Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
DETERMINATION OF A SHARED EPITOPE ON CELLS FROM ACUTE MYELOGENIC LEUKEMIA (AML) AND T-ACUTE LYMPHOBLASTIC LEUKEMIA ( T-ALL)
253
255
EN
ABBAS A.
GHADERI
From the Dept. of Microbiology and Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Y
MH
AGAHI
N
Z
AMIRGHOFRAN
N
S
ARDEHALI
N
Two IgM monoclonal antibodies (MAb) with strong reactivity for granulocytes
and to a lesser extent for lurkat cell lines were established by immunizing BALBI
c mice with a histiocytic cell line (UY37). These two MAbs (designated as 6C9 and
4C4) reacted with blast cells of T-acute lymphoblastic leukemia (T-ALL) and
acute myelogenous leukemia (AML) patients as well as leukemic cells from
patients known as unclassified leukemia (UL). According to their pattern of
reactivity, it is most probable that these two IgM MAbs react with some highly
glycosylated membrane determinants such as 3-fucosyl-N-acetyllactosamine (3-
FAL) which are exclusively expressed on some subsets of granulocytes and AML
cells.
Granulocyte, Leukemia, CDI5
http://mjiri.iums.ac.ir/article-1-1328-en.html
http://mjiri.iums.ac.ir/article-1-1328-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
METABOLIC ACIDOSIS AND SEVERE HYPOTENSION: INFLUENCE ON SURVIVAL TIME AND SHOCK PERIOD DURING HEMORRHAGE IN THE CAT
247
252
EN
GA
DEHGHANI
From the Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
Y
H
NAJAFIPOUR
N
Metabolic acidosis and severe hypotension are the main causes of irreversibility
during hemorrhagic shock. The influence of these two factors on durations of shock
period and survival time were studied in four groups of anesthetized cats. In group
I the animals were made hypotensive by reducing mean arterial blood pressure (Pa)
to 45 mmHg with concurrent metabolic acidosis. [n group II the same level of
hypotension was produced, along with an intravenous infusion of 12% sodium
bicarbonate solution (0.25 ml/kg/min.) thus metabolic acidosis was prevented and
arterial blood pH (pHa) was kept within its normal range. In group III the Pa was kept
at 50 mmHg in the presence of metabolic acidosis, and in group IV, the Pa was kept
at 50 mmHg (the same as group Ill) but acidosis was prevented. Durations of shock
period and survival times of all groups were compared. The results of this study show
that I) preventing metabolic acidosis increased survival time by 400%, 2) keeping
the Pa at 50 mmHg increased survival time by 800 percent, and 3) prevention of
metabolic acidosis at a Pa of 50 mmHg still augmented survival time by more than
250 percent. We therefore conclude that control of pHa and prevention of severe
hypotension may increase survival rates in patients suffering from hemorrhage.
Hemorrhage; hypotension; metabolic acidosis; survival time
http://mjiri.iums.ac.ir/article-1-1327-en.html
http://mjiri.iums.ac.ir/article-1-1327-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
RAPID IDENTIFICATION OF GROUP A STREPTOCOCCI BY PYRROLIDONYL-β-APHTHYLAMIDE HYDROLYSIS
243
245
EN
M. MEHDI
ASLANI
From the Department of Microbiology, Pasteur Institute of Iran, Pasteur Avenue, Tehran
Y
REZA
GHARAGOZLOO
the Department of Pathobiology School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
N
In a clinical trial a new pyrrolidonyl-β-naphthylamide (PYR) hydrolysis test
was compared with the bacitracin disk susceptibility test for accuracy in the
presumptive identification of group A streptococci (GAS). Among 128 isolates of
beta-hemolytic streptococci 93 group A isolates were found. The sensitivity of the
PYR and bacitracin tests were similar (98.9%), but the bacitracin test had a lower
specificity (80%) than the PYR test (100%). The efficiency of the PYR and
bacitracin test were 99.2% and 93.7%, respectively. All bacitracin tests were
performed on subcultures of the isolates from the primary plate, whereas PYR
testing was performed on colonies from the primary plate. This shortened the
turnaround time for the PYR test compared to the bacitracin test by at least 24
hours.
http://mjiri.iums.ac.ir/article-1-1326-en.html
http://mjiri.iums.ac.ir/article-1-1326-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
HYPERTONIC LACTATED RINGER\'S SOLUTION IN EXPERIMENTAL VASOGENIC BRAIN EDEMA IN RABBITS: EFFECT ON BLOOD PRESSURE, ELEC TROLYTES, BLOOD UREA NITROGEN , TOTAL PROTEIN CONCENTRATION, PLASMA OSMOLALITY, AND CEREBRAL WATER CONTENT
239
241
EN
MEHDI
NEMATBAKHSH
From the Departments of Physiology and Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Y
NEPTON
SOLTANI
N
HOSSEIN
SAMARIAN
N
AKBAR
BORDBAR
N
MOHAMMAD ALI
ATTARI
N
Hypertonic solutions play an important role in the treatment of tissue edema.
Following the induction of experimental vasogenic brain edema by occlusion of
the common carotid arteries in eight rabbits, the effect of hypertonic lactated
Ringer's solution (subjects), vs. isotonic lactated Ringer's solution (control), was
studied on blood pressure, electrolyte (sodium, potassium, and calcium)
concentrations, blood urea nitrogen, total protein concentration, plasma osmolality,
urine volume, and cerebral water content.
Significant differences were seen in calcium concentration (lI.S4 ± 1.2 vs.
13.16±1.18 P- O.O5), final urine volume (I7.S±3.53 vs. 5.25±2.06 P<0.05),
systolic blood pressure (I0S.2±12.9 vs. I 22.9±5.8I P< 0.05), diastolic blood
pressure (60±15.2 vs. 79.1±6.8 P<0.05), and mean arterial pressures (74.9±14.2
vs. 93.7±6.2 P<0.05) between study and control groups. The results also indicate
that no significant differences existed in sodium and potassium concentrations,
blood urea nitrogen, total protein concentration, plasma osmolality, and tissue
brain water content between the two groups.
http://mjiri.iums.ac.ir/article-1-1325-en.html
http://mjiri.iums.ac.ir/article-1-1325-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
DEVELOPMENT OF A METHOD FOR ALUMINIUM DETERMINATION IN SERUM AND DIALYSIS FLUID BY FLAMELESS ATOMIC ABSORPTION WITH GRAPHITE FURNACE
233
237
EN
AA
MOSHTAGHIE
From the Department of Biochemistry, School of Pharmacy Isfahan University of Medical Sciences, Isfahan
Y
M
SANDUGHCHIN
From the Department of Biochemistry, School of Pharmacy Isfahan University of Medical Sciences, Isfahan
N
A
BADIL
From the Department of Biochemistry, School of Pharmacy Isfahan University of Medical Sciences, Isfahan
N
M
AZANI
the Dialysis Center, Shariati Hospital, Isfahan, I.R. Iran.
N
Aluminium determination was carried out in serum and dialysis fluid by a
simple and reliable method of nameless atomic absorption with graphite furnace . .
No preparatory procedures are required for water and dialysis fluid. In this method
serum was mixed with 0.2% HNO, to allow complete combustion of the samples
in order to improve analytical precision. The method has a sensitivity of 15 pg and
detection limit of 2.1 µg AI/L.
The aluminium contents of the main water supply, be-distilled water and
dialysis fluid were 52, I, and 44 µg/L respectively. The mean value for normal
serum aluminium in Isfahan was 3.6 µg/L. Serum aluminium concentration in
chronic renal failure was measured in pre- and post-dialysis samples. The mean
values for the serum aluminium levels pre- and post-dialysis were 30.5 and 71.08
µg/L with a range of 9-60 and 21-123 µg/L, respectively. Pre- and post-dialysis
serum aluminium values in female patients were within the range of 1-42 and 12-
66 µg/L with mean values of 18.25 and 40.5 µg/L, respectively. Instrumental
settings and sample handling are discussed.
http://mjiri.iums.ac.ir/article-1-1324-en.html
http://mjiri.iums.ac.ir/article-1-1324-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
DETERMINATION OF PHA RMACOKINETIC PARAMETERS OF PHENYTOIN IN IRANIAN EPILEPTIC PATIENTS
227
231
EN
M
MAHMOUDIAN
From the Pharmacology Dept., Pars Biopharmacy Research Co., P. O. Box 14515-717, Tehran
Y
M
ABBASI
TDM Center, Refrence lab, Ministry of Health, Tehran, I.R. Iran.
N
AJ
JAMSHIDI
From the Pharmacology Dept., Pars Biopharmacy Research Co., P. O. Box 14515-717, Tehran
N
Adjustment of phenytoin dosage in patients is very difficult due to its nonlinear
metabolism and patient to patient variation in its kinetics. It has been
recommended that the dosage of phenytoin should be adjusted according to its
plasma concentration and requirements of the patients. Therefore, the present
study was carried out to identify the various factors which may influence the
plasma level of this drug. The phenytoin plasma concentration was determined in
91 patients with steady-state concentrations according to the EMIT method. In a
further 14 patients, who had recieved at least two different doses of phenytoin, the
Km, and Vmax of phenytoin metabolism were determined according to Mullen's
direct linear plot. The results of this study showed that the plasma level of
phenytoin was below the therapeutic level in 62 (68.2%) of the patients and above
the therapeutic level in 8 (8.8%). Statistical analysis did not show any correlation
between plasma level and factors such as sex, age, or type of drug administered.
Only a small correlation was found between dosage and plasma level. The K", of
phenytoin metabolism in the group studied was found to be in the range of 1.8-
26j..Lg/mI and that of V max in the range of 5.33-13.88 mg/kg/day. The mean values
of Km, (8.4±1.7µg/mI) and V max (7.3±O.S8 mg/kg/day) were slightly higher than
reported values in the literature (S.7±2.9 µg/mI and 5.9±1.2 mg/kg/day,
respectively). However, this difference was not statistically significant.
http://mjiri.iums.ac.ir/article-1-1323-en.html
http://mjiri.iums.ac.ir/article-1-1323-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
ORGANOPHOSPHATE-INDUCED CHRONIC TOXICITY IN OCCUPATIONALLY EXPOSED WORKERS
221
225
EN
MOHAMMAD
ABDOLLAHI
From the Department of Toxicology and Pharmacology, Tehran University of Medical Sciences
Y
NASER
JALALI
the Poisoning and drug Overdose Ward, Loghman-Hakim Hospita, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
N
AMIR ALI
JAFARI
From the Department of Toxicology and Pharmacology, Tehran University of Medical Sciences
N
Organophosphate chronic toxicity has been evaluated in this study. Biological
screening for organophosphate insecticide-exposed workers is mostly recommended
for mixers, loaders, formulators and spraymen. We have studied 17 occupationally
exposed persons to pesticides. Using Ellman's colorimetric method, their plasma
cholinesterase activities have been measured. Results show that the appearance of
some of the symptoms of chronic organophosphate toxicity depends on the extent
of plasma cholinesterase activity reduction. Our results also indicate that headache,
weakness, nervousness, memory difficulty, tremors, insomnia and dizziness are•
the main problems demonstrated in these workers.
http://mjiri.iums.ac.ir/article-1-1322-en.html
http://mjiri.iums.ac.ir/article-1-1322-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
BINDING OF NAPROXEN TO SERUM PROTEINS IN PATIENTS WITH LIVER CIRRHOSIS AND HEALTHY INDIVIDUALS
217
219
EN
EUGENE J
KUCHARZ
From the Fourth Department of Internal Medicine, Silesian University School of medicine, ul. Edukacji 102, pl 43- 100 Tychy, Poland.
Y
A three-fold decrease of the in vitro ability of serum proteins to bind naproxen
was shown in patients with cirrhosis of the liver compared to healthy individuals.
This decrease was caused by quantitative changes in serum proteins in the sera of
patients with liver damage. Lower doses of naproxen are therefore suggested in the
treatment of patients with liver dysfunction.
Naproxen, Liver, cirrhosis, Serum proteins.
http://mjiri.iums.ac.ir/article-1-1321-en.html
http://mjiri.iums.ac.ir/article-1-1321-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
SERUM IgE AND BETA 2 MICROGLOBULIN LEVELS AFTER MYOCARDIAL INFARCTION
213
215
EN
A
AJAMI
From the Department of Immunology, Sari Medical School, Mazandaran University of
Y
A
MASOOD
N
E
NAZERI
N
Serum IgE and beta 2 microglobulin levels were determined in 31 patients suffering from acute myocardial infarction and 30 patients with other
forms of ischemic heart disease.
The levels of these parameters were studied on the first, third and seventh
day after the onset of disease. The immunological method used for the
determinations was ELISA
Patients with myocardial infarction showed an elevated level of both
parameters. The peak value of IgE was observed on the seventh day (P<0.05)
but that of beta 2 microglobulin on the third day (P<0.05) after the onset of
myocardial infarction.
http://mjiri.iums.ac.ir/article-1-1320-en.html
http://mjiri.iums.ac.ir/article-1-1320-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
HEARING LOSS IN CHRONIC RENAL FAILURE AND CHANGES WITH KIDNEY TRANSPLANTATION
209
211
EN
M
KAVIANI
From the Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Y
M
ALBORZI
N
Loss of hearing is a known problem in patients with chronic renal failure,
occurring in 40-XO% of cases and being most often of the high frequency sensorineural
type. We performed a study on 50 patients with this disease, including 20
who had undergone a successful kidney transplantation. Our results show an 80%
incidence of hearing loss in these patients and a chance of improvement in at least
60% of cases after transplantation.
Chronic renal failure, kidney transplantation, sensorineural hearing loss.
http://mjiri.iums.ac.ir/article-1-1319-en.html
http://mjiri.iums.ac.ir/article-1-1319-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
EVALUATION OF INDIRECT IMMUNOFLUORESCENT TEST AND CD4/CD8 RATIO IN CANDIDIASIS
205
208
EN
GR
ANSARI
From the Tarbiat Modarress University. School of Medical Sciences,
N
AA
POURFATHOLLAH
From the Tarbiat Modarress University. School of Medical Sciences,
Y
AR
SALEKMOGHADDAM
Iran University of Medical Sciences, Tehran, I.R. Iran.
N
A
TABATABAEI
Iran University of Medical Sciences, Tehran, I.R. Iran.
N
In order to study and evaluate the indirect immunofluorescent test and the ratio
of CD41ymphocytes to CD8 lymphocytes, 97 cases of positive candida cultures were
selected from among 400 patients referring to the hospital and suspected of
candidiasis. In this study 39% of the patients had an antibody titer less than 1: 160
No significant correlation was seen between canclidiasis and the results of the indirect
immunofluorescent test. But, considering the site of isolation, the antibody titer was
above I: 160 in all cases in• which candida was isolated from blood, whereas only4X'Y,
of samples in which candida was isolated from urine had an antibody titer above
I: 160 7% of cases in which candida was isolated from the vagina had an antibody
titer above I: 160. Patients suffering from systemic candidiasis had a decreased CD4/
CD8 lymphocyte ratio compared to normal subjects, whereas in vaginal and skin
candidiasis, the ratio had not differed significantly.
http://mjiri.iums.ac.ir/article-1-1318-en.html
http://mjiri.iums.ac.ir/article-1-1318-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
ANTI-BACTERIAL EFFECTS OF BISMUTH COMPOUNDS AND ITS SYNERGY WITH TETRACYCLINE AND METRONIDAZOLE ON HELICOBACTER PYLORl
201
204
EN
ADEL
RADJABI
From the Department of Microbiology, Medical School, Tarbiat Modarres University,Tehran, Islamic Republic 0f Iran.
Y
BAHRAM
FATOLLAH ZADEH
N
NASRIN
MOAZAMl
N
AKBAR
MIRSALEHIAN
N
HADI
GHOFRANI
N
A bacteriological investigation performed on the biopsies of 1 30 patients with
gastrointestinal disorders at the GI section of Imam Khomeini hospital concluded in
the isolation of 100 cases of Helicobacler pylori. The antibacterial effects of bismuth
salts alone and in synergy with tetracycline and metronidazole were evaluated on the
basis of disc diffusion method on 5 randomly selected pure cultures of H. pylori - the
main target - and 4 standard cultures of other bacteria including Staphylococcus
aureus (ATCC 25923), Brucella abortus (CS BPI- A 10 3) S99, Salmonella typhi (CS
BPI - 196) 0-90 I and Escherichia coli (A TCC 25922) in order to control the accuracy
of procedures.
In this research, growth inhibition zones by bismuth subcitrate (128 µg/disc
potency) were determined as 15 ± 2.4 mm diameter against H. pylori (mean ± SO),
and 15 ± 2.6, 20±3.1 and 14 ± 2.5 mm against the given standard cultures,
respectively, except for E. coli. Tetracycline (30 µg potency) produced inhibition
zones of 30 ± 2.6 mm against H. pylori and 30 ± 2.4,40 ± 2.9,25 ± 2. 3 and 21 ± 2.8
mm against the standard strains, respectively. Diameters of inhibition zones by
metronidazole were 4± I against H. pylori, and 3± 1.2, 8±2.4 and 3 ± 1. 3 mm against
the standard strains, respectively, except for the resistant E. coli.
[n another test in order to demonstrate the synergistic effects of bismuth
subcitrate together with the two mentioned antibacterial agents, a composition of 4
parts of bismuth subcitrate, one part tetracycline and 6 parts metronidazole was used
(359 µg potency). The obtained data were as follows: the growth inhibition zone
againstH. pylori was 40±3 mm and 42±2.2, 45±2.1, 35±2.6 and 27 ±2. 3 mm against
the control strains. Therefore, these results indicate that bismuth cubcitrate has a
remarkable antibacterial effect against H. pylori among the bismuth salts which
increases when used together with tetracycline and metronidazole in peptic ulcers.
http://mjiri.iums.ac.ir/article-1-1317-en.html
http://mjiri.iums.ac.ir/article-1-1317-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
DIAGNOSIS OF PRIMARY CARDIAC TUMORS: REPORT OF 30 CASES
197
199
EN
I
I. NAZERY
From the Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, I.R. Iran.
Y
A
GHAEMIAN
N
M
ESLAMI
N
Between I 9H I and 1993,30 cases of primary cardiac tumors were diagnosed
at the Imam Khomeini Hospital. 20 patients were female and 10 were male, with
an average age of 32 years (ranging from 17 days to 65 years of age). The mean
duration of symptoms before diagnosis was 6 months, with dyspnea and palpitation
being the most common symptoms (60%) and cardiac' murmurs the most usual
signs (X4%). The diagnosis of cardiac tumors was made by echocardiography in
all patients.
Transesophageal echocardiography and cardiac catheterization were
performed in X and LJ patients respectively for more precise localization of the
tumor and evaluation of the coronary arteries. The left atrium was the only site of
tumor in 60%. 4 patients had tumors in more than one chamber. 27 patients
underwent surgery without mortality while J patients did not undergo surgery.
Pathological examination revealed benign myxoma in 23 patients, fibroma (1
patient), round cell sarcoma (1 patient), chondrosarcoma (1 patient), liposarcoma
(1 patient), and undifferentiated sarcoma (1 patient).
Primary Cardic Tumors, Transesaphageal Echocardiology.
http://mjiri.iums.ac.ir/article-1-1316-en.html
http://mjiri.iums.ac.ir/article-1-1316-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
DOPPLER ECHOCARDIOGRAPHY IN SUBCLINICAL RHEUMATIC VALVULAR REGURGITATION: ALONGTERM STUDY
193
195
EN
M
BORZOEE
From the Department of Pediatrics, Division of Pediatric Cardiology, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Y
JH
AJAMI
N
Doppler echocardiography (DE) is known to be a valuable tool for detecting
subclinical forms of valvular regurgitation (VRJ in theacutephase of rheumatic fever
(RF). Previous studies have mostly dealt with the acute phase problem with only
short-term follow-up. In this study, 24 children between 4-15 years of age (mean age
II.X±2.7 years) with RF without clinically diagnosed carditis (most with arthritis)
who had two or more DE studies in the course of follow-up (more than 12 months)
were assessed utilizing DE.
Twenty-one patients had positive DE findings in one or more valve(s) (g7.5%).
VR disappeared within I -X months (mean 4.4±2.3mo.) in 9(42.8%) and persisted in
12 (57.2%) patients during 12-60 months follow-up, whereas DE in children with
normal heart structure was rarely associated with left-sided VR (P<0.001). Therefore
DE can be a more valuable tool for detection of acute and late phase disease, and
follow-up and prevention of RF, and since endocarditis may be the only significant
finding of organic cardiac involvement, it may be accepted as a major diagnostic
criterion.
Duppler ochocardiography, valvular regurgitation, rheumatic fever.
http://mjiri.iums.ac.ir/article-1-1315-en.html
http://mjiri.iums.ac.ir/article-1-1315-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
ADVERSE REACTIONS OF GOLD SODIUM THIOMALATE IN RHEUMATOID ARTHRI TIS PATIENTS IN SOUTHERN IRAN
189
192
EN
A
RAJAEE
From the Deparment of Medicine, Rheumatology Unit, Hafez Hospital, Shiraz University Of Medical Sciences, Shiraz, I.R. Iran.
Y
To confirm the side-effects of gold sodium thiomalate (GSTM), we carried
out a retrospective study examining 102 consecutive patients with rheumatoid
arthritis attending the Rheumatology Unit of Hafez Hospital, Shiraz, Iran, in
whom GSTM was initiated between 1983-1989. Only patients with classical or
definite RA (ARA criteria) we(e included in this study. Patients were categorized
as having developed toxicity to gold if rash, stomatitis, leukopenia «4000/mm3),
thrombocytopenia «IOO,000/mm3), anemia (Hb<10gm/dL), microscopic hematuria
(more than 5 RBC in each HPF) and proteinuria (1 +or more) appeared
during chrysotherapy. Sixty-six (64.7%) patients developed adverse reactions.
More significant side-effects were pruritus (57.8%), eosinophilia (23.5%),
microscopic hematuria (20.5%), and low Hb (20.5%). Inadequate primary
response and relapses on therapy accounted for termination in 15.6% of patients,
nephrotic syndrome in 0.9%, hepatitis in 1.9%, colitis in 2.9%, persistent pruritus
in 1.9%, extensive lichenoid rash in 3.9%, persistent stomal ulcer in 0.9% and
persistent hematuria in 1.9% of patients. Lichenoid rash was more significant and
more extensive in our series compared to others.
Gold therapy; eosinophilia; gold sodium thiomalale; rheumatoid arthritis; adverse.
http://mjiri.iums.ac.ir/article-1-1314-en.html
http://mjiri.iums.ac.ir/article-1-1314-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
IN TRAOPERATIVE RADIATION THERAPY FOR GASTRIC ADENOCARCINOMA
183
187
EN
B
SADEGHl-LOOYEH
From the Departments of Digestive Surgery and Radiotherapy, Centre Hospitalier Univesitaire Lyon Sud, 69495, Pierre Benite Cedex, France.
Y
FN
GILLY
N
PY
CARRY
N
AC
SAYAG
N
JB
GRIOT
N
P
ROMESTAING
N
I
SENTENAC
N
G
BRAILLON
N
JP
GERARD
N
Intraoperative radiation therapy (IORT) is a multidisciplinary approach in
which residual tumors or tumor beds are directly irradiated during a surgical
procedure. To evaluate its efficacy, from 1985, we conducted a prospective study
including non-metastatic gastric adenocarcinoma treated by surgery, IORT (15
Grays) and postoperative external beam radiotherapy (44 Grays). Up to 1993, 51
cases of gastric adenocarcinoma (20 pN0 and 31 pN1-2) have been included in the
study. Mortality and morbidity rates were not different from those of surgery alone.
The overall 5 year survival rate was 59.1 %, and the pN1N2 5 year survival rate was
50.6'70. These promising results are comparable with those of Asian randomized
studies which demonstrate the possible value of IORT in the treatment of gastric
adenocarcinoma.
Gastric adenocarcinoma. Radiotherapy. Intraoperative radiation therapy.
http://mjiri.iums.ac.ir/article-1-1313-en.html
http://mjiri.iums.ac.ir/article-1-1313-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
9
3
1995
10
1
RHEUMATIC FEVER IN lRANIAN CHILDREN: CLINICAL AND PREVENTIVE ASPECTS
179
182
EN
SHAHLA
ROODPEYMA
From the Department of Pediatrics, Ayatollah Taleghani Medical Center, Shahid Beheshti University of Medical Science, Tehran, I.R. Iran.
Y
A total of70 children aged 6 to 15 years with rheumatic fever and completed
in-hospital data were reviewed from 19XX to 1993. In 5X.6% of patients this was
the first attack of disease, while in 41.4'10 the episode represented a recurrence.
Noncompliance of antimicrobial prophylaxis was noted in all of the subjects with
recurrences. 61.4% of cases gave a previous history of sore throat, and inappropriate
or inadequate antibiotics had been prescribed for all of them. Carditis had occurred
in 76% of patients and 51 % of them had developed heart failure. Congestive heart
failure was three times more prevalent in recurrences than in initial attacks. The
study showed an urgent requirement for a national training program for all health
personnel (including doctors), along with the education of healthy children,
patients, and their families in order to establish effective primary and secondary
prophylaxis in this area.
http://mjiri.iums.ac.ir/article-1-1312-en.html
http://mjiri.iums.ac.ir/article-1-1312-en.pdf