@article{ author = {SAMADI, ABBAS K. and MALEKNIA, NASSER}, title = {SEPARATION OF NONHISTONE HIGH MOBILITY GROUP (HMG) FROM HUMAN LYMPHOCYTES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY}, abstract ={The high mobility group (HMG) of nonhistone proteins have been investigated using two high performance liquid chromatographic techniques (HPLC). Reversed-phase HPLC under conditions of 50 mM triethylamine adjusted to pH 2.2 with phosphoric acid (solvent A) and 95% acetonitrile in water (solvent B) was used to separate proteins primarily on the basis of differences in the overall hydrophobicity. Size exclusion HPLC under conditions of two different solvents (A, 0.1 % trifluoroacetic acid 1FA B, 1.0% sodium dodecyl sulphate, SDS) was used to separate proteins. HMG proteins from human lymphocytes were separated into the HMG 1, HMG 2, HMG 14 and HMG 17 components. RP-HPLC is a proper method to resolve all the human lymphocyte HMG-proteins. Size exclusion HPLC was employed to resolve the HMG-protein subunits and determine their molecular weights. Ideal SE-HPLC is not capable of resolving HMG 1 from HMG 2 or HMG 14 from HM G 17 due to their molecular weight similarities. The purity of protein fractions were examined by acetic acid-urea-triton X-100 gel electrophoresis.}, Keywords = {}, volume = {4}, Number = {1}, pages = {65-70}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1573-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1573-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {NOURMOHAMMADI, ISSA and HONARI, ZOHREH and KESHAVARZ, ALI and NILFORUSHAN, MOSTAFA}, title = {PLASMA DEHYDROASCORBIC ACID LEVELS IN IRANIAN SUBJECTS WITH DIABETES MELLITUS}, abstract ={Several reports concerning high plasma dehydroascorbic acid (DHAsA) levels in diabetics have been published and from these reports, suggestions that monitoring of DHAsA levels in those persons with a predisposition to diabetes mellitus would be of value. However, conflicting reports have also appeared which do not confirm high levels of DHAsA in diabetic subjects when compared to controls. Because of these conflicting results, this investigation using Iranian diabetic subjects was undertaken to ascertain whether or not periodic monitoring of DHAsA levels would be of value as an indicator of prediabetic conditions. Our results do not confirm high levels of DHAsA in diabetics but because of the many theories concerning the mechanism of action and the metabolism of DHAsA, previous findings cannot be disregarded.}, Keywords = {}, volume = {4}, Number = {1}, pages = {61-64}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1572-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1572-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {A. NAJAFI-FARASHAH, A}, title = {ENDOGENOUS RELEASE OF OPIATES BY REPETITIVE ELECTRICAL FIELD STIMULATION IN THE GUINEA-PIG AND RAT ILEAL LONGITUDINAL MUSCLE}, abstract ={The effect of repetitive electrical field stimulation and the response of the guinea-pig and rat ileal longitudinal muscle to single pulse stimulations was examined. Single pulse field stimulation produced twitch contraction which was inhibited by repetitive field stimulation (10 Hz, 40V, 0.5 msec for 5 m). This inhibition was largely, though never completely, reversed by naloxone. Contractions due to exogenous acetylcholine and histamine were also inhibited after repetitive field stimulation. The inhibition of acetylcholine response was party reversed by naloxone whereas that of histamine was not. Contractions due to single pulse field stimulation or to either acetylcholine or histamine were inhibited by prior exposure to high concentrations of acetylcholine as a substitute for high frequency stimulation. The inhibitory responses were resistant to naloxone. The inhibitory responses to acetylcholine and histamine after exposure to the lowest concentration of acetylcholine was seen in preparations treated with tetrodotoxin or hemicholinium. The inhibition of the histamine response by acetylcholine pretreatment was prevented by mepyramine. Response to histamine, but not those to single pulse field stimulation or acetylcholine, were inhibited by prior exposure to histamine. It is concluded that repetitive field stimulation possibly initiates two distinct inhibitory processes. One involves the release of endogenous opiates and is probably mediated by inhibition of acetylcholine release. The second type of inhibition is not mediated by endogenous opiates and can be explained by post-junctional desensitization. The non-specific desensitization to histamine is probably a consequence of histamine release from mast cells by acetylcholine.}, Keywords = {}, volume = {4}, Number = {1}, pages = {53-59}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1571-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1571-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {NOBAKHT, M and SIMFOROOSH, N and MOHAMADIAN, ALI and AMIR-ANSARI, B}, title = {THE ROLE OF T-L YMPHOCYTE SUBPOPULATION IN RENAL ALLOGRAFT REJECTION}, abstract ={Twenty-two recipients of HLA-nonidentical living related and nonrelated renal allografts were studied for alterations in the relative percentage of OKT4-positive peripheral blood T-cells after transplantation. Characteristic shifts in the ratio of T-helper to T -suppressor/cytotoxic cells (TH/TS-C), but not absolute cell numbers, were demonstrated to correspond with the status of the allograft. Our results are indicative of a correlation between rejection episodes and the increase in OKT4:0KT8 ratios, that were characterized by a significant rise in the percentage of OKT4-positive cells (P=0.001), and a decrease in the percentage of OKT8-positive cells (P=0.001).}, Keywords = {}, volume = {4}, Number = {1}, pages = {47-52}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1570-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1570-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {MOHARRERI, MR}, title = {NEUROPSYCHIATRIC DISORDERS IN THE OLDEST MEDICAL TEXTBOOK IN PERSIAN WRITTEN AROUND 990 A.D.}, abstract ={Written around 990 A.D., Hidayat-MllIaallemill Fit Tibb (Student's Guide ill Medicine) is the oldest general medical text known to have been written in modern Persian. Little is known of the author other than the fact that he was apparently a well experienced practicing physician by the name of Abu Bah Rabi' bin Ahmad al-Akhawaini from Bukhara who claimed to bea second generation student of Razi. The neuropsychiatric sections of the book are of particular interest because the author apparently had a personal interest in and reputation for treating the insane. According to one of the manuscripts he was known as the "Physician of the Insane" by his contemporaries. Following the line of other Islamic medical writers, the author has described the major neuropsychiatric disorders in the chapter dealing with the "Diseases of the Head and Brain". These include Melancholia, Mania, Epilepsy, Phrenitis, Lethargy, and Delerium. Hysteria is, however, described among the diseases of the female reproductive system. Both the terminology used and the authorities quoted betray the author's schooling in and devotion to the Graeco-Roman medical traditions adopted by early Islamic medical writers. He emerges as a hard-headed organic physician dedicated to the humoral doctrines of mental illness.}, Keywords = {}, volume = {4}, Number = {1}, pages = {37-46}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1569-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1569-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {VAHEDI, PARVIZ}, title = {A STUDY OF 17 PATIENTS WITH PULMONARY SARCOIDOSIS IN MASHAD}, abstract ={Thirty patients with bilateral lymph node enlargement with or without parenchymal infiltrates on the chest x- ray suspected to have sarcoidosis were studied between June 1980 and December 1989 in our institution. Eleven of these patients who were free of parenchymal infiltrates did not have a biopsy performed and the diagnosis of sarcoidosis was made based on self-limited regression and clearing of the chest X-ray findings. However, these cases Were excluded from our study along With two other cases which upon transbronchial lung biopsy (TBLB) failed to show the disease. Seventeen of our cases had sarcoidosis, fourteen proven by TBLB, two by skin biopsy and one by parotid gland biopsy. Our study shows that sarcoidosis is not a rare disease in IRAN. TBLB is a good way to diagnose sarcoidosis especially when parenchymal involvement is present on the chest X-ray. Although stage I of the disease was more common in our series, it is probable that this is a false findingimd if TBLB were repeated more cases of stage III of the disease would be found.}, Keywords = {}, volume = {4}, Number = {1}, pages = {31-36}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1568-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1568-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {AMINI, SAFIEH and SOLATI, ALI ASGHAR and FAYAZ, AHMAD and MAHMOODI, MAHMOOD}, title = {ROTAVIRUS INFECTION IN CHILDREN WITH ACUTE DIARRHEA IN TEHRAN}, abstract ={The etiology of acute diarrhea was studied in 915 children under 5 years of age between March 1986 and August 1987, in 7 hospitals in Tehran. 65 healthy children in similar age groups served as controls. Rotavirus was found in 25% of the patients and 1.5% of controls with the highest detection rate occurring in the 7-24 month age group (28%) and declining beyond 25 months of age (5%). The infection rate was also high (19%) in the first 6 months of life and breast feeding was not protective. The rate of rotavirus infection was highest during the months of April and May (30% and 37% respectively) and lowest during December and January (7%).}, Keywords = {}, volume = {4}, Number = {1}, pages = {25-28}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1567-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1567-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {MUFTI, TARIQ and SULTAN, SYED and AHMED, R and ALI, G and AZIZI, A and NAWAZ, M}, title = {SIMPLE LIGATION VERSUS STUMP INVAGINATION DURING APPENDICECTOMY-A PROSPECTIVE TRIAL}, abstract ={A prospective, randomized trial on 416 consecutive cases of appendicectomies was carried out in which half of the cases had simple ligation of the stump and the rest had invagination of the stump in addition. The two groups were matched for age, sex, state of personal hygiene and nutrition. The incidence of wound infection, and early and late post-operative complications remained comparable between the two groups. However, the mean operating time was significantly less in case of simple ligation. Barium enema in suspected cases of caecal neoplasm in post-operative cases did not reveal any ceacal deformity in the group of simple ligation thus avoiding confusion of mistaking deformed caecum due to the invaginated stumps as neoplasm. Simple ligation of the appendiceal stump is therefore advocated during appendicectomy.}, Keywords = {}, volume = {4}, Number = {1}, pages = {21-23}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1566-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1566-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {JANGHORBANI, MOHSEN and HEDLEY, ANTHONY J. and JONES, RAYMOND B and GILMOUR, HARPER and ZHIANPOUR, MOTAHAREH and GILLIS, CHARLES R. and HAWTHORNE, VICTOR M.}, title = {BLOOD PRESSURE COMPONENTS AS PREDICTORS OF STROKE MORTALITY IN WEST SCOTLAND}, abstract ={The relative importance of systolic (SBP) versus diastolic blood pressure (DBP) and other combinations of SBP and DBP in the prediction of stroke have been re-examined in a long term cohort study of 10,541 men and women aged 45-64 in West Scotland. During a mean follow-up of 11.6 years 1, 616 deaths occurred, among which 160 (9.9% 80 male, 80 female) were due to stroke. In a multiple logistic regression (MLR) model the predictive values of SBP, DBP, mean arterial pressure (MAP), mean arterial index (MAl) and pulse pressure (PP) were examined in relation to stroke mortality after adjustment for age, body mass index (BMI), casual blood glucose, serum cholesterol, and cigarette smoking at entry. All blood pressure measures were associated with stroke mortality in females the risk of stroke mortality was more strongly associated with DBP in males SSP and DBP have the same predictive influence on stroke mortality and the MAP and MAl have stronger associations with it than either SBP and DBP. PP is associated with the least excess risk in both genders.}, Keywords = {}, volume = {4}, Number = {1}, pages = {13-19}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1565-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1565-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {EMAMI, MASOOD and GHAHRI, MOHAMMAD}, title = {PREVALENCE OF PITYRIASIS VERSICOLOR IN WAR-WOUNDED AND CHEMICAL (MUSTARD) GAS-WOUNDED PATIENTS IN IRAN-IRAQ WAR}, abstract ={A total of 1118 soldiers who were wounded in war and hospitalized in Tehran, were examined for P .versicolor-a superficial mycotic infection. Of these, 213 were war-wounded, 54 chemical (mustard) gas-wounded, 42 both war and chemical gas-wounded, 105 had infectious and noninfectious diseases, and 704 were apparently healthy soldiers serving in war fronts who were examined for P. versicolor and its relation with a history of contact with mustard gas. In this study the prevalence of P. versicolor among the above groups was: 7.40%, 1.85%, 9.52%, 11.42% and 6.11 % respectively. Upon microscopic examination (Scotch tape method) from hyperpigmented parts of the skin resulting from mustard gas, P. orbiculare (the etiologic agent of P. versicolor) was seen abundantly. This observation leads us to hypothesize that there may be a relation between P. versicolor and previous contact with mustard gas.}, Keywords = {}, volume = {4}, Number = {1}, pages = {9-11}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1564-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1564-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {MOGHARI, AHMAD and FOROOTAN, KS and EMAMI, SA}, title = {THE CLINICAL APPLICATION OF PREFABRICATED FREE FLAPS FOR NASAL RECONSTRUCTION}, abstract ={We have found prefabrication of hairless radial forearm free flap to be a useful technique for nasal reconstruction. Prior skin grafting and a suitable period of maturation permits safe, reliable surgery. Its use should be considered in those patients whose forehead tissue is not suitable or in whom appropriate distant flaps are not available, as is often the case with hirsute males.}, Keywords = {}, volume = {4}, Number = {1}, pages = {5-8}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1563-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1563-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} } @article{ author = {VELAYATI, AA and MOHAMMADI, M}, title = {CHILDHOOD RESPIRATORY TUBERCULOSIS IN IRAN}, abstract ={To estimate the bacterio-epidemiological situation of childhood respiratory tuberculosis in Iran, 2185 symptomatic patients of 0-14 years old were studied. Among 110 bacteriologically confirmed cases, 60% were less than five years old and the number of females was slightly more than males. In 21 % of patients, the Mantoux test was negative. None of the miliary cases had a history of BCG vaccination. In 54.6% of patients less than two years old, one of the family members was suffering from infectious tuberculosis. Clinical findings were fever, cough, weight loss and respiratory distress respectively. Radiological findings were mostly pneumonia or bronchopneumonia-like infiltrations and in 44% of cases were found in the right lung. Mycobacterium tuberculosis strains in 11.7% of patients were resistant to isoniazid or streptomycin.}, Keywords = {}, volume = {4}, Number = {1}, pages = {1-4}, publisher = {Iran University of Medical Sciences}, url = {http://mjiri.iums.ac.ir/article-1-1562-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-1562-en.pdf}, journal = {Medical Journal of The Islamic Republic of Iran (MJIRI)}, issn = {1016-1430}, eissn = {2251-6840}, year = {1990} }