OTHERS_CITABLE
OCCURRENCE OF REPEATED FETAL DEATHS AND A SON WITH SEVERE PHYSICAL AND MENTAL RETARDATION AMONG PROGENIES OF AN IRANIAN CHEMICAL WARFARE VICTIM
http://mjiri.iums.ac.ir/article-1-709-en.pdf
2003-08-15
171
172
AR
Monsef
1
Pathology and Genetics Dept., Medical School, P.O.Box: 518, Hamadan, Iran.
AUTHOR
CASE_STUDY
MULTIPLE PRIMARY EXTRAMEDULLARY PLASMACYTOMAS: AN UNUSUAL PRESENTATION
Extramedullary plasmacytoma (EMP) is a rare neoplasm of soft tissue which
usually arises in the respiratory tract, nasal cavity, sinuses and nasopharynx. Multiple
extramedullary plasmacytomas are extremely rare, especially those that are
not associated with multiple myeloma.We describe multiple primary EMP in a 37
year old man, without involvement of bone or bone marrow. EMP usually has a
good prognosis but our patient survived only 15 months after diagnosis.
http://mjiri.iums.ac.ir/article-1-708-en.pdf
2003-08-15
167
170
Plasmacytoma-Primary-Multiple-Iran.
S
SADIGHI
1
From the Cancer Institute, Tehran University of Medical Sciences, Tehran, I.R. Iran
AUTHOR
M
MOHAGHEGHI
2
AUTHOR
CASE_STUDY
HISTIOCYTE-RICH B-CELL LYMPHOMA: A CASE REPORT OF A RARE VARIANT OF DIFFUSE LARGE B-CELL LYMPHOMA
The authors describe a case of histiocyte-rich B-cell lymphoma (HR-BCL), a
variant of diffuse large B-cell lymphoma, in a 51-year-old man. The patient presented
with large axillary lymphadenopathy. Histopathologic and immunohistochemical
examination of lymph node biopsy revealed diffuse effacement of the
lymph node architecture by reactive histiocytes and neoplastic CD20 positive B
cells. Reactive histiocytes were negative for CD15 and CD30 immunostaining.
The final diagnosis was histiocyte-rich B-cell lymphoma (HR-BCL) and the patient
was referred to the oncology clinic for treatment.
http://mjiri.iums.ac.ir/article-1-707-en.pdf
2003-08-15
159
161
Histocyte - rich B-cell lymphoma
diffuse large B-ce1 l lymphoma
T
GHIASI MOGHADDAM
1
From the Department of Pathology, Ghaem Hospital, Mashhad University oj Medical Sciences, Mashhad, I.R. Iran.
AUTHOR
K
GHAFARZADEGAN
Kghafarzadegan@hotmail.com
2
AUTHOR
N
SHARIFI
3
AUTHOR
ORIGINAL_ARTICLE
EFFECTS OF LEVOTHYROXINE ADMINISTRATION ON OVULATION RATE AND SEX HORMONE LEVELS IN PREPUBERTAL AND ADULT RATS
Thyroid gland dysfunction is associated with disorders of female reproductive
functions. The aim of this study was to examine the effects of hyperthyroidism
on ovulation rate and peripheral sex steroid levels in prepubertal and adult
rats.
Two groups of female rats aging 30 days (prepubertal rats) and 60 days (adult
rats) were made hyperthyroid by oral administration of levothyroxine daily. In the
two control groups (n=lO) rats with the same ages received the same volume of
normal saline. After 10 days the serum levels of T3, T4, LH, FSH, estradiol and
progesterone were measured by RIA technique and also sections of ovaries were
prepared for histological studies. All ovarian follicles and corpora lutea were
counted to estimate ovulation rate.
The results indicated that serum estradiol and progesterone levels of adult
hyperthyroid rats were significantly lower than those of the control group (p<0.05).
However, there was no significant difference between estradiol levels in the prepubertal
hyperthyroid group and its control group. In the hyperthyroid groups the
mean number of primary, secondary and antral follicles and corpora lutea was
significantly less than those of control groups.
It was concluded that high levels of plasma thyroid hormones resulted in
lowered body weight and disturbed ovarian follicle development and differentiation
leading to reduction in ovarian steroidogenesis and ovulation.
http://mjiri.iums.ac.ir/article-1-706-en.pdf
2003-08-15
153
157
Ovulation
Levothyroxine
Hyperthyroidism
Prepubertal rats
A
A. ZARIFKAR
1
From the Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
P
HOOSHMAND
2
AUTHOR
ORIGINAL_ARTICLE
PURIFICATION AND MOLECULAR ANALYSIS OF BCG ANTIGEN 60
Tuberculosis remains as an important socioeconomical and medical problem
throughout the world and especially in Iran. Early and timely diagnosis of
pulmonary and extrapulmonary tuberculosis is vital to initiate prompt treatment.
Current diagnostic methods are either slow or lack enough sensitivity or specificity.
Several mycobacterial antigens are involved in the complex interaction with
the immune system of the host. Their identification is important for both diagnosis
and protection against mycobacteria. Antigen 60 (A60) is a thermostable antigen
found in the cytosol of M. bovis and M. tuberculosis. An ELISA test using
A60 is designed for diagnosis of tuberculosis with satisfactory results. In previous
studies, A60 has also showed a protective effect against experimental infections
and useful immunotherapeutic effects in promotion of cancer development.
In the present work we tried to purify A60 from the cytoplasm of BCG. A60
was purified by exclusion gel chromatography using sepharose 4B. A60 was
recognized by bidimensional immunoelectrophoresis with anti-BCG and anti-A60
antiserum, where it appears as the less mobile component. In agarose electrophoresis,
A60 showed only one band but in immunodiffusion it showed two
immunoprecipitinogen lines with anti-BCG anti-serum. In analyzing with dot blotting,
both cytoplasm and cell wall of BCG showed positive reaction with antiA60
anti-serum. When A60 was fractionated by SDS-PAGE and analyzed by:
western blot using anti-A60 antibody, 65,46, 40, 38 and 35 KDa protein fractions'
were identified.
It is concluded that A60 is a macromolecular antigen of BCG with a molecular
weight of 106_107 Da and is a lipoprotein-polysaccharide complex which contains
several proteins. A60 is present in both cytoplasm and cell wall of BCG and
can easily be purified from BCG vaccine using exclusion chromatography by
sepharose 4B, to be used for designing diagnostic tests for TB.
http://mjiri.iums.ac.ir/article-1-705-en.pdf
2003-08-15
147
152
Antigen 60 (A60)
BCG
Size Exclusion Chromatography.
H
GOUDARZI
1
From the Department of Microbiology, Shaheed Beheshti University of Medical Sciences, Tehran
AUTHOR
B
KAZEMI
2
the Cellular and Molecular Research Center; Shaheed Beheshti University of Medical Sciences, Tehran, I.R.Iran.
AUTHOR
F
FALAH
3
From the Department of Microbiology, Shaheed Beheshti University of Medical Sciences, Tehran
AUTHOR
G
ESLAMI
4
From the Department of Microbiology, Shaheed Beheshti University of Medical Sciences, Tehran
AUTHOR
M
GHAZI
5
From the Department of Microbiology, Shaheed Beheshti University of Medical Sciences, Tehran
AUTHOR
F
DOUSTDAR
F_ doustdar@yahoo.com
6
the Cellular and Molecular Research Center; Shaheed Beheshti University of Medical Sciences, Tehran, I.R.Iran.
AUTHOR
ORIGINAL_ARTICLE
RAPID DETECTION OF MYCOBACTERIUM TUBERCULOSIS IN CLINICAL SPECIMENS BY POLYMERASE CHAIN REACTION
We investigated the use of DNA amplification by polymerase chain reaction
(peR) for detection of Mycobacterium tuberculosis in 300 patients who were
suspected of having pulmonary tuberculosis and compared the results with culture
results which were performed in parallel with PCR. Two-thirds of each sample
was processed for smear and culture by standard methods and one-third was prepared
for DNA extraction, amplification and detection using Mycobacterium tuberculosis
specific PCR primers. In this study 45 patients were positive for M.
tuberculosis by PCR and probe hybridization (sensitivity and specificity 100%)
whereas 42 patients (93%) exhibited growth of M. tuberculosis. Of 42 culture
positive specimens 3 exhibited negative PCR results.
Smear positivity rate for PCR positive specimens was 73.2%. For analysis of
discrepant results 3 variables such as the source of specimen, the concentration of
bacteria in the original specimen and the presence of inhibitor were examined. It
was found that only 3 sputum specimens (6.6%) gave discrepant results, which
were found to contain inhibitor of amplification. It remains to be shown whether
positive PCR results in smear and culture negative patients mean false positivity
or an early laboratory finding which predicts a subsequent reactivation of a prior
tuberculosis infection or whether asymptomatic patients may carry PCR amplifiable
Mycobacterium tuberculosis DNA without any clinical relevance.
http://mjiri.iums.ac.ir/article-1-704-en.pdf
2003-08-15
141
146
PCR
Mycobacterium tuberculosis
Sputum
Probe
M
NASROLLAHEI
mnasrolahei@yahoo.com
1
From the Dept. of Microbiology, Sari Medical School, Khazar Boulevard, Sari, I.R. Iran.
AUTHOR
HG
ROBSON
2
AUTHOR
ORIGINAL_ARTICLE
A COMPARISON OF IL-2 IN NORMAL AND SYMPTOMATIC PULPS
Normal healthy pulpal tissues were obtained from 19 impacted molars and
symptomatic samples were obtained from 18 carious molars and premolars clinically
diagnosed in all vital pulpal tissues. Student's t-test revealed significant
differences in IL-2 concentrations, comparing symptomatic pulpal tissues with
normal healthy samples (657, p<O.OI). These results suggest that IL -2 may serve
as a marker of changes in pulp tissue.
http://mjiri.iums.ac.ir/article-1-703-en.pdf
2003-08-15
137
140
pulp tissue
inflammation
chemical transmitters
cytokines
interleukins
T lymphocytes
IL-2.
SB
MOUSAVI
sbmousavi2@ yahoo.com
1
From the Department of Endodontics, School of Dentistry, Isfahan University of Medical Sciences, the Department of Immunology, Isfahan University of Medical Sciences, and the School of Dentistry, Yazd University, Yazd, Iran.
AUTHOR
A
REZAIE
2
AUTHOR
R
SHEKAR-AMIZ
3
AUTHOR
ORIGINAL_ARTICLE
THE USE OF 0.5% LIDOCAINE WITH FENTANYL AND PANCURONIUM FOR AXILLARY BLOCK
The present study was designed to assess the efficacy of fentanyl and
pancuronium combined with dilute lidocaine solution for axillary block. Onehundred
adult patients undergoing upper limb surgery were randomly allocated to
receive either 0.6 mL/kg of 1 % lidocaine (6 mg/kg) or 0.6 mLlkg of 0.5% lidocaine
(3 mg/kg) with 1 µg/kg of fentanyl and 0.5 mg of pancuronium. The onset of
sensory and motor blocks was significantly shorter in the 1 % lidocaine group
(p<0.05). However no differences in analgesia or motor blockade were found
between the two groups, during the later 20 min. after block. The procedure was
considered successful in 100% of patients without the necessity of supplementary
medication, and no adverse effect were observed in the two groups, and the time
of the first request for analgesia was not significantly different between the two
groups. We conclude that the addition of fentanyl plus pancuronium to the lidocaine
solution, with an unknown mechanism of effect on major nerve block, reduces
the dose of the local anesthetic and possibly systemic toxicity.
http://mjiri.iums.ac.ir/article-1-702-en.pdf
2003-08-15
133
135
Axillary block
Lidocaine
Fentanyl
Pancuronium.
M
HASSANI
1
From the Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, I.R.Iran
AUTHOR
F
MIRMOHAMMADY
2
AUTHOR
ORIGINAL_ARTICLE
EPIDEMIOLOGICAL, CLINICAL AND ELECTRODIAGNOSTIC FINDINGS IN CHILDHOOD GUILLAIN-BARRE SYNDROME
In order to identify the clinical and electrophysiological characteristics of
childhood Guillain-Barre Syndrome (GBS) in East Azarbaijan province, clinical
and electrophysiological data on 40 consecutive children with GBS, admitted to
Tabriz Children's Medical Center from March 21st 1999 to March 20th 2002,
were analyzed. All patients received intravenous immunoglobulin, 400 mg /kg/
day for five consecutive days. They were prospectively followed up for at least 3
months. Analysis of age distribution showed a high occurrence (55%) among
children aged 1- 5 years old. Male patients outnumbered females with a sex ratio
of 1.3: 1. The most frequent antecedent events were upper respiratory tract infections.
The study subjects were subclassified according to electrophysiological data:
52.5% were found to have predominantly acute demyelinating neuropathy, 27.5%
had acute motor axonal neuropathy and in 20% of patients the demyelinating type
of GBS was observed with secondary axonal loss. The disease symptoms were
relatively severe in our patients as only 15% of them were able (with and without
aid) to walk at the peak of their illness. Electrodiagnostic criteria associated with
poor outcome were severe reduction in compound muscle action potential (CMAP)
amplitude and fibrillation potentials (p= 0.034).
http://mjiri.iums.ac.ir/article-1-701-en.pdf
2003-08-15
123
127
Childhood Guillain-Barre syndrome
Epidemiology
Clinical features
Electrodiagnosis
prognosis.
M
BARZEGAR
mm_barzegar@yahoo.com
1
From the Department of Pediatric Neurology, Tabriz Children s Medical Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, I.R Iran.
AUTHOR
Z
JALALI
2
AUTHOR
V
TOPCHIZADEH
3
AUTHOR
ORIGINAL_ARTICLE
ELECTRODIAGNOSTIC STU DY OF PERIPHERAL NERVOUS SYSTEM (PNS) IN 30 PATIENTS WITH MULTIPLE MYELOMA
Involvement of the peripheral nervous system is one of the complications of
multiple myeloma with a varying incidence of clinical and subclinical neuropathy
in different studies. As most of the patients with multiple myeloma suffer from
generalized systemic symptoms such as malaise, bone and low back pain, the
clinical clues to the diagnosis of the neuropathy in its initial stages could be ignored.
In this study, we tried to determine the frequency of peripheral nervous
system involvement in these patients by electromyography/nerve conduction
(EMGINCV) studies. This cross-sectional descriptive study of 30 patients with
multiple myeloma revealed that 70% of cases showed peripheral nervous system
involvement, of whom 57% were found to be asymptomatic and 43% symptomatic
for peripheral nervous system disease.
The pattern of peripheral nervous system involvement was polyneuropathy
(62%) followed by radiculopathy and carpal tunnel syndrome, 52% and 29%,
respectively. Most of the neuropathies were of the sensorimotor axonal type. L5,
S I roots were the most common sites of radiculopathies. Therefore we conclude
that the frequency of subclinical peripheral nervous system involvement in multiple
myeloma patients was so rampant that evaluation of multiple myeloma patients
with EMGINCV studies was necessary.
http://mjiri.iums.ac.ir/article-1-700-en.pdf
2003-08-15
113
116
Multiple myeloma
PNS
Electrodiagnosis
Neuropathy
H
AYROMLOU
1
From the Departments of Neurology Tabriz University of Medical Sciences, Tabriz, I.R. Iran.
AUTHOR
J
EIVAZI
2
Internal Medicine, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.
AUTHOR
R
KHANDAGI
3
From the Departments of Neurology Tabriz University of Medical Sciences, Tabriz, I.R. Iran.
AUTHOR
B
JALALIAN
4
From the Departments of Neurology Tabriz University of Medical Sciences, Tabriz, I.R. Iran.
AUTHOR
ORIGINAL_ARTICLE
A COMPARATIV E , DOUBLE -BLIND, RANDOMIZE D, PLACEBO- CONTROLLED TRIAL OF INTRAPERITONEAL ADMINISTRATION OF BUPIVACAINE AND LIDOCAINE FOR PAIN CONTROL AFTER DIAGNOSTIC LAPARO SCOPY
The purpose of this study was to compare the effect of intraperitoneal
bupivacaine and lidocaine administration on pain reduction after diagnostic
laparoscopy. In this randomized, double blind, placebo controlled study, diagnostic
laparoscopy was done for one-hundred and ninety-six infertile women with
unexplained infertility. Patients were randomized to 4 groups (A, B,C, and D). At
the end of the procedure, 30 mL of 0.125% bupivacaine, 30 mL of 5% lidocaine
and 30 mL of normal saline was instilled in the pelvic cavity and 15 mL of the
same solution over the diaphragmatic vault in group A, B and C, respectively.
Group D received no intraperitoneal substance. The verbal pain scale questionnaire
was used for assessment of postoperative pain.
In conclusion, when instilled intraperitoneally after diagnostic laparoscopy,
bupivacaine significantly decreases postoperative pain for a long period. It also
reduces the rate of analgesic needed, increases the rate at which patients were
discharged 2 hours after surgery, and decreases hospital stay. It is highly effective
compared to lidocaine and placebo.
http://mjiri.iums.ac.ir/article-1-699-en.pdf
2003-08-15
107
111
Infertility
laparoscopy
pain
bupivacaine
lidocaine.
ME
PARSANEZHAD
parsame@sums.ac.ir
1
From the Department of Obstetrics & Gynecology, Shiraz University of Medical Sciences
AUTHOR
H
VAFAEI
2
From the Department of Obstetrics & Gynecology, Shiraz University of Medical Sciences
AUTHOR
M
LAHSAEE
3
the Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
AUTHOR
S
ALBORZI
4
the Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran
AUTHOR
EH
SCHMIDT
5
the Department of Obstetrics & Gynecology, Diakonie Teaching Hospital of Gottingen University, Beremen, Germany.
AUTHOR
ORIGINAL_ARTICLE
PSORIATIC ARTHRITIS IN 300 PSORIATIC PATIENTS IN IMA M REZA HO SPITAL, MASH H AD UNIVERSITY OF MEDICAL SCIENCES
In order to study the prevalence of psoriatic arthritis in Imam Reza Hospital
and determine the effects of factors like age, sex, familial history, type of skin
involvement, nail involvement and duration of disease on psoriatic arthritis, 300
psoriatic patients over a period of 4 years were admitted and examined in the
Department of Dermatology and Rheumatology in Imam Reza Teaching Hospital,
(MUMS). A special form was designed for collecting needed data (data collection
sheet). Statistical analysis was done on these data.
In the studied population, the prevalence of psoritaic arthritis was 16.6%.
T he most common involved joints were the wrist and fingers (52%). Asymmetrical
peripheral oligoarthritis was the most prevalent type of joint involvement.
Most of the patients were between the 3rd and 4th decades of life. Familial history
was positive in 20% of psoriatic patients and 18% of psoriatic arthritis. From a
clinical point of view 78% of psoriatic arthritis patients had psoriasis vulgaris.
Nail involvement in this group was seen in 72%. Nail pitting was present in 68%.
In general, the vulgaris type was seen in 89.2% and nail involvement in only
42.8%.
In conclusion, psoriatic arthritis was present in 16.6% of 300 patients with
psoriasis. It is recommended that joint and spine exams be performed in all cases
of psoriasis, especially those with nail involvement.
http://mjiri.iums.ac.ir/article-1-698-en.pdf
2003-08-15
101
105
Psoriasis
Psoriatic Arthritis. Mashhad
Iran.
J
SHARIATI
jshariati@yahoo.com
1
From the Departments of Rheumatology and Dermatology, Imam Reza Teaching Hospital, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
AUTHOR
Z
JAVIDI
2
AUTHOR
M
TAVALLAI
3
AUTHOR
ORIGINAL_ARTICLE
INDUCTION OF LABOR WITH USE OF A FOLEY CATHETER AND EXTRAAMNIOTIC CORTICOSTEROIDS
The purpose of this study is to show the effect of extraamniotic administration
of corticosteroids to shorten the times to either active labor and/or delivery.
This is a double blind randomized study. 65 patients who were candidates for
the termination of pregnancy between the ages of 16-45, with intact membranes
and unripe cervix were randomly divided into two groups, a study group
(n=34) and a control group (n=31). In the study group, 20mg of dexamethasone
was infused through a Foley catheter into the extraamniotic space and the infusion
was continued with normal saline in both groups.
The result of the study showed that the interval of induction to active
phase of labor was 6.6±2.33 hours in the study group and 8.2±3 hours in the
control group (t= 2.413, p=O.0187). The interval of induction to delivery was
8.4±2.62 hours in the study group and 1O.05±3.35 hours in the control group (t=
2.828, p=O.0063).
In conclusion, corticosteroids may have a role in shortening the interval
of induction to active phase of labor and the interval of induction to delivery.
http://mjiri.iums.ac.ir/article-1-697-en.pdf
2003-08-15
97
100
Corticosteroids
Induction of labor
Foley catheter.
M
MANSOURI
mansouri@mums.ac.ir
1
From the Department of Obstetrics and Gynecology, Mashhad University of Medical Sciences, Mashhad, I.R.lran
AUTHOR
A
POURJAVAD
samimohmed@yahoo.com
2
AUTHOR
G
PANAHI
drghzalpanahi@yahoo.com
3
AUTHOR
ORIGINAL_ARTICLE
SAFETY AND EFFICACY OF INTERFERON ALFA FOR THE TREATMENT OF CHRONIC HEPATITIS C INFECTED SUBJECTS WITH TRANSFUSION DEPENDENT THALASSEMIA IN IRAN
Up to 30% of Iranian adult multi-transfused thalassemic patients are infected
with hepatitis C virus (HCV) which can intensify the progression of liver disease
caused by iron overload in this group of patients. Our aim was to assess the biochemical
and virological response of interferon alfa (INF-α) and its safety in thalassemic
patients with chronic HCV infection. This trial was a single center, open
label, single treatment prospective study of INF-a (Heberon alfa R, 3 MU, every
other day) for a period of 12 months. 29 subjects, 13 to 56 years old (mean ± SD:
25.1 ± 10.4 years), whose serum HCV-RNA was positive and mean ALT remained
greater than 1.5 times upper limit of normal in the last 6 months before
the study were enrolled. A percutaneous liver biopsy was performed before treatment
and all patients underwent monthly assessment for adverse events and monitoring
of serum ALT. Qualitative serum HCV-RNA was obtained in months 3
and 6 and at the end of therapy.
Pretreatment liver biopsy showed mild fibrosis in 33.3%, moderate fibrosis
in 56.7% and cirrhosis in 10% of patients. Siderosis was severe in 14 patients
(46.7%). Two nonsplenectomized patients discontinued INF becau'se of mild cytopenia,
which resolved in less than one week after interruption of therapy. The
following were some of the important adverse events observed during the study
period: Flu syndrome in 29(100%), chills or fever>39°C in 14(48%), local pain
in 14(48%), transient gastrointestinal symptoms in 13(44%), weakness in 5(17%),
local induration in 3(10%) and edema in 2(7%) of the patients. By the end of 12
months of therapy, 15 patients out of 27 (55.6%) had a normal ALT and negative
HCV-RNA (complete end-treatment response), they were followed up for a mean
duration of 10.5 months (range: 6 to 22 months) and in 8 of them (53.3%) the
condition relapsed (abnormal ALT with positive PCR). Viral clearance was a delayed
event in our patients (29% by the end of month 3 and 63% by month 7) but
ALT normalization occurred in 94% of responders by the end of month 3.
Our experience indicates that the cure of HCV -related liver disease in thalassemic
patients is not an unrealistic aim and may be achieved with a safe and
inexpensive INF preparation (Heberon Alfa R) in a sizeable portion of cases. As
opposed to non-thalassemic patients, in whom most viral responses happen in the
first 3 months of therapy, in this group of thalassemic patients we found that
maximum virologic response happened between 3 to 6 months of therapy. Although
INF-a is an effective drug for initial treatment in thalassemic patients
infected with HCV, its efficacy with the above dose and duration, for maintaining
long term remission is under question.
http://mjiri.iums.ac.ir/article-1-696-en.pdf
2003-08-15
87
95
Thalassemia
Interferon
Hepatitis C
Heberon
S
MIRMOMEN
minnomen@ams.ac.ir
1
From the Digestive Disease Research Unit of Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
AUTHOR
H
GHOFRANI
2
AUTHOR
H
FOROOTAN PISHBUARY
3
AUTHOR
N
EBRAHIMI DARYANI
4
AUTHOR
M
JAFAR FARAHVASH
5
AUTHOR
RA
SHARIFIAN
6
AUTHOR
F
AZMODEH
7
AUTHOR
R
MALEKZADEH
8
AUTHOR
ORIGINAL_ARTICLE
SUCCESSFUL PREGNANCY OUTCOME WITH lUI IN PATIENTS WITH UNEXPLAINED RECURRENT MISCARRIAGE, WHOSE MALE PARTNERS HAVE LOW SCORE HYPO-OSMOTIC SWELLING TEST
In order to determine outcome of pregnancy with lUI in patients with unexplained
recurrent miscarriage whose husbands have low hypo-osmotic swelling
test scores, a prospective clinical intervention was performed at a university referral
clinic of recurrent abortion.
Out of 56 patients whose husbands had abnormal hypo-osmotic swelling
tests, 43 patients underwent lUI, from which only 14 patients became pregnant
(treatment group) and 13 patients became spontaneously pregnant without lUI as
control group.
Our main outcome measure was successful pregnancy (continuation of pregnancy
after 20 weeks).
Among the 14 patients who became pregnant, 3 patients aborted below 20
weeks (21.4%), and 11 patients continued pregnancy after 20 weeks of gestation
(78.6%). In the control group among the 13 patients with spontaneous pregnancy,
8 patients aborted below 20 weeks (61.5%) and 5 patients continued pregnancy
over 20 weeks (36.4%), success rate ratio was 2.04% and the difference was statistically
significant (d= 4.49, p<0.05).
Treating the unexplained recurrent aborter whose male partner has a low
hypo-osmotic swelling test score with lUI could be effective. This is the first
study to present an ideal way for selection of recurrent aborters who benefit from
lUI. The probable mechanism for this effect may be selection of the best quality
sperms which will be discussed in detail.
http://mjiri.iums.ac.ir/article-1-716-en.pdf
2003-08-15
25
27
Recurrent miscarriage
Hypo-osmotic swelling test
lUI.
J
ZOLGHADRI
JzoIghad@yahoo.com
1
From the Department of Obstetrics & Gynecology Shiraz University of Medical Sciences, Shiraz, I.R.Iran.
AUTHOR
A
GHADERI
2
From the Department of Immunology, Shiraz University of Medical Sciences, Shiraz, I.R.Iran.
AUTHOR
S
ALBORZI
3
AUTHOR
ME
PARSANEZHAD
4
From the Department of Obstetrics & Gynecology Shiraz University of Medical Sciences, Shiraz, I.R.Iran.
AUTHOR
ORIGINAL_ARTICLE
ASSESSMENT OF THE RELATION BETWEEN AGE AT MENARCHE, ANTHROP OMETRIC PARAMETERS AND INTELLIGENCE QUOTIENT IN MASHHAD, IRAN
The present study was initiated to derive an indirect method for estimating
body fat mass (BFM) and to evaluate the correlation between indirect anthropometric
techniques for this estimation and to examine the relation of these parameters
and of IQ to age of menarche.
A total of 578 adolescent girls of ten junior high schools in five educational
districts of Mashhad, participated in a cross sectional study during autumn 2000.
The data were gathered through questionnaires, interview, measurement of anthropometric
parameters including: weight, height, BMI (Body Mass Index), TSF
(Triceps Skin Fold) thickness, SSSF (Sub-Scapular Skin Fold) thickness, MUAC
(Middle Upper Arm Circumference), and measurement of IQ by Raven test.
We demonstrated that anthropometric parameters for estimating BFM correlated
well with each other. Age at menarche did not correlate with BFM measured
by anthropometric parameters when studied at the onset of menarche, but it did
well correlate negatively with these indices if studied any time postmenarche,
regardless of the interval between the onset of menarche and the present age
(p<0.001).
IQ correlated negatively to the age at menarche (p< 0.001). These findings
implicate that BFM does not trigger puberty onset in healthy girls, but it does
accumulate with a faster rate in the postmenarcheal period so that girls who have
an earlier menarche have a higher weight and BMI and greater skinfold thickness
than those who enter the menarcheal stage at a later time, and that mental development
and physical growth are parallel processes, so that a slower mental development
would be expected when physical growth is delayed.
http://mjiri.iums.ac.ir/article-1-715-en.pdf
2003-08-15
19
24
Menarche
BM!
MUAC
TSF
SSSF
IQ
Age at Menarche
Z
YUSOFI
1
From the Department of Gynecology, Qaem Medical Center; Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
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RAJAIE
2
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