Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
A STUDY ON THE APPLICATION AND EFFICACY OF SOLVENT-DETERGENT (SID) TREATMENT IN THE PROCESS OF PURIFYING FACTOR VII FROM PROTHROMBIN COMPLEX
179
182
EN
H
REZVAN
From the Research and Development Department, Blood Research and Fractionation Co., Tehran
Y
S
NASIRI
From the Research and Development Department, Blood Research and Fractionation Co., Tehran
N
K
MOUSAVI
From the Research and Development Department, Blood Research and Fractionation Co., Tehran
N
M
GOLABI
Virology Dept., Iran University of Medical Sciences, Tehran, I.R. Iran.
N
The risks of transmitting viral infection by blood and plasma-derived products
have long been known and still remain an area of concern. In this study, in
the process of purifying human factor VII from prothrombin complex, SID treatment
using tri-n-butyl phosphate and Tween 80 was employed and its capability
and efficacy was studied.
The results indicated that the process did not affect the biological function of
the essential coagulation factors studied. In addition, the process was shown to be
effective on enveloped viruses, where its inactivation factor for the model used,
Herpes Simplex type I, was 5.5 logs. However, the procedure was not effective on
poliovirus which was used as a model for non-enveloped viruses. It is therefore
concluded that for increasing viral safety it is best to apply at least one more
inactivating procedure which will be effective on non-enveloped viruses as well.
Human Factor VII concentrate, viral inactivation, solvent-detergent treatment.
http://mjiri.iums.ac.ir/article-1-751-en.html
http://mjiri.iums.ac.ir/article-1-751-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF PANCREATIC ISLET BETA CELLS OF DIABETIC RATS TREATED WITH ORAL VANADYL SULPHATE
173
178
EN
S
AHMADI
From the Departments of Physiology School of Medicine,Tehran University of Medical Sciences, Tehran, I.R. Iran.
Y
SM
KARIMIAN
From the Departments of Physiology School of Medicine,Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
M
SOTOUDEH
From the Departments of Pathology, School of Medicine,Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
M
BAHADORI
From the Departments of Pathology, School of Medicine,Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
Vanadium salts have been suggested as a possible therapeutic agent for the
treatment of diabetes. The aim of the present study was to clarify histological and
immunohistochemical changes that occur in the pancreatic beta (β) cells of vanadyl
sulphate (VS)-treated streptozotocin (STZ) induced diabetic rats.
Male Wi star rats were made diabetic by injecting a single intravenous dose
of STZ (40 mg/kg) and were divided into two groups seven days after STZ injection.
In the first group VS was administered via drinking water at a concentration
of 1 mg/mL and treatment was maintained until normoglycemia appeared (DT).
A second group of diabetic animals received distilled water for the same period
and were considered as control diabetic (DC). One group of animals (NC) was
injected intravenously with the same amount of vehicle as the diabetic rats and
was considered as non-diabetic control. VS treatment was accompanied by amelioration
of the signs of diabetes in DT rats while DC animals remained diabetic
during this period.
Hemotoxylin - Eosin stained pancreatic sections of DC rats showed a decrease
in the number and size of islets and a disruption in their architecture. In DT
rats the histological appearance of the islets was normal, their shape and size
being within normal limits.
In horseradish peroxidase procedure (using guinea pig antiserum to insulin
as primary antibody) performed on pancreatic islet paraffin sections of rats, insulin
immunoreactivity was found in the majority of the islets in DT rats while in
the islets of DC rats immunoreactivity was rare.
The results of this study indicated that amelioration of diabetes in vanadyl
sulphate treated diabetic rats was accompanied with well preservation of islet
structure and insulin immunoreactivity.
Vanadyl Sulphate, Pancreas, Beta cell, Diabetes.
http://mjiri.iums.ac.ir/article-1-750-en.html
http://mjiri.iums.ac.ir/article-1-750-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
A SURVEY OF CELLULAR IMMUNITY, TOTAL T-LYMPHOCYTE, T-ACTIVE , B-LYMPHOCYTE A ND T-CELL FUNCTION IN RELATION TO PHYTOHEMAGGLUTININ (PHA) IN THALASSEMIC PATIENTS
169
172
EN
T
ZANDIEH
From the Iranian Blood Transfusion Service, Tehran
TZ7892000@Yahoo.com
Y
F
TARABADI
From the Iranian Blood Transfusion Service, Tehran
N
A
TABATABAIYAN
From the Iranian Blood Transfusion Service, Tehran
N
M
IZADYAR
the Department of Hematology, Pediatric Medical Center, Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
The aim of this study was to evaluate the immune system and lymphocyte
function in 41 Iranian β-thalassemic patients and 50 controls, ages ranging
from 2 to 18 years. The patients consisted of 20 splenectomized and 21
non-splenectomized patients. They were treated with Desferal, and had received
repeated blood transfusion. Laboratory investigations included measurement
of total T lymphocytes, active T lymphocytes, B-Iymphocytes and
function of lymphocytes treated with PHA. In this study we observed a significant
reduction of active T lymphocytes and total T lymphocytes in the
patient group compared to controls (p<0.005 & p<0.001), but there was no
significant difference between splenectomized and non-splenectomized patients.
Also in both groups, lymphocyte function was reduced against PHA
(phytohemagglutinin) compared with the controls, and the numbers of B cells
were increased. These results lead to the conclusion that the deficient immune
system in β-thalassemia causes infectious diseases, which finally leads
to death. Therefore, stimulation of the immune system as well as clinical treatment
may prevent infectious disease in patients with β- thalassemia.
Thalassemic patient, Immune system, Cytomegalovirus, Blood transfusion.
http://mjiri.iums.ac.ir/article-1-748-en.html
http://mjiri.iums.ac.ir/article-1-748-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
SPECIES IDENTIFICATION AND INV ESTIGATION OF VANCOMYCIN AND HIGH-LEVEL AMINOGLYCOSIDE AMONG CLINICAL ISOLATES OF ENTEROCOCCAL STRAINS
165
168
EN
SR
MOADDAB
From the *Department of Clinical Microbiology, Istanbul University, Istanbul, Turkey, and the *Department of Pathobiology, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.
Y
A
RAFI
N
A study was performed to determine the species and antimicrobial susceptibility
of 100 enterococcus strains from various clinical specimens as etiological agents
at the Clinical Microbiology Laboratory, Istanbul University, Medical Faculty
Hospital.
Out of 100 enterococcal isolates, 86 were identified as E. faecalis, 11 as E.
faecium, 1 as E. avium and 2 as E. raffinosus.
By the disk diffusion tests 36 of 100 strains were found to be resistant to erythromycin,
32 to penicillin, 30 to ampicillin, 7 to ciprofloxacin, 6 to norfloxacin
and 5 to nitrofurantoin. No resistance was observed to vancomycin or teicoplanin.
Twenty-six strains showed high-level resistance to streptomycin (2000 )..lg/mL)
and 13 strains exhibited high-level resistance to gentamicin (500 )..lg/mL). Ten of
these strains had high-level resistance to both aminoglycosides. None of the strains
produced beta -lactamase.
http://mjiri.iums.ac.ir/article-1-747-en.html
http://mjiri.iums.ac.ir/article-1-747-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
PLASMID MEDIATED METAL AND ANTIBIOTIC RESISTANCE IN PSEUDOMONAS AERUGINOSA STRAINS ISOLATED FROM BURN PATIENTS
159
163
EN
MOHAMMAD REZA
SHAKIBAIE,
From the Department of Genetics, Research Center, Kelman University of Medical Sciences, Kerman,I.R.Iran
shakibaie@arg3.uk.ac.ir
Y
Pseudomonas aeruginosa is a leading cause of bum infections, and antibiotic-
resistant strains of this bacterium are emerging due to extensive application
of antibiotics in the bum unit of hospitals. In this study 50 strains of P. aeruginosa
were isolated from bum patients infected with this micro-organism in the bum
unit of a general hospital in Kerman, Iran over one year [May 1999-ApriI2000].
Sensitivity/ resistance of the isolates for antibiotics and metals was determined
by MIC test. 46% of the isolates were resistant to ciprofioxacin, kanamycin (K),
gentamicin (Gm), tetracycline (Te) and chloramphenicol ( c ). 35% were resistant
to amikacin (AN), ceftriaxone (Ceft), and cefotaxime (CTX), and 10% were resistant
to imipenem (Imp) and piperacillin (PIP). The isolates exhibited varied
MIC's to metal ions. 87% were sensitive to cadmium (Cd), 62% to lead (Pb),
91 % to mercury (Hg), 54% to zinc (Zn), 85% to chromium (Cr), and 83% to
arsenate (Ars). Among them, strain 16 was found to be resistant to Pb, Cr, and Zn
as well as Te, C, Gm, and K. Conjugation and transformation experiments revealed
the transfer of Ter, Cr, Krand Gmr along with Pbr to a sensitive strain of P.
aeruginosa PTCC1074.1 (Rif) but not to E. coli K12 HB101.1(Rifr). Subsequent
plasmid isolation and agarose gel electrophoresis (0.7%) confirmed the
presence of three-plasmid bands in strain 16 and the transconjugant. Furthermore,
strain 16 accumulated a maximum amount of Pb (50µM) within 60 min. and
reached a plateau afterwards.
Pseudomonas, antibiotic resistance, lead resistance, plasmid
http://mjiri.iums.ac.ir/article-1-746-en.html
http://mjiri.iums.ac.ir/article-1-746-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
ANTI CARDIOLIPIN ANTIBODIES IN PATIENTS WITH ISCHEMIC EVENTS
155
157
EN
A
GHAEMIAN
From Mazandaran University of Medical Sciences, Sari, I.R. Iran.
Y
M
MOBINI
N
A
AJAMI
N
To determine the presence of anticardiolipin (aCL) antibodies in patients
with ischemic events, we designed a case-control study. We studied 33 patients
with unstable angina, 33 male patients with myocardial infarction and
34 control subjects with no evidence of ischemic heart disease. Plasma samples
were assessed for IgG anticardiolipin antibodies by enzyme-linked
immunosorbent assay (ELISA). The levels of aCL were (mean±SD of optical
density multiplied by 1000): 624±319, 486±318, and 239±202 for patients
with unstable angina, myocardial infarction and controls, respectively (F=
15.74 and p=0.0000). High aCL levels were found more often in patients with
acute ischemic events.
Anticardiolipin antibodies, Myocardial infarction, Ischemic events.
http://mjiri.iums.ac.ir/article-1-745-en.html
http://mjiri.iums.ac.ir/article-1-745-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
THE PROPHYLACTIC EFFECT OF LACTULOSE ON NEONATAL HYPERBILIRUBINEMIA BY ACCELERATION OF MECONIUM PASSAGE
151
154
EN
K
SAKHA
From the Department of Pediatrics, Tabriz University of Medical Sciences, Tabriz, I. R. Iran.
Y
H
SULTANI
N
One of the causes of neonatal hyperbilirubinemia is increased reabsorption
of bilirubin from meconium in the gastrointestinal tract. This occurs when the
conjugated bilirubin which is excreted into the colon is 'unconjugated by beta
glucuronidase activity, present in the neonatal intestine, which hydrolyzes bilirubin
diglucuronide into unconjugated bilirubin, which subsequently is reabsorbed
into the portal circulation, contributing to the bilirubin overload on hepatic excretory
pathways. Thus, delayed passage of meconium can cause an elevation in the
serum bilirubin level.
We accelerated meconium transit by lactulose and evaluated the relationship
between meconium passage, neonatal jaundice and bilirubin level.
150 newborns were selected after birth in Tabriz Al-zahra Hospital with special
criteria. Half of them were given 4.5-5 mL lactulose by gavage 2 hours after
birth. Time of meconium passage, appearance of jaundice and level of bilirubin
were studied in both groups. Results showed that 40% of neonates in the study.
group and 26.6% in the control group were non-icteric. Bilirubin level more than
12 mg/dL was seen in 28% of the study group and 53.4% of neonates in the
control group. There was a statistically significant correlation between lactulose
receivers and the control group (p=0.0028).
This investigation showed that acceleration of meconium passage in newborns
decreases the incidence of jaundice and hyperbilirubinemia.
Jaundice, Hyperbilirubinemia, Lactulose, Meconium.
http://mjiri.iums.ac.ir/article-1-743-en.html
http://mjiri.iums.ac.ir/article-1-743-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
KIDNEY TRANSPLANTATION IN CHILDREN: RESULTS OF TEN YEARS EXP ERIENCE IN IMAM REZA HOSPITAL
145
149
EN
R
MAHDAVI
From the Departments of Urology and Nephrology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
Y
M
NAGHIB
From the Departments of Urology and Nephrology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
N
Advances in nephrology and pediatric urology have increased the number of
children who survive renal disease and become candidates for renal transplantation.
Ten years of experience in pediatric renal transplantation are reviewed to
determine the rates of patient morbidity and graft survival.
Of the 450 renal transplantations performed in Imam Reza Hospital (1989-
1999), fifty-one were done on children (6-18yrs.). Causes of renal failure included:
reflux nephropathy, 8 cases neurogenic bladder, 5 cases posterior urethral valve,
one case prune belly syndrome, 1 case small kidney due to chronic glomerulonephritis,
8 cases the remaining failures were of unknown etiology.
All kidneys were harvested from living donors,3o related and unrelated.20
Immunosuppressive therapy was given with three drugs in all children: prednisolone,
azathioprine, and cyclosporine, with the exception of 6 recipients of HLA identical
siblings who did not receive cyclosporine. The Kaplan-Meier curve was
constructed to assess graft and patient survival and the Log rank test was used to
assess the effect of kidney source and date of renal transplant.
Immediate dieresis occurred in all graft. Surgical complications included
two urinary fistulae and one clinical lymphocele which were all repaired surgically.
There were eleven acute rejections. The most common causes of graft failure
were chronic rejection and recurrence of primary renal diseases. The graft
survival rates after 1, 2, 5 and 10 years were 95%, 84%, 76%, and 62% respectively.
By all measures, renal transplantation is still the treatment of choice for children
with ESRD. Renal transplantation in children results in improvement in physical
growth, mental development and rate of survival. Hypertension, chronic rejection,
infection, obesity and medical noncompliance continue to be problematic.
Graft Survival, renal transplantation, living donor, children
http://mjiri.iums.ac.ir/article-1-1638-en.html
http://mjiri.iums.ac.ir/article-1-1638-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
THE EFFICACY AND SA FETY OF INTERFERON ALFA FOR THE TREATMENT OF CHRONIC HEPATITIS B INFECTED SUBJECTS IN IRAN
139
134
EN
H
FOROOTAN PISHBUARY
From the Digestive Disease Research Unit of Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
emamddrc@mirmomen.com
Y
S
MIRMOMEN
From the Digestive Disease Research Unit of Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
S
ALAMDARY
From the Digestive Disease Research Unit of Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
H
GHOFRANI
From the Digestive Disease Research Unit of Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
MJ
FARAHVASH
From the Digestive Disease Research Unit of Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
M
Y OSSEFI MASHHOOR
From the Digestive Disease Research Unit of Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
F
GHANAIE
From the Digestive Disease Research Unit of Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
N
This preliminary study was designed to evaluate the effects of Heberon Alfa
for the treatment of chronic hepatitis B infected subjects in Iran. A single center,
open label, single treatment prospective study of Interferon Alfa (Heberon Alfa),
5 million units every other day for a period of 4 months, was performed between
1996 to 1998. A total number of 30 patients with histologically documented chronic
hepatitis and positive serum HBsAg were included in the study. Serum ALT of all
patients was greater than 1.5 times normal before start of therapy. Effect of therapy
on aminotransferase activity and HBsAg, HBeAg seroconversion was monitored
and all the patients underwent a second liver biopsy at the end of the study period.
Mean age of patients was 35.5 ± 12 (17 to 60 years old) and 73% of patients
were male. Most patients experienced adverse effects, but none warranted stopping
the treatment. No serious or unexpected adverse event was reported during
the study period. Thrombocytopenia was recorded in 2 patients. Liver biopsy
showed a decrease in hepatic inflammation in 53.5% of patients, no change in
36.70/0 and increase in hepatic inflammation in 100/0 of patients after the treatment.
Serum ALT returned to normal in 18 patients (60%), decreased in 7 patients
(23.3%) and didn't change in 5 patients (16.7%). There was a strong correlation
between serum ALT normalization and histological improvement. HBsAg
became negative in 5 patients (16.6%). 10 patients had positive HBeAg prior to
therapy, which became negative in 4 of then1 (40%) by the end of the study.
The current study confirms the result of other clinical trials and indicates that
Heberon Alfa is a safe and effective drug for the treatment of chronic hepatitis B
infected subjects with histologically documented chronic hepatitis.
Interferon, chronic hepatitis B, Heberon
http://mjiri.iums.ac.ir/article-1-1637-en.html
http://mjiri.iums.ac.ir/article-1-1637-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
THE EFFECT OF URINE AND BLOOD METABOLIC RISK FACTORS ON CALCIUM STONE FORMATION
133
137
EN
A
BASIRI
From the Urology Research Center, Shahid Labbafi-Nejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Y
A
TABIBI
From the Urology Research Center, Shahid Labbafi-Nejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
N
M
PARVIN
From the Urology Research Center, Shahid Labbafi-Nejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
N
In spite of vast improvements in urinary stone treatment (ESWL, PNL,
ureteroscopy, etc.), metabolic workup concerning the existence of stone forming
risk factors are of great importance and can lead to control and even prevention of
urinary stone formation in these patients.
In this analytical case-control study performed on 266 persons [110 normal
persons (56 males and 54 females), 76 patients with one episode of stone formation
(40 males and 36 females), and 80 patients with recurrent stone formation
(40 males and 40 females)] aged between 30 to 45 (with an average of 37.6) in
Shahid Doctor Labbafinejad Medical Center from May to July 1999, serum parameters
and 24-hour urine parameters have been investigated and compared
among the three groups. Results of this study revealed considerable differences in
urinary calcium levels of these three groups, with and without considering sex
(p<0.05). Averages of 24-hour urinary calcium calculated for normal, one episode
and recurrent stone formers in male groups were 159±43, 219± 71, and 283± 74
mg/24h respective1y, and for normal, one episode and recurrent stone formers in
female groups were 124±37, 190±58, and 287:t152 mg/24h respectively. Although
24-hour urine citrate in females obviously showed higher values than males, there
was no significant difference among the studied groups of the same sex. Levels of
serum calcium, potassium and magnesium between groups of females and 24-
hour urine magnesium and phosphate levels between groups of males had statistical
differences also (p<0.05 for all of the cases mentioned above).
According to the results obtained from this study, it was realized that in the
studied society levels of 24-hour urinary calcium which are higher than 200 mg/
24h (sensitivity 80%, specificity 94% and FPR 6.4%) and calcium creatinine ratios
of 24-hour urine which are higher than 0.17 (sensitivity 7.5%, specificity
88.1 % and FPR 11.9%) can be regarded as hypercalciuria. However, the results
of this study should be confirmed by more general and extended studies.
Kidney stone, Hypercalciuria, Hypocitraturia, Hypomagnesuria
http://mjiri.iums.ac.ir/article-1-1630-en.html
http://mjiri.iums.ac.ir/article-1-1630-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
DOPPLER-DERIVED RIGHT VEN T RICU L AR MYOC ARD IAL PERFORMANCE IN DEX IN NEON ATES: N ORMAL VALUES
129
132
EN
E
MALAKAN RAD
From the Department of Pediatric Cardiology, Kashan University of Medical Sciences, Kashan, I.R. Iran.
malakan_rad @kaums.a c.ir
Y
N
MOMTAZMANESH
Momtazmanesh@kaums.ac.ir
N
Doppler-derived myocardial performance index (MPI) , defined as the s um
of isovolumetric contraction and relaxation durations divided by ejection time, is
an easily measured and reproducible index that shows both systolic and diastolic
myocardial function. The goal of this study was to define normal values of right
ventricular MPI in neonates in the first 48 to 72 hours of life.
Fifty-one quiet or sleeping healthy and term neonates underwent complete
M-mode, two-dimensional color-Doppler echocardiographic examination and RV
MPI was calculated in them. Statistical analysis was performed using SPSS software.
A P value less than 0.05 was considered as significant.
RV MPI was shown to be 0.23±0.14 in healthy neonates. There was no correlation
between RV MPI and either age or weight of the newborn infants. While
this value closely resembles the results of some researchers, it is lower than that
previously reported by other investigators in healthy children. The lower value of
RV MPI in neonates may be possibly related to the higher pulmonary arterial
pressure or right ventricular mass in the first few days of life in neonates. Further
study to evaluate the effect of pulmonary arterial pressure and right ventricular
mass on RV MPI is recommended.
RVMPI, neonates, normal values
http://mjiri.iums.ac.ir/article-1-742-en.html
http://mjiri.iums.ac.ir/article-1-742-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
16
3
2002
11
1
A 20-YEAR SURVEY OF INFECTIOUS COMPLICATIONS IN 64 PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
123
128
EN
A
AGHAMOHAMMADI
From the Department (If Clinical Immunology, Allergy and Asthma, Children s Medical Center, Tehran University of Medical Sciences, Tehran. I.R. Iran.
Y
A
FARHOUDI
N
M
MOEIN
N
Z
POURPAK
N
N
REZAEI
rezaei_nima@yahoo.com
N
K
ABOLMAALI
N
M
MOVAHEDI
N
M
GHARAGOZLOU
N
B
MIRSAEIDGHAZI
N
M
MAHMOUDI
N
Common variable immunodeficiency (CV ID) is a heterogeneous primary
immunodeficiency disorder, characterized by hypogammaglobulinemia and increased
susceptibility to recurrent bacterial infections.
To determine the spectrum of infectious complications in patients with common
variable immunodeficiency (CV ID), we reviewed the hospital records of 64
CVID patients, who were diagnosed in Children's Medical Center during a period
of 20 years.
Among our patients, there were 38 males and 26 females, with a median age
of 12 years (2-42 years) at the time of study. The median age of diagnosis was 6.1
years, with an average diagnostic delay of 5.2 years in our patient's group. Almost
all of our patients have suffered from acute and recurrent infections, particularly
in the respiratory and gastrointestinal systems. The majority of patients (82.5%)
had pneumonia prior to diagnosis. The other infectious complications seen in our
patients were as follows: recurrent otitis media (54%), recurrent sinusitis (50.8%),
diarrhea (65.1 %), and bacterial meningitis (11.1 %). Unusual or opportunistic infections
were also seen in some of our patient population, including oral candidiasis
in 10 patients, and Pneumocystis carinii pneumonia in 2 subjects.
Based on this study, we suggest that hypogammaglobulinemia should be considered
in any patient with a history of recurrent infections in different organs,
and such patients should have a full assessment of the immune system.
Common variable immunodeficiency (CYID), Infection, Complication, hypogammaglobulinemia.
http://mjiri.iums.ac.ir/article-1-741-en.html
http://mjiri.iums.ac.ir/article-1-741-en.pdf