a specific PCR product and anorma1 female DNA did not. Whenever sufficient DNA was available, deletions detected by PCR were verifed by Southern hybridization. Of the 45 oligozoospermic men, 4 (9010) had deletions of one or more STSs. These deletions were verified by Southern hybridization. All. 4 deletions were located in distal interval 6 (6C and 6D) and included the DAZ (Deleted in Azoospermia) gene, a Y-specific gene that has been proposed as a candidate for male infertility. All four patients had sperm densities of less than 1 million/mL and three out of these 4 patients had mean testis volume of less than 15 mL. Two of the infertile men with Y deletions had a testicular biopsy testicular histology in both of these patients was consistent with germ cell arrest, spermatocyte stage. Yq microdeletions are not unique to infertile men with azoospermia but are abserved also in infertile men with oligozoospermia Taken together with previously reported studies on azoospermic men, these results indicate that Yq deletions are predominantly obselVed in, but are not limited to, infertile men with relatively severe defects of spermatogenesis.}, Keywords = {Oligozoospermia, Idiopathic infertility, Yq deletions, DAZ gene, REM gene, Azoospermia,}, volume = {14}, Number = {2}, pages = {119-125}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-875-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-875-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {MOMTAZ, M and MUGHAL, N and SIDDIQUE, AZHAR and MAHBOOB, TABASSUM}, title = {CHANGES IN BLOOD LEVELS OF TRACE ELEMENTS AND ELECTROLYTES IN HYP ERTENSIVE PATIENTS}, abstract ={The involvement of elements in the pathological process of primary hypertension has been established. The serum levels of copper, iron, zinc, sodium, potassium and calcium were studied by atomic absorption spectrophotometery and flame photometry in hypertensive and normal subjects. Serum copper and zinc levels were increased in hypertensive patients (25.5% and 14.7% respectively) as compared to normal subjects. A decrease in serum sodium (21".9%), potassium (31.02%), iron (44.7%) and calcium (34.23%) was observed in hypertensive as compared to control subjects. The role of these serum element variations and their possible involvement in hypertension is discussed.}, Keywords = {}, volume = {14}, Number = {2}, pages = {115-118}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-874-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-874-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {AMIRGHOFRAN, Z and SHAMSEDDIN, A and SHAHRIARI, M}, title = {PROGNOSTIC VALUE OF MYELOID ANTIGEN EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKEMIA}, abstract ={Expression of cell surface molecules associated with lymphoid and myeloid lineage differentiation on the blasts of 53 patients with acute lymphoblastic leukemia (ALL) was investigated. 1.9% of cases were only HLA"7DR+ 7.6% were HLA-DR+, CDI9+ 22.6% were HLA-DR+, CDI9+, CDI0+ 30.2% were HLADR+, CDI9+, CDlO±, CD20+ and 37.7% were HLA-DR±, CD7+, CD5±. Aberrant expression of one or more myeloid antigens including CDI3, CDI5, CD33 and CD34 was found in 30.2% of cases. The relationship of myeloid positive (MY+ ALL) and negative cases (MY- ALL) with patient characteristics were studied. No significant differences in clinical features, response to therapy or survival was found between the two groups. Study of each marker separately indicated an association between expression of CD5 and CD 1 0 with age and expression of CD20 and CD33 with decrease in hemoglobin (p<0.03). No correlation between expression of markers and survival was found except for CD 13 and CD 15 antigens (p<0.03). CDI5+ cases showed longer survival than negative cases (541±72 vs. 364±34 days) whereas CDI3+ cases showed shorter survival than negative ones (378±32 vs. 616±,106). showed a trend towards a longer or shorter survival.}, Keywords = {Myeloid antigens, Acute lymphoblastic leukemia, Myeloid positive ALL.}, volume = {14}, Number = {2}, pages = {111-114}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-873-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-873-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} } @article{ author = {NAKHAEE, N and SADEGHI-HASSANABADI, A and TABATABAEE, HR}, title = {DIAGNOSTIC VALUE OF MEAN PEROXIDASE INDEX IN EARLY KAWASAKI DISEASE}, abstract ={The charts of 27 patients with Kawasaki disease (KD) admitted to Nemazee Hospital in Shiraz from January 1991 to October 1998 were reviewed to identify the results of mean peroxidase index (MPXI) values, a measure of neutrophil staining intensity, obtained by the Technicon HI analyzer (Technicon Instruments Corp., Tarrytown, NY) within the first 10 days of the illness 2 separate groups of patients were assessed as control subjects: 27 disease control (DC) children with fever plus one other KD criterion and 27 laboratory control (LC) subjects with nonfebrile disorders interpreting also as a normal reference population. Compared with control groups, patients with KD had lower quantities of MPXI [(Mean±SD, -11.71±5.87 in KD group) vs. (1.53±4.30 p<0.001 in DC group, and 1.74±6.52,p<0.001 in LC group)]. Depending on the location of the cut-off point expressed on an interval scale, this test had the ability to be 100% specific ( if MPXI0). Considering the low prevalence of hereditary myeloperoxidase (MPO) deficiency ( 1 in 2000), measurement of MPXI, when performed as part of a complete count on an automated hematology instrument, could be counted as an important adjunct to clinical evaluation and also according to the low values of MPXI in patients with KD, it can be included among the acquired causes of MPO deficiency.}, Keywords = {Acute phase, Mucocutaneous lymph node syndrome, Myeloperoxidase deficiency.}, volume = {14}, Number = {2}, pages = {107-110}, publisher = {Iran University of Medical Sciences}, title_fa = {}, abstract_fa ={}, keywords_fa = {}, url = {http://mjiri.iums.ac.ir/article-1-872-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-872-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {2000} }