en
jalali
1380
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2001
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*Correspondence: M. Ghazi-Khansari. Ph.D., Department ofPharmacology,
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a by-product o f t he
trichlorophenol (herbicide) production and is also produced through a variety of
combustion processes. It appears that TCDD is a ubiquitous chemical, particularly
in industrialised countries, and the liver is the target organ of its toxicity. The
prominent hepatotoxic effect of TCDD is progressive centrilobular necrosis. The
isolated rat liver perfusion system approaches the normal physiology of the liver
and is ideal for studying biochemical alterations of the liver since hepatocytes are
easily exposed to various concentrations of chemicals with minimum neural-hormonal
effects. In this study, the liver was perfused with Krebs-Henseleit butfer
containing different concentrations of TCDD (0.3, 3, 20 and 30).lg/L). During the
perfusion many factors including gross liver appearance, bile formation, and aminotransferase
activities were assessed as indicators of liver viability. Consequently,
sections of liver tissue were examined for any histopathological changes. The
results showed that histopathological changes in liver tissues were related in a
dose-dependent manner to TCDD concentrations. In this instance doses of 20 and
30 ).lglL caused a significant (p<0.05) histopathological change in liver sections.
Liver necrosis and hemorrhage were also increased significantly in a dose-dependent
manner.
TCDD, Liver perfusion, Krebs-Henseleit buffer, Histopathological, necrosis.
55
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2012/09/17
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M
KARAMI
From the Department of Toxicology, School of Pharmacy, Tehran University of Medical Sciences
0031947532846004249
0031947532846004249
No
M
GHAZI-KHANSARI
the Departments of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran
ircongpp@nrcgeb.ac.ir
0031947532846004250
0031947532846004250
Yes
M
REZAYAT
the Departments of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran
0031947532846004251
0031947532846004251
No
B
MINAEI
the Departments of Histology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran
0031947532846004252
0031947532846004252
No
M
ABDOLLAHI
From the Department of Toxicology, School of Pharmacy, Tehran University of Medical Sciences
0031947532846004253
0031947532846004253
No
O
SABZEVARI
From the Department of Toxicology, School of Pharmacy, Tehran University of Medical Sciences
0031947532846004254
0031947532846004254
No
en
A NOVEL METHOD OF PURIFICATION OF SPECIFIC HYDATID CYST ANTIGEN
Hydatid cyst fluid has been used as a source of antigen for the serodiagnosis
of Echinococcus granulosus infection. Due to cross-reactions with antigens shared
by other helminthes, the specific antigen from hydatid cyst fluid was purified by
many workers. We used a relatively simple technique for purification of specific
antigen from sheep hydatid cyst fluid. Isopycnic ultracentrifugation with 30%
KEr was used followed by SDS-PAGE to check the purity of the antigen. The
antigen was of 48 kDa and used in ELISA and IRA with high sensitivity and
specificity.
Echinococcus granulosus, specific antigen, isopycnic ultracentrifugation
49
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2012/09/172012/09/17
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Z
ZAMANI
0031947532846004243
0031947532846004243
No
M
ASSMAR
From the Departments of Parasitology and Biochemistry, Pasteur Institute of Iran, Tehran, I.R. Iran.
0031947532846004244
0031947532846004244
Yes
N
PYAZAK
0031947532846004245
0031947532846004245
No
K
WAFAIE
0031947532846004246
0031947532846004246
No
M
ASSADIAN
0031947532846004247
0031947532846004247
No
A
AMIRKHANI
0031947532846004248
0031947532846004248
No
en
NMDA RECEPTOR ANTAGONISTS ATTENUATE TOLERANCE INDUCED BY MORPHINE AND NERVE LIGATION IN MICE
The effect of NMDA (N-methyl-D-aspartate) receptor antagonists on tolerance
to morphine antinociception was investigated in mice. Daily subcutaneous
administration of 50 mg/kg of morphine hydrochloride for three days induced
tolerance to different (3,6 and 9 mg/kg) test doses of morphine. The tolerance
obtained was decreased by pretreatment of animals with single or repeated doses
of competitive NMDA receptor antagonists D-( -)-2-amino-5-phosphonovaleric
acid (DAP5 0.1-0.3 mg/kg) and D-(-)-2-amino-7-phosphonoheptanoic acid
(DAP7 0.1-0.3 mg/kg).
Tolerance to morphine response was also obtained 7, 14, 21 and 30 days
after unilateral sciatic nerve ligation. Single or repeated doses (0.2 mg/kg) of
DAP5 or DAP7 increased the antinociceptive response induced by morphine (9
mg/kg) in the nerve ligated animals. We report that these agents attenuate the
development of morphine tolerance, and increase the antinociceptive effect of
morphine on sciatic neuropathic pain in mice.
41
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GR
TAGHIZADEH-JAHROMI
0031947532846004240
0031947532846004240
No
M
REZAYAT
0031947532846004241
0031947532846004241
No
MR
ZARRINDAST
From the Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. Iran.
0031947532846004242
0031947532846004242
Yes
en
LEVELS OF ANTI-STREP TOKINASE AND ANTI-MYCOBACTERIAL HEAT SHOCK PROTEIN 65 KILODALTON (ANTI-MHSP 65) ANTIBODIES IN PATIENTS WITH AUTOIMMUNE DISEASES
Bacterial and viral triggers are suspected agents in the initial etiology of autoimmune
diseases. There are some studies on the etiology of autoimmune disorders
which have focused on streptococcal infection and a possible relation with
microbial heat shock proteins (hsp) which show significant homology with human
heat shock proteins. In addition, some serotypes of streptococci cross-react
with human hsp, namely 65kD hsp. Therefore, we have examined isotype specific
antibody responses to streptokinase, the antigen released during infection
with the common bacterium streptococcus, together with IgG responses to mycobacterium
heat shock protein 65 (mhsp 65), a possible superantigen for autoimmune
diseases. The levels of these antibodies were examined in patients with
rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), thyroiditis and
Henoch Schonlein purpura (HSP) and a group of normal controls. Patients with
RA showed a statistically significant elevation in levels oflgM anti-streptokinase
antibodies compared to the control group (p<0.001). In Henoch Schonlein purpura
patients, the levels of lgG and neutralising anti-streptokinase antibodies correlated
with the levels of IgG anti-mhsp 65 (r= 0.56, p<0.09 and r= 0.57, p<0.08,
respectively). According to these findings, we suggest that streptococcal infections
may have an important role in the pathogenesis of rheumatoid arthritis and
Henoch Schonlein purpura.
Streptokinase, Heat shock protein (hsp), autoimmune.
37
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1391/6/27
A
AFSHARI
From the Department of Pathobiology, Section of Immunology, Qazvin University of Medical Sciences & Health Services, Qazvin, I.R. Iran
Afshari2000@yahoo.com
0031947532846004237
0031947532846004237
Yes
D
BURNIE
the Departments of Cardiology and Immunology, Western Infirmary, Glasgow, U.K.
0031947532846004238
0031947532846004238
No
ER
HOLME
the Departments of Cardiology and Immunology, Western Infirmary, Glasgow, U.K.
0031947532846004239
0031947532846004239
No
en
APPLICATION OF DOT IMMUNOASSAY (DIA) FOR DETECTION AND TITRATION OF MEASLES VIRUS ANTIBODIES
Measles is one of the most contagious human diseases. Although mass vaccination
programs have reduced the incidence of this disease, measles is still an
important cause of morbidity and mortality among children in developing countries.
Therefore the use of sensitive techniques to evaluate vaccine efficacy and
level of immunity among members of susceptible communities is crucial. Serum
neutralization test (SNT) and Dot immunoassay (DIA) are among the best methods
utilized for evaluating measles virus antibodies. In this study, DIA was applied
for detection and titration of measles virus antibodies. This test was developed
for the first time in Iran in the Virology Department of the School of Medical
Sciences, Tarbiat Modarres University.
Viral antigen was first prepared and titrated. Then human IgG was isolated
by affinity chromatography. Anti-human immunoglobulin was prepared by immunizing
rabbits with human IgG and was later conjugated with peroxidase. DIA
was applied using these reagents.
The results indicated that the specificity and sensitivity of DIA in comparison
with SNT was 96% and 89%, respectively. This study demonstrated that DIA
is a rapid and simple test which can be applied for the detection of mass immunity
against the measles virus.
Measles virus, Serum neutralization test, DIA, Anti-human immunoglobulin.
31
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2012/09/172012/09/172012/09/172012/09/172012/09/17
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F
FOTOHI
From the Department of Virology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Islamic Republic of Iran
0031947532846004231
0031947532846004231
Yes
MH
ROUSTAEE
0031947532846004232
0031947532846004232
No
H
SOLEIMANGAHI
0031947532846004233
0031947532846004233
No
AR
KHABIRI
0031947532846004234
0031947532846004234
No
M
MALEKANE
0031947532846004235
0031947532846004235
No
F
SABAHI
0031947532846004236
0031947532846004236
No
en
ETIOLOGY OF END STAGE RENAL DISEASE (ESRD) IN SHIRAZ PEDIATRIC HEMODIALYSIS CENTER
One-hundred and sixteen children with ESRD were registered in Shiraz Pediatric
Hemodialysis Center in Nemazee Hospital, a referral center in the south of
Iran, from 1990 to 1999. Very small children are not dialysed in this center due to
technical problems. The age range of children in this center was 2-16 years, mean
age was 10.4±3.6 years and male to female ratio was 1.4. Major causes of ESRD
in order of frequency were glomerulopathies 23 (19.83%), reflux 15 (12.93%),
chronic pyelonephritis without reflux 11 (9.5%), neurogenic bladder 10 (8.62%),
cystic diseases 10 (8.62%), stone disease 9 (7.75%), posterior urethral valve 7
(6.03%), ureteropelvic junction obstruction 7 (6.03%), and unknown 12 (10.35%).
Despite the low number for statistical analysis, reflux, neurogenic bladder, FSGS,
nephronophthisis and stone disease were found to be more common here compared
with other centers, which means more consideration is required. Thirtynine
of these children (33.6%) have been transplanted, mostly from parents.
End-stage renal failure, Pediatrics, Etiology, Epidemiology, Ira
23
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A
A. DERAKHSHAN
From the Department of Pediatrics, Division of Pediatric Nephrology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
0031947532846004230
0031947532846004230
Yes
en
VASCULAR COMPLICATIONS IN 417 CONSECUTIV E RENAL TRANSPLANTS
The vascular complications, their management and results of treatment in
417 consecutive renal transplantations performed at Taleghani Hospital from September
1989 to December 1997, are presented. There were 7 (1.6%) vascular
complications. Among them renal artery stenosis occurred in 2 cases (0.4%), renal
artery thrombosis in 2 cases (0.4%), renal vein thrombosis in one case (0.2%),
bleeding from the venous suture line in the immediate peri operative period in one
case and renal pelvic necrosis in another one. Arterial reconstruction was performed
in 2 patients and allograft removal took place in 3 patients. There was no
death due to vascular complication.
19
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I
GHODOUSSI
From the Department of Vascular Surgery and Organ Transplantation, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran
0031947532846004225
0031947532846004225
Yes
P
AZIMI NEZHADAN
0031947532846004226
0031947532846004226
No
H
PEYRAVI
0031947532846004227
0031947532846004227
No
MT
SALEHIAN
0031947532846004228
0031947532846004228
No
I
FAZEL
0031947532846004229
0031947532846004229
No
en
KIDNEY TRANSPLANTATION AND PREGNANCY: A REPORT OF 50 CASES
A retrospective study was conducted on 50 pregnancies in 41 kidney transplant
recipients. 37 pregnancies were successful (74%), while in 13 cases the
pregnancy was lost (7 abortions,S intra-uterine fetal deaths and one therapeutic
termination). The pregnancy course was uneventful in 38 cases (76%) but in 12
there were complications, such as hypertension or slight rise in serum creatinine.
Pregnancy was terminated in one case because of acute rejection, which then
responded well to treatment and graft function returned to normal. Two cases of
congenital anomaly were detected.
Kidney transplantation, renal transplantation, congenital anomaly, pregnancy.
17
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2012/09/172012/09/172012/09/172012/09/172012/09/172012/09/172012/09/172012/09/17
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S
GHAZIZADEH
From the Department of Nephrology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
0031947532846004221
0031947532846004221
Yes
M
LESAN PEZESHKI
0031947532846004222
0031947532846004222
No
B
EINOLLAHI
0031947532846004223
0031947532846004223
No
MR
KHATAMI
0031947532846004224
0031947532846004224
No
en
RANDOMIZED TRIAL COMPARING ROLLERBALL ABLATION WITH CUTTING LOOP ENDOMETRIAL RESECTION IN THE TREATMENT OF MENORRHAGIA
In order to compare the clinical efficacy, safety, success rate and probable
complications of rollerball ablation with cutting loop endometrial resection in the
treatment of menorrhagia, eighty-three women in reproductive age suffering from
menorrhagia who did not respond to medication were treated in a randomized
study comparing cutting loop endometrial resection with hysteroscopic rollerball
ablation for treatment of menorrhagia between Sep. 1995-Aug. 1999 at Shiraz
University of Medical Sciences' affiliated hospitals.
After at least twelve months of follow up, results indicated that both techniques
significantly reduced menstrual blood flow with no clinically significant
difference between the two groups as reflected by return to normal bleeding or
less (rollerball 95% and endometrial resection 93%). Rate of amenorrhea was
20.5% in rollerball and 25% in the resection group. Rate of post-op amenorrhea,
hypomenorrhea and normal menses was almost similar in both series and the
method of ablation had no influence on success rate. Only five patients (6%) were
considered treatment failures, two from the rollerball and three patients from the
resection group. Four of these required reoperation and one patient became amenorrheic
after starting medication. None of the eighty-three patients experienced
intra- or postoperative complications.
Endometrial ablation by either rollerball or resection methods is therefore a
successful, safe and cost-effective alternative for hysterectomy in the treatment of
intractable menorrhagia.
Endometrial ablation, Endometrial resection, Menorrhagia, Hysteroscopy.
11
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2012/09/172012/09/172012/09/172012/09/172012/09/172012/09/172012/09/172012/09/172012/09/17
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S
ALBORZI
From the Department of Obstetrics and Gynecology, Division of Endoscopy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
alborzis@sums.ac.ir
0031947532846004219
0031947532846004219
Yes
ME
PARSANEZHAD
0031947532846004220
0031947532846004220
No
en
ULCERATIVE COLITIS AND HLA CLASS II PHENOTYPING IN IRAN
Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel
disease that diffusely involves the colonic mucosa. The etiology of UC has not yet
been elucidated fully. However, many studies have found that immunologic disorders
may play a role in the pathogenesis of UC. In addition, due to an increased
frequency of UC in families, especially an increased monozygotic compared with
dizygotic twin concordance, many implicate genetic factors in the development
and regulation of the immune responses, such as the HLA class II genes, as candidates
for conferring the genetic susceptibility. We studied the distribution of HLADR
and DQ antigens and duration of sickness in 42 Iranian patients suffering
from DC using the standard microlymphocytotoxicity technique. The phenotypic
frequencies ofHLA-DR2 were present in 24 of 84 controls and 18 of 42 patients
(p= 0.24, corrected p, not significant). The present study reveals no association
between HLA class II antigens and UC, suggesting that the HLA-DR2 is not a
predominant susceptibility gene for UC in the population studied.
Ulcerative colitis; HLA phenotyping
7
9
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H
FOROOTAN
From the Departments of Internal Medicine and Immunogenetics, School of Medicine, Tehran University of Medical Sciences, Tehran
0031947532846004216
0031947532846004216
Yes
B
NIKBIN
the Department of Immunology, School of Medicine, Birjand University of Medical Sciences, Birjand, I.R. Iran.
0031947532846004217
0031947532846004217
No
GH
ANANI SARAB
From the Departments of Internal Medicine and Immunogenetics, School of Medicine, Tehran University of Medical Sciences, Tehran
0031947532846004218
0031947532846004218
No
en
VARIATIONS IN THE CIRCULUS ARTERIOSUS OF WILLIS: AUTOPSY FINDINDS IN 101 HUMAN CADAV ERS
In order to evaluate the microvascular anatomy and the interconnections,
101 fixed brains from human cadavers with a mean age of 41.3 years
were subjected to objective scrutiny. Symmetry was visualized with an
unaided eye and measurements made under microscopic magnification technique
using a micrometer.
Classic symmetry was observed in only 19 of the specimens, whereas the
rest of the 82 specimens revealed considerable variations in the form of diverse
anomalies. These anomalies consisted of hypoplasia (45 cases), duplication (40
cases), triplication (6 cases), fenestration (6 cases), aplasia (5 cases), aneurysm (2
cases), common trunk (1 case) and a rare presentation where the internal carotid
artery was found to have anastomosis with the posterior cerebral artery.
The frequency of anatomic variations and the presence of prevalent anomalies
at the circle of Willis underscore the difficulty in understanding various cerebral
vascular diseases and their anatomical knowledge and information serve to
adopt effective strategies in tackling such microvascular diseases.
Cerebral arteries, Circulus arteriosus, Circle of Willis, Arterial anomalies, Autopsy fi
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GHOLAMHUSSAIN
KHOSRAVI
From the Depts. Of Neurosurgery, Neurology Tehran University of Medical Sciences, Tehran, I.R. Iran.
0031947532846004212
0031947532846004212
Yes
SEYED ALI
FAKHR TABATABAI
0031947532846004213
0031947532846004213
No
MAJID
GHAFARPOUR
From the Depts. Of Neurosurgery, Neurology Tehran University of Medical Sciences, Tehran, I.R. Iran.
0031947532846004214
0031947532846004214
No
HASSAN
TOUFIGHI
From the Depts. Of Forensic MedicineTehran University of Medical Sciences, Tehran, I.R. Iran.
0031947532846004215
0031947532846004215
No