REVIEW_ARTICLE IgE AND ITS RECEPTORS, A REVIEW http://mjiri.iums.ac.ir/article-1-1227-en.pdf 1996-05-15 89 97 IgE Receptor B-cells. ABBAS A GHADERI 1 From the Department of Microbiology and Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran. AUTHOR
CASE_STUDY ANTIPHOSPHOLIPID ANTIBODY SYNDROME-A CASE OF AORTIC VALVE INSUFFICIENCY A 31 year old woman was hospitalized for evaluation of aortic valve insufficiency and her present cardiac status. Clinical and paraclinical findings strongly suggested the presence of a collagen vascular inflammatory processprecisely, the antiphospholipid antibody syndrome (APS), with systemic lupus erythematosus as the underlying disease. http://mjiri.iums.ac.ir/article-1-1226-en.pdf 1996-05-15 85 88 F NOOHI 1 From the Cardiovascular Research Center, Shahid Rajai Heart Hospital, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran AUTHOR V SINEH SEPEHR 2 AUTHOR A MOHEBBI 3 AUTHOR HA BASSIRI 4 AUTHOR
CASE_STUDY MALIGNANT HISTIOCYTOSIS: A CASE REPORT AND REVIEW OF THE LITERATURE Malignant histiocytosis (MH) is a rare hematologic malignancy, especially in the first decade of life. The disease is clinically characterized by fever, hepatosplenomegaly, lymphadenopathy, pancytopenia and jaundice, and histologically by systemic proliferation of malignant histiocytes and hemophagocytosis. The prognosis is poor and often the diagnosis is not made before death. Because of the rarity of this disease, it is unusual for practitioners to diagnose it by bone marrow aspiration (BMA) alone http://mjiri.iums.ac.ir/article-1-1225-en.pdf 1996-05-15 79 83 A BANIHASHEM 1 From the Departments of Pediatrics Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran. AUTHOR T GHIASSI 2 From the Departments of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran. AUTHOR S ZABIHYAN 3 AUTHOR
ORIGINAL_ARTICLE PREPARATION AN D CLINICAL EVALUATION OF SOME ANTI-ANORECTAL DISEASE DRUGS OBTAINED FROM MEDICINAL PLANTS The hydroalcoholic extracts of dried ligulate florets of Calendula officinalis L., dried leaves of Plantago major L., and dried aerial parts of Vinca major L. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. Benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate was used in the other. The effects of both prepared formulations were investigated in patients suffering from anorectal diseases, using relevant placebos for comparison. The results indicated that the prepared drugs were significantly effective in the treatment of anorectal diseases. Formulations containing benzocaine proved to be more effective in patients suffering from hemorrhoids, while formulations containing belladonna dry extract and ephedrine sulfate were more effective in anal fissure and proctitis. http://mjiri.iums.ac.ir/article-1-1224-en.pdf 1996-05-15 73 77 Anti-Anorectal Disease Plants; Calendula officinalis; Plantago major; Vinca major. SULEIMAN AFSHARYPOUR 1 From the Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan AUTHOR KlANDOKHT SHAFII 2 From the Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan AUTHOR MOHAMMAD ESMAIL AKBARY 3 the School of Medicine, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran AUTHOR MOHAMMAD REZA ZARGARZADEH 4 From the Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan AUTHOR
ORIGINAL_ARTICLE PREPARATION AN D CLINICAL EVALUATION OF SOME ANTI-ANORECTAL DISEASE DRUGS OBTAINED FROM MEDICINAL PLANTS The hydroalcoholic extracts of dried ligulate florets of Calendula officinalis L., dried leaves of Plantago major L., and dried aerial parts of Vinca major L. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. Benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate was used in the other. The effects of both prepared formulations were investigated in patients suffering from anorectal diseases, using relevant placebos for comparison. The results indicated that the prepared drugs were significantly effective in the treatment of anorectal diseases. Formulations containing benzocaine proved to be more effective in patients suffering from hemorrhoids, while formulations containing belladonna dry extract and ephedrine sulfate were more effective in anal fissure and proctitis. http://mjiri.iums.ac.ir/article-1-1223-en.pdf 1996-05-15 73 77 Anti-Anorectal Disease Plants; Calendula officinalis; Plantago major; Vinca major. SULEIMAN AFSHARYPOUR 1 From the Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan AUTHOR KlANDOKHT SHAFII 2 From the Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan AUTHOR MOHAMMAD ESMAIL AKBARY 3 the School of Medicine, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran AUTHOR MOHAMMAD REZA ZARGARZADEH 4 From the Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan AUTHOR
ORIGINAL_ARTICLE MONITORING OF LEAD POISONING IN SIMPLE WORKERS OF A COPYING CENTER BY FLAME ATOMIC ABSORPTION SPECTROSCOPY Inorganic lead compounds are used most widely in paint and pigment industries. Because of exposure to lead dust in workers in a copying center, we compared blood lead levels in these workers to normal individuals and investigated the relationship between job tenures of the workers and their blood lead levels. This survey was performed on 20 simple workers in a copying center of Tehran University. The ages of the workers were between 27 and 62 years, and job tenures of the workers were between I and 27 years. Our results indicated that 94% of the workers had high blood lead concentrations (>49.9 µg/dl) and only 6% showed acceptable (30-49.9 µg/dl) blood lead levels. Blood lead levels of these workers were significantly higher than that of controls (P<0.01). Their blood lead levels and job tenures showed a direct but imperfect correlation [coefficient of correlation (r)=0.68] and the confidence interval was between 0.3-1.36 (95% confidence). Clinical manifestations of intoxication in these workers included clumsiness, abdominal pain, lumbar pain and peripheral pain as main symptoms. The results of this study indicate that copying rooms are at high risk for lead poisoning. http://mjiri.iums.ac.ir/article-1-1222-en.pdf 1996-05-15 69 72 MOHAMMAD ABDOLLAHI 1 From the Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. AUTHOR MAASOUMEH EBRAHIMI-MEHR 2 AUTHOR SHEKOUFEH NIKFAR 3 AUTHOR NASER JALALI 4 AUTHOR
ORIGINAL_ARTICLE EVALUATION OF SERUM OPSONIC CAPACITY AGAINST BORDETELLA PERTUSSIS BY CHEMILUMINESCENCE Serum opsonic capacity against B. pertussis was studied by using quantitative chemiluminescence (CL), a method known to have several advantages over conventional methods in evaluating opsonization and phagocytosis. Sera from unvaccinated infants was shown not to contain opsonins against B. pertussis and in unvaccinated infants suffering from whooping cough, no opsonins were detected. In adults fully vaccinated during childhood, antibody titers decreased with time. Therefore, antibody transfer to infants is negligible. The CL assay is simple, rapid, and reproducible, offering new possibilities to evaluate humoral immune mechanisms and phagocytosis in whooping cough. http://mjiri.iums.ac.ir/article-1-1221-en.pdf 1996-05-15 65 67 A A. ISAIAN 1 From the Department of Immunology and Allergy, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. AUTHOR A FARHOUDI 2 AUTHOR
ORIGINAL_ARTICLE RESPONSE OF METACARPAL FRACTURE FIXATION CONSTRUCTS TO PHYSIOLOGICAL LOADINGS This study compares the functional capabilities of different metacarpal fixation constructs under physiological loadings in an attempt to identify the optimal construct rather than the strongest one. One hundred and twenty-six preserved human metacarpals were mechanically tested after oblique osteotomies and internal fixation. Maximum load to failure, average structural rigidity, and energy absorbed were determined. All the fixations, except the intramedullary rods, tolerated the assigned physiological loadings below their failure limits in tension and torsion. The safety factor for K-wire tension band in bendings was only 1.4, which is very low compared to those of dorsal plate fixation (4.3) and the two interfragmentary lag screw fixation (4.0). Both torsional and axial rigidity of the K-wire tension band fixation were significantly less than the two interfragmentary lag screw fixation. Fixation by two interfragmentary lag screws was the optimal method, providing adequate strength and stability while requiring less soft tissue dissection than dorsal plate fixation. http://mjiri.iums.ac.ir/article-1-1220-en.pdf 1996-05-15 59 63 KEIKHOSROW FIROOZBAKHSH 1 From the Department of Mechanical Engineering, Biomechanics Division, Sharif University of Technology, Tehran, Islamic Republic of Iran AUTHOR MOHEB S. MONEIM 2 the Department of Orthopedics and Rehabilitation, Medical School, University of New Mexico, Albuquerque, New Mexico, U.S.A. AUTHOR
ORIGINAL_ARTICLE RELATIONSHIPS BETWEEN LIPOPHILIC CHARACTER AND BIOLOGICAL ACTIVITY OF NEW POTENTIAL LONG-ACTING LOCAL ANESTHETICS The partition coefficients (P-values) of certain new potential, stereoselective, reversible, long-acting local anesthetics have been determined in an n-octanol/ phosphate buffer system. These are derivatives of 2-phenoxyethyldialkylamine hydrochloride, and almost all of them are readily soluble in water. Their aqueous solutions have shown different absorption maxima, and these have been used quantitatively to determine the concentration of solute in aqueous phase using the Beer-Lambert equation and the calibration curve, which has been a straight line within the test concentrations. The values of P have been calculated as the ratio of the concentration of solute in the octanol phase divided by the concentration in the aqueous phase the former value has been obtained from mass balance. The mass balance is confirmed by obtaining the absorption measurements of the organic phase. The guinea pig intradermal wheal test has been used to determine the anesthetic properties of the test agents. They have exhibited better anesthetic profiles than those of the bupivacaine standard. Moreover, they have displayed no apparent side-effects neither locally nor systemically. Although there has been no sharp general correlation between the P-values and duration of action (WT), it is observed, in many cases, that derivatives with low P-values have shorter WT than those with high P-values. Therefore, it seems that the duration of action of these compounds is not influenced only by this property, i.e. P-values, and other factors such as physicochemical, pharmacokinetic, and pharmacodynamic parameters as well as non-specific binding characteristics at adjacent tissues are also involved. Thus, the action of these new compounds is due to the molecule as a whole and not to any one particular physical or chemical property. Furthermore, these are reversible and stereoselective agents. http://mjiri.iums.ac.ir/article-1-1219-en.pdf 1996-05-15 53 57 Partition Coefficient determination; Local Anesthesia duration of action; Local Anesthetics new derivatives. D AL-SAADI 1 From the School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran AUTHOR WE SNEADER 2 the School of Pharmacy and Pharmacology, University of Strathclyde, Glasgow, Scotland. AUTHOR NG WATON 3 the School of Pharmacy and Pharmacology, University of Strathclyde, Glasgow, Scotland. AUTHOR
ORIGINAL_ARTICLE DOWN\'S SYNDROME: CYTOGENETIC STUDIES IN 150 CASES IN TEHRAN Cytogenetic studies were performed on 150 cases of Down's syndrome (DS) in Iran. The standard trisomy 21 was found in 132 (88 % ) and translocation-trisomy 21 (+21) in 18 (12%) patients, i.e., t(21,21) in 1(0.63%) and mosaicism in 17(11.33%) cases. The comparison of the frequencies for mosaicism between different populations such as Denmark, Hungary, Egypt, Iraq, India, Australia and Iran demonstrated a difference in geographic distribution. There was a high incidence in the north of Europe towards Egypt and Iraq which decreased towards Iran and further towards the eastern region in the Indian ocean and India and further decreased towards Australia. Statistical analyses demonstrated significant differences between the data in Iran and Copenhagen, Hungary and Australia for mosaicism and translocation +21, and India, for translocation +21. The occurrence of translocation +21 decreased significantly from Denmark towards Egypt in Africa and Iraq in southwest Asia, then it increased from Iran towards Australia in the Pacific ocean. The comparison of cells having satellite associations (SA), significantly indicated the involvement of two and three SAs in DS cases. The study on the position of chromosomes in the metaphase plate, the occurrence of chromatid breaks and endoreduplication did not present any significance in DS cases. http://mjiri.iums.ac.ir/article-1-1218-en.pdf 1996-05-15 47 52 Down\'s syndrome Cytogenetics Geographic distribution Iran P MEHDIPOUR 1 From the Department of Human Genetics, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran AUTHOR M SAADAT 2 , the Department of Genetics, Faculty of Basic Sciences, Tarbiat Modarres University, Tehran AUTHOR MR NOORI-DALOII 3 the Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. AUTHOR
ORIGINAL_ARTICLE CYTOGENETIC BIOMONITORING OF 65 RADIOLOGY TECHNOLOGISTS OCCUPATIONALLY EXPOSED TO CHRONIC DOSES OF X-IRRADIATION IN IRAN The frequency of chromosomal aberrations was studied in the peripheral blood lymphocytes of 65 radiology technologists CRT) working at hospitals chronically exposed to x-rays. Although film dosimetry did not show the maximal annual permitted dose in any of the examined subjects, cytogenetic analysis detected fairly high levels of chromosomal aberrations in R T compared to unexposed controls. The mean frequencies of structural chromosome aberration per 100 lymphocyte metaphases of workers and the controls were 2.93 and 0.54 respectively, excluding the high level of achromatic lesions registered. The difference between them was statistically significant with a P-value of <0.05. http://mjiri.iums.ac.ir/article-1-1217-en.pdf 1996-05-15 43 46 Cytogenetic biomonitoring Chromosomal aberrations Lymphocytes Low-dose x-irradiation Occupational exposure. HOSSEIN MOZDARANI 1 From the School of Medical Sciences, Tarbiat Modarres University, Tehran, P.O. Box 141554838, Islamic Republic of Iran. AUTHOR HAMID SAMAVAT 2 AUTHOR
ORIGINAL_ARTICLE HLA CLASS I IN IRANIAN P SORIATIC PATIENTS The association of HLA and disease varies in different populations. We have . studied the association of HLA class I in Iranian psoriatic patients, in order to compare this association with other reports. Fifty-one Iranian patients with psoriasis were HLA typed. The frequency of HLA antigens in patients and patient subgroups, based on clinical patterns, age of onset, family history and provocative factors, were compared with each other and with normal controls. The results indicate that the disease is strongly associated with HLA-Cw6 (chi-square, corrected P-value (Pc)≤0.0009), and negatively associated with Cw3 (Pc≤ 0.00009 and Pc≤ 0.03, respectively). Psoriatic patients with early onset disease and non-pustular psoriasis (NPP) showed a more significant association with HLA-Cw6 (Pc≤ 0.0004 and Pc≤ 0.0003, respectively). There was no statistically significant relationship between the presence of a positive family history and early onset of disease. http://mjiri.iums.ac.ir/article-1-1216-en.pdf 1996-05-15 37 41 HM NIKNAM 1 From the Department of Immunology, Pasteur Institute, Tehran AUTHOR P MANSOORI 2 the Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, AUTHOR B NIKBIN 3 the Department of Immunology, Tehran University of Medical Sciences, Tehran AUTHOR M DANESHPAJOUH 4 the Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, AUTHOR A AMIRKHANI 5 the Department of Epidemiology, Pasteur Institute, Tehran, Islamic Republic of Iran. AUTHOR MH ALIMOHAMMADIAN 6 From the Department of Immunology, Pasteur Institute, Tehran AUTHOR
ORIGINAL_ARTICLE TUBERCULIN SENSITIVITY IN AN URBAN POPULATION IN IRAN Mantoux test using 2 IU of tuberculin prepared in Iran was performed on 6675 healthy persons randomly selected from an urban population (Shiraz) of Iran. In 3776 persons with no evidence of previous BCG vaccination the rate of positive reaction was less than 2% up to the age of 14, slightly more than 2% among those 15-19 years of age, but strikingly higher (45.5%) in older age groups (P<0.001). The rate of positive reaction was higher among females (P90%) again. The differences between different age groups as well as the two sexes were statistically significant (P<0.005), though the sex difference was reversed in this group. http://mjiri.iums.ac.ir/article-1-1215-en.pdf 1996-05-15 31 35 Mantoux test prevalence of tuberculin positive age and sex differences Iran ALI SADEGHl-HASSANABADI 1 From the Department of Community Medicine, Shiraz Medical School, Shiraz, Islamic Republic of Iran. AUTHOR IRAJ JAVIDIAN 2 AUTHOR
ORIGINAL_ARTICLE SURV EY OF THE PREVALENCE RATE OF BEHAVIORAL DISORDERS AMONG THALASSEMI C PATIENTS IN ISFAHAN Chronic diseases have been identified as predisposing factors in behavioral disorders and the prevalence of these disorders is known to be higher in patients than in control groups. Thalassemia too, plays an effective role in increasing the prevalence of behavioral disorders. In order to recognize the prevalence of behavioral disorders in thalassemic patients, a study was performed on 257 patients (144 boys and 113 girls). A control group was considered for comparison, the members of which were chosen from healthy sisters and brothers of the patients, otherwise from their fIrst class family members, and ultimately from their neighbours. The diagnosis of behavioral disorders was based on DSM-III-R and the required information was collected by questionnaires that were filled in by the parents and by interviewing the patients themselves. The following results were obtained in the final inspection: 1) the prevalence of separation anxiety (P = 0.000), enuresis (P = 0.021) and depression (P = 0.002) was higher in thalassemic patients, and 2) other disorders under study (oppositional disorders, attention deficit disorder with hyperactivity, conduct disorder, avoidance disorder,- over-anxious disorder, pica, encopresis, stuttering, elective mutism and stereotyped-habitual behaviors) did not show a significant difference regarding a P-value above 0.05. http://mjiri.iums.ac.ir/article-1-1214-en.pdf 1996-05-15 27 30 GH ASADOLLAHI 1 From the Psychiatry Department, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan. AUTHOR M GHANEI 2 theThalassemia Prevention and Research Center, Seyyed AI-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran. AUTHOR M AZAMI 3 theThalassemia Prevention and Research Center, Seyyed AI-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran. AUTHOR A PEZESHKI 4 theThalassemia Prevention and Research Center, Seyyed AI-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran. AUTHOR
ORIGINAL_ARTICLE PAUWELS\' OSTEOTOMY FOR FEMORAL NECK NON-:union: During a period of nine years (1982-1991), Pauwels' osteotomy was performed for 38 cases of femoral neck non-:::union:::. 32 led to consolidation with one osteotomy (84%) and 6 failed (3 needed revision (92%), one died and two were lost to follow-up). The length of follow-up was 2-11 years, the average time of non-:::union::: 12 months (ranging from 4 months to 13 years) and the mean patient age 33 years (ranging from 3-58 years). According to the method of fixation the cases were divided into 3 groups, and the best results were achieved in group III which were treated via a modification of Pauwels' technique. http://mjiri.iums.ac.ir/article-1-1213-en.pdf 1996-05-15 21 26 F ABDlNEJAD 1 From the Department of Orthopedics, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran AUTHOR MJ EMAMIE 2 AUTHOR
ORIGINAL_ARTICLE EXPERIENCE WITH 115 PATIENTS WITH CONGENITAL A DREN AL HYPERPLASIA AND EVALUATION OF GROWTH PATTERNS IN 24 PATIENTS WITH THE SALT-LOSING TYPE In this study the data on 115 cases of congenital adrenal hyperplasia (CAH) who were followed in the Pediatric Endocrine Clinic at Nemazee Hospital, Shiraz will be reported. Among these cases 51 were male and 64 female. The most common type of CAH in these patients was the salt-losing type of 21 -hydroxylase deficiency (85 .2%). ll-hydroxylase deficiency was present in 13.04% of patients. There was only one case with 20 ,22 -desmolase deficiency and one also with 3-betahydroxysteroid dehydrogenase deficiency. Presenting complaints were ambiguous genitalia, vomiting, failure to thrive, precocious puberty and hypertension. The analysis of data on 24 patients with the salt-losing type of21-hydroxylase deficiency who were followed for at least 2 years showed that these patients suffered from abnormal growth patterns. Growth failure was maximal during the first year of life. http://mjiri.iums.ac.ir/article-1-1212-en.pdf 1996-05-15 17 20 Z KARAMIZADEH 1 From the Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran. AUTHOR GH AMIRHAKIMI 2 AUTHOR
ORIGINAL_ARTICLE OMENTAL GRAFT APPLICABILITY IN EXPERIMENTALLY INDUCED SPINAL CORD COMPRESSION IN RATS One of the most important factors responsible for axonal degeneration following spinal cord trauma is ischemia produced by cord compression. Previous studies have revealed that omental transposition upon the injured site of the spinal cord could be beneficial in the induction of partial improvement of neuroelectrical and motor function in laboratory animals. The purpose of this study is to verify the effects of early placement of pedicled omentum on recently traumatized rat spinal cord as measured by subsequent clinical, electromyography (EMG), motor evoked potential (MEP) and horse-radish peroxidase (HRP) labelling methods. Forty rats were divided into two groups (A;B). Atter anesthesia, laminectomies were performed at T12level and the left lateral half of.the spinal cord was compressed intradurally by an aneurysm clip for seven minutes in both groups. The omentum was transposed in group B rats on the lesioned site. After 3-5 months, evaluation of the muscular forces in the affected limb according to modified Tarlov's classification showed a significant difference between the two groups (P < 0.01). EMG showed a greater degree of spasticity in nongrafted animals than grafted ones. MEP showed a powerful signal in grafted animals, but only a weak signal was recorded in the nongrafted group. Injection of HRP into the spinal cord below the compression site demonstrated retrogradely labelle d neurons above the compression site in grafted animals, but transmission of HRP was not seen in nongrafted animals. These results show that transposition of omentum on the injured site of recently traumatized rat spinal cord could be helpful in axonal regeneration. http://mjiri.iums.ac.ir/article-1-1211-en.pdf 1996-05-15 11 16 Spinal cord injury Omental transposition Electromyography Motor evoked potential Horseradish peroxidase. ABDOLREZA SHEIKHREZAE 1 From the Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran AUTHOR SEYYED ALI F. TABATABAI 2 AUTHOR REZA NAZARI 3 the Department of Physiology, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. AUTHOR GILA BEHZADI 4 AUTHOR ZAHID HUSSAIN KHAN 5 AUTHOR
ORIGINAL_ARTICLE KIDNEY TRANSPLANTATION IN CHILDREN AND ADOLESCENTS OF SOUTHERN IRAN In this first report on the experience with renal transplantation in children and adolescents in southern Iran during the past five years, thirty-two patients (aged 5- 19 years old 18 males, 14 females) received renal allografts. Pretransplantation pathologic diagnoses by kidney biopsy were: membranoproliferative glomerulonephritis (MPGN), rapidly progressive glomerulonephritis (RPGN), chronic glomerulonephritis, chronic pyelonephritis, reflux nephropathy, obstructive uropathy and renal tubular acidosis (RTA). The cause of ESRD was unknown in eleven cases. Overall one year graft survival was 89%, 71 % at two years, and 50% at four years. The overall patient survival at one year was 93% and at two years, 86%. Well-being and remarkable improvement of physical, emotional, biochemical and endocrinological impairment were noticeable in 74% of the patients. No recurrence of primary disease was detected during the study period. http://mjiri.iums.ac.ir/article-1-1210-en.pdf 1996-05-15 7 9 GH HASHEMI 1 From the Renal Transplantation Unit, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran. AUTHOR SA MALEK HOSSEINI 2 AUTHOR MH FALLAH-ZADEH 3 AUTHOR R JAVID 4 AUTHOR N GHAHRAMANI 5 AUTHOR
ORIGINAL_ARTICLE CEREBRAL HYDATIDOSIS: A REAPPRAISAL The remarkable evolution of surgical management of cerebral hydatidosis towards an earlier diagnosis and proper treatment is evident from this 22-year retrospective study of our experience with 19 cases seen at Shiraz University Medical Institutions. Both cases of iatrogenically-induced infected cysts were seen during the pre-CT era. The optimistic view of being able to remove all the cysts intact seems to be elusive because six cysts ruptured during extraction even with application of the Dowling technique. These cases were followed for a mean of 44 months and in only one case was the patient referred again with subarachnoid cysts of the lumbosacral region after two years. In six cases we had involvement of other organs also. There were two cases of multiple cysts in the brain, a case with de novo infection of the cyst contents, and one in which the cyst was epidural in the parieto-occipital region. One patient died pre-operatively and three were lost to follow-up however, fifteen patients were followed for a mean of27 months with eleven being neurologically intact and four with focal neurological deficits. One patient with a tapped cyst before extraction was readmitted two years later with paraplegia due to drop parasitic infestation of the thoracolumbar region. http://mjiri.iums.ac.ir/article-1-1209-en.pdf 1996-05-15 1 5 BIZHAN AARABI 1 From the Nemazee and Beheshti Hospitals, Shiraz University of Medical Sciences, Shiraz, IslamicRepublic of Iran. AUTHOR MUSA TAGHIPOUR 2 AUTHOR AHMAD KAMGARPOUR 3 AUTHOR